PubRank

Luc Van Kaer

Author PubWeight™ 139.40‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 NKT cells: what's in a name? Nat Rev Immunol 2004 7.84
2 Glycolipid antigen induces long-term natural killer T cell anergy in mice. J Clin Invest 2005 2.85
3 The response of natural killer T cells to glycolipid antigens is characterized by surface receptor down-modulation and expansion. Proc Natl Acad Sci U S A 2003 2.62
4 Natural killer T cell ligand alpha-galactosylceramide enhances protective immunity induced by malaria vaccines. J Exp Med 2002 2.38
5 CD1d-restricted human natural killer T cells are highly susceptible to human immunodeficiency virus 1 infection. J Exp Med 2002 2.00
6 Osteopontin as a mediator of NKT cell function in T cell-mediated liver diseases. Immunity 2004 1.93
7 Transforming growth factor beta is dispensable for the molecular orchestration of Th17 cell differentiation. J Exp Med 2009 1.89
8 Granulocyte-macrophage colony-stimulating factor regulates effector differentiation of invariant natural killer T cells during thymic ontogeny. Immunity 2006 1.82
9 Defective presentation of the CD1d1-restricted natural Va14Ja18 NKT lymphocyte antigen caused by beta-D-glucosylceramide synthase deficiency. Proc Natl Acad Sci U S A 2003 1.80
10 In vivo role of ER-associated peptidase activity in tailoring peptides for presentation by MHC class Ia and class Ib molecules. J Exp Med 2006 1.79
11 Quantitative and qualitative differences in the in vivo response of NKT cells to distinct alpha- and beta-anomeric glycolipids. J Immunol 2004 1.73
12 Expansion of regulatory T cells via IL-2/anti-IL-2 mAb complexes suppresses experimental myasthenia. Eur J Immunol 2010 1.72
13 Central nervous system (CNS)-resident natural killer cells suppress Th17 responses and CNS autoimmune pathology. J Exp Med 2010 1.70
14 Follicular B cell trafficking within the spleen actively restricts humoral immune responses. Immunity 2010 1.69
15 Interleukin-2/interleukin-2 antibody therapy induces target organ natural killer cells that inhibit central nervous system inflammation. Ann Neurol 2011 1.67
16 Distinct roles of dendritic cells and B cells in Va14Ja18 natural T cell activation in vivo. J Immunol 2005 1.67
17 CD4+CD25+ Tregs and NKT cells: regulators regulating regulators. Trends Immunol 2006 1.66
18 Evidence for a role of immunoproteasomes in regulating cardiac muscle mass in diabetic mice. J Mol Cell Cardiol 2010 1.61
19 De novo central nervous system processing of myelin antigen is required for the initiation of experimental autoimmune encephalomyelitis. J Immunol 2002 1.58
20 NK T cells contribute to expansion of CD8(+) T cells and amplification of antiviral immune responses to respiratory syncytial virus. J Virol 2002 1.55
21 Natural killer T cells and autoimmune disease. Curr Mol Med 2009 1.55
22 NF-kappa B controls cell fate specification, survival, and molecular differentiation of immunoregulatory natural T lymphocytes. J Immunol 2004 1.51
23 Organ-specific features of natural killer cells. Nat Rev Immunol 2011 1.48
24 Early secreted antigen ESAT-6 of Mycobacterium tuberculosis promotes protective T helper 17 cell responses in a toll-like receptor-2-dependent manner. PLoS Pathog 2011 1.46
25 NK cells promote islet allograft tolerance via a perforin-dependent mechanism. Nat Med 2005 1.45
26 Immunoregulatory role of CD1d in the hydrocarbon oil-induced model of lupus nephritis. J Immunol 2003 1.44
27 Reciprocal regulation between natural killer cells and autoreactive T cells. Nat Rev Immunol 2006 1.42
28 Cutting edge: the ontogeny and function of Va14Ja18 natural T lymphocytes require signal processing by protein kinase C theta and NF-kappa B. J Immunol 2004 1.41
29 Commitment toward the natural T (iNKT) cell lineage occurs at the CD4+8+ stage of thymic ontogeny. Proc Natl Acad Sci U S A 2005 1.40
30 Another view of T cell antigen recognition: cooperative engagement of glycolipid antigens by Va14Ja18 natural T(iNKT) cell receptor [corrected]. J Immunol 2003 1.38
31 Activation of invariant natural killer T cells by lipid excess promotes tissue inflammation, insulin resistance, and hepatic steatosis in obese mice. Proc Natl Acad Sci U S A 2012 1.35
32 Cooperation of invariant NKT cells and CD4+CD25+ T regulatory cells in the prevention of autoimmune myasthenia. J Immunol 2005 1.35
33 IFN-gamma-mediated inhibition of tumor angiogenesis by natural killer T-cell ligand, alpha-galactosylceramide. Blood 2002 1.34
34 Cutting edge: V alpha 14-J alpha 281 NKT cells naturally regulate experimental autoimmune encephalomyelitis in nonobese diabetic mice. J Immunol 2002 1.31
35 Repeated alpha-galactosylceramide administration results in expansion of NK T cells and alleviates inflammatory dermatitis in MRL-lpr/lpr mice. J Immunol 2003 1.29
36 IL-15 regulates homeostasis and terminal maturation of NKT cells. J Immunol 2011 1.29
37 Natural killer T cells accelerate atherogenesis in mice. Blood 2004 1.28
38 Nonredundant roles for CD1d-restricted natural killer T cells and conventional CD4+ T cells in the induction of immunoglobulin E antibodies in response to interleukin 18 treatment of mice. J Exp Med 2003 1.28
39 Direct effects of T-bet and MHC class I expression, but not STAT1, on peripheral NK cell maturation. Eur J Immunol 2005 1.27
40 The natural killer T cell ligand alpha-galactosylceramide prevents or promotes pristane-induced lupus in mice. Eur J Immunol 2005 1.20
41 Impact of bacteria on the phenotype, functions, and therapeutic activities of invariant NKT cells in mice. J Clin Invest 2008 1.19
42 Quantitative and qualitative differences in proatherogenic NKT cells in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 2004 1.19
43 CD1d deficiency exacerbates inflammatory dermatitis in MRL-lpr/lpr mice. Eur J Immunol 2004 1.18
44 Examining the role of CD1d and natural killer T cells in the development of nephritis in a genetically susceptible lupus model. Arthritis Rheum 2007 1.18
45 Immunotherapy with ligands of natural killer T cells. Trends Mol Med 2002 1.17
46 CD1d1-dependent control of the magnitude of an acute antiviral immune response. J Immunol 2004 1.16
47 Mucosal memory CD8⁺ T cells are selected in the periphery by an MHC class I molecule. Nat Immunol 2011 1.15
48 Natural killer T cells restricted by the monomorphic MHC class 1b CD1d1 molecules behave like inflammatory cells. J Immunol 2002 1.15
49 Ischemic preconditioning-induced cardioprotection is lost in mice with immunoproteasome subunit low molecular mass polypeptide-2 deficiency. FASEB J 2008 1.14
50 Thymus leukemia antigen controls intraepithelial lymphocyte function and inflammatory bowel disease. Proc Natl Acad Sci U S A 2008 1.14
51 Cutting edge: K63-linked polyubiquitination of NEMO modulates TLR signaling and inflammation in vivo. J Immunol 2008 1.11
52 Natural killer T cells and CD8+ T cells are dispensable for T cell-dependent allergic airway inflammation. Nat Med 2006 1.10
53 Identification and simian immunodeficiency virus infection of CD1d-restricted macaque natural killer T cells. J Virol 2003 1.08
54 Stimulation of host NKT cells by synthetic glycolipid regulates acute graft-versus-host disease by inducing Th2 polarization of donor T cells. J Immunol 2005 1.06
55 iNKT-cell responses to glycolipids. Crit Rev Immunol 2005 1.03
56 Mycobacterium tuberculosis evades host immunity by recruiting mesenchymal stem cells. Proc Natl Acad Sci U S A 2010 1.02
57 Endonuclease G is required for early embryogenesis and normal apoptosis in mice. Proc Natl Acad Sci U S A 2003 1.02
58 Inhibition of antitumor immunity by invariant natural killer T cells in a T-cell lymphoma model in vivo. Int J Cancer 2006 1.02
59 TL and CD8αα: Enigmatic partners in mucosal immunity. Immunol Lett 2010 1.01
60 Mycobacterium tuberculosis controls microRNA-99b (miR-99b) expression in infected murine dendritic cells to modulate host immunity. J Biol Chem 2012 1.01
61 Impaired autophagy, defective T cell homeostasis, and a wasting syndrome in mice with a T cell-specific deletion of Vps34. J Immunol 2013 0.99
62 NK cells, but not NKT cells, are involved in Pseudomonas aeruginosa exotoxin A-induced hepatotoxicity in mice. J Immunol 2004 0.98
63 Autoreactive T cells mediate NK cell degeneration in autoimmune disease. J Immunol 2006 0.97
64 Human natural killer T cells are heterogeneous in their capacity to reprogram their effector functions. PLoS One 2006 0.97
65 Reducing the activity and secretion of microbial antioxidants enhances the immunogenicity of BCG. PLoS One 2009 0.97
66 T cells from Programmed Death-1 deficient mice respond poorly to Mycobacterium tuberculosis infection. PLoS One 2011 0.97
67 The Ig-like domain of tapasin influences intermolecular interactions. J Immunol 2004 0.97
68 Osteopontin regulates development and function of invariant natural killer T cells. Proc Natl Acad Sci U S A 2008 0.97
69 STAT6 deficiency ameliorates severity of oxazolone colitis by decreasing expression of claudin-2 and Th2-inducing cytokines. J Immunol 2013 0.96
70 Tapasin-/- and TAP1-/- macrophages are deficient in vacuolar alternate class I MHC (MHC-I) processing due to decreased MHC-I stability at phagolysosomal pH. J Immunol 2003 0.95
71 Antigen presentation by CD1d contributes to the amplification of Th2 responses to Schistosoma mansoni glycoconjugates in mice. J Immunol 2002 0.95
72 Mycobacterium tuberculosis directs T helper 2 cell differentiation by inducing interleukin-1β production in dendritic cells. J Biol Chem 2012 0.95
73 STAT1 negatively regulates lung basophil IL-4 expression induced by respiratory syncytial virus infection. J Immunol 2009 0.94
74 CD1-restricted antigen presentation: an oily matter. Curr Opin Immunol 2003 0.94
75 Natural killer T cells in health and disease. Front Biosci (Schol Ed) 2011 0.94
76 Hepatocytes express abundant surface class I MHC and efficiently use transporter associated with antigen processing, tapasin, and low molecular weight polypeptide proteasome subunit components of antigen processing and presentation pathway. J Immunol 2005 0.93
77 Activated invariant NKT cells control central nervous system autoimmunity in a mechanism that involves myeloid-derived suppressor cells. J Immunol 2013 0.92
78 Toll-like receptor 4 (TLR4)-dependent proinflammatory and immunomodulatory properties of the glycoinositolphospholipid (GIPL) from Trypanosoma cruzi. J Leukoc Biol 2007 0.92
79 Contribution of CD1d-unrestricted hepatic DX5+ NKT cells to liver injury in Plasmodium berghei-parasitized erythrocyte-injected mice. Int Immunol 2004 0.91
80 NKT cell costimulation: experimental progress and therapeutic promise. Trends Mol Med 2010 0.91
81 ERAAP and tapasin independently edit the amino and carboxyl termini of MHC class I peptides. J Immunol 2013 0.90
82 Intestinal epithelial cells modulate CD4 T cell responses via the thymus leukemia antigen. J Immunol 2011 0.90
83 Activation of the epidermal growth factor receptor in macrophages regulates cytokine production and experimental colitis. J Immunol 2014 0.89
84 A murine locus on chromosome 18 controls NKT cell homeostasis and Th cell differentiation. J Immunol 2003 0.89
85 The in vivo response of invariant natural killer T cells to glycolipid antigens. Int Rev Immunol 2007 0.88
86 Genetic dissection of V alpha 14J alpha 18 natural T cell number and function in autoimmune-prone mice. J Immunol 2003 0.88
87 Viral evasion of antigen presentation: not just for peptides anymore. Nat Immunol 2006 0.87
88 Lipid metabolism, atherogenesis and CD1-restricted antigen presentation. Trends Mol Med 2006 0.86
89 Glycolipid ligands of invariant natural killer T cells as vaccine adjuvants. Expert Rev Vaccines 2008 0.86
90 Flexibility accompanies commitment of memory CD4 lymphocytes derived from IL-4 locus-activated precursors. Proc Natl Acad Sci U S A 2008 0.85
91 Assessing the role of immuno-proteasomes in a mouse model of familial ALS. Exp Neurol 2007 0.85
92 Infiltration of the inflamed eye by NKT cells in a rat model of experimental autoimmune uveitis. J Autoimmun 2003 0.84
93 Role of NKT cells in the digestive system. II. NKT cells and diabetes. Am J Physiol Gastrointest Liver Physiol 2007 0.84
94 The role of invariant natural killer T cells in lupus and atherogenesis. Immunol Res 2006 0.84
95 Contribution of lipid-reactive natural killer T cells to obesity-associated inflammation and insulin resistance. Adipocyte 2013 0.83
96 An important role of prostanoid receptor EP2 in host resistance to Mycobacterium tuberculosis infection in mice. J Infect Dis 2012 0.82
97 Natural killer T cells are required for lipopolysaccharide-mediated enhancement of atherosclerosis in apolipoprotein E-deficient mice. Immunobiology 2012 0.82
98 Development of spontaneous anergy in invariant natural killer T cells in a mouse model of dyslipidemia. Arterioscler Thromb Vasc Biol 2010 0.81
99 Deletion of the G6pc2 gene encoding the islet-specific glucose-6-phosphatase catalytic subunit-related protein does not affect the progression or incidence of type 1 diabetes in NOD/ShiLtJ mice. Diabetes 2011 0.81
100 CD4+ T cell-derived novel peptide Thp5 induces interleukin-4 production in CD4+ T cells to direct T helper 2 cell differentiation. J Biol Chem 2011 0.81
101 Genetic complementation in yeast reveals functional similarities between the catalytic subunits of mammalian signal peptidase complex. J Biol Chem 2003 0.81
102 Transforming growth factor-β protein inversely regulates in vivo differentiation of interleukin-17 (IL-17)-producing CD4+ and CD8+ T cells. J Biol Chem 2011 0.80
103 Sculpting MHC class II-restricted self and non-self peptidome by the class I Ag-processing machinery and its impact on Th-cell responses. Eur J Immunol 2013 0.80
104 Human invariant Valpha24+ natural killer T cells acquire regulatory functions by interacting with IL-10-treated dendritic cells. Blood 2008 0.80
105 Differential requirement for tapasin in the presentation of leader- and insulin-derived peptide antigens to Qa-1b-restricted CTLs. J Immunol 2004 0.80
106 Proteasomes, TAP, and endoplasmic reticulum-associated aminopeptidase associated with antigen processing control CD4+ Th cell responses by regulating indirect presentation of MHC class II-restricted cytoplasmic antigens. J Immunol 2011 0.79
107 Pivotal roles of CD8+ T cells restricted by MHC class I-like molecules in autoimmune diseases. J Exp Med 2006 0.79
108 KSR1 protects from interleukin-10 deficiency-induced colitis in mice by suppressing T-lymphocyte interferon-γ production. Gastroenterology 2010 0.79
109 Invariant natural killer T cells trigger adaptive lymphocytes to churn up bile. Cell Host Microbe 2008 0.78
110 Lung NKT cell commotion takes your breath away. Nat Med 2008 0.78
111 Rejection of grafts with no H-2 disparity in TAP1 mutant mice: CD4 T cells are important effector cells and self H-2b class I molecules are target. Transpl Immunol 2002 0.78
112 Prostanoid receptor 2 signaling protects T helper 2 cells from BALB/c mice against activation-induced cell death. J Biol Chem 2012 0.78
113 Engagement of glycosylphosphatidylinositol-anchored proteins results in enhanced mouse and human invariant natural killer T cell responses. Immunology 2010 0.77
114 Cutting edge: Guillain-Barre syndrome-associated IgG responses to gangliosides are generated independently of CD1 function in mice. J Immunol 2008 0.76
115 Generation of antibody responses to pneumococcal capsular polysaccharides is independent of CD1 expression in mice. Infect Immun 2009 0.75
116 Natural killer T cells ameliorate antibody-induced arthritis in macrophage migration inhibitory factor transgenic mice. Int J Mol Med 2006 0.75