Published in Nat Methods on December 01, 2008
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COT drives resistance to RAF inhibition through MAP kinase pathway reactivation. Nature (2010) 14.62
A mitochondrial protein compendium elucidates complex I disease biology. Cell (2008) 13.51
High-quality binary protein interaction map of the yeast interactome network. Science (2008) 10.65
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. Cell (2006) 8.61
Integrative genomic approaches identify IKBKE as a breast cancer oncogene. Cell (2007) 7.60
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An empirical framework for binary interactome mapping. Nat Methods (2008) 6.59
Toward improving Caenorhabditis elegans phenome mapping with an ORFeome-based RNAi library. Genome Res (2004) 5.81
An experimentally derived confidence score for binary protein-protein interactions. Nat Methods (2008) 5.27
A public genome-scale lentiviral expression library of human ORFs. Nat Methods (2011) 4.98
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SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression. Nature (2011) 4.57
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Edgetic perturbation models of human inherited disorders. Mol Syst Biol (2009) 3.96
Combined functional genomic maps of the C. elegans DNA damage response. Science (2002) 3.74
Independently evolved virulence effectors converge onto hubs in a plant immune system network. Science (2011) 3.72
Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1. Nature (2008) 3.68
Systematic analysis of genes required for synapse structure and function. Nature (2005) 3.67
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Systematic sequencing of cDNA clones using the transposon Tn5. Nucleic Acids Res (2002) 2.78
Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Nat Methods (2009) 2.50
Concerted assembly and cloning of multiple DNA segments using in vitro site-specific recombination: functional analysis of multi-segment expression clones. Genome Res (2004) 2.49
Metabolic network reconstruction of Chlamydomonas offers insight into light-driven algal metabolism. Mol Syst Biol (2011) 2.44
A protein domain-based interactome network for C. elegans early embryogenesis. Cell (2008) 2.23
The completion of the Mammalian Gene Collection (MGC). Genome Res (2009) 2.21
Next-generation sequencing to generate interactome datasets. Nat Methods (2011) 2.06
Protein interactome reveals converging molecular pathways among autism disorders. Sci Transl Med (2011) 2.04
Isoform discovery by targeted cloning, 'deep-well' pooling and parallel sequencing. Nat Methods (2008) 2.03
High-quality binary interactome mapping. Methods Enzymol (2010) 1.94
C. elegans ORFeome version 3.1: increasing the coverage of ORFeome resources with improved gene predictions. Genome Res (2004) 1.92
Generation of the Brucella melitensis ORFeome version 1.1. Genome Res (2004) 1.86
ORFeome cloning and systems biology: standardized mass production of the parts from the parts-list. Genome Res (2004) 1.85
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Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. Genome Res (2009) 1.68
Efficient targeted transcript discovery via array-based normalization of RACE libraries. Nat Methods (2008) 1.66
Genome-wide coactivation analysis of PGC-1alpha identifies BAF60a as a regulator of hepatic lipid metabolism. Cell Metab (2008) 1.65
Viral perturbations of host networks reflect disease etiology. PLoS Comput Biol (2012) 1.54
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High-throughput expression of C. elegans proteins. Genome Res (2004) 1.32
Shifted Transversal Design smart-pooling for high coverage interactome mapping. Genome Res (2009) 1.22
Identification of a Brucella spp. secreted effector specifically interacting with human small GTPase Rab2. Cell Microbiol (2011) 1.22
Extensive rewiring and complex evolutionary dynamics in a C. elegans multiparameter transcription factor network. Mol Cell (2013) 1.21
From genome to proteome: developing expression clone resources for the human genome. Hum Mol Genet (2006) 1.21
Metabolic network analysis integrated with transcript verification for sequenced genomes. Nat Methods (2009) 1.21
Evidence for transcript networks composed of chimeric RNAs in human cells. PLoS One (2012) 1.16
Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia. Hum Mol Genet (2010) 1.16
Host-pathogen interactome mapping for HTLV-1 and -2 retroviruses. Retrovirology (2012) 1.16
Filovirus-like particles produced in insect cells: immunogenicity and protection in rodents. J Infect Dis (2007) 1.13
Yeast one-hybrid assays for gene-centered human gene regulatory network mapping. Nat Methods (2011) 1.12
Mycobacterium tuberculosis type VII secreted effector EsxH targets host ESCRT to impair trafficking. PLoS Pathog (2013) 1.10
Revisiting the Saccharomyces cerevisiae predicted ORFeome. Genome Res (2008) 1.07
New genes with roles in the C. elegans embryo revealed using RNAi of ovary-enriched ORFeome clones. Genome Res (2005) 1.07
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A novel cell-free protein synthesis system. J Biotechnol (2004) 1.01
A genome-wide gene function prediction resource for Drosophila melanogaster. PLoS One (2010) 1.00
Blocking oligonucleotides improve sequencing through inverted repeats. Biotechniques (2003) 0.99
Recombinant production of anti-HIV protein, griffithsin, by auto-induction in a fermentor culture. Protein Expr Purif (2005) 0.98
Identification of FAM111A as an SV40 host range restriction and adenovirus helper factor. PLoS Pathog (2012) 0.95
Purify First: rapid expression and purification of proteins from XMRV. Protein Expr Purif (2010) 0.94
SH3 interactome conserves general function over specific form. Mol Syst Biol (2013) 0.94
Large-scale RACE approach for proactive experimental definition of C. elegans ORFeome. Genome Res (2009) 0.93
Comparative analysis of virus-host interactomes with a mammalian high-throughput protein complementation assay based on Gaussia princeps luciferase. Methods (2012) 0.93
Metabolic systems analysis to advance algal biotechnology. Biotechnol J (2010) 0.93
Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor. Mol Cell Proteomics (2010) 0.92
C. elegans network biology: a beginning. WormBook (2006) 0.91
Systematic identification of pathological lamin A interactors. Mol Biol Cell (2014) 0.86
Protein-protein interactions and networks: forward and reverse edgetics. Methods Mol Biol (2011) 0.85
Genome-wide functional annotation and structural verification of metabolic ORFeome of Chlamydomonas reinhardtii. BMC Genomics (2011) 0.83
Biochemical clustering of monomeric GTPases of the Ras superfamily. Mol Cell Proteomics (2005) 0.82
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CKIP-1 regulates mammalian and zebrafish myoblast fusion. J Cell Sci (2012) 0.81
Pooled ORF expression technology (POET): using proteomics to screen pools of open reading frames for protein expression. Mol Cell Proteomics (2005) 0.79
An RS motif within the Epstein-Barr virus BLRF2 tegument protein is phosphorylated by SRPK2 and is important for viral replication. PLoS One (2013) 0.79
A set of aspartyl protease-deficient strains for improved expression of heterologous proteins in Kluyveromyces lactis. FEMS Yeast Res (2010) 0.77
Gateway cloning is compatible with protein secretion from Pichia pastoris. Protein Expr Purif (2005) 0.77
Academia-industry collaboration: an integral element for building "omic" resources. Genome Res (2004) 0.75
Saffron-Based Crocin Prevents Early Lesions of Liver Cancer: In vivo, In vitro and Network Analyses. Recent Pat Anticancer Drug Discov (2016) 0.75
Dynamic Role of trans Regulation of Gene Expression in Relation to Complex Traits. Am J Hum Genet (2017) 0.75
Dynamic Ligand Exchange as a Mechanistic Probe in Pd-Catalyzed Enantioselective C-H Functionalization Reactions Using Monoprotected Amino Acid Ligands. J Am Chem Soc (2017) 0.75