Published in Transl Res on October 31, 2008
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Stretching the search for therapeutic targets in acute lung injury. Transl Res (2008) 0.76
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Microarray-based analysis of ventilator-induced lung injury. Proc Am Thorac Soc (2007) 1.58
Bioinformatic identification of novel early stress response genes in rodent models of lung injury. Am J Physiol Lung Cell Mol Physiol (2005) 1.55
The role of cytokines during the pathogenesis of ventilator-associated and ventilator-induced lung injury. Semin Respir Crit Care Med (2006) 1.44
Genetic and pharmacologic evidence links oxidative stress to ventilator-induced lung injury in mice. Am J Respir Crit Care Med (2007) 1.41
Cytokines and biotrauma in ventilator-induced lung injury: a critical review of the literature. Neth J Med (2005) 1.41
Bronchial epithelial compression regulates MAP kinase signaling and HB-EGF-like growth factor expression. Am J Physiol Lung Cell Mol Physiol (2002) 1.40
In vitro identification and in silico utilization of interspecies sequence similarities using GeneChip technology. BMC Genomics (2005) 1.39
Cyclic stretch activates ERK1/2 via G proteins and EGFR in alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol (2002) 1.18
Redox imbalance and ventilator-induced lung injury. Antioxid Redox Signal (2007) 1.10
EGFR-activated signaling and actin remodeling regulate cyclic stretch-induced NRF2-ARE activation. Am J Respir Cell Mol Biol (2006) 1.02
Reactive oxygen species in mechanotransduction. Am J Physiol Lung Cell Mol Physiol (2004) 1.01
EGFR autocrine signaling in a compliant interstitial space: mechanotransduction from the outside in. Cell Cycle (2004) 0.89
Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis. J Clin Invest (2006) 4.41
Accuracy of Doppler echocardiography in the hemodynamic assessment of pulmonary hypertension. Am J Respir Crit Care Med (2009) 3.96
Tricuspid annular displacement predicts survival in pulmonary hypertension. Am J Respir Crit Care Med (2006) 3.59
Protective effects of sphingosine 1-phosphate in murine endotoxin-induced inflammatory lung injury. Am J Respir Crit Care Med (2004) 3.59
Nrf2 defends the lung from oxidative stress. Antioxid Redox Signal (2006) 2.96
Endothelial dysfunction in pulmonary hypertension. Circulation (2004) 2.82
Sphingosine 1-phosphate reduces vascular leak in murine and canine models of acute lung injury. Am J Respir Crit Care Med (2004) 2.73
Functional polymorphisms in the transcription factor NRF2 in humans increase the risk of acute lung injury. FASEB J (2007) 2.65
Imatinib mesylate as add-on therapy for pulmonary arterial hypertension: results of the randomized IMPRES study. Circulation (2013) 2.64
Reactive oxygen species in inflammation and tissue injury. Antioxid Redox Signal (2013) 2.59
Tricuspid annular plane systolic excursion is a robust outcome measure in systemic sclerosis-associated pulmonary arterial hypertension. J Rheumatol (2011) 2.48
Characterization of connective tissue disease-associated pulmonary arterial hypertension from REVEAL: identifying systemic sclerosis as a unique phenotype. Chest (2010) 2.35
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Clinical differences between idiopathic and scleroderma-related pulmonary hypertension. Arthritis Rheum (2006) 2.04
Perspectives on oral pulmonary hypertension therapies recently approved by the U.S. Food and Drug Administration. Ann Am Thorac Soc (2015) 2.02
Nrf2-regulated PPAR{gamma} expression is critical to protection against acute lung injury in mice. Am J Respir Crit Care Med (2010) 2.02
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Pulmonary capillary wedge pressure augments right ventricular pulsatile loading. Circulation (2011) 1.92
Randomized clinical trial of aspirin and simvastatin for pulmonary arterial hypertension: ASA-STAT. Circulation (2011) 1.91
Use of consomic rats for genomic insights into ventilator-associated lung injury. Am J Physiol Lung Cell Mol Physiol (2007) 1.86
Diagnosis, assessment, and treatment of non-pulmonary arterial hypertension pulmonary hypertension. J Am Coll Cardiol (2009) 1.78
Gene expression profiling of NRF2-mediated protection against oxidative injury. Free Radic Biol Med (2005) 1.76
PDE5A inhibitor treatment of persistent pulmonary hypertension after mechanical circulatory support. Circ Heart Fail (2008) 1.75
NADPH oxidase and ERK signaling regulates hyperoxia-induced Nrf2-ARE transcriptional response in pulmonary epithelial cells. J Biol Chem (2004) 1.73
Treatment of sarcoidosis-associated pulmonary hypertension. A two-center experience. Chest (2008) 1.57
Transcription factor Nrf2 is protective during ischemic and nephrotoxic acute kidney injury in mice. Kidney Int (2009) 1.56
Modulation of inducible nitric oxide synthase by hypoxia in pulmonary artery endothelial cells. Am J Respir Cell Mol Biol (2002) 1.55
Disruption of Nrf2 impairs the resolution of hyperoxia-induced acute lung injury and inflammation in mice. J Immunol (2009) 1.53
Oxidants and signaling by mitogen-activated protein kinases in lung epithelium. Am J Respir Cell Mol Biol (2006) 1.51
Genetic dissection of the Nrf2-dependent redox signaling-regulated transcriptional programs of cell proliferation and cytoprotection. Physiol Genomics (2007) 1.45
Hemodynamic predictors of survival in scleroderma-related pulmonary arterial hypertension. Am J Respir Crit Care Med (2010) 1.44
Hyperoxia stimulates an Nrf2-ARE transcriptional response via ROS-EGFR-PI3K-Akt/ERK MAP kinase signaling in pulmonary epithelial cells. Antioxid Redox Signal (2006) 1.44
Mechanical stress activates xanthine oxidoreductase through MAP kinase-dependent pathways. Am J Physiol Lung Cell Mol Physiol (2006) 1.42
CD36 participates in a signaling pathway that regulates ROS formation in murine VSMCs. J Clin Invest (2010) 1.41
Genetic and pharmacologic evidence links oxidative stress to ventilator-induced lung injury in mice. Am J Respir Crit Care Med (2007) 1.41
Survival in pulmonary hypertension associated with the scleroderma spectrum of diseases: impact of interstitial lung disease. Arthritis Rheum (2009) 1.40
Cytoskeletal changes in hypoxic pulmonary endothelial cells are dependent on MAPK-activated protein kinase MK2. J Biol Chem (2002) 1.40
Hyponatremia predicts right heart failure and poor survival in pulmonary arterial hypertension. Am J Respir Crit Care Med (2008) 1.38
Deficiency in Nrf2-GSH signaling impairs type II cell growth and enhances sensitivity to oxidants. Am J Respir Cell Mol Biol (2007) 1.36
Inducible nitric oxide synthase contributes to ventilator-induced lung injury. Am J Respir Crit Care Med (2005) 1.35
Attenuation of chronic hypoxic pulmonary hypertension by simvastatin. Am J Physiol Heart Circ Physiol (2003) 1.34
Regulation of endothelial barrier function by reactive oxygen and nitrogen species. Microvasc Res (2008) 1.34
Schistosomiasis-induced experimental pulmonary hypertension: role of interleukin-13 signaling. Am J Pathol (2010) 1.33
Multiple nuclear localization signals function in the nuclear import of the transcription factor Nrf2. J Biol Chem (2008) 1.33
Regression of chronic hypoxic pulmonary hypertension by simvastatin. Am J Physiol Lung Cell Mol Physiol (2007) 1.30
The transcription factor encyclopedia. Genome Biol (2012) 1.28
Identification of candidate genes in scleroderma-related pulmonary arterial hypertension. Transl Res (2008) 1.27
FRA-1 proto-oncogene induces lung epithelial cell invasion and anchorage-independent growth in vitro, but is insufficient to promote tumor growth in vivo. Cancer Res (2007) 1.27
Enhancing Nrf2 pathway by disruption of Keap1 in myeloid leukocytes protects against sepsis. Am J Respir Crit Care Med (2011) 1.27
Activation of the STAT pathway in acute lung injury. Am J Physiol Lung Cell Mol Physiol (2004) 1.25
Mitogen activated protein kinase activated protein kinase 2 regulates actin polymerization and vascular leak in ventilator associated lung injury. PLoS One (2009) 1.24
Right ventricular dysfunction in systemic sclerosis-associated pulmonary arterial hypertension. Circ Heart Fail (2013) 1.21
Conditional deletion of Nrf2 in airway epithelium exacerbates acute lung injury and impairs the resolution of inflammation. Am J Respir Cell Mol Biol (2011) 1.19
Hypoxia alters biophysical properties of endothelial cells via p38 MAPK- and Rho kinase-dependent pathways. Am J Physiol Cell Physiol (2005) 1.18
Soluble guanylyl cyclase contributes to ventilator-induced lung injury in mice. Am J Physiol Lung Cell Mol Physiol (2008) 1.18
Myocardial delayed enhancement in pulmonary hypertension: pulmonary hemodynamics, right ventricular function, and remodeling. AJR Am J Roentgenol (2011) 1.15
Transcription repressor activity of spleen tyrosine kinase mediates breast tumor suppression. Cancer Res (2005) 1.12
Resistin-like molecule-beta in scleroderma-associated pulmonary hypertension. Am J Respir Cell Mol Biol (2009) 1.12
Redox imbalance and ventilator-induced lung injury. Antioxid Redox Signal (2007) 1.10
Matrix metalloproteinase/epidermal growth factor receptor/mitogen-activated protein kinase signaling regulate fra-1 induction by cigarette smoke in lung epithelial cells. Am J Respir Cell Mol Biol (2004) 1.10
Long-term outcome of bosentan treatment in idiopathic pulmonary arterial hypertension and pulmonary arterial hypertension associated with the scleroderma spectrum of diseases. J Heart Lung Transplant (2005) 1.09
Innate immunity against bacterial infection following hyperoxia exposure is impaired in NRF2-deficient mice. J Immunol (2009) 1.09
Activated protein C protects against ventilator-induced pulmonary capillary leak. Am J Physiol Lung Cell Mol Physiol (2009) 1.09
Strategic plan for lung vascular research: An NHLBI-ORDR Workshop Report. Am J Respir Crit Care Med (2010) 1.09
Vascular receptor autoantibodies in pulmonary arterial hypertension. Am J Respir Crit Care Med (2015) 1.08
Alveolar cell apoptosis is dependent on p38 MAP kinase-mediated activation of xanthine oxidoreductase in ventilator-induced lung injury. J Appl Physiol (1985) (2008) 1.08
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Protective role of PI3-kinase/Akt/eNOS signaling in mechanical stress through inhibition of p38 mitogen-activated protein kinase in mouse lung. Acta Pharmacol Sin (2010) 1.06
The triterpenoid CDDO-imidazolide confers potent protection against hyperoxic acute lung injury in mice. Am J Respir Crit Care Med (2009) 1.05
One hundred years of research in the pathogenesis of pulmonary hypertension. Am J Respir Cell Mol Biol (2005) 1.05
Nrf2 regulates hyperoxia-induced Nox4 expression in human lung endothelium: identification of functional antioxidant response elements on the Nox4 promoter. Free Radic Biol Med (2011) 1.05
Tumor-suppressive activity of the cell death activator GRIM-19 on a constitutively active signal transducer and activator of transcription 3. Cancer Res (2007) 1.04
Immune and inflammatory mechanisms in pulmonary arterial hypertension. Prog Cardiovasc Dis (2012) 1.03
Systemic sclerosis-associated pulmonary arterial hypertension. Am J Respir Crit Care Med (2010) 1.03
EGFR-activated signaling and actin remodeling regulate cyclic stretch-induced NRF2-ARE activation. Am J Respir Cell Mol Biol (2006) 1.02
Xanthine oxidoreductase in respiratory and cardiovascular disorders. Am J Physiol Lung Cell Mol Physiol (2008) 1.02
An official American Thoracic Society Statement: pulmonary hypertension phenotypes. Am J Respir Crit Care Med (2014) 1.02
Mitogen regulated induction of FRA-1 proto-oncogene is controlled by the transcription factors binding to both serum and TPA response elements. Oncogene (2005) 1.01
Targeting sphingosine kinase 1 attenuates bleomycin-induced pulmonary fibrosis. FASEB J (2013) 1.01
Portopulmonary hypertension: a tale of two circulations. Chest (2003) 1.00
Multiple cis-elements mediate the transcriptional activation of human fra-1 by 12-O-tetradecanoylphorbol-13-acetate in bronchial epithelial cells. J Biol Chem (2003) 1.00
p53 mediates cigarette smoke-induced apoptosis of pulmonary endothelial cells: inhibitory effects of macrophage migration inhibitor factor. Am J Respir Cell Mol Biol (2010) 1.00
Systemic sclerosis-associated pulmonary arterial hypertension. Chest (2013) 1.00
The Med1 subunit of transcriptional mediator plays a central role in regulating CCAAT/enhancer-binding protein-beta-driven transcription in response to interferon-gamma. J Biol Chem (2008) 0.99
Right and left ventricular myocardial perfusion reserves correlate with right ventricular function and pulmonary hemodynamics in patients with pulmonary arterial hypertension. Radiology (2010) 0.99
DEP-induced fra-1 expression correlates with a distinct activation of AP-1-dependent gene transcription in the lung. Am J Physiol Lung Cell Mol Physiol (2003) 0.98
A Fra-1-dependent, matrix metalloproteinase driven EGFR activation promotes human lung epithelial cell motility and invasion. J Cell Physiol (2008) 0.98
Pulmonary artery measurements in pulmonary hypertension: the role of computed tomography. J Thorac Imaging (2013) 0.98