Published in Cytotechnology on April 21, 2007
Continuous cultures of fused cells secreting antibody of predefined specificity. Nature (1975) 83.56
Phage antibodies: filamentous phage displaying antibody variable domains. Nature (1990) 8.67
Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells. J Biol Chem (1999) 6.67
By-passing immunization. Human antibodies from V-gene libraries displayed on phage. J Mol Biol (1991) 6.62
Potent antibody therapeutics by design. Nat Rev Immunol (2006) 4.87
Reshaping human antibodies for therapy. Nature (1988) 4.82
Selecting and screening recombinant antibody libraries. Nat Biotechnol (2005) 4.51
Monoclonal antibody successes in the clinic. Nat Biotechnol (2005) 4.43
Replacing the complementarity-determining regions in a human antibody with those from a mouse. Nature (1986) 4.19
Chimeric human antibody molecules: mouse antigen-binding domains with human constant region domains. Proc Natl Acad Sci U S A (1984) 3.32
AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts. Science (2002) 3.09
Differences in promiscuity for antibody-FcRn interactions across species: implications for therapeutic antibodies. Int Immunol (2001) 2.87
Improving the efficacy of antibody-based cancer therapies. Nat Rev Cancer (2001) 2.69
Antigen-specific human antibodies from mice comprising four distinct genetic modifications. Nature (1994) 2.39
Production of functional chimaeric mouse/human antibody. Nature (1985) 2.35
Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas. Nature (2002) 2.35
Establishment of FUT8 knockout Chinese hamster ovary cells: an ideal host cell line for producing completely defucosylated antibodies with enhanced antibody-dependent cellular cytotoxicity. Biotechnol Bioeng (2004) 2.22
Human antibodies from transgenic animals. Nat Biotechnol (2005) 2.04
Reshaping human antibodies: grafting an antilysozyme activity. Science (1988) 1.92
In vitro immunization of human peripheral blood lymphocytes: establishment of B cell lines secreting IgM specific for cholera toxin B subunit from lymphocytes stimulated with IL-2 and IL-4. Cytotechnology (1999) 1.88
Antibodies from phage antibody libraries. J Immunol Methods (2004) 1.75
In vitro antibody evolution targeting germline hot spots to increase activity of an anti-CD22 immunotoxin. J Biol Chem (2004) 1.54
Antigen-specific human monoclonal antibodies from mice engineered with human Ig heavy and light chain YACs. Nat Genet (1994) 1.50
Overview of antibody phage-display technology and its applications. Methods Mol Biol (2002) 1.27
Antibody engineering: facing new challenges in cancer therapy. Acta Pharmacol Sin (2005) 1.14
Generation and production of engineered antibodies. Mol Biotechnol (2004) 0.94
Different individual immune responses elicited by in vitro immunization. Cytotechnology (2002) 0.90
Minimizing the immunogenicity of antibodies for clinical application. Tumour Biol (2005) 0.89
Tailor-made antibody therapeutics. Methods (2005) 0.84
Combinatorial protein biochemistry for therapeutics and proteomics. Curr Pharm Biotechnol (2004) 0.79
Kinetic analysis of superoxide anion radical-scavenging and hydroxyl radical-scavenging activities of platinum nanoparticles. Langmuir (2008) 1.21
Enzyme-digested Fucoidan Extracts Derived from Seaweed Mozuku of Cladosiphon novae-caledoniae kylin Inhibit Invasion and Angiogenesis of Tumor Cells. Cytotechnology (2005) 1.19
Retinoic acid improves a hybridoma culture in a fructose-based medium by up-regulation of fructose incorporation via retinoid nuclear receptors. Biosci Biotechnol Biochem (2006) 1.18
Fucoidan extract induces apoptosis in MCF-7 cells via a mechanism involving the ROS-dependent JNK activation and mitochondria-mediated pathways. PLoS One (2011) 1.17
Extension of the lifespan of Caenorhabditis elegans by the use of electrolyzed reduced water. Biosci Biotechnol Biochem (2010) 1.08
Protective mechanism of reduced water against alloxan-induced pancreatic beta-cell damage: Scavenging effect against reactive oxygen species. Cytotechnology (2002) 1.07
IL-10 augments antibody production in in vitro immunized lymphocytes by inducing a Th2-type response and B cell maturation. Biosci Biotechnol Biochem (2004) 1.04
Molecular hydrogen reduces LPS-induced neuroinflammation and promotes recovery from sickness behaviour in mice. PLoS One (2012) 1.03
Suppressive effects of electrolyzed reduced water on alloxan-induced apoptosis and type 1 diabetes mellitus. Cytotechnology (2010) 0.98
Different individual immune responses elicited by in vitro immunization. Cytotechnology (2002) 0.90
Fucoidan extract enhances the anti-cancer activity of chemotherapeutic agents in MDA-MB-231 and MCF-7 breast cancer cells. Mar Drugs (2013) 0.90
Inhibitory effect of electrolyzed reduced water on tumor angiogenesis. Biol Pharm Bull (2008) 0.89
Protein kinase C delta plays a key role in cellular senescence programs of human normal diploid cells. J Biochem (2009) 0.87
Generation of a human anti-tumor necrosis factor-α monoclonal antibody by in vitro immunization with a multiple antigen peptide. Biosci Biotechnol Biochem (2010) 0.84
Suppressive effects of natural reduced waters on alloxan-induced apoptosis and type 1 diabetes mellitus. Cytotechnology (2011) 0.82
Propionibacterium acnes acts as an adjuvant in in vitro immunization of human peripheral blood mononuclear cells. Biosci Biotechnol Biochem (2007) 0.82
Mechanism of the lifespan extension of Caenorhabditis elegans by electrolyzed reduced water--participation of Pt nanoparticles. Biosci Biotechnol Biochem (2011) 0.82
Protective effects of the fermented milk Kefir on X-ray irradiation-induced intestinal damage in B6C3F1 mice. Biol Pharm Bull (2012) 0.81
In vitro immunization can elicit the expansion of diverse repertoire of B cells from peripheral blood mononuclear cells. Cytotechnology (2006) 0.81
Anti-peptide antibody production elicited by in vitro immunization of human peripheral blood mononuclear cells. Biosci Biotechnol Biochem (2007) 0.81
Decreased tumorigenicity in vivo when transforming growth factor beta treatment causes cancer cell senescence. Biosci Biotechnol Biochem (2003) 0.81
Regulatory mechanisms of human and mouse telomerase reverse transcriptase gene transcription: distinct dependency on c-Myc. Cytotechnology (2010) 0.80
Fermented milk, Kefram-Kefir enhances glucose uptake into insulin-responsive muscle cells. Cytotechnology (2002) 0.80
A regulatable selective system facilitates isolation of heterologous protein hyper-producing mammalian cells without gene amplification. Cytotechnology (2002) 0.80
Functional impairment of telomerase in sublines derived from human lung adenocarcinoma exposed to mild oxidative stress. Biochem Biophys Res Commun (2005) 0.79
The protective effect of fermented milk kefir on radiation-induced apoptosis in colonic crypt cells of rats. J Radiat Res (2003) 0.79
Induction of apoptosis by low-molecular-weight fucoidan through calcium- and caspase-dependent mitochondrial pathways in MDA-MB-231 breast cancer cells. Biosci Biotechnol Biochem (2013) 0.79
Suppressive effects of electrochemically reduced water on matrix metalloproteinase-2 activities and in vitro invasion of human fibrosarcoma HT1080 cells. Cytotechnology (2012) 0.78
Production of human monoclonal antibodies against Fc(epsilon)RI(alpha) by a method combining in vitro immunization with phage display. Biosci Biotechnol Biochem (2009) 0.78
Construction of an in vitro allergy reaction evaluation system using human leukemia cell lines. Cytotechnology (2002) 0.77
An Approach to Further Enhance the Cellular Productivity of Exogenous Protein Hyper-producing Chinese Hamster Ovary (CHO) Cells. Cytotechnology (2005) 0.77
A hybrid system using both promoter activation and gene amplification for establishing exogenous protein hyper-producing cell lines. Cytotechnology (2003) 0.77
Electrolyzed Reduced Water Supplemented with Platinum Nanoparticles Suppresses Promotion of Two-stage Cell Transformation. Cytotechnology (2005) 0.76
A rapid and efficient strategy to generate antigen-specific human monoclonal antibody by in vitro immunization and the phage display method. J Immunol Methods (2008) 0.76
NFAT5 regulates transcription of the mouse telomerase reverse transcriptase gene. Exp Cell Res (2010) 0.76
Catalyser-21(TM), a mineral water derived from leaf soil, inhibits tumor cell invasion and angiogenesis. Cytotechnology (2007) 0.75
Generation of human monoclonal antibodies against Propionibacterium acnes by applying the phage display method to human peripheral blood mononuclear cells immunized in vitro. Cytotechnology (2008) 0.75
Involvement of IL-10 in the suppression of antibody production by in vitro immunized peripheral blood mononuclear cells. Cytotechnology (2007) 0.75
In vitro immunization of Epstein-Barr virus-immortalized B cells augments antigen-specific antibody production. Cytotechnology (2013) 0.75
Suppression of UVC-induced cell damage and enhancement of DNA repair by the fermented milk, Kefir. Cytotechnology (2002) 0.75
Erratum to: Catalyser-21™, a mineral water derived from leaf soil, inhibits tumor cell invasion and angiogenesis. Cytotechnology (2014) 0.75
Erratum to: Suppression of UVC-induced cell damage and enhancement of DNA repair by the fermented milk, Kefir. Cytotechnology (2012) 0.75
Erratum to: Suppressive effects of natural reduced waters on alloxan-induced apoptosis and type 1 diabetes mellitus. Cytotechnology (2012) 0.75
Preface. Cytotechnology (2012) 0.75
Erratum to: Preface. Cytotechnology (2012) 0.75
Construction of a regulatable cancer-specific adenoviral expression system using human telomerase reverse transcriptase gene promoter. Biosci Biotechnol Biochem (2008) 0.75
Preface. Cytotechnology (2013) 0.75
Antigen-specific in vitro immunization: a source for human monoclonal antibodies. Methods Mol Biol (2014) 0.75
A rapid screening and production method using a novel mammalian cell display to isolate human monoclonal antibodies. Biochem Biophys Res Commun (2013) 0.75
Preface. Cytotechnology (2009) 0.75
Identification of genes involved in the suppression of antibody production from human peripheral blood lymphocytes. Biosci Biotechnol Biochem (2006) 0.75
Pro-senescent effect of hydrogen peroxide on cancer cells and its possible application to tumor suppression. Biosci Biotechnol Biochem (2009) 0.75
Preface. Cytotechnology (2010) 0.75
Increased antibody production by retinoids is related to the fusion partner of human hybridomas. Biosci Biotechnol Biochem (2002) 0.75
Preface. Cytotechnology (2011) 0.75