Published in J Vis Exp on January 16, 2008
Attenuation of donor-reactive T cells allows effective control of allograft rejection using regulatory T cell therapy. Am J Transplant (2013) 1.60
Teplizumab induces human gut-tropic regulatory cells in humanized mice and patients. Sci Transl Med (2012) 1.10
Antibody-functionalized peptidic membranes for neutralization of allogeneic skin antigen-presenting cells. Acta Biomater (2014) 0.85
Role of the nuclear receptor coactivator AIB1/SRC-3 in angiogenesis and wound healing. Am J Pathol (2012) 0.83
Anti-TCRβ mAb induces long-term allograft survival by reducing antigen-reactive T cells and sparing regulatory T cells. Am J Transplant (2012) 0.82
Transient combination therapy targeting the immune synapse abrogates T cell responses and prolongs allograft survival in mice. PLoS One (2013) 0.76
A biodegradable killer microparticle to selectively deplete antigen-specific T cells in vitro and in vivo. Oncotarget (2016) 0.76
An Antigen-Presenting and Apoptosis-Inducing Polymer Microparticle Prolongs Alloskin Graft Survival by Selectively and Markedly Depleting Alloreactive CD8(+) T Cells. Front Immunol (2017) 0.75
Defects in Stratum Corneum Desquamation Are the Predominant Effect of Impaired ABCA12 Function in a Novel Mouse Model of Harlequin Ichthyosis. PLoS One (2016) 0.75
Trichinella spiralis infection changes immune response in mice performed abdominal heterotopic cardiac transplantation and prolongs cardiac allograft survival time. Parasitol Res (2015) 0.75
STIM1, an essential and conserved component of store-operated Ca2+ channel function. J Cell Biol (2005) 13.11
STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane. Nature (2005) 8.96
Two-photon imaging of lymphocyte motility and antigen response in intact lymph node. Science (2002) 8.94
Genome-wide RNAi screen of Ca(2+) influx identifies genes that regulate Ca(2+) release-activated Ca(2+) channel activity. Proc Natl Acad Sci U S A (2006) 7.26
Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai. Nature (2006) 7.22
Imaging the single cell dynamics of CD4+ T cell activation by dendritic cells in lymph nodes. J Exp Med (2004) 5.08
Autonomous T cell trafficking examined in vivo with intravital two-photon microscopy. Proc Natl Acad Sci U S A (2003) 4.22
Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo. Nat Chem Biol (2006) 4.20
Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells. PLoS Biol (2005) 4.01
T cell repertoire scanning is promoted by dynamic dendritic cell behavior and random T cell motility in the lymph node. Proc Natl Acad Sci U S A (2004) 3.99
Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses. Nat Immunol (2005) 3.70
The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers. Nature (2008) 3.46
K+ channels as targets for specific immunomodulation. Trends Pharmacol Sci (2004) 3.12
Store-dependent and -independent modes regulating Ca2+ release-activated Ca2+ channel activity of human Orai1 and Orai3. J Biol Chem (2008) 2.75
Distinct properties of CRAC and MIC channels in RBL cells. J Gen Physiol (2002) 2.59
A store-operated calcium channel in Drosophila S2 cells. J Gen Physiol (2004) 2.54
Imaging of effector memory T cells during a delayed-type hypersensitivity reaction and suppression by Kv1.3 channel block. Immunity (2008) 2.23
Orai1 and STIM1 move to the immunological synapse and are up-regulated during T cell activation. Proc Natl Acad Sci U S A (2008) 2.22
A functional single-nucleotide polymorphism in the TRPC6 gene promoter associated with idiopathic pulmonary arterial hypertension. Circulation (2009) 2.17
A decade of imaging cellular motility and interaction dynamics in the immune system. Science (2012) 1.94
Channel function is dissociated from the intrinsic kinase activity and autophosphorylation of TRPM7/ChaK1. J Biol Chem (2005) 1.57
Class IA phosphoinositide 3-kinase modulates basal lymphocyte motility in the lymph node. J Immunol (2007) 1.56
Charge screening by internal pH and polyvalent cations as a mechanism for activation, inhibition, and rundown of TRPM7/MIC channels. J Gen Physiol (2005) 1.55
A stochastic view of lymphocyte motility and trafficking within the lymph node. Immunol Rev (2003) 1.51
Ca2+ signals in CD4+ T cells during early contacts with antigen-bearing dendritic cells in lymph node. J Immunol (2007) 1.37
Polyvalent cations as permeant probes of MIC and TRPM7 pores. Biophys J (2003) 1.36
MIC channels are inhibited by internal divalent cations but not ATP. Biophys J (2003) 1.35
Subunit stoichiometry of human Orai1 and Orai3 channels in closed and open states. Proc Natl Acad Sci U S A (2011) 1.28
Mutations in Orai1 transmembrane segment 1 cause STIM1-independent activation of Orai1 channels at glycine 98 and channel closure at arginine 91. Proc Natl Acad Sci U S A (2011) 1.27
A novel fluorescent toxin to detect and investigate Kv1.3 channel up-regulation in chronically activated T lymphocytes. J Biol Chem (2003) 1.22
Regulation of membrane trafficking and subcellular organization of endocytic compartments revealed with FM1-43 in resting and activated human T cells. Exp Cell Res (2003) 1.16
Natural killer cells actively patrol peripheral lymph nodes forming stable conjugates to eliminate MHC-mismatched targets. Proc Natl Acad Sci U S A (2007) 1.13
Isolation of CD4+ T cells from mouse lymph nodes using Miltenyi MACS purification. J Vis Exp (2007) 1.08
Selective and site-specific mobilization of dermal dendritic cells and Langerhans cells by Th1- and Th2-polarizing adjuvants. Proc Natl Acad Sci U S A (2010) 1.06
NK cell patrolling and elimination of donor-derived dendritic cells favor indirect alloreactivity. J Immunol (2010) 1.04
Generation of bone marrow derived murine dendritic cells for use in 2-photon imaging. J Vis Exp (2008) 1.03
Two-photon imaging in intact lymphoid tissue. Adv Exp Med Biol (2002) 1.02
Quantum dots for tracking dendritic cells and priming an immune response in vitro and in vivo. PLoS One (2008) 0.99
SK3-1C, a dominant-negative suppressor of SKCa and IKCa channels. J Biol Chem (2003) 0.97
The immunological synapse: a dynamic platform for local signaling. J Clin Immunol (2010) 0.94
Modulation of mouse Paneth cell alpha-defensin secretion by mIKCa1, a Ca2+-activated, intermediate conductance potassium channel. J Biol Chem (2001) 0.94
Mzb1 protein regulates calcium homeostasis, antibody secretion, and integrin activation in innate-like B cells. Immunity (2010) 0.92
Toll-like receptor 4-activated B cells out-compete Toll-like receptor 9-activated B cells to establish peripheral immunological tolerance. Proc Natl Acad Sci U S A (2012) 0.89
Immunoimaging: studying immune system dynamics using two-photon microscopy. Cold Spring Harb Protoc (2011) 0.89
CD95 triggers Orai1-mediated localized Ca2+ entry, regulates recruitment of protein kinase C (PKC) β2, and prevents death-inducing signaling complex formation. Proc Natl Acad Sci U S A (2011) 0.88
Orai3 TM3 point mutation G158C alters kinetics of 2-APB-induced gating by disulfide bridge formation with TM2 C101. J Gen Physiol (2013) 0.87
Three phases of CD8 T cell response in the lung following H1N1 influenza infection and sphingosine 1 phosphate agonist therapy. PLoS One (2013) 0.86
Analysis of transient migration behavior of natural killer cells imaged in situ and in vitro. Integr Biol (Camb) (2011) 0.84
State-dependent block of Orai3 TM1 and TM3 cysteine mutants: insights into 2-APB activation. J Gen Physiol (2014) 0.84
Orai1 function is essential for T cell homing to lymph nodes. J Immunol (2013) 0.83
Dissection and 2-photon imaging of peripheral lymph nodes in mice. J Vis Exp (2007) 0.83
Protein kinase D orchestrates the activation of DRAK2 in response to TCR-induced Ca2+ influx and mitochondrial reactive oxygen generation. J Immunol (2010) 0.81
Imaging transplant rejection: a new view. Nat Med (2011) 0.78
Purifying plasmid DNA from bacterial colonies using the QIAGEN Miniprep Kit. J Vis Exp (2007) 0.77
In vivo lymph node imaging. Cold Spring Harb Protoc (2011) 0.77
General approach to adoptive transfer and cell labeling for immunoimaging. Cold Spring Harb Protoc (2011) 0.76
STOP! In the name of positive selection. Nat Immunol (2005) 0.76
The ins and outs of polycystin-2 as a calcium release channel. Nat Cell Biol (2002) 0.75
Promoting remyelination: utilizing a viral model of demyelination to assess cell-based therapies. Expert Rev Neurother (2014) 0.75
Induction of an immune response for imaging antigen-presenting cell/T-cell interactions. Cold Spring Harb Protoc (2011) 0.75
In situ lymph node imaging. Cold Spring Harb Protoc (2011) 0.75