Published in Chem Biol Drug Des on December 01, 2008
Thumb inhibitor binding eliminates functionally important dynamics in the hepatitis C virus RNA polymerase. Proteins (2012) 0.91
Structure-based virtual screening, synthesis and SAR of novel inhibitors of hepatitis C virus NS5B polymerase. Bioorg Med Chem (2010) 0.84
Multiple virtual screening approaches for finding new hepatitis C virus RNA-dependent RNA polymerase inhibitors: structure-based screens and molecular dynamics for the pursue of new poly pharmacological inhibitors. BMC Bioinformatics (2012) 0.80
Antiviral activities and cellular toxicities of modified 2',3'-dideoxy-2',3'-didehydrocytidine analogues. Antimicrob Agents Chemother (2002) 1.79
Mechanochemistry of transcription termination factor Rho. Mol Cell (2006) 1.79
Mechanochemistry of t7 DNA helicase. J Mol Biol (2005) 1.40
Natural derivatives of curcumin attenuate the Wnt/beta-catenin pathway through down-regulation of the transcriptional coactivator p300. Biochem Biophys Res Commun (2008) 1.20
Hexachlorophene inhibits Wnt/beta-catenin pathway by promoting Siah-mediated beta-catenin degradation. Mol Pharmacol (2006) 1.16
Protein-kinase-C-mediated beta-catenin phosphorylation negatively regulates the Wnt/beta-catenin pathway. J Cell Sci (2006) 1.12
Amplification of an RNA ligase ribozyme under alternating temperature conditions. FEBS Lett (2008) 1.09
Isothermal DNA amplification in vitro: the helicase-dependent amplification system. Cell Mol Life Sci (2009) 1.01
Diclofenac attenuates Wnt/beta-catenin signaling in colon cancer cells by activation of NF-kappaB. FEBS Lett (2005) 0.99
L-nucleosides: antiviral activity and molecular mechanism. Curr Top Med Chem (2002) 0.99
Production of a novel quercetin glycoside through metabolic engineering of Escherichia coli. Appl Environ Microbiol (2012) 0.97
Evaluation of generations 2, 3 and 4 arginine modified PAMAM dendrimers for gene delivery. Int J Pharm (2008) 0.97
Small molecule-based disruption of the Axin/β-catenin protein complex regulates mesenchymal stem cell differentiation. Cell Res (2011) 0.97
An amino acid at position 142 in nitrilase from Rhodococcus rhodochrous ATCC 33278 determines the substrate specificity for aliphatic and aromatic nitriles. Biochem J (2008) 0.94
Cardamonin suppresses melanogenesis by inhibition of Wnt/beta-catenin signaling. Biochem Biophys Res Commun (2009) 0.93
Stimulation of protein kinase C-alpha suppresses colon cancer cell proliferation by down-regulation of beta-catenin. J Cell Mol Med (2009) 0.92
A graphene-based platform for the assay of duplex-DNA unwinding by helicase. Angew Chem Int Ed Engl (2010) 0.91
Femoral shaft bowing in the coronal plane has more significant effect on the coronal alignment of TKA than proximal or distal variations of femoral shape. Knee Surg Sports Traumatol Arthrosc (2014) 0.90
Isoeugenol suppression of inducible nitric oxide synthase expression is mediated by down-regulation of NF-kappaB, ERK1/2, and p38 kinase. Eur J Pharmacol (2007) 0.90
Peptide-mediated shape- and size-tunable synthesis of gold nanostructures. Acta Biomater (2010) 0.90
Selection of an antiviral RNA aptamer against hemagglutinin of the subtype H5 avian influenza virus. Nucleic Acid Ther (2011) 0.89
Synthesis, anti-HIV activity, and molecular mechanism of drug resistance of L-2',3'-didehydro-2',3'-dideoxy-2'-fluoro-4'-thionucleosides. J Med Chem (2003) 0.87
Development of RNA aptamers for detection of Salmonella Enteritidis. J Microbiol Methods (2012) 0.87
Apoptotic cell imaging using phosphatidylserine-specific receptor-conjugated Ru(bpy)(3) (2+)-doped silica nanoparticles. Small (2010) 0.86
Chemical approach for specific enrichment and mass analysis of nitrated peptides. Anal Chem (2009) 0.86
Isolation of inhibitory RNA aptamers against severe acute respiratory syndrome (SARS) coronavirus NTPase/Helicase. Biochem Biophys Res Commun (2007) 0.84
Galangin suppresses the proliferation of β-catenin response transcription-positive cancer cells by promoting adenomatous polyposis coli/Axin/glycogen synthase kinase-3β-independent β-catenin degradation. Mol Pharmacol (2011) 0.84
Cation dependent O-methyltransferases from rice. Planta (2007) 0.84
Inhibition kinetics of mushroom tyrosinase by copper-chelating ammonium tetrathiomolybdate. Biochim Biophys Acta (2005) 0.84
Location of flavone B-ring controls regioselectivity and stereoselectivity of naphthalene dioxygenase from Pseudomonas sp. strain NCIB 9816-4. Appl Microbiol Biotechnol (2009) 0.83
Absolute configuration-dependent epoxide formation from isoflavan-4-ol stereoisomers by biphenyl dioxygenase of Pseudomonas pseudoalcaligenes strain KF707. Appl Microbiol Biotechnol (2010) 0.83
Synthesis, structure-activity relationships, and mechanism of drug resistance of D- and L-beta-3'-fluoro-2',3'-unsaturated-4'-thionucleosides as anti-HIV agents. J Med Chem (2004) 0.83
Structure-based design, synthesis, evaluation, and crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase. J Biol Chem (2007) 0.83
Kinetic pathway of dTTP hydrolysis by hexameric T7 helicase-primase in the absence of DNA. J Biol Chem (2002) 0.83
Decursin suppresses human androgen-independent PC3 prostate cancer cell proliferation by promoting the degradation of beta-catenin. Mol Pharmacol (2007) 0.83
Mechanism of DNA adsorption and desorption on graphene oxide. Langmuir (2014) 0.82
Cooperative translocation enhances the unwinding of duplex DNA by SARS coronavirus helicase nsP13. Nucleic Acids Res (2010) 0.82
Synthesis, structure-activity relationships, and drug resistance of beta-d-3'-fluoro-2',3'-unsaturated nucleosides as anti-HIV Agents. J Med Chem (2004) 0.82
Synthesis and biological evaluation of N-[4-[5-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-2-(2,2,2-trifluoroacetyl)pentyl]benzoyl]-L-glutamic acid as a potential inhibitor of GAR Tfase and the de novo purine biosynthetic pathway. Bioorg Med Chem (2005) 0.82
Characterization of an isoeugenol monooxygenase (Iem) from Pseudomonas nitroreducens Jin1 that transforms isoeugenol to vanillin. Biosci Biotechnol Biochem (2013) 0.82
Homologous expression and T3SS-dependent secretion of TAP-tagged Xo2276 in Xanthomonas oryzae pv. oryzae induced by rice leaf extract and its direct in vitro recognition of putative target DNA sequence. J Microbiol Biotechnol (2013) 0.82
Nucleotide binding induces conformational changes in Escherichia coli transcription termination factor Rho. J Biol Chem (2004) 0.81
Engineering of flavonoid O-methyltransferase for a novel regioselectivity. Mol Cells (2010) 0.81
Polysiphonia japonica extract suppresses the Wnt/beta-catenin pathway in colon cancer cells by activation of NF-kappaB. Int J Mol Med (2006) 0.80
Aryl diketoacids (ADK) selectively inhibit duplex DNA-unwinding activity of SARS coronavirus NTPase/helicase. Bioorg Med Chem Lett (2009) 0.80
Kocuria gwangalliensis sp. nov., an actinobacterium isolated from seawater. Int J Syst Evol Microbiol (2009) 0.80
Desorption of single-stranded nucleic acids from graphene oxide by disruption of hydrogen bonding. Analyst (2013) 0.80
Facilitation of polymerase chain reaction with thermostable inorganic pyrophosphatase from hyperthermophilic archaeon Pyrococcus horikoshii. Appl Microbiol Biotechnol (2010) 0.80
In vitro solubility, stability and permeability of novel quercetin-amino acid conjugates. Bioorg Med Chem (2008) 0.80
Amino acid substitutions in naphthalene dioxygenase from Pseudomonas sp. strain NCIB 9816-4 result in regio- and stereo-specific hydroxylation of flavanone and isoflavanone. Appl Microbiol Biotechnol (2012) 0.80
Bacterial synthesis of a flavonoid deoxyaminosugar conjugate in Escherichia coli expressing a glycosyltransferase of Arabidopsis thaliana. Chembiochem (2010) 0.79
4-Aminoethylpiperazinyl aryl ketones with 5-HT₁A/5-HT₇ selectivity. Bioorg Med Chem (2011) 0.79
Characterization of uridine-diphosphate dependent flavonoid glucosyltransferase from Oryza sativa. J Biochem Mol Biol (2007) 0.79
Change of Bacillus cereus flavonoid O-triglucosyltransferase into flavonoid O-monoglucosyltransferase by error-prone polymerase chain reaction. J Microbiol Biotechnol (2010) 0.79
Expression of glucocorticoid receptor mRNAs in glucocorticoid-resistant nasal polyps. Exp Mol Med (2006) 0.79
Suppression of interleukin-2 gene expression by isoeugenol is mediated through down-regulation of NF-AT and NF-kappaB. Int Immunopharmacol (2007) 0.79
Novel PPARγ partial agonists with weak activity and no cytotoxicity; identified by a simple PPARγ ligand screening system. Mol Cell Biochem (2011) 0.79
Synthesis of the 5-phosphono-pent-2-en-1-yl nucleosides: a new class of antiviral acyclic nucleoside phosphonates. Bioorg Med Chem (2006) 0.79
Enhanced stability and intracellular accumulation of quercetin by protection of the chemically or metabolically susceptible hydroxyl groups with a pivaloxymethyl (POM) promoiety. J Med Chem (2010) 0.79
Sniffing for gene-silencing efficiency of siRNAs in HeLa cells in comparison with that in HEK293T cells: correlation between knockdown efficiency and sustainability of sirnas revealed by FRET-based probing. Nucleic Acid Ther (2013) 0.79
Two O-methyltransferases from Picea abies: characterization and molecular basis of different reactivity. Planta (2010) 0.79
Bisindoylmaleimide I suppresses adipocyte differentiation through stabilization of intracellular beta-catenin protein. Biochem Biophys Res Commun (2008) 0.79
Synthesis of flavonoid O-pentosides by Escherichia coli through engineering of nucleotide sugar pathways and glycosyltransferase. Appl Environ Microbiol (2014) 0.79
Deoxyribozyme-loaded nano-graphene oxide for simultaneous sensing and silencing of the hepatitis C virus gene in liver cells. Chem Commun (Camb) (2013) 0.78
Synthesis of beta-enantiomers of N4-hydroxy-3'-deoxypyrimidine nucleosides and their evaluation against bovine viral diarrhoea virus and hepatitis C virus in cell culture. Antivir Chem Chemother (2004) 0.78
Water-soluble and cleavable quercetin-amino acid conjugates as safe modulators for P-glycoprotein-based multidrug resistance. J Med Chem (2014) 0.78
Detection of single-base mutation in RNA using T4 RNA ligase-based nick-joining or DNAzyme-based nick-generation. Anal Biochem (2011) 0.78
Functional delivery of DNAzyme with iron oxide nanoparticles for hepatitis C virus gene knockdown. Biomaterials (2011) 0.78
Suppression of hepatitis C virus genome replication in cells with RNA-cleaving DNA enzymes and short-hairpin RNA. Oligonucleotides (2010) 0.78
FRET-based probing to gain direct information on siRNA sustainability in live cells: Asymmetric degradation of siRNA strands. Mol Biosyst (2011) 0.78
The role of 2',3'-unsaturation on the antiviral activity of anti-HIV nucleosides against 3TC-resistant mutant (M184V). Bioorg Med Chem Lett (2003) 0.78
Quercetin-POC conjugates: Differential stability and bioactivity profiles between breast cancer (MCF-7) and colorectal carcinoma (HCT116) cell lines. Bioorg Med Chem (2013) 0.78
Dicyanovinyl-substituted J147 analogue inhibits oligomerization and fibrillation of β-amyloid peptides and protects neuronal cells from β-amyloid-induced cytotoxicity. Org Biomol Chem (2015) 0.77
Inhibitory effect of ammonium tetrathiotungstate on tyrosinase and its kinetic mechanism. Chem Pharm Bull (Tokyo) (2006) 0.77
2-Arylmethylaminomethyl-5,6-dihydroxychromone derivatives with selective anti-HCV activity. Bioorg Med Chem Lett (2011) 0.77
Discovery of hepatitis C virus NS3 helicase inhibitors by a multiplexed, high-throughput helicase activity assay based on graphene oxide. Angew Chem Int Ed Engl (2013) 0.77
Properties of the alpha subunit of a Chaperonin from the hyperthermophilic Crenarchaeon Aeropyrum pernix K1. FEMS Microbiol Lett (2007) 0.77
Characterization of bacteriophage φPto-bp6g, a novel phage that lyses Pseudomonas tolaasii causing brown blotch disease in mushrooms. J Microbiol Methods (2012) 0.77
2,6-Bis-arylmethyloxy-5-hydroxychromones with antiviral activity against both hepatitis C virus (HCV) and SARS-associated coronavirus (SCV). Eur J Med Chem (2011) 0.77
Fluorescence-based detection of single-nucleotide changes in RNA using graphene oxide and DNAzyme. Chem Commun (Camb) (2015) 0.77
Time-dependent density functional theory-assisted absolute configuration determination of cis-dihydrodiol metabolite produced from isoflavone by biphenyl dioxygenase. Anal Biochem (2009) 0.77
Effects of spermatozoa during in vitro meiosis progression in the porcine germinal vesicle oocytes. Anim Reprod Sci (2007) 0.77
Synthesis and potent anti-HIV activity of L-2',3'-didehydro-2',3'-dideoxy-2'-fluoro-4'-thiocytidine. Org Lett (2002) 0.77
Identification of the catalytic subunit of acetohydroxyacid synthase in Haemophilus influenzae and its potent inhibitors. Arch Biochem Biophys (2007) 0.77
Proteasome inhibitors with pyrazole scaffolds from structure-based virtual screening. J Med Chem (2015) 0.77
Engineering flavonoid glycosyltransferases for enhanced catalytic efficiency and extended sugar-donor selectivity. Planta (2013) 0.77
Oligodeoxyribozymes that cleave beta-catenin messenger RNA inhibit growth of colon cancer cells via reduction of beta-catenin response transcription. Mol Cancer Ther (2010) 0.77
Sendai F/HN viroplexes for efficient transfection of leukemic T cells. Yonsei Med J (2013) 0.76
O-Methylation of flavonoids using DnrK based on molecular docking. J Microbiol Biotechnol (2007) 0.76
An efficient colorimetric assay for RNA synthesis by viral RNA-dependent RNA polymerases, using thermostable pyrophosphatase. Anal Biochem (2012) 0.76
Site-specific cleavage of mutant ABL mRNA by DNAzyme is facilitated by peptide nucleic acid binding to RNA substrate. FEBS Lett (2012) 0.76
Purification of a fibrinolytic enzyme (myulchikinase) from pickled anchovy and its cytotoxicity to the tumor cell lines. Biotechnol Lett (2004) 0.76
Design, synthesis, and biological evaluation of 10-methanesulfonyl-DDACTHF, 10-methanesulfonyl-5-DACTHF, and 10-methylthio-DDACTHF as potent inhibitors of GAR Tfase and the de novo purine biosynthetic pathway. Bioorg Med Chem (2005) 0.76
Shell-crosslinked hyaluronic acid nanogels for live monitoring of hyaluronidase activity in vivo. Macromol Biosci (2014) 0.75
Investigation of the pharmacophore space of Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) NTPase/helicase by dihydroxychromone derivatives. Bioorg Med Chem Lett (2009) 0.75