Published in J Pharmacol Sci on November 13, 2008
Dendrimer-based postnatal therapy for neuroinflammation and cerebral palsy in a rabbit model. Sci Transl Med (2012) 3.43
Cellular metabolic and autophagic pathways: traffic control by redox signaling. Free Radic Biol Med (2013) 1.46
Emerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotection. Prog Neurobiol (2012) 1.41
Reactive oxygen species in the regulation of synaptic plasticity and memory. Antioxid Redox Signal (2010) 1.37
Aberrant Rab11-dependent trafficking of the neuronal glutamate transporter EAAC1 causes oxidative stress and cell death in Huntington's disease. J Neurosci (2010) 1.23
Zinc and the modulation of redox homeostasis. Free Radic Biol Med (2012) 1.23
Dysregulation of glutathione homeostasis in neurodegenerative diseases. Nutrients (2012) 1.18
Curcumin pretreatment induces Nrf2 and an antioxidant response and prevents hemin-induced toxicity in primary cultures of cerebellar granule neurons of rats. Oxid Med Cell Longev (2013) 1.01
Astaxanthin protects against MPTP/MPP+-induced mitochondrial dysfunction and ROS production in vivo and in vitro. Food Chem Toxicol (2010) 1.01
Extracellular glutamate: functional compartments operate in different concentration ranges. Front Syst Neurosci (2011) 1.00
Age-dependent and tissue-related glutathione redox status in a mouse model of Alzheimer's disease. J Alzheimers Dis (2012) 1.00
Oxidative stress in genetic mouse models of Parkinson's disease. Oxid Med Cell Longev (2012) 0.98
Morphine induces redox-based changes in global DNA methylation and retrotransposon transcription by inhibition of excitatory amino acid transporter type 3-mediated cysteine uptake. Mol Pharmacol (2014) 0.97
Differential effects of iodoacetamide and iodoacetate on glycolysis and glutathione metabolism of cultured astrocytes. Front Neuroenergetics (2009) 0.97
Nuclear factor erythroid 2-related factor 2 facilitates neuronal glutathione synthesis by upregulating neuronal excitatory amino acid transporter 3 expression. J Neurosci (2011) 0.95
Lanthionine synthetase C-like protein 1 interacts with and inhibits cystathionine β-synthase: a target for neuronal antioxidant defense. J Biol Chem (2012) 0.95
Noninvasive quantification of human brain ascorbate concentration using 1H NMR spectroscopy at 7 T. NMR Biomed (2010) 0.95
Prenatal and Postnatal Epigenetic Programming: Implications for GI, Immune, and Neuronal Function in Autism. Autism Res Treat (2012) 0.94
N-Acetylcysteine boosts brain and blood glutathione in Gaucher and Parkinson diseases. Clin Neuropharmacol (2013) 0.93
Antioxidant gene therapy against neuronal cell death. Pharmacol Ther (2013) 0.92
Food-derived opioid peptides inhibit cysteine uptake with redox and epigenetic consequences. J Nutr Biochem (2014) 0.92
Enhanced phosphatidylinositol 3-kinase (PI3K)/Akt signaling has pleiotropic targets in hippocampal neurons exposed to iron-induced oxidative stress. J Biol Chem (2013) 0.91
S-nitrosoglutathione prevents experimental cerebral malaria. J Neuroimmune Pharmacol (2012) 0.91
Glutathione is a physiologic reservoir of neuronal glutamate. Biochem Biophys Res Commun (2011) 0.90
Attenuation of oxidative stress, inflammation and apoptosis by minocycline prevents retrovirus-induced neurodegeneration in mice. Brain Res (2009) 0.89
Uptake of inorganic mercury by human locus ceruleus and corticomotor neurons: implications for amyotrophic lateral sclerosis. Acta Neuropathol Commun (2013) 0.88
Inhibition of glycolysis attenuates 4-hydroxynonenal-dependent autophagy and exacerbates apoptosis in differentiated SH-SY5Y neuroblastoma cells. Autophagy (2013) 0.88
FK506 neuroprotection after cavernous nerve injury is mediated by thioredoxin and glutathione redox systems. J Sex Med (2011) 0.87
Attenuation of β-amyloid-induced oxidative cell death by sulforaphane via activation of NF-E2-related factor 2. Oxid Med Cell Longev (2013) 0.86
N-Acetyl Cysteine Protects against Methamphetamine-Induced Dopaminergic Neurodegeneration via Modulation of Redox Status and Autophagy in Dopaminergic Cells. Parkinsons Dis (2012) 0.86
Glutamate receptor-like channel3.3 is involved in mediating glutathione-triggered cytosolic calcium transients, transcriptional changes, and innate immunity responses in Arabidopsis. Plant Physiol (2013) 0.86
Glutathione restores the mechanism of synaptic plasticity in aged mice to that of the adult. PLoS One (2011) 0.86
Metabolic theory of septic shock. World J Crit Care Med (2014) 0.84
Integration of a precolumn fluorogenic reaction, separation, and detection of reduced glutathione. Anal Chem (2010) 0.84
Impaired glutathione synthesis in neurodegeneration. Int J Mol Sci (2013) 0.84
Loss of glutathione homeostasis associated with neuronal senescence facilitates TRPM2 channel activation in cultured hippocampal pyramidal neurons. Mol Brain (2012) 0.84
HIV-1 gp120 and morphine induced oxidative stress: role in cell cycle regulation. Front Microbiol (2015) 0.83
The potential therapeutic effect of guanosine after cortical focal ischemia in rats. PLoS One (2014) 0.83
Rhythmic oscillations of the microRNA miR-96-5p play a neuroprotective role by indirectly regulating glutathione levels. Nat Commun (2014) 0.83
Inhibition of GTRAP3-18 may increase neuroprotective glutathione (GSH) synthesis. Int J Mol Sci (2012) 0.82
Common mechanisms in neurodegeneration and neuroinflammation: a BrainNet Europe gene expression microarray study. J Neural Transm (Vienna) (2014) 0.82
Regional variations of antioxidant capacity and oxidative stress responses in HIV-1 transgenic rats with and without methamphetamine administration. J Neuroimmune Pharmacol (2013) 0.82
Decreased zinc availability affects glutathione metabolism in neuronal cells and in the developing brain. Toxicol Sci (2013) 0.81
LOWER POSTERIOR CINGULATE CORTEX GLUTATHIONE LEVELS IN OBSESSIVE-COMPULSIVE DISORDER. Biol Psychiatry Cogn Neurosci Neuroimaging (2016) 0.80
Assessment at the single-cell level identifies neuronal glutathione depletion as both a cause and effect of ischemia-reperfusion oxidative stress. J Neurosci (2015) 0.80
Changes in ascorbate, glutathione and α-tocopherol concentrations in the brain regions during normal development and moderate hypoglycemia in rats. Neurosci Lett (2014) 0.79
Effect of chronic glutathione deficiency on the behavioral phenotype of Gclm-/- knockout mice. Neurotoxicol Teratol (2012) 0.78
Mitigation of ROS insults by Streptomyces secondary metabolites in primary cortical neurons. ACS Chem Neurosci (2013) 0.78
Comparison of oxygen-induced radical intermediates in iNOS oxygenase domain with those from nNOS and eNOS. J Inorg Biochem (2014) 0.78
EAAC1 gene deletion increases neuronal death and blood brain barrier disruption after transient cerebral ischemia in female mice. Int J Mol Sci (2014) 0.77
Diminished brain resilience syndrome: A modern day neurological pathology of increased susceptibility to mild brain trauma, concussion, and downstream neurodegeneration. Surg Neurol Int (2014) 0.77
Genetic Polymorphisms of Glutathione-Related Enzymes (GSTM1, GSTT1, and GSTP1) and Schizophrenia Risk: A Meta-Analysis. Int J Mol Sci (2015) 0.77
The Metabonomic Studies of Tongue Coating in H. pylori Positive Chronic Gastritis Patients. Evid Based Complement Alternat Med (2015) 0.77
Oxidative stress and apoptosis after acute respiratory hypoxia and reoxygenation in rat brain. Redox Biol (2017) 0.75
Experimental Cancer Cachexia Changes Neuron Numbers and Peptide Levels in the Intestine: Partial Protective Effects after Dietary Supplementation with L-Glutamine. PLoS One (2016) 0.75
Characterization of a Novel Mutation in SLC1A1 Associated with Schizophrenia. Mol Neuropsychiatry (2015) 0.75
Astrocytes Prevent Ethanol Induced Apoptosis of Nrf2 Depleted Neurons by Maintaining GSH Homeostasis. Open J Apoptosis (2012) 0.75
Cerebral ganglionic variations and movement behaviors of Lumbricus terrestris on exposure to neurotoxin. Ann Neurosci (2015) 0.75
Glutamate carboxypeptidase II and folate deficiencies result in reciprocal protection against cognitive and social deficits in mice: implications for neurodevelopmental disorders. Dev Neurobiol (2012) 0.75
Allium cepa Extract and Quercetin Protect Neuronal Cells from Oxidative Stress via PKC-ε Inactivation/ERK1/2 Activation. Oxid Med Cell Longev (2016) 0.75
K-Ras Activation Induces Differential Sensitivity to Sulfur Amino Acid Limitation and Deprivation and to Oxidative and Anti-Oxidative Stress in Mouse Fibroblasts. PLoS One (2016) 0.75
Nit1 is a metabolite repair enzyme that hydrolyzes deaminated glutathione. Proc Natl Acad Sci U S A (2017) 0.75
Post-translational Activation of Glutamate Cysteine Ligase with Dimercaprol: A NOVEL MECHANISM OF INHIBITING NEUROINFLAMMATION IN VITRO. J Biol Chem (2017) 0.75
Protective Potential of the Glutathione Peroxidase-1 Gene in Abnormal Behaviors Induced by Phencyclidine in Mice. Mol Neurobiol (2016) 0.75
Preventive and protective roles of dietary Nrf2 activators against central nervous system diseases. CNS Neurol Disord Drug Targets (2017) 0.75
Metabolic Dysfunction in Parkinson's Disease: Bioenergetics, Redox Homeostasis and Central Carbon Metabolism. Brain Res Bull (2017) 0.75
Effect of N-acetyl cysteine and glycine supplementation on growth performance, glutathione synthesis, and antioxidative ability of grass carp, Ctenopharyngodon idella. Fish Physiol Biochem (2017) 0.75
Musculin/MyoR is expressed in kidney side population cells and can regulate their function. J Cell Biol (2005) 1.31
Caffeic acid phenethyl ester induces apoptosis by inhibition of NFkappaB and activation of Fas in human breast cancer MCF-7 cells. J Biol Chem (2003) 1.27
Mitochondrial complex I inhibitor rotenone inhibits and redistributes vesicular monoamine transporter 2 via nitration in human dopaminergic SH-SY5Y cells. Mol Pharmacol (2008) 1.01
Protein kinase CK2 regulates the formation and clearance of aggresomes in response to stress. J Cell Sci (2011) 1.00
Aconiti tuber increases plasma nitrite and nitrate levels in humans. J Ethnopharmacol (2005) 1.00
Oral flavonoid supplementation attenuates atherosclerosis development in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol (2004) 0.98
A dominant role of GTRAP3-18 in neuronal glutathione synthesis. J Neurosci (2008) 0.92
ATP depletion does not account for apoptosis induced by inhibition of mitochondrial electron transport chain in human dopaminergic cells. Neuropharmacology (2006) 0.89
Rotenone induces apoptosis via activation of bad in human dopaminergic SH-SY5Y cells. J Pharmacol Exp Ther (2004) 0.89
Mitochondrial complex I inhibitor rotenone-elicited dopamine redistribution from vesicles to cytosol in human dopaminergic SH-SY5Y cells. J Pharmacol Exp Ther (2007) 0.88
Oxidative stress on EAAC1 is involved in MPTP-induced glutathione depletion and motor dysfunction. Eur J Neurosci (2007) 0.88
Leukemia inhibitory factor induces multi-lineage differentiation of adult stem-like cells in kidney via kidney-specific cadherin 16. Biochem Biophys Res Commun (2005) 0.88
Interstitial cells of Cajal in dysmotility in intestinal ischemia and reperfusion injury in rats. J Surg Res (2006) 0.87
Glutathione in Cellular Redox Homeostasis: Association with the Excitatory Amino Acid Carrier 1 (EAAC1). Molecules (2015) 0.86
Identification of interleukin-8 converting enzyme as cathepsin L. Biochim Biophys Acta (2003) 0.86
Regulation of glutathione synthesis via interaction between glutamate transport-associated protein 3-18 (GTRAP3-18) and excitatory amino acid carrier-1 (EAAC1) at plasma membrane. Mol Pharmacol (2007) 0.85
Activities of 7-nitroindazole and 1-(2-(trifluoromethylphenyl)-imidazole independent of neuronal nitric-oxide synthase inhibition. J Pharmacol Exp Ther (2008) 0.85
Impaired glutathione synthesis in neurodegeneration. Int J Mol Sci (2013) 0.84
Regulation of ERK-mediated signal transduction by p38 MAP kinase in human monocytic THP-1 cells. J Biochem (2003) 0.83
Inhibition of GTRAP3-18 may increase neuroprotective glutathione (GSH) synthesis. Int J Mol Sci (2012) 0.82
Plasma nitrate levels in deficit versus non-deficit forms of schizophrenia. J Psychiatry Neurosci (2003) 0.82
Modulation of neuronal glutathione synthesis by EAAC1 and its interacting protein GTRAP3-18. Amino Acids (2011) 0.82
Induction of regulatory T cells and indefinite survival of fully allogeneic cardiac grafts by ursodeoxycholic acid in mice. Transplantation (2009) 0.81
Increased neuronal glutathione and neuroprotection in GTRAP3-18-deficient mice. Neurobiol Dis (2011) 0.81
Imatinib blocks spontaneous mechanical activities in the adult mouse small intestine: possible inhibition of c-Kit signaling. Pharmacology (2005) 0.81
Neuroprotective properties of the excitatory amino acid carrier 1 (EAAC1). Amino Acids (2013) 0.79
Chronic treatment with a selective ligand for the sigma-1 receptor chaperone, SA4503, up-regulates BDNF protein levels in the rat hippocampus. Neurosci Lett (2008) 0.78
Antipsychotic, antidepressant, anxiolytic, and anticonvulsant drugs induce type II nitric oxide synthase mRNA in rat brain. Neurosci Lett (2002) 0.78
Anticonvulsant action of indazole. Epilepsy Res (2012) 0.77
Suppression of phosphorylation of extracellular-signal-regulated kinase and p38 mitogen-activated protein kinase in polymorphonuclear leukocytes by the proton pump inhibitor lansoprazole. J Infect Chemother (2010) 0.77
CK2 as anti-stress factor. Commun Integr Biol (2012) 0.76
Nitric oxide induced heat shock protein 70 mRNA in rat hypothalamus during acute restraint stress under sucrose diet. Cell Mol Neurobiol (2003) 0.76
Long-term imipramine treatment increases nitrate levels in the rat hypothalamus. Cell Mol Neurobiol (2003) 0.75
[Control mechanism for the glutathione level in neurons]. Nihon Yakurigaku Zasshi (2012) 0.75
Downregulation of immunomodulator gene expression in LPS-stimulated human polymorphonuclear leukocytes by the proton pump inhibitor lansoprazole. J Infect Chemother (2009) 0.75
Reduced renal ClC-5 Cl- channel expression in spontaneously hypertensive rats with microalbuminuria. Eur J Pharmacol (2004) 0.75
Possible identity of IL-8 converting enzyme in human fibroblasts as a cysteine protease. Int Immunopharmacol (2003) 0.75
Alpha(1A)-adrenergic control of piloerection and palpebral fissure width in rats. Auton Neurosci (2013) 0.75
Involvement of the α(1D)-adrenergic receptor in methamphetamine-induced hyperthermia and neurotoxicity in rats. Neurotox Res (2013) 0.75