Physical approaches to biomaterial design.

Strategies in the design of nanoparticles for therapeutic applications. Nat Rev Drug Discov (2010) 7.48

Transferrin-functionalized nanoparticles lose their targeting capabilities when a biomolecule corona adsorbs on the surface. Nat Nanotechnol (2013) 3.39

Growth factor delivery-based tissue engineering: general approaches and a review of recent developments. J R Soc Interface (2010) 2.69

Using mechanobiological mimicry of red blood cells to extend circulation times of hydrogel microparticles. Proc Natl Acad Sci U S A (2011) 2.63

A tissue-engineered jellyfish with biomimetic propulsion. Nat Biotechnol (2012) 2.30

Polymer particle shape independently influences binding and internalization by macrophages. J Control Release (2010) 2.05

Synthetic nanoparticles functionalized with biomimetic leukocyte membranes possess cell-like functions. Nat Nanotechnol (2012) 1.85

Perspectives and opportunities for nanomedicine in the management of atherosclerosis. Nat Rev Drug Discov (2011) 1.78

Engineering nano- and microparticles to tune immunity. Adv Mater (2012) 1.75

The effect of 3D hydrogel scaffold modulus on osteoblast differentiation and mineralization revealed by combinatorial screening. Biomaterials (2010) 1.71

Substrate elasticity provides mechanical signals for the expansion of hemopoietic stem and progenitor cells. Nat Biotechnol (2010) 1.66

Active scaffolds for on-demand drug and cell delivery. Proc Natl Acad Sci U S A (2010) 1.58

Strategies for advancing cancer nanomedicine. Nat Mater (2013) 1.48

Computer simulation of the translocation of nanoparticles with different shapes across a lipid bilayer. Nat Nanotechnol (2010) 1.45

Nanofibrous hollow microspheres self-assembled from star-shaped polymers as injectable cell carriers for knee repair. Nat Mater (2011) 1.39

Red blood cell-mimicking synthetic biomaterial particles. Proc Natl Acad Sci U S A (2009) 1.38

Aspect ratio determines the quantity of mesoporous silica nanoparticle uptake by a small GTPase-dependent macropinocytosis mechanism. ACS Nano (2011) 1.38

Using shape effects to target antibody-coated nanoparticles to lung and brain endothelium. Proc Natl Acad Sci U S A (2013) 1.37

Flow and adhesion of drug carriers in blood vessels depend on their shape: a study using model synthetic microvascular networks. J Control Release (2010) 1.35

Surface characterization of extracellular matrix scaffolds. Biomaterials (2009) 1.28

Neurons sense nanoscale roughness with nanometer sensitivity. Proc Natl Acad Sci U S A (2010) 1.27

Biomimetic delivery with micro- and nanoparticles. Adv Mater (2012) 1.25

The preferential targeting of the diseased microvasculature by disk-like particles. Biomaterials (2012) 1.25

Photothermal effects of supramolecularly assembled gold nanoparticles for the targeted treatment of cancer cells. Angew Chem Int Ed Engl (2010) 1.25

Synthesis and biological response of size-specific, monodisperse drug-silica nanoconjugates. ACS Nano (2012) 1.23

Polymer particles that switch shape in response to a stimulus. Proc Natl Acad Sci U S A (2010) 1.16

Hybrid nanoparticles for detection and treatment of cancer. Adv Mater (2012) 1.16

The influence of size, shape and vessel geometry on nanoparticle distribution. Microfluid Nanofluidics (2012) 1.13

Investigating the optimal size of anticancer nanomedicine. Proc Natl Acad Sci U S A (2014) 1.13

A rapid pathway toward a superb gene delivery system: programming structural and functional diversity into a supramolecular nanoparticle library. ACS Nano (2010) 1.10

Self-folding polymeric containers for encapsulation and delivery of drugs. Adv Drug Deliv Rev (2012) 1.09

Squishy non-spherical hydrogel microparticles. Macromol Rapid Commun (2009) 1.07

Needle-shaped polymeric particles induce transient disruption of cell membranes. J R Soc Interface (2010) 1.06

Accelerating the Translation of Nanomaterials in Biomedicine. ACS Nano (2015) 1.05

Squeezing protein shells: how continuum elastic models, molecular dynamics simulations, and experiments coalesce at the nanoscale. Biophys J (2010) 1.05

Biomimetic hybrid scaffolds for engineering human tooth-ligament interfaces. Biomaterials (2010) 1.03

The shape of things to come: importance of design in nanotechnology for drug delivery. Ther Deliv (2012) 1.03

The effect of surface nanometre-scale morphology on protein adsorption. PLoS One (2010) 1.01

Effects of microparticle size and Fc density on macrophage phagocytosis. PLoS One (2013) 1.01

Microgel translocation through pores under confinement. Angew Chem Int Ed Engl (2010) 0.99

The effect of particle size on the biodistribution of low-modulus hydrogel PRINT particles. J Control Release (2012) 0.96

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Modular enzymatically crosslinked protein polymer hydrogels for in situ gelation. Biomaterials (2010) 0.95

Cell microenvironment engineering and monitoring for tissue engineering and regenerative medicine: the recent advances. Biomed Res Int (2014) 0.94

Development of functional biomaterials with micro- and nanoscale technologies for tissue engineering and drug delivery applications. J Tissue Eng Regen Med (2012) 0.94

Vascular bursts enhance permeability of tumour blood vessels and improve nanoparticle delivery. Nat Nanotechnol (2016) 0.93

Effect of temperature during assembly on the structure and mechanical properties of peptide-based materials. Biomacromolecules (2010) 0.93

Blood-stable, tumor-adaptable disulfide bonded mPEG-(Cys)4-PDLLA micelles for chemotherapy. Biomaterials (2012) 0.93

Cicada-inspired cell-instructive nanopatterned arrays. Sci Rep (2014) 0.91

Advances in the surface modification techniques of bone-related implants for last 10 years. Regen Biomater (2014) 0.90

Prestress strengthens the shell of Norwalk virus nanoparticles. Nano Lett (2011) 0.89

Engineering nanomedicines using stimuli-responsive biomaterials. Adv Drug Deliv Rev (2012) 0.89

Size mapping of electric field-assisted production of polycaprolactone particles. J R Soc Interface (2010) 0.89

Microworm optode sensors limit particle diffusion to enable in vivo measurements. Proc Natl Acad Sci U S A (2011) 0.88

Delivery of cancer therapeutics using nanotechnology. Pharmaceutics (2013) 0.88

Perfluorocarbon particle size influences magnetic resonance signal and immunological properties of dendritic cells. PLoS One (2011) 0.88

Stimuli-responsive clustered nanoparticles for improved tumor penetration and therapeutic efficacy. Proc Natl Acad Sci U S A (2016) 0.87

Controlling cellular uptake of nanoparticles with pH-sensitive polymers. Sci Rep (2013) 0.87

Superparamagnetic iron oxide nanoparticle-based delivery systems for biotherapeutics. Expert Opin Drug Deliv (2012) 0.86

Immune complement activation is attenuated by surface nanotopography. Int J Nanomedicine (2011) 0.86

Low modulus biomimetic microgel particles with high loading of hemoglobin. Biomacromolecules (2012) 0.86

Recent progress on magnetic iron oxide nanoparticles: synthesis, surface functional strategies and biomedical applications. Sci Technol Adv Mater (2015) 0.86

Self-assembly of amphiphilic Janus dendrimers into uniform onion-like dendrimersomes with predictable size and number of bilayers. Proc Natl Acad Sci U S A (2014) 0.84

Size limits of self-assembled colloidal structures made using specific interactions. Proc Natl Acad Sci U S A (2014) 0.84

Nanotechnology: emerging tools for biology and medicine. Genes Dev (2013) 0.84

Neural responses to electrical stimulation on patterned silk films. J Biomed Mater Res A (2013) 0.84

De novo design of bioactive protein-resembling nanospheres via dendrimer-templated peptide amphiphile assembly. Nano Lett (2011) 0.84

A Microfluidic Platform to design crosslinked Hyaluronic Acid Nanoparticles (cHANPs) for enhanced MRI. Sci Rep (2016) 0.83

Biomaterials and stem cells for tissue engineering. Expert Opin Biol Ther (2013) 0.83

Polyphosphoester-based cationic nanoparticles serendipitously release integral biologically-active components to serve as novel degradable inducible nitric oxide synthase inhibitors. Adv Mater (2013) 0.83

Entropic and electrostatic effects on the folding free energy of a surface-attached biomolecule: an experimental and theoretical study. J Am Chem Soc (2012) 0.83

Shape switching of hollow layer-by-layer hydrogel microcontainers. Chem Commun (Camb) (2011) 0.82

Comprehensive genetic analysis of early host body reactions to the bioactive and bio-inert porous scaffolds. PLoS One (2014) 0.82

Detection and imaging of quorum sensing in Pseudomonas aeruginosa biofilm communities by surface-enhanced resonance Raman scattering. Nat Mater (2016) 0.82

Cancer targeted therapeutics: From molecules to drug delivery vehicles. J Control Release (2015) 0.82

Advancing biomaterials of human origin for tissue engineering. Prog Polym Sci (2015) 0.81

Primary human chondrocyte extracellular matrix formation and phenotype maintenance using RGD-derivatized PEGDM hydrogels possessing a continuous Young's modulus gradient. Acta Biomater (2013) 0.81

Fabricating gradient hydrogel scaffolds for 3D cell culture. Comb Chem High Throughput Screen (2011) 0.81

Mechanisms of budding of nanoscale particles through lipid bilayers. J Phys Chem B (2012) 0.81

Emergence and Utility of Nonspherical Particles in Biomedicine. Ind Eng Chem Res (2015) 0.81

Evaluation of multifunctional polysaccharide hydrogels with varying stiffness for bone tissue engineering. Tissue Eng Part A (2013) 0.81

Mesoporous organohydrogels from thermogelling photocrosslinkable nanoemulsions. Nat Mater (2012) 0.81

Engaging adaptive immunity with biomaterials. J Mater Chem B Mater Biol Med (2014) 0.81

Astrocytes increase ATP exocytosis mediated calcium signaling in response to microgroove structures. Sci Rep (2015) 0.81

FRET imaging reveals different cellular entry routes of self-assembled and disulfide bonded polymeric micelles. Mol Pharm (2013) 0.81

The surface properties of nanoparticles determine the agglomeration state and the size of the particles under physiological conditions. Beilstein J Nanotechnol (2014) 0.80

Drug Carrier for Photodynamic Cancer Therapy. Int J Mol Sci (2015) 0.80

Biomaterials for Bone Regenerative Engineering. Adv Healthc Mater (2015) 0.80

Nanoparticles for Cardiovascular Imaging and Therapeutic Delivery, Part 1: Compositions and Features. J Nucl Med (2015) 0.80

Composite materials. Taking a leaf from nature's book. Nat Nanotechnol (2012) 0.80

The role of surface chemistry-induced cell characteristics on nonviral gene delivery to mouse fibroblasts. J Biol Eng (2012) 0.80

Self-assembled micelles based on pH-sensitive PAE-g-MPEG-cholesterol block copolymer for anticancer drug delivery. Int J Nanomedicine (2014) 0.80

Geometric guidance of integrin mediated traction stress during stem cell differentiation. Biomaterials (2015) 0.80

Polymeric nanomaterials for islet targeting and immunotherapeutic delivery. Nano Lett (2011) 0.80

Preferential cell response to anisotropic electro-spun fibrous scaffolds under tension-free conditions. J Mater Sci Mater Med (2011) 0.80

Macrophages, Foreign Body Giant Cells and Their Response to Implantable Biomaterials. Materials (Basel) (2015) 0.79

Internalization of red blood cell-mimicking hydrogel capsules with pH-triggered shape responses. ACS Nano (2014) 0.79

Spontaneous shape reconfigurations in multicompartmental microcylinders. Proc Natl Acad Sci U S A (2012) 0.79

Proteins, platelets, and blood coagulation at biomaterial interfaces. Colloids Surf B Biointerfaces (2014) 0.79

Microgel mechanics in biomaterial design. Acc Chem Res (2014) 0.79

Matrix elasticity directs stem cell lineage specification. Cell (2006) 43.00

Tissue cells feel and respond to the stiffness of their substrate. Science (2005) 23.42

Click Chemistry: Diverse Chemical Function from a Few Good Reactions. Angew Chem Int Ed Engl (2001) 19.25

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The immunological synapse: a molecular machine controlling T cell activation. Science (1999) 17.41

Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment. Dev Cell (2004) 16.89

Cancer nanotechnology: opportunities and challenges. Nat Rev Cancer (2005) 13.49

Local force and geometry sensing regulate cell functions. Nat Rev Mol Cell Biol (2006) 11.29

Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells. Nano Lett (2006) 10.12

Long-circulating and target-specific nanoparticles: theory to practice. Pharmacol Rev (2001) 10.02

Capturing complex 3D tissue physiology in vitro. Nat Rev Mol Cell Biol (2006) 8.81

Designing materials for biology and medicine. Nature (2004) 7.73

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Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles. Int J Pharm (2005) 7.53

Biodegradable long-circulating polymeric nanospheres. Science (1994) 7.46

Myotubes differentiate optimally on substrates with tissue-like stiffness: pathological implications for soft or stiff microenvironments. J Cell Biol (2004) 7.38

The effect of particle design on cellular internalization pathways. Proc Natl Acad Sci U S A (2008) 7.06

Size-dependent internalization of particles via the pathways of clathrin- and caveolae-mediated endocytosis. Biochem J (2004) 6.90

Shape effects of filaments versus spherical particles in flow and drug delivery. Nat Nanotechnol (2007) 6.85

Role of target geometry in phagocytosis. Proc Natl Acad Sci U S A (2006) 6.62

Selective differentiation of neural progenitor cells by high-epitope density nanofibers. Science (2004) 6.38

Cellular mechanotransduction: putting all the pieces together again. FASEB J (2006) 5.84

Anisotropy of building blocks and their assembly into complex structures. Nat Mater (2007) 5.76

Exploring and engineering the cell surface interface. Science (2005) 5.54

Force mapping in epithelial cell migration. Proc Natl Acad Sci U S A (2005) 5.08

Temporal targeting of tumour cells and neovasculature with a nanoscale delivery system. Nature (2005) 4.97

Surface-structure-regulated cell-membrane penetration by monolayer-protected nanoparticles. Nat Mater (2008) 4.81

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Cancer immunotherapy: a treatment for the masses. Science (2004) 4.04

Direct fabrication and harvesting of monodisperse, shape-specific nanobiomaterials. J Am Chem Soc (2005) 4.02

The selective value of bacterial shape. Microbiol Mol Biol Rev (2006) 3.97

Forced unfolding of proteins within cells. Science (2007) 3.95

Mechanics of receptor-mediated endocytosis. Proc Natl Acad Sci U S A (2005) 3.78

Phagocytosis and the actin cytoskeleton. J Cell Sci (2001) 3.52

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Gold nanorod assisted near-infrared plasmonic photothermal therapy (PPTT) of squamous cell carcinoma in mice. Cancer Lett (2008) 3.20

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Multifunctional encoded particles for high-throughput biomolecule analysis. Science (2007) 2.75

Particle shape: a new design parameter for micro- and nanoscale drug delivery carriers. J Control Release (2007) 2.74

The adhesive strength of non-spherical particles mediated by specific interactions. Biomaterials (2006) 2.71

Control of endothelial targeting and intracellular delivery of therapeutic enzymes by modulating the size and shape of ICAM-1-targeted carriers. Mol Ther (2008) 2.69

Flexible substrata for the detection of cellular traction forces. Trends Cell Biol (2002) 2.62

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Fc-receptor-mediated phagocytosis is regulated by mechanical properties of the target. J Cell Sci (2002) 2.54

Continuous-flow lithography for high-throughput microparticle synthesis. Nat Mater (2006) 2.49

A quantum dot conjugated sugar ball and its cellular uptake. On the size effects of endocytosis in the subviral region. J Am Chem Soc (2004) 2.49

Nanofiber alignment and direction of mechanical strain affect the ECM production of human ACL fibroblast. Biomaterials (2005) 2.33

Micro/nano encapsulation via electrified coaxial liquid jets. Science (2002) 2.24

Role of particle size in phagocytosis of polymeric microspheres. Pharm Res (2008) 2.23

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Cell behaviour on micropatterned substrata: limits of extracellular matrix geometry for spreading and adhesion. J Cell Sci (2004) 2.12

Nanofabricated particles for engineered drug therapies: a preliminary biodistribution study of PRINT nanoparticles. J Control Release (2007) 2.09

Multifunctional nanorods for gene delivery. Nat Mater (2003) 2.09

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Nano and microparticles as controlled drug delivery devices. J Pharm Pharm Sci (2000) 2.05

Spontaneous assembly of subnanometre-ordered domains in the ligand shell of monolayer-protected nanoparticles. Nat Mater (2004) 2.05

Noninvasive Raman spectroscopy in living mice for evaluation of tumor targeting with carbon nanotubes. Nano Lett (2008) 2.01

Fabrication of PLG microspheres with precisely controlled and monodisperse size distributions. J Control Release (2001) 1.94

Cell responses to the mechanochemical microenvironment--implications for regenerative medicine and drug delivery. Adv Drug Deliv Rev (2007) 1.94

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Imparting size, shape, and composition control of materials for nanomedicine. Chem Soc Rev (2006) 1.91

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Making polymeric micro- and nanoparticles of complex shapes. Proc Natl Acad Sci U S A (2007) 1.84

Co-delivery of drugs and DNA from cationic core-shell nanoparticles self-assembled from a biodegradable copolymer. Nat Mater (2006) 1.84

Non-viral gene delivery regulated by stiffness of cell adhesion substrates. Nat Mater (2005) 1.83

Nanoparticles and microparticles as vaccine-delivery systems. Expert Rev Vaccines (2007) 1.76

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A surface-modified sperm sorting device with long-term stability. Biomed Microdevices (2006) 0.86

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Bio-orthogonal "double-click" chemistry based on multifunctional coatings. Angew Chem Int Ed Engl (2011) 0.80

Multicompartmental particles for combined imaging and siRNA delivery. Adv Mater (2012) 0.80

Microstructured materials based on multicompartmental fibers. J Am Chem Soc (2009) 0.79

A biologically active surface enzyme assembly that attenuates thrombus formation. Adv Funct Mater (2011) 0.79

Multifunctional polymer scaffolds with adjustable pore size and chemoattractant gradients for studying cell matrix invasion. Biomaterials (2013) 0.79

Spontaneous shape reconfigurations in multicompartmental microcylinders. Proc Natl Acad Sci U S A (2012) 0.79

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Anisotropic hybrid particles based on electrohydrodynamic co-jetting of nanoparticle suspensions. Phys Chem Chem Phys (2010) 0.76

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Co-immobilization of biomolecules on ultrathin reactive chemical vapor deposition coatings using multiple click chemistry strategies. ACS Appl Mater Interfaces (2013) 0.76

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Environmentally responsive core/shell particles via electrohydrodynamic co-jetting of fully miscible polymer solutions. Small (2008) 0.75

Water-stable biphasic nanocolloids with potential use as anisotropic imaging probes. Langmuir (2007) 0.75

A synthetic surface that undergoes spatiotemporal remodeling. Nano Lett (2008) 0.75

Hierarchically functionalized magnetic core/multishell particles and their postsynthetic conversion to polymer capsules. ACS Nano (2015) 0.75

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