Published in Lab Invest on November 10, 2008
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Klotho inhibits transforming growth factor-beta1 (TGF-beta1) signaling and suppresses renal fibrosis and cancer metastasis in mice. J Biol Chem (2011) 2.46
Assessment of renal fibrosis with diffusion-weighted MR imaging: study with murine model of unilateral ureteral obstruction. Radiology (2010) 2.08
Low-level laser therapy decreases renal interstitial fibrosis. Photomed Laser Surg (2012) 2.01
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TGF-β1 → SMAD/p53/USF2 → PAI-1 transcriptional axis in ureteral obstruction-induced renal fibrosis. Cell Tissue Res (2011) 1.37
Leptin promotes fibroproliferative acute respiratory distress syndrome by inhibiting peroxisome proliferator-activated receptor-γ. Am J Respir Crit Care Med (2011) 1.34
Autoimmune kidney disease and impaired engulfment of apoptotic cells in mice with macrophage peroxisome proliferator-activated receptor gamma or retinoid X receptor alpha deficiency. J Immunol (2010) 1.31
PPARγ downregulation by TGFß in fibroblast and impaired expression and function in systemic sclerosis: a novel mechanism for progressive fibrogenesis. PLoS One (2010) 1.29
miR-200b precursor can ameliorate renal tubulointerstitial fibrosis. PLoS One (2010) 1.23
Role of heme oxygenase in inflammation, insulin-signalling, diabetes and obesity. Mediators Inflamm (2010) 1.18
Induction of heme oxygenase-1 can halt and even reverse renal tubule-interstitial fibrosis. PLoS One (2010) 1.15
Curcumin inhibits transforming growth factor-β1-induced EMT via PPARγ pathway, not Smad pathway in renal tubular epithelial cells. PLoS One (2013) 1.07
Cellular and molecular mechanisms of intestinal fibrosis. World J Gastroenterol (2012) 1.07
PPAR-gamma agonist ameliorates kidney and liver disease in an orthologous rat model of human autosomal recessive polycystic kidney disease. Am J Physiol Renal Physiol (2010) 1.05
Childhood nephrotic syndrome--current and future therapies. Nat Rev Nephrol (2012) 1.02
Integrin alpha1beta1 regulates epidermal growth factor receptor activation by controlling peroxisome proliferator-activated receptor gamma-dependent caveolin-1 expression. Mol Cell Biol (2010) 1.00
Functional implications of microRNA-215 in TGF-β1-induced phenotypic transition of mesangial cells by targeting CTNNBIP1. PLoS One (2013) 0.99
Biomechanics of TGFβ-induced epithelial-mesenchymal transition: implications for fibrosis and cancer. Clin Transl Med (2014) 0.99
Pioglitazone Attenuates Cystic Burden in the PCK Rodent Model of Polycystic Kidney Disease. PPAR Res (2010) 0.99
The wound healing, chronic fibrosis, and cancer progression triad. Physiol Genomics (2014) 0.99
Evidence for the regulatory role of lipocalin 2 in high-fat diet-induced adipose tissue remodeling in male mice. Endocrinology (2013) 0.93
A synthetic PPAR-γ agonist triterpenoid ameliorates experimental fibrosis: PPAR-γ-independent suppression of fibrotic responses. Ann Rheum Dis (2013) 0.93
Inhibition of soluble epoxide hydrolase prevents renal interstitial fibrosis and inflammation. Am J Physiol Renal Physiol (2014) 0.91
Pharmacological inhibition of soluble epoxide hydrolase prevents renal interstitial fibrogenesis in obstructive nephropathy. Am J Physiol Renal Physiol (2014) 0.91
Congenital hepatic fibrosis in autosomal recessive polycystic kidney disease. Clin Transl Sci (2011) 0.89
Opposite action of peroxisome proliferator-activated receptor-gamma in regulating renal inflammation: functional switch by its ligand. J Biol Chem (2010) 0.89
Protective effects of PPARγ agonist in acute nephrotic syndrome. Nephrol Dial Transplant (2011) 0.88
Rosiglitazone inhibits transforming growth factor-β1 mediated fibrogenesis in ADPKD cyst-lining epithelial cells. PLoS One (2011) 0.86
Cardiac and renal protective effects of irbesartan via peroxisome proliferator-activated receptorγ-hepatocyte growth factor pathway independent of angiotensin II Type 1a receptor blockade in mouse model of salt-sensitive hypertension. J Am Heart Assoc (2013) 0.86
The orphan nuclear receptor SHP attenuates renal fibrosis. J Am Soc Nephrol (2009) 0.85
Electrophilic PPARγ ligands inhibit corneal fibroblast to myofibroblast differentiation in vitro: a potentially novel therapy for corneal scarring. Exp Eye Res (2011) 0.84
Enhancer of Zeste Homolog 2 Inhibition Attenuates Renal Fibrosis by Maintaining Smad7 and Phosphatase and Tensin Homolog Expression. J Am Soc Nephrol (2015) 0.84
Intronic polyadenylation of PDGFRα in resident stem cells attenuates muscle fibrosis. Nature (2016) 0.82
The Elusive Antifibrotic Macrophage. Front Med (Lausanne) (2015) 0.80
MicroRNA-27a promotes renal tubulointerstitial fibrosis via suppressing PPARγ pathway in diabetic nephropathy. Oncotarget (2016) 0.79
Localization of ανβ6 integrin-TGF-β1/Smad3, mTOR and PPARγ in experimental colorectal fibrosis. Eur J Histochem (2013) 0.79
Rosiglitazone inhibits TGF-β 1 induced activation of human Tenon fibroblasts via p38 signal pathway. PLoS One (2014) 0.79
Activation of PPARγ by Rosiglitazone does not negatively impact male sex steroid hormones in diabetic rats. PPAR Res (2009) 0.78
Thiazolidinedione-dependent activation of sphingosine kinase 1 causes an anti-fibrotic effect in renal mesangial cells. Br J Pharmacol (2012) 0.78
Lobeglitazone, a Novel Peroxisome Proliferator-Activated Receptor γ Agonist, Attenuates Renal Fibrosis Caused by Unilateral Ureteral Obstruction in Mice. Endocrinol Metab (Seoul) (2017) 0.77
Telmisartan ameliorates fibrocystic liver disease in an orthologous rat model of human autosomal recessive polycystic kidney disease. PLoS One (2013) 0.77
The renoprotective effect of L-carnitine in hypertensive rats is mediated by modulation of oxidative stress-related gene expression. Eur J Nutr (2012) 0.77
The Antifibrosis Effects of Peroxisome Proliferator-Activated Receptor δ on Rat Corneal Wound Healing after Excimer Laser Keratectomy. PPAR Res (2014) 0.76
Pharmacologic targets and peritoneal membrane remodeling. Perit Dial Int (2014) 0.76
Novel PPARγ Modulator GED-0507-34 Levo Ameliorates Inflammation-driven Intestinal Fibrosis. Inflamm Bowel Dis (2016) 0.76
Peroxisome Proliferator-Activated Receptor- γ in Thyroid Autoimmunity. PPAR Res (2015) 0.76
Peroxisome proliferator-activated receptor agonists: do they increase cardiovascular risk? PPAR Res (2009) 0.76
Effect of mesenchymal stem cells on anti-Thy1,1 induced kidney injury in albino rats. Asian Pac J Trop Biomed (2013) 0.76
Therapeutic Effects of Quercetin on Inflammation, Obesity, and Type 2 Diabetes. Mediators Inflamm (2016) 0.75
Renal tubular epithelium-targeted peroxisome proliferator-activated receptor-γ maintains the epithelial phenotype and antagonizes renal fibrogenesis. Oncotarget (2016) 0.75
Curcumin Suppresses Intestinal Fibrosis by Inhibition of PPARγ-Mediated Epithelial-Mesenchymal Transition. Evid Based Complement Alternat Med (2017) 0.75
Peroxisome proliferator-activated receptor-γ agonist troglitazone suppresses transforming growth factor-β1 signalling through miR-92b upregulation-inhibited Axl expression in human keloid fibroblasts in vitro. Am J Transl Res (2016) 0.75
Pathogenic pathways are activated in each major cell type of the glomerulus in the Cd2ap mutant mouse model of focal segmental glomerulosclerosis. BMC Nephrol (2015) 0.75
Effect of astragalus injection on renal tubular epithelial transdifferentiation in type 2 diabetic mice. BMC Complement Altern Med (2016) 0.75
Klotho inhibits transforming growth factor-beta1 (TGF-beta1) signaling and suppresses renal fibrosis and cancer metastasis in mice. J Biol Chem (2011) 2.46
Characterization of noncalcified coronary plaques and identification of culprit lesions in patients with acute coronary syndrome by 64-slice computed tomography. JACC Cardiovasc Imaging (2009) 2.20
Different MUC1 gene polymorphisms in German and Japanese ethnicities affect serum KL-6 levels. Respir Med (2012) 2.12
Assessment of renal fibrosis with diffusion-weighted MR imaging: study with murine model of unilateral ureteral obstruction. Radiology (2010) 2.08
Significance of bronchoalveolar lavage for the diagnosis of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med (2009) 1.88
Comparative study of KL-6, surfactant protein-A, surfactant protein-D, and monocyte chemoattractant protein-1 as serum markers for interstitial lung diseases. Am J Respir Crit Care Med (2002) 1.84
Airflow limitation in smokers is associated with subclinical atherosclerosis. Am J Respir Crit Care Med (2008) 1.83
Elevation of KL-6, a lung epithelial cell marker, in plasma and epithelial lining fluid in acute respiratory distress syndrome. Am J Physiol Lung Cell Mol Physiol (2003) 1.82
Vascular calcification in chronic kidney disease. Am J Kidney Dis (2004) 1.81
Angiotensin II induces thrombospondin-1 production in human mesangial cells via p38 MAPK and JNK: a mechanism for activation of latent TGF-beta1. Am J Physiol Renal Physiol (2003) 1.79
Dikkopf-1 as a novel serologic and prognostic biomarker for lung and esophageal carcinomas. Cancer Res (2007) 1.68
Prospective versus retrospective ECG-gated 64-detector coronary CT angiography: assessment of image quality, stenosis, and radiation dose. Radiology (2008) 1.65
Pulse wave velocity predicts cardiovascular mortality: findings from the Hawaii-Los Angeles-Hiroshima study. Circ J (2005) 1.62
White blood cell count, especially neutrophil count, as a predictor of hypertension in a Japanese population. Hypertens Res (2008) 1.54
Anti-Ku antibody-positive scleroderma-dermatomyositis overlap syndrome developing Graves' disease and immune thrombocytopenic purpura. Intern Med (2002) 1.49
Production of eosinophilic chemokines by normal pleural mesothelial cells. Am J Respir Cell Mol Biol (2002) 1.46
Neutropenic enterocolitis in lung cancer: a report of two cases and a review of the literature. Intern Med (2005) 1.45
Decreased total and high molecular weight adiponectin are independent risk factors for the development of type 2 diabetes in Japanese-Americans. J Clin Endocrinol Metab (2006) 1.43
Identification of nectin-4 oncoprotein as a diagnostic and therapeutic target for lung cancer. Cancer Res (2009) 1.42
Prognosis and risk factors for idiopathic membranous nephropathy with nephrotic syndrome in Japan. Kidney Int (2004) 1.42
Effect of glucose polymer on the intercellular junctions of cultured human peritoneal mesothelial cells. Nephron Clin Pract (2003) 1.42
Visceral fat accumulation as a predictor of coronary artery calcium as assessed by multislice computed tomography in Japanese patients. Atherosclerosis (2008) 1.42
Cancer-testis antigen lymphocyte antigen 6 complex locus K is a serologic biomarker and a therapeutic target for lung and esophageal carcinomas. Cancer Res (2007) 1.42
Different risk factors for the maximum and the mean carotid intima-media thickness in hemodialysis patients. Intern Med (2003) 1.39
Aminopeptidase N is involved in cell motility and angiogenesis: its clinical significance in human colon cancer. Gastroenterology (2002) 1.39
Gene expression profiles of small-cell lung cancers: molecular signatures of lung cancer. Int J Oncol (2006) 1.38
Bone mineral density may be related to atherosclerosis in hemodialysis patients. Osteoporos Int (2003) 1.38
Prognostic value of circulating KL-6 in idiopathic pulmonary fibrosis. Respirology (2006) 1.37
Prediction of sensitivity of advanced non-small cell lung cancers to gefitinib (Iressa, ZD1839). Hum Mol Genet (2004) 1.35
Paramyxovirus Sendai virus-like particle formation by expression of multiple viral proteins and acceleration of its release by C protein. Virology (2004) 1.34
DEC1 modulates the circadian phase of clock gene expression. Mol Cell Biol (2008) 1.31
Wnt inhibitor Dickkopf-1 as a target for passive cancer immunotherapy. Cancer Res (2010) 1.31
Adoptive transfer studies demonstrate that macrophages can induce proteinuria and mesangial cell proliferation. Kidney Int (2003) 1.30
Utility of KL-6/MUC1 in the clinical management of interstitial lung diseases. Respir Investig (2012) 1.29
Low heart rate variability is a risk factor for sudden cardiac death in type 2 diabetes. Diabetes Res Clin Pract (2004) 1.28
Increased plasma ghrelin level in lung cancer cachexia. Clin Cancer Res (2003) 1.27
Erlotinib efficacy and cerebrospinal fluid concentration in patients with lung adenocarcinoma developing leptomeningeal metastases during gefitinib therapy. Cancer Chemother Pharmacol (2011) 1.24
Increases of amphiregulin and transforming growth factor-alpha in serum as predictors of poor response to gefitinib among patients with advanced non-small cell lung cancers. Cancer Res (2005) 1.24
Suppression of plasminogen activator inhibitor-1 by RNA interference attenuates pulmonary fibrosis. Thorax (2010) 1.23
Effect of a carbonaceous oral adsorbent on the progression of CKD: a multicenter, randomized, controlled trial. Am J Kidney Dis (2009) 1.23
A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta. J Biol Chem (2002) 1.22
Elevated C-reactive protein is a risk factor for the development of type 2 diabetes in Japanese Americans. Diabetes Care (2003) 1.18
Phthalic acid diamides activate ryanodine-sensitive Ca2+ release channels in insects. Cell Calcium (2005) 1.14
Association between visceral adipose tissue area and coronary plaque morphology assessed by CT angiography. JACC Cardiovasc Imaging (2010) 1.13
The role of p38alpha mitogen-activated protein kinase activation in renal fibrosis. J Am Soc Nephrol (2004) 1.12
Westernization of lifestyle markedly increases carotid intima-media wall thickness (IMT) in Japanese people. Atherosclerosis (2003) 1.12
Polymorphisms in the thymidylate synthase and methylenetetrahydrofolate reductase genes and sensitivity to the low-dose methotrexate therapy in patients with rheumatoid arthritis. Int J Mol Med (2003) 1.12
Identification of Epstein-Barr virus-induced gene 3 as a novel serum and tissue biomarker and a therapeutic target for lung cancer. Clin Cancer Res (2011) 1.11
ADAM8 as a novel serological and histochemical marker for lung cancer. Clin Cancer Res (2004) 1.10
Role of osteoprotegerin in arterial calcification: development of new animal model. Arterioscler Thromb Vasc Biol (2007) 1.09
Effects of icodextrin on glycemic and lipid profiles in diabetic patients undergoing peritoneal dialysis. Am J Nephrol (2007) 1.08
Telomerase expression in noncancerous bronchial epithelia is a possible marker of early development of lung cancer. Cancer Res (2005) 1.08
Signal transducer and activator of transcription 3 involvement in the development of renal interstitial fibrosis after unilateral ureteral obstruction. Nephrology (Carlton) (2007) 1.08
Circulating visfatin level is correlated with inflammation, but not with insulin resistance. Clin Endocrinol (Oxf) (2007) 1.08
Ultra-short echo time (UTE) MR imaging of the lung: comparison between normal and emphysematous lungs in mutant mice. J Magn Reson Imaging (2010) 1.05
Activation of KIF4A as a prognostic biomarker and therapeutic target for lung cancer. Clin Cancer Res (2007) 1.04
Associations between small dense LDL, HDL subfractions (HDL2, HDL3) and risk of atherosclerosis in Japanese-Americans. J Atheroscler Thromb (2011) 1.04
MUC5B promoter polymorphism in Japanese patients with idiopathic pulmonary fibrosis. Respirology (2015) 1.04
Intra-airway administration of small interfering RNA targeting plasminogen activator inhibitor-1 attenuates allergic asthma in mice. Am J Physiol Lung Cell Mol Physiol (2011) 1.03
Elevated white blood cell count in subjects with impaired glucose tolerance. Diabetes Care (2004) 1.03
Effectiveness of Semmes-Weinstein monofilament examination for diabetic peripheral neuropathy screening. J Diabetes Complications (2005) 1.03
Ghrelin improves endothelial dysfunction through growth hormone-independent mechanisms in rats. Biochem Biophys Res Commun (2003) 1.01
Integrin alpha3 expression as a prognostic factor in colon cancer: association with MRP-1/CD9 and KAI1/CD82. Int J Cancer (2002) 1.01
Effect of aerobic exercise training on oxidative stress in patients with type 2 diabetes mellitus. Metabolism (2008) 1.01
Endobronchial ultrasonography in the assessment of centrally located early-stage lung cancer before photodynamic therapy. Am J Respir Crit Care Med (2002) 1.00
A protective effect of adiponectin against oxidative stress in Japanese Americans: the association between adiponectin or leptin and urinary isoprostane. Metabolism (2005) 1.00
KL-6, a human MUC1 mucin, promotes proliferation and survival of lung fibroblasts. Biochem Biophys Res Commun (2005) 1.00
Influence of the extent of westernization of lifestyle on the progression of preclinical atherosclerosis in Japanese subjects. J Atheroscler Thromb (2002) 1.00
Mesenchymal stem cells ameliorate experimental peritoneal fibrosis by suppressing inflammation and inhibiting TGF-β1 signaling. Kidney Int (2013) 0.99
Development of serum glycoproteomic profiling technique; simultaneous identification of glycosylation sites and site-specific quantification of glycan structure changes. Mol Cell Proteomics (2010) 0.98
Comprehensive evaluation of noncalcified coronary plaque characteristics detected using 64-slice computed tomography in patients with proven or suspected coronary artery disease. Am Heart J (2007) 0.98
Circulating KL-6/MUC1 mucin carrying sialyl Lewisa oligosaccharide is an independent prognostic factor in patients with lung adenocarcinoma. Int J Cancer (2007) 0.98
The single nucleotide polymorphism upstream of insulin-induced gene 2 ( INSIG2) is associated with the prevalence of hypercholesterolaemia, but not with obesity, in Japanese American women. Br J Nutr (2008) 0.98
Activation of signal transducer and activator of transcription 3 correlates with cell proliferation and renal injury in human glomerulonephritis. Nephrol Dial Transplant (2008) 0.97
Suberoylanilide hydroxamic acid enhances gap junctional intercellular communication via acetylation of histone containing connexin 43 gene locus. Cancer Res (2005) 0.97
Directional disorientation following left retrosplenial hemorrhage: a case report with fMRI studies. Cortex (2007) 0.96
Serum leptin and adiponectin are positively associated with bone mineral density at the distal radius in patients with type 2 diabetes mellitus. Metabolism (2007) 0.95
Effect of CPAP on brachial-ankle pulse wave velocity in patients with OSAHS: an open-labelled study. Respir Med (2006) 0.95
Molecular characterization of flubendiamide sensitivity in the lepidopterous ryanodine receptor Ca(2+) release channel. Biochemistry (2009) 0.94
Prevalence of metabolic syndrome compared between native Japanese and Japanese-Americans. Diabetes Res Clin Pract (2007) 0.94