PubRank

Klaus Okkenhaug

Author PubWeight™ 99.43‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Requirement of bic/microRNA-155 for normal immune function. Science 2007 16.24
2 Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Science 2009 7.80
3 Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking. Nat Immunol 2008 4.69
4 Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice. FASEB J 2007 3.83
5 Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation. Nature 2006 3.71
6 Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage. Science 2013 3.33
7 The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma. Proc Natl Acad Sci U S A 2008 2.81
8 Essential role for the p110delta phosphoinositide 3-kinase in the allergic response. Nature 2004 2.73
9 PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells. J Exp Med 2012 2.58
10 Cutting edge: the Foxp3 target miR-155 contributes to the development of regulatory T cells. J Immunol 2009 2.51
11 Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils. Blood 2005 2.35
12 Cutting edge: the phosphoinositide 3-kinase p110 delta is critical for the function of CD4+CD25+Foxp3+ regulatory T cells. J Immunol 2006 2.29
13 Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism. Immunity 2011 2.17
14 The PI3K isoforms p110alpha and p110delta are essential for pre-B cell receptor signaling and B cell development. Sci Signal 2010 2.15
15 Key role of the p110delta isoform of PI3K in B-cell antigen and IL-4 receptor signaling: comparative analysis of genetic and pharmacologic interference with p110delta function in B cells. Blood 2005 2.05
16 P-Rex1 regulates neutrophil function. Curr Biol 2005 1.97
17 PI3Kβ plays a critical role in neutrophil activation by immune complexes. Sci Signal 2011 1.95
18 Cutting edge: differential roles for phosphoinositide 3-kinases, p110gamma and p110delta, in lymphocyte chemotaxis and homing. J Immunol 2004 1.81
19 PI3K p110delta regulates T-cell cytokine production during primary and secondary immune responses in mice and humans. Blood 2010 1.76
20 Phosphoinositide 3-kinase activity in T cells regulates the magnitude of the germinal center reaction. J Immunol 2010 1.63
21 CD28 provides T-cell costimulation and enhances PI3K activity at the immune synapse independently of its capacity to interact with the p85/p110 heterodimer. Blood 2007 1.60
22 MAPK, phosphatidylinositol 3-kinase, and mammalian target of rapamycin pathways converge at the level of ribosomal protein S6 phosphorylation to control metabolic signaling in CD8 T cells. J Immunol 2009 1.42
23 Inactivation of PI3Kgamma and PI3Kdelta distorts T-cell development and causes multiple organ inflammation. Blood 2007 1.27
24 Role of the phosphoinositide 3-kinase p110delta in generation of type 2 cytokine responses and allergic airway inflammation. Eur J Immunol 2007 1.23
25 Physiologic and aberrant regulation of memory T-cell trafficking by the costimulatory molecule CD28. Blood 2007 1.20
26 CCL21 mediates CD4+ T-cell costimulation via a DOCK2/Rac-dependent pathway. Blood 2009 1.14
27 A two-signal model for T cell trafficking. Trends Immunol 2007 1.13
28 T cell receptor-induced phosphoinositide-3-kinase p110delta activity is required for T cell localization to antigenic tissue in mice. J Clin Invest 2008 1.13
29 The p110delta isoform of phosphatidylinositol 3-kinase controls susceptibility to Leishmania major by regulating expansion and tissue homing of regulatory T cells. J Immunol 2009 1.12
30 Ig gene-like molecule CD31 plays a nonredundant role in the regulation of T-cell immunity and tolerance. Proc Natl Acad Sci U S A 2010 1.11
31 Class I phosphoinositide 3-kinase p110beta is required for apoptotic cell and Fcgamma receptor-mediated phagocytosis by macrophages. J Biol Chem 2003 1.11
32 The PI3K p110δ regulates expression of CD38 on regulatory T cells. PLoS One 2011 1.10
33 Firefly luciferin-activated rose bengal: in vitro photodynamic therapy by intracellular chemiluminescence in transgenic NIH 3T3 cells. Cancer Res 2003 1.01
34 Cross talk between phosphatidylinositol 3-kinase and cyclic AMP (cAMP)-protein kinase a signaling pathways at the level of a protein kinase B/beta-arrestin/cAMP phosphodiesterase 4 complex. Mol Cell Biol 2010 1.01
35 Genetic or pharmaceutical blockade of p110delta phosphoinositide 3-kinase enhances IgE production. J Allergy Clin Immunol 2008 1.00
36 p110gamma and p110delta isoforms of phosphoinositide 3-kinase differentially regulate natural killer cell migration in health and disease. Proc Natl Acad Sci U S A 2009 1.00
37 Pten loss in CD4 T cells enhances their helper function but does not lead to autoimmunity or lymphoma. J Immunol 2012 0.97
38 The Therapeutic Potential for PI3K Inhibitors in Autoimmune Rheumatic Diseases. Open Rheumatol J 2012 0.97
39 Blockade of phosphatidylinositol 3-kinase PI3Kδ or PI3Kγ reduces IL-17 and ameliorates imiquimod-induced psoriasis-like dermatitis. J Immunol 2012 0.96
40 Genetic or pharmaceutical blockade of phosphoinositide 3-kinase p110δ prevents chronic rejection of heart allografts. PLoS One 2012 0.94
41 CD28 regulates the translation of Bcl-xL via the phosphatidylinositol 3-kinase/mammalian target of rapamycin pathway. J Immunol 2005 0.93
42 Does the PI3K pathway promote or antagonize regulatory T cell development and function? Front Immunol 2012 0.91
43 Gene-targeting reveals physiological roles and complex regulation of the phosphoinositide 3-kinases. Arch Biochem Biophys 2003 0.89
44 Requirement for phosphoinositide 3-kinase p110delta signaling in B cell antigen receptor-mediated antigen presentation. J Immunol 2007 0.89
45 Gene targeting in mice: a review. Methods Mol Biol 2013 0.88
46 IL-21 promotes CD4 T cell responses by phosphatidylinositol 3-kinase-dependent upregulation of CD86 on B cells. J Immunol 2014 0.87
47 Role of the p110delta PI 3-kinase in integrin and ITAM receptor signalling in platelets. Platelets 2005 0.85
48 Proliferative signals mediated by CD28 superagonists require the exchange factor Vav1 but not phosphoinositide 3-kinase in primary peripheral T cells. Eur J Immunol 2008 0.81
49 The transcription factor BACH2 promotes tumor immunosuppression. J Clin Invest 2016 0.78
50 A protocol for construction of gene targeting vectors and generation of homologous recombinant embryonic stem cells. Methods Mol Biol 2013 0.76
51 PI3K p110δ is expressed by gp38(-)CD31(+) and gp38(+)CD31(+) spleen stromal cells and regulates their CCL19, CCL21, and LTβR mRNA levels. PLoS One 2013 0.75
52 Corrigendum: Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer. Nature 2016 0.75