Published in Trends Immunol on November 18, 2008
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A genome-wide association study identifies a locus on chromosome 14q21 as a predictor of leukocyte telomere length and as a marker of susceptibility for bladder cancer. Cancer Prev Res (Phila) (2011) 1.86
Recent advances in PAMP-triggered immunity against bacteria: pattern recognition receptors watch over and raise the alarm. Plant Physiol (2009) 1.84
Neddylation plays an important role in the regulation of murine and human dendritic cell function. Blood (2013) 1.69
The ubiquitin ligase Peli1 negatively regulates T cell activation and prevents autoimmunity. Nat Immunol (2011) 1.45
A genome-wide association analysis reveals 1p31 and 2p13.3 as susceptibility loci for Kawasaki disease. Hum Genet (2011) 1.19
Peli1 promotes microglia-mediated CNS inflammation by regulating Traf3 degradation. Nat Med (2013) 1.08
TAK1 Lys-158 but not Lys-209 is required for IL-1β-induced Lys63-linked TAK1 polyubiquitination and IKK/NF-κB activation. Cell Signal (2010) 1.07
Regulation of TLR7/9 signaling in plasmacytoid dendritic cells. Protein Cell (2012) 1.05
Assessment of risk factors for Korean children with Kawasaki disease. Pediatr Cardiol (2011) 1.04
Peli: a family of signal-responsive E3 ubiquitin ligases mediating TLR signaling and T-cell tolerance. Cell Mol Immunol (2012) 1.04
Pellino3 targets the IRF7 pathway and facilitates autoregulation of TLR3- and viral-induced expression of type I interferons. Nat Immunol (2012) 0.96
Inhibition of neddylation represses lipopolysaccharide-induced proinflammatory cytokine production in macrophage cells. J Biol Chem (2012) 0.94
PYK2 interacts with MyD88 and regulates MyD88-mediated NF-kappaB activation in macrophages. J Leukoc Biol (2009) 0.93
Toll-like receptor polymorphisms, inflammatory and infectious diseases, allergies, and cancer. J Interferon Cytokine Res (2013) 0.93
Arc of a vicious circle: pathways activated by Mycobacterium tuberculosis that target the HIV-1 long terminal repeat. Am J Respir Cell Mol Biol (2011) 0.93
Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis. Nat Immunol (2013) 0.92
Pellino-1 selectively regulates epithelial cell responses to rhinovirus. J Virol (2012) 0.87
A Toll-like receptor-responsive kinase, protein kinase R, is inactivated in endotoxin tolerance through differential K63/K48 ubiquitination. MBio (2010) 0.85
New insight into the functions of the interleukin-17 receptor adaptor protein Act1 in psoriatic arthritis. Arthritis Res Ther (2012) 0.85
Cell-surface localization of Pellino antagonizes Toll-mediated innate immune signalling by controlling MyD88 turnover in Drosophila. Nat Commun (2014) 0.84
Toll-like receptor 2 mediates high-fat diet-induced impairment of vasodilator actions of insulin. Am J Physiol Endocrinol Metab (2013) 0.84
Pellino 1 promotes lymphomagenesis by deregulating BCL6 polyubiquitination. J Clin Invest (2014) 0.83
Autophagy-dependent PELI3 degradation inhibits proinflammatory IL1B expression. Autophagy (2014) 0.82
The 'ubiquitous' reality of vector immunology. Cell Microbiol (2013) 0.82
A role for c-Myc in regulating anti-mycobacterial responses. Proc Natl Acad Sci U S A (2011) 0.81
The IRAK-ERK-p67phox-Nox-2 axis mediates TLR4, 2-induced ROS production for IL-1β transcription and processing in monocytes. Cell Mol Immunol (2015) 0.81
Pellino-1, an adaptor protein of interleukin-1 receptor/toll-like receptor signaling, is sumoylated by Ubc9. Mol Cells (2010) 0.81
Peli1 (rel)ieves autoimmunity. Nat Immunol (2011) 0.80
Peli1 sets the CNS on fire. Nat Med (2013) 0.79
The pellino e3 ubiquitin ligases recognize specific phosphothreonine motifs and have distinct substrate specificities. Biochemistry (2014) 0.78
B cell antigen receptor-induced activation of an IRAK4-dependent signaling pathway revealed by a MALT1-IRAK4 double knockout mouse model. Cell Commun Signal (2011) 0.78
Contextualization procedure and modeling of monocyte specific TLR signaling. PLoS One (2012) 0.77
Targeting IRAK1 in T-cell acute lymphoblastic leukemia. Oncotarget (2015) 0.77
Inhibition of lethal inflammatory responses through the targeting of membrane-associated Toll-like receptor 4 signaling complexes with a Smad6-derived peptide. EMBO Mol Med (2015) 0.77
β-Arrestins Negatively Regulate the Toll Pathway in Shrimp by Preventing Dorsal Translocation and Inhibiting Dorsal Transcriptional Activity. J Biol Chem (2016) 0.77
Functional conservation of an ancestral Pellino protein in helminth species. Sci Rep (2015) 0.75
Thymoquinone: An IRAK1 inhibitor with in vivo and in vitro anti-inflammatory activities. Sci Rep (2017) 0.75