| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
The involvement of P-glycoprotein in berberine absorption.
|
Pharmacol Toxicol
|
2002
|
1.24
|
|
2
|
Extensive intestinal first-pass elimination and predominant hepatic distribution of berberine explain its low plasma levels in rats.
|
Drug Metab Dispos
|
2010
|
1.23
|
|
3
|
Drugs as CYP3A probes, inducers, and inhibitors.
|
Drug Metab Rev
|
2007
|
1.17
|
|
4
|
Berberine promotes glucagon-like peptide-1 (7-36) amide secretion in streptozotocin-induced diabetic rats.
|
J Endocrinol
|
2008
|
1.10
|
|
5
|
High performance liquid chromatographic-mass spectrometric determination of ginsenoside Rg3 and its metabolites in rat plasma using solid-phase extraction for pharmacokinetic studies.
|
J Chromatogr B Analyt Technol Biomed Life Sci
|
2005
|
1.06
|
|
6
|
The antihyperglycaemic activity of berberine arises from a decrease of glucose absorption.
|
Planta Med
|
2003
|
1.05
|
|
7
|
Simple, sensitive and rapid LC-ESI-MS method for the quantitation of lafutidine in human plasma--application to pharmacokinetic studies.
|
J Pharm Biomed Anal
|
2005
|
1.00
|
|
8
|
Berberine suppresses intestinal disaccharidases with beneficial metabolic effects in diabetic states, evidences from in vivo and in vitro study.
|
Naunyn Schmiedebergs Arch Pharmacol
|
2010
|
0.99
|
|
9
|
Pharmacokinetic characterization of ginsenoside Rh2, an anticancer nutrient from ginseng, in rats and dogs.
|
Food Chem Toxicol
|
2009
|
0.96
|
|
10
|
Quantitative determination of ginsenoside Rh2 in rat biosamples by liquid chromatography electrospray ionization mass spectrometry.
|
Anal Bioanal Chem
|
2006
|
0.86
|
|
11
|
Uptake and metabolism of ginsenoside Rh2 and its aglycon protopanaxadiol by Caco-2 cells.
|
Biol Pharm Bull
|
2005
|
0.84
|
|
12
|
Warfarin maintenance dose adjustment with indirect pharmacodynamic model in rats.
|
Eur J Pharm Sci
|
2006
|
0.84
|
|
13
|
Skin solubility determines maximum transepidermal flux for similar size molecules.
|
Pharm Res
|
2009
|
0.84
|
|
14
|
Impaired expression and function of breast cancer resistance protein (Bcrp) in brain cortex of streptozocin-induced diabetic rats.
|
Biochem Pharmacol
|
2007
|
0.84
|
|
15
|
Huang-lian-jie-du-decoction modulates glucagon-like peptide-1 secretion in diabetic rats.
|
J Ethnopharmacol
|
2009
|
0.84
|
|
16
|
Strategies for integral metabolism profile of multiple compounds in herbal medicines: pharmacokinetics, metabolites characterization and metabolic interactions.
|
Curr Drug Metab
|
2011
|
0.83
|
|
17
|
Adeno-associated virus mediated interferon-gamma inhibits the progression of hepatic fibrosis in vitro and in vivo.
|
World J Gastroenterol
|
2005
|
0.82
|
|
18
|
Determination of ginsenoside Rd in dog plasma by liquid chromatography-mass spectrometry after solid-phase extraction and its application in dog pharmacokinetics studies.
|
J Chromatogr B Analyt Technol Biomed Life Sci
|
2007
|
0.82
|
|
19
|
Determination of betamethasone and betamethasone 17-monopropionate in human plasma by liquid chromatography-positive/negative electrospray ionization tandem mass spectrometry.
|
J Chromatogr B Analyt Technol Biomed Life Sci
|
2008
|
0.81
|
|
20
|
Effect of 21-day exposure of phenobarbital, carbamazepine and phenytoin on P-glycoprotein expression and activity in the rat brain.
|
J Neurol Sci
|
2008
|
0.81
|
|
21
|
Influence of UDP-glucuronosyltransferase polymorphisms on valproic acid pharmacokinetics in Chinese epilepsy patients.
|
Eur J Clin Pharmacol
|
2012
|
0.81
|
|
22
|
Increased oral AUC of baicalin in streptozotocin-induced diabetic rats due to the increased activity of intestinal beta-glucuronidase.
|
Planta Med
|
2009
|
0.80
|
|
23
|
Pharmacokinetic properties of S-adenosylmethionine after oral and intravenous administration of its tosylate disulfate salt: a multiple-dose, open-label, parallel-group study in healthy Chinese volunteers.
|
Clin Ther
|
2009
|
0.80
|
|
24
|
Adeno-associated virus mediated expression of human erythropoietin in vitro.
|
Acta Pharmacol Sin
|
2002
|
0.80
|
|
25
|
Sensitive determination of 20(S)-protopanaxadiol in rat plasma using HPLC-APCI-MS: application of pharmacokinetic study in rats.
|
J Pharm Biomed Anal
|
2008
|
0.80
|
|
26
|
Pharmacokinetics, tissue distribution and excretion of gambogic acid in rats.
|
Eur J Drug Metab Pharmacokinet
|
2007
|
0.80
|
|
27
|
Gender difference regarding schizandrin pharmacokinetics in rats.
|
Eur J Drug Metab Pharmacokinet
|
2008
|
0.80
|
|
28
|
Comprehensive chemical profiling of guizhi fuling capsule by the combined use of gas chromatography-mass spectrometry with a deconvolution software and rapid-resolution liquid chromatography quadrupole time-of-flight tandem mass spectrometry.
|
Biomed Chromatogr
|
2012
|
0.79
|
|
29
|
Study on the plasma protein binding rate of Schisandra lignans based on the LC-IT-TOF/MS technique with relative quantitative analysis.
|
Chin J Nat Med
|
2013
|
0.79
|
|
30
|
Pharmacokinetics of the ginkgo B following intravenous administration of ginkgo B emulsion in rats.
|
Biol Pharm Bull
|
2007
|
0.79
|
|
31
|
Pharmacokinetic interactions between 20(S)-ginsenoside Rh2 and the HIV protease inhibitor ritonavir in vitro and in vivo.
|
Acta Pharmacol Sin
|
2013
|
0.79
|
|
32
|
A new method for plasma citrate determination by reversed-phase high-performance liquid chromatography after ultrafiltration extraction: an example for bioequivalence evaluation of a medicinal endogenous substance.
|
Methods Find Exp Clin Pharmacol
|
2008
|
0.79
|
|
33
|
Hormonal regulation of dipeptide transporter (PepT1) in Caco-2 cells with normal and anoxia/reoxygenation management.
|
World J Gastroenterol
|
2003
|
0.78
|
|
34
|
Transport and uptake characteristics of a new derivative of berberine (CPU-86017) by human intestinal epithelial cell line: Caco-2.
|
Acta Pharmacol Sin
|
2003
|
0.78
|
|
35
|
Mechanism-based pharmacokinetic-pharmacodynamic modeling of the estrogen-like effect of ginsenoside Rb1 on neural 5-HT in ovariectomized mice.
|
Eur J Pharm Sci
|
2011
|
0.78
|
|
36
|
Liver transporters in hepatic drug disposition: an update.
|
Curr Drug Metab
|
2009
|
0.78
|
|
37
|
Effect of diammonium glycyrrhizinate on entecavir pharmacokinetics in rats.
|
Chin J Nat Med
|
2013
|
0.78
|
|
38
|
Metabolism and metabolic inhibition of cilnidipine in human liver microsomes.
|
Acta Pharmacol Sin
|
2003
|
0.78
|
|
39
|
Quantitative determination of ophiopogonin d by liquid chromatography/electrospray ionization mass spectrometry and its pharmacokinetics in rat.
|
Planta Med
|
2008
|
0.77
|
|
40
|
[Study of pharmacokinetics of aristolochic acid I and II in rats].
|
Zhongguo Zhong Yao Za Zhi
|
2008
|
0.77
|
|
41
|
CYP3A4 mediated in vitro metabolism of vinflunine in human liver microsomes.
|
Acta Pharmacol Sin
|
2007
|
0.77
|
|
42
|
P-glycoprotein restricted transport of nimodipine across blood-brain barrier.
|
Acta Pharmacol Sin
|
2003
|
0.77
|
|
43
|
Increased P-glycoprotein function and level after long-term exposure of four antiepileptic drugs to rat brain microvascular endothelial cells in vitro.
|
Neurosci Lett
|
2008
|
0.77
|
|
44
|
Simultaneous determination of docetaxel and ketoconazole in rat plasma by liquid chromatography/electrospray ionization tandem mass spectrometry.
|
Rapid Commun Mass Spectrom
|
2007
|
0.77
|
|
45
|
Determination of pitavastatin in human plasma via HPLC-ESI-MS/MS and subsequent application to a clinical study in healthy Chinese volunteers.
|
Clin Chim Acta
|
2007
|
0.77
|
|
46
|
[Pharmacokinetics of triptolide in Beagle dogs].
|
Yao Xue Xue Bao
|
2007
|
0.77
|
|
47
|
Influence of CYP2C19 loss-of-function variants on the antiplatelet effects and cardiovascular events in clopidogrel-treated Chinese patients undergoing percutaneous coronary intervention.
|
Eur J Clin Pharmacol
|
2012
|
0.77
|
|
48
|
Identification of tanshinone IIA metabolites in rat liver microsomes by liquid chromatography-tandem mass spectrometry.
|
J Chromatogr A
|
2006
|
0.77
|
|
49
|
Changes of biological functions of dipeptide transporter (PepT1) and hormonal regulation in severe scald rats.
|
World J Gastroenterol
|
2003
|
0.76
|
|
50
|
Characterization of metabolites of tanshinone IIA in rats by liquid chromatography/tandem mass spectrometry.
|
J Mass Spectrom
|
2006
|
0.76
|
|
51
|
The prediction of the hepatic clearance of tanshinone IIA in rat liver subcellular fractions: accuracy improvement.
|
Curr Drug Metab
|
2008
|
0.76
|
|
52
|
Influence of segmental and selected ion monitoring on quantitation of multi-component using high-pressure liquid chromatography-quadrupole mass spectrometry: Simultaneous detection of 16 saponins in rat plasma as a case.
|
J Chromatogr A
|
2010
|
0.76
|
|
53
|
Determination of gambogic acid in dog plasma by high-performance liquid chromatography for a pharmacokinetic study.
|
Biomed Chromatogr
|
2007
|
0.76
|
|
54
|
Effect of Huang-Lian-Jie-Du-Decoction on pharmacokinetics of verapamil in rats.
|
J Pharm Pharmacol
|
2010
|
0.76
|
|
55
|
Pharmacokinetics of recombinant human basic fibroblast growth factor in rabbits and mice serum and rabbits aqueous humor.
|
Acta Pharmacol Sin
|
2004
|
0.76
|
|
56
|
Pharmacokinetic-pharmacodynamic modeling of telmisartan using an indirect response model in spontaneously hypertensive rats.
|
Acta Pharmacol Sin
|
2007
|
0.75
|
|
57
|
Bioequivalence and pharmacokinetic comparison of a single 200-mg dose of meclofenoxate hydrochloride capsule and tablet formulations in healthy Chinese adult male volunteers: a randomized sequence, open-label, two-period crossover study.
|
Clin Ther
|
2008
|
0.75
|
|
58
|
Simultaneous determination of tanshinone IIA and its three hydroxylated metabolites by liquid chromatography/tandem mass spectrometry.
|
Rapid Commun Mass Spectrom
|
2006
|
0.75
|
|
59
|
[Application and development of in vitro metabolism study at early drug discovery stage].
|
Yao Xue Xue Bao
|
2013
|
0.75
|
|
60
|
Simultaneous determination of GFA and its active metabolites in human plasma by liquid chromatography electrospray ionization mass spectrometry and its application to pharmacokinetic studies.
|
J Pharm Biomed Anal
|
2007
|
0.75
|
|
61
|
Validation and application of an LC-ESI-MS method for simultaneous determination of astilbin and its major metabolite 3'-O-methylastilbin in rat plasma.
|
J Chromatogr B Analyt Technol Biomed Life Sci
|
2009
|
0.75
|
|
62
|
[Evaluation of myocardial ischemia rat model based on metabonomic method of small molecule metabolites of plasma and cardiac muscle].
|
Yao Xue Xue Bao
|
2013
|
0.75
|
|
63
|
Simultaneous quantification of oxysophocarpine and its active metabolite sophocarpine in rat plasma by liquid chromatography/mass spectrometry for a pharmacokinetic study.
|
Biomed Chromatogr
|
2007
|
0.75
|
|
64
|
Pharmacokinetics of clopidogrel in healthy Chinese volunteers.
|
Pharmazie
|
2012
|
0.75
|
|
65
|
Verapamil exerts biphasic modulation on phenobarbital transport across the blood-brain barrier: evidence from an in vivo and in vitro study.
|
Naunyn Schmiedebergs Arch Pharmacol
|
2011
|
0.75
|
|
66
|
[Effect of phospholipid on absorption of diammonium glycyrrhizinate].
|
Yao Xue Xue Bao
|
2008
|
0.75
|
|
67
|
[Metabonomic profiling of plasma metabolites in Wistar rats to study the effect of aging by means of GC/TOFMS-based techniques].
|
Yao Xue Xue Bao
|
2009
|
0.75
|
|
68
|
[Study on the extraction recovery of ginsenoside Re in plasma by different solid-phase cartridges].
|
Zhongguo Zhong Yao Za Zhi
|
2005
|
0.75
|
|
69
|
Determination of domperidone in human plasma by LC-MS and its pharmacokinetics in healthy Chinese volunteers.
|
Acta Pharmacol Sin
|
2002
|
0.75
|
|
70
|
[Metabonomic phenotype of "formula corresponding to pattern types" based on "qi and yin deficiency pattern" of myocardial ischemia rat model].
|
Yao Xue Xue Bao
|
2011
|
0.75
|
|
71
|
Simple, sensitive and rapid LC-MS method for the quantitation of indapamide in human plasma--application to pharmacokinetic studies.
|
J Chromatogr B Analyt Technol Biomed Life Sci
|
2006
|
0.75
|
|
72
|
Pharmacokinetics, tissue distribution, excretion, and metabolism of a new cardioprotective agent 10-O-dimethylaminoethylginkgolide B in rats.
|
J Asian Nat Prod Res
|
2012
|
0.75
|
|
73
|
[Progress in the role of farnesoid X receptor in metabolic regulation and tumor cell proliferation].
|
Sheng Li Xue Bao
|
2014
|
0.75
|
|
74
|
[Intestinal absorption barrier and novel strategies for absorption enhancement].
|
Yao Xue Xue Bao
|
2005
|
0.75
|
|
75
|
Determination of limonin in rat plasma by liquid chromatography-electrospray mass spectrometry.
|
J Pharm Biomed Anal
|
2005
|
0.75
|
|
76
|
CYP2C19 681G > A polymorphism and pharmacokinetics of clopidogrel in Chinese healthy volunteers.
|
Pharmazie
|
2012
|
0.75
|
|
77
|
[Fluorescence characteristic of terbium-ciprofloxacin complex and its application].
|
Guang Pu Xue Yu Guang Pu Fen Xi
|
2006
|
0.75
|
|
78
|
Development of a HPLC-MS assay for ginsenoside Rh2, a new anti-tumor substance from natural product and its pharacokinetic study in dogs.
|
Eur J Drug Metab Pharmacokinet
|
2005
|
0.75
|
|
79
|
Hypoglycemic efficacy of pulmonary delivered insulin dry powder aerosol in rats.
|
Acta Pharmacol Sin
|
2002
|
0.75
|
|
80
|
Simple, sensitive and rapid liquid chromatography/atmospheric pressure chemical ionization mass spectrometric method for the quantitation of Ranolazine in rat plasma.
|
Rapid Commun Mass Spectrom
|
2006
|
0.75
|
|
81
|
Pharmacokinetics, tissue distribution and excretion of vinflunine.
|
Eur J Drug Metab Pharmacokinet
|
2006
|
0.75
|
|
82
|
Identification of guanfu base A hydrochloride phase I and phase II metabolites in rat bile by liquid chromatography mass spectrometry.
|
Acta Pharmacol Sin
|
2002
|
0.75
|