Published in Neuron on December 10, 2008
In embryonic stem cells, ZFP57/KAP1 recognize a methylated hexanucleotide to affect chromatin and DNA methylation of imprinting control regions. Mol Cell (2011) 3.67
Trim28 Haploinsufficiency Triggers Bi-stable Epigenetic Obesity. Cell (2016) 2.75
Bromodomains as therapeutic targets. Expert Rev Mol Med (2011) 2.52
KRAB-zinc finger proteins and KAP1 can mediate long-range transcriptional repression through heterochromatin spreading. PLoS Genet (2010) 2.44
KAP1 protein: an enigmatic master regulator of the genome. J Biol Chem (2011) 2.15
Regulation of hippocampal H3 histone methylation by acute and chronic stress. Proc Natl Acad Sci U S A (2009) 1.72
Epigenetic mechanisms of depression and antidepressant action. Annu Rev Pharmacol Toxicol (2012) 1.45
Setdb1 histone methyltransferase regulates mood-related behaviors and expression of the NMDA receptor subunit NR2B. J Neurosci (2010) 1.33
TRIM28 repression of retrotransposon-based enhancers is necessary to preserve transcriptional dynamics in embryonic stem cells. Genome Res (2012) 1.29
The KRAB-ZFP/KAP1 system contributes to the early embryonic establishment of site-specific DNA methylation patterns maintained during development. Cell Rep (2012) 1.28
A KRAB/KAP1-miRNA cascade regulates erythropoiesis through stage-specific control of mitophagy. Science (2013) 1.18
Behavioral epigenetics. Ann N Y Acad Sci (2011) 1.14
Balancing histone methylation activities in psychiatric disorders. Trends Mol Med (2011) 1.14
Reduced levels of two modifiers of epigenetic gene silencing, Dnmt3a and Trim28, cause increased phenotypic noise. Genome Biol (2010) 1.10
Acute stress and hippocampal histone H3 lysine 9 trimethylation, a retrotransposon silencing response. Proc Natl Acad Sci U S A (2012) 1.08
KAP1 regulates gene networks controlling mouse B-lymphoid cell differentiation and function. Blood (2012) 1.05
KAP1 regulates gene networks controlling T-cell development and responsiveness. FASEB J (2012) 1.02
Liver-specific ablation of Krüppel-associated box-associated protein 1 in mice leads to male-predominant hepatosteatosis and development of liver adenoma. Hepatology (2012) 1.01
The ancient mammalian KRAB zinc finger gene cluster on human chromosome 8q24.3 illustrates principles of C2H2 zinc finger evolution associated with unique expression profiles in human tissues. BMC Genomics (2010) 0.98
Genetic and epigenetic underpinnings of sex differences in the brain and in neurological and psychiatric disease susceptibility. Prog Brain Res (2010) 0.97
Epigenetic mechanisms in mood disorders: targeting neuroplasticity. Neuroscience (2013) 0.96
Peripuberty stress leads to abnormal aggression, altered amygdala and orbitofrontal reactivity and increased prefrontal MAOA gene expression. Transl Psychiatry (2013) 0.94
How the epigenome contributes to the development of psychiatric disorders. Dev Psychobiol (2010) 0.92
TRIM28 represses transcription of endogenous retroviruses in neural progenitor cells. Cell Rep (2014) 0.91
TRIM28 is required by the mouse KRAB domain protein ZFP568 to control convergent extension and morphogenesis of extra-embryonic tissues. Development (2011) 0.90
KAPtain in charge of multiple missions: Emerging roles of KAP1. World J Biol Chem (2014) 0.89
Paraquat induces epigenetic changes by promoting histone acetylation in cell culture models of dopaminergic degeneration. Neurotoxicology (2011) 0.89
Should I stay or should I go: protection and maintenance of DNA methylation at imprinted genes. Epigenetics (2012) 0.88
TRIM28 is essential for erythroblast differentiation in the mouse. Blood (2013) 0.88
Sensitive periods in epigenetics: bringing us closer to complex behavioral phenotypes. Epigenomics (2012) 0.87
Epigenetic modification of TLRs in leukocytes is associated with increased susceptibility to Salmonella enteritidis in chickens. PLoS One (2012) 0.86
Release of human cytomegalovirus from latency by a KAP1/TRIM28 phosphorylation switch. Elife (2015) 0.83
Gastrodia elata Blume (tianma) mobilizes neuro-protective capacities. Int J Biochem Mol Biol (2012) 0.82
Putting a KAP on transcription and stress. Neuron (2008) 0.82
Kruppel-associated box (KRAB) proteins in the adaptive immune system. Nucleus (2014) 0.80
Epigenetic (de)regulation of adult hippocampal neurogenesis: implications for depression. Clin Epigenetics (2011) 0.80
Epigenetics components of aging in the central nervous system. Neurotherapeutics (2013) 0.79
Epigenetics in the nervous system: An overview of its essential role. Indian J Hum Genet (2013) 0.79
Transposable Elements, Polydactyl Proteins, and the Genesis of Human-Specific Transcription Networks. Cold Spring Harb Symp Quant Biol (2016) 0.78
MAS promoter regulation: a role for Sry and tyrosine nitration of the KRAB domain of ZNF274 as a feedback mechanism. Clin Sci (Lond) (2014) 0.78
[A KRAB/KAP1-miRNA cascade regulates erythropoiesis through stage-specific control of mitophagy]. Med Sci (Paris) (2014) 0.77
Signal transducer and activator of transcription 3 regulation by novel binding partners. World J Biol Chem (2015) 0.75
Don't worry; be informed about the epigenetics of anxiety. Pharmacol Biochem Behav (2016) 0.75
Cognition and mood-related behaviors in L3mbtl1 null mutant mice. PLoS One (2015) 0.75
Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts. Nature (2003) 13.24
Conditional suppression of cellular genes: lentivirus vector-mediated drug-inducible RNA interference. J Virol (2003) 6.21
Inhibition of hepatitis B virus replication by APOBEC3G. Science (2004) 5.15
KAP1 controls endogenous retroviruses in embryonic stem cells. Nature (2010) 4.02
Embryonic stem cell potency fluctuates with endogenous retrovirus activity. Nature (2012) 3.96
Genetic reactivation of cone photoreceptors restores visual responses in retinitis pigmentosa. Science (2010) 3.92
EZH2 oncogenic activity in castration-resistant prostate cancer cells is Polycomb-independent. Science (2012) 3.74
Light-activated channels targeted to ON bipolar cells restore visual function in retinal degeneration. Nat Neurosci (2008) 3.73
In embryonic stem cells, ZFP57/KAP1 recognize a methylated hexanucleotide to affect chromatin and DNA methylation of imprinting control regions. Mol Cell (2011) 3.67
Characterizing light-regulated retinal microRNAs reveals rapid turnover as a common property of neuronal microRNAs. Cell (2010) 3.57
Epigenetic transmission of the impact of early stress across generations. Biol Psychiatry (2010) 3.55
A versatile tool for conditional gene expression and knockdown. Nat Methods (2006) 2.92
Protein phosphatase 1 is a molecular constraint on learning and memory. Nature (2002) 2.91
A switch between topological domains underlies HoxD genes collinearity in mouse limbs. Science (2013) 2.86
Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS. Nat Med (2005) 2.80
A single amino acid determinant governs the species-specific sensitivity of APOBEC3G to Vif action. J Biol Chem (2004) 2.79
NSD1 is essential for early post-implantation development and has a catalytically active SET domain. EMBO J (2003) 2.72
KRAB-zinc finger proteins and KAP1 can mediate long-range transcriptional repression through heterochromatin spreading. PLoS Genet (2010) 2.44
Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy. Nat Rev Drug Discov (2012) 2.44
Prion protein and Abeta-related synaptic toxicity impairment. EMBO Mol Med (2010) 2.25
The gamma 2 subunit of GABA(A) receptors is required for maintenance of receptors at mature synapses. Mol Cell Neurosci (2003) 2.18
Proteolytic degradation of SCOP in the hippocampus contributes to activation of MAP kinase and memory. Cell (2007) 2.12
Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Mol Cell Proteomics (2006) 2.09
Dendritic spine loss and synaptic alterations in Alzheimer's disease. Mol Neurobiol (2008) 2.03
APOBEC3G genetic variants and their influence on the progression to AIDS. J Virol (2004) 1.97
Role for human immunodeficiency virus type 1 membrane cholesterol in viral internalization. J Virol (2002) 1.81
Association of the transcriptional corepressor TIF1beta with heterochromatin protein 1 (HP1): an essential role for progression through differentiation. Genes Dev (2004) 1.76
Abnormal fear conditioning and amygdala processing in an animal model of autism. Neuropsychopharmacology (2007) 1.73
Loss of Trim24 (Tif1alpha) gene function confers oncogenic activity to retinoic acid receptor alpha. Nat Genet (2007) 1.68
Entry and transcription as key determinants of differences in CD4 T-cell permissiveness to human immunodeficiency virus type 1 infection. J Virol (2004) 1.68
Dynamic control of endogenous retroviruses during development. Virology (2011) 1.66
T:G mismatch-specific thymine-DNA glycosylase potentiates transcription of estrogen-regulated genes through direct interaction with estrogen receptor alpha. J Biol Chem (2003) 1.62
An epigenetic silencing pathway controlling T helper 2 cell lineage commitment. Nature (2012) 1.60
The Kruppel-associated box repressor domain can trigger de novo promoter methylation during mouse early embryogenesis. J Biol Chem (2007) 1.59
Cell differentiation induces TIF1beta association with centromeric heterochromatin via an HP1 interaction. J Cell Sci (2002) 1.59
Epigenetic codes in cognition and behaviour. Behav Brain Res (2008) 1.56
Inactivation of TIF1gamma cooperates with Kras to induce cystic tumors of the pancreas. PLoS Genet (2009) 1.55
Controlled release nanoparticle-embedded coatings reduce the tissue reaction to neuroprostheses. J Control Release (2010) 1.54
A human TRIM5alpha B30.2/SPRY domain mutant gains the ability to restrict and prematurely uncoat B-tropic murine leukemia virus. Virology (2008) 1.52
Differentiation of trophoblast giant cells and their metabolic functions are dependent on peroxisome proliferator-activated receptor beta/delta. Mol Cell Biol (2006) 1.49
Statins reduce interleukin-6-induced C-reactive protein in human hepatocytes: new evidence for direct antiinflammatory effects of statins. Arterioscler Thromb Vasc Biol (2005) 1.49
Primer binding site-dependent restriction of murine leukemia virus requires HP1 binding by TRIM28. J Virol (2008) 1.49
Lentiviral vector transduction of NOD/SCID repopulating cells results in multiple vector integrations per transduced cell: risk of insertional mutagenesis. Blood (2002) 1.49
Highly efficient lentiviral vector-mediated transduction of nondividing, fully reimplantable primary hepatocytes. Mol Ther (2002) 1.46
Hide, shield and strike back: how HIV-infected cells avoid immune eradication. Nat Rev Immunol (2003) 1.45
Protein phosphatase 1 regulates the histone code for long-term memory. J Neurosci (2009) 1.44
Comprehensive mapping of post-translational modifications on synaptic, nuclear, and histone proteins in the adult mouse brain. J Proteome Res (2009) 1.43
MicroRNA-124 is a subventricular zone neuronal fate determinant. J Neurosci (2012) 1.43
Transcription cofactors TRIM24, TRIM28, and TRIM33 associate to form regulatory complexes that suppress murine hepatocellular carcinoma. Proc Natl Acad Sci U S A (2011) 1.42
iNKT cell development is orchestrated by different branches of TGF-beta signaling. J Exp Med (2009) 1.42
Tuning silence: conditional systems for RNA interference. Nat Methods (2006) 1.41
Editing at the crossroad of innate and adaptive immunity. Science (2005) 1.40
Deficiency of ribosomal protein S19 in CD34+ cells generated by siRNA blocks erythroid development and mimics defects seen in Diamond-Blackfan anemia. Blood (2004) 1.40
Structure-function analyses point to a polynucleotide-accommodating groove essential for APOBEC3A restriction activities. J Virol (2010) 1.40
Stress effects on working memory, explicit memory, and implicit memory for neutral and emotional stimuli in healthy men. Front Behav Neurosci (2009) 1.39
Genetically timed, activity-sensor and rainbow transsynaptic viral tools. Nat Methods (2009) 1.38
Oncogenesis following delivery of a nonprimate lentiviral gene therapy vector to fetal and neonatal mice. Mol Ther (2005) 1.38
Lentivirus-mediated RNA interference of DC-SIGN expression inhibits human immunodeficiency virus transmission from dendritic cells to T cells. J Virol (2004) 1.37
APOBEC3G-depleted resting CD4+ T cells remain refractory to HIV1 infection. PLoS One (2009) 1.37
Production and titration of lentiviral vectors. Curr Protoc Hum Genet (2007) 1.36
Control of the establishment of aversive memory by calcineurin and Zif268. Nat Neurosci (2008) 1.36
The innate antiretroviral factor APOBEC3G does not affect human LINE-1 retrotransposition in a cell culture assay. J Biol Chem (2004) 1.36
Negative control of Smad activity by ectodermin/Tif1gamma patterns the mammalian embryo. Development (2010) 1.35
Selective interaction between the chromatin-remodeling factor BRG1 and the heterochromatin-associated protein HP1alpha. EMBO J (2002) 1.35
Characterization of APOBEC3G binding to 7SL RNA. Retrovirology (2008) 1.34
DNA damage sensors ATM, ATR, DNA-PKcs, and PARP-1 are dispensable for human immunodeficiency virus type 1 integration. J Virol (2005) 1.34
Rescue of a severe mouse model for spinal muscular atrophy by U7 snRNA-mediated splicing modulation. Hum Mol Genet (2008) 1.33
Efficient gene transfer into human primary blood lymphocytes by surface-engineered lentiviral vectors that display a T cell-activating polypeptide. Blood (2002) 1.32
TRIM28 repression of retrotransposon-based enhancers is necessary to preserve transcriptional dynamics in embryonic stem cells. Genome Res (2012) 1.29
Modalities of interleukin-7-induced human immunodeficiency virus permissiveness in quiescent T lymphocytes. J Virol (2002) 1.29
NCS-1 in the dentate gyrus promotes exploration, synaptic plasticity, and rapid acquisition of spatial memory. Neuron (2009) 1.29
Neural mechanisms of stress resilience and vulnerability. Neuron (2012) 1.29
Abeta oligomer-mediated long-term potentiation impairment involves protein phosphatase 1-dependent mechanisms. J Neurosci (2007) 1.28
The KRAB-ZFP/KAP1 system contributes to the early embryonic establishment of site-specific DNA methylation patterns maintained during development. Cell Rep (2012) 1.28
Lentivector-mediated transfer of Bmi-1 and telomerase in muscle satellite cells yields a duchenne myoblast cell line with long-term genotypic and phenotypic stability. Hum Gene Ther (2003) 1.27
Epigenetic inactivation of the Sotos overgrowth syndrome gene histone methyltransferase NSD1 in human neuroblastoma and glioma. Proc Natl Acad Sci U S A (2009) 1.27
Epigenetic tethering of AID to the donor switch region during immunoglobulin class switch recombination. J Exp Med (2011) 1.26
Model structure of human APOBEC3G. PLoS One (2007) 1.24
Production and titration of lentiviral vectors. Curr Protoc Neurosci (2010) 1.24
The ATM substrate KAP1 controls DNA repair in heterochromatin: regulation by HP1 proteins and serine 473/824 phosphorylation. Mol Cancer Res (2011) 1.23
De novo DNA methylation of endogenous retroviruses is shaped by KRAB-ZFPs/KAP1 and ESET. Development (2013) 1.23
Contribution of proteoglycans to human immunodeficiency virus type 1 brain invasion. J Virol (2004) 1.23
Influence of early stress on social abilities and serotonergic functions across generations in mice. PLoS One (2011) 1.22
IL-7 surface-engineered lentiviral vectors promote survival and efficient gene transfer in resting primary T lymphocytes. Blood (2002) 1.21
Prior exposure to a single stress session facilitates subsequent contextual fear conditioning in rats. Evidence for a role of corticosterone. Horm Behav (2003) 1.20
Phosphoinositide-3-kinase activation controls synaptogenesis and spinogenesis in hippocampal neurons. J Neurosci (2011) 1.19
A KRAB/KAP1-miRNA cascade regulates erythropoiesis through stage-specific control of mitophagy. Science (2013) 1.18
Production and titration of lentiviral vectors. Curr Protoc Neurosci (2006) 1.18
Stress at learning facilitates memory formation by regulating AMPA receptor trafficking through a glucocorticoid action. Neuropsychopharmacology (2009) 1.17
Harnessing HIV for therapy, basic research and biotechnology. Trends Biotechnol (2005) 1.17
A facilitative role for corticosterone in the acquisition of a spatial task under moderate stress. Learn Mem (2004) 1.17
Transcription intermediary factor 1γ is a tumor suppressor in mouse and human chronic myelomonocytic leukemia. J Clin Invest (2011) 1.16