Published in J Mol Endocrinol on December 22, 2008
Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors. Nat Commun (2012) 1.48
The role of osteocalcin in human glucose metabolism: marker or mediator? Nat Rev Endocrinol (2012) 1.31
Multiligand specificity and wide tissue expression of GPRC6A reveals new endocrine networks. Endocrinology (2012) 1.03
The calcium-sensing receptor mediates bone turnover induced by dietary calcium and parathyroid hormone in neonates. J Bone Miner Res (2011) 0.91
The GPCR, class C, group 6, subtype A (GPRC6A) receptor: from cloning to physiological function. Br J Pharmacol (2014) 0.91
Minireview: Nutrient sensing by G protein-coupled receptors. Mol Endocrinol (2013) 0.90
Nutrient sensing receptors in gastric endocrine cells. J Mol Histol (2011) 0.90
Impaired osteoblast function in GPRC6A null mice. J Bone Miner Res (2010) 0.87
The L-Cell in Nutritional Sensing and the Regulation of Appetite. Front Nutr (2015) 0.81
GPRC6a is not required for the effects of a high-protein diet on body weight in mice. Obesity (Silver Spring) (2015) 0.81
Novel regulatory aspects of the extracellular Ca2+-sensing receptor, CaR. Pflugers Arch (2009) 0.81
An overview of osteocalcin progress. J Bone Miner Metab (2016) 0.81
The calcium-sensing receptor in bone metabolism: from bench to bedside and back. Osteoporos Int (2015) 0.81
Murine GPRC6A Mediates Cellular Responses to L-Amino Acids, but Not Osteocalcin Variants. PLoS One (2016) 0.79
L-arginine promotes gut hormone release and reduces food intake in rodents. Diabetes Obes Metab (2016) 0.78
Insulin secretion stimulated by L-arginine and its metabolite L-ornithine depends on Gα(i2). Am J Physiol Endocrinol Metab (2014) 0.76
GPRC6A mediates Alum-induced Nlrp3 inflammasome activation but limits Th2 type antibody responses. Sci Rep (2015) 0.76
Nerve Growth Factor, Brain-Derived Neurotrophic Factor and Osteocalcin Gene Relationship in Energy Regulation, Bone Homeostasis and Reproductive Organs Analyzed by mRNA Quantitative Evaluation and Linear Correlation Analysis. Front Physiol (2016) 0.75
Genetic Variations in the Human GPRC6A Receptor Control Cell Surface Expression and Function. J Biol Chem (2016) 0.75
GPRC6A: Jack of all metabolism (or master of none). Mol Metab (2016) 0.75
CB1 cannabinoid receptors and on-demand defense against excitotoxicity. Science (2003) 5.22
Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy. Cell Metab (2008) 4.91
Molecular structure and physiological functions of GABA(B) receptors. Physiol Rev (2004) 3.53
Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass. J Bone Miner Res (2006) 3.44
Neuregulin-1 enhances depolarization-induced GABA release. Neuron (2007) 2.89
Differential compartmentalization and distinct functions of GABAB receptor variants. Neuron (2006) 2.53
Short- and long-range attraction of cortical GABAergic interneurons by neuregulin-1. Neuron (2004) 2.51
Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest, and p53-mediated apoptosis. Mol Cell (2005) 2.46
The GABAB1b isoform mediates long-lasting inhibition of dendritic Ca2+ spikes in layer 5 somatosensory pyramidal neurons. Neuron (2006) 2.39
Neural and mammary gland defects in ErbB4 knockout mice genetically rescued from embryonic lethality. Proc Natl Acad Sci U S A (2003) 2.38
Impairment of hepatic growth hormone and glucocorticoid receptor signaling causes steatosis and hepatocellular carcinoma in mice. Hepatology (2011) 2.33
Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids. Mol Pharmacol (2004) 2.30
Receptor tyrosine kinase ErbB4 modulates neuroblast migration and placement in the adult forebrain. Nat Neurosci (2004) 2.13
A case series of symptomatic intraluminal duodenal duplication cysts: presentation, endoscopic therapy, and long-term outcome (with video). Gastrointest Endosc (2008) 2.06
Native GABA(B) receptors are heteromultimers with a family of auxiliary subunits. Nature (2010) 1.86
Generalization of amygdala LTP and conditioned fear in the absence of presynaptic inhibition. Nat Neurosci (2006) 1.78
Efficacy of endoscopic closure of acute perforations of the gastrointestinal tract. Clin Gastroenterol Hepatol (2012) 1.77
Trace amine-associated receptor 1 modulates dopaminergic activity. J Pharmacol Exp Ther (2007) 1.69
GABAergic inhibition of histaminergic neurons regulates active waking but not the sleep-wake switch or propofol-induced loss of consciousness. J Neurosci (2012) 1.67
Redistribution of GABAB(1) protein and atypical GABAB responses in GABAB(2)-deficient mice. J Neurosci (2004) 1.66
Constitutive Notch2 signaling induces hepatic tumors in mice. Hepatology (2013) 1.65
Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors. Curr Drug Targets (2007) 1.64
Neuronal migration in the murine rostral migratory stream requires serum response factor. Proc Natl Acad Sci U S A (2005) 1.64
Stat3 is a negative regulator of intestinal tumor progression in Apc(Min) mice. Gastroenterology (2009) 1.64
Tumor alphavbeta3 integrin is a therapeutic target for breast cancer bone metastases. Cancer Res (2007) 1.55
TAAR1 activation modulates monoaminergic neurotransmission, preventing hyperdopaminergic and hypoglutamatergic activity. Proc Natl Acad Sci U S A (2011) 1.55
A novel Ncr1-Cre mouse reveals the essential role of STAT5 for NK-cell survival and development. Blood (2010) 1.50
A single subunit (GB2) is required for G-protein activation by the heterodimeric GABA(B) receptor. J Biol Chem (2001) 1.49
Growth hormone resistance exacerbates cholestasis-induced murine liver fibrosis. Hepatology (2015) 1.49
Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors. Nat Commun (2012) 1.48
Compartment-dependent colocalization of Kir3.2-containing K+ channels and GABAB receptors in hippocampal pyramidal cells. J Neurosci (2006) 1.45
Behavioral characterization of the novel GABAB receptor-positive modulator GS39783 (N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine): anxiolytic-like activity without side effects associated with baclofen or benzodiazepines. J Pharmacol Exp Ther (2004) 1.45
Selective loss of GABA(B) receptors in orexin-producing neurons results in disrupted sleep/wakefulness architecture. Proc Natl Acad Sci U S A (2009) 1.44
Molecular cloning, expression, and sequence analysis of GPRC6A, a novel family C G-protein-coupled receptor. Gene (2004) 1.42
Targeted disruption of the Wnt regulator Kremen induces limb defects and high bone density. Mol Cell Biol (2008) 1.41
A functional androgen receptor is not sufficient to allow estradiol to protect bone after gonadectomy in estradiol receptor-deficient mice. J Clin Invest (2003) 1.40
The selective antagonist EPPTB reveals TAAR1-mediated regulatory mechanisms in dopaminergic neurons of the mesolimbic system. Proc Natl Acad Sci U S A (2009) 1.38
Regulation of neuronal GABA(B) receptor functions by subunit composition. Nat Rev Neurosci (2012) 1.36
GABA(B) receptors: synaptic functions and mechanisms of diversity. Curr Opin Neurobiol (2007) 1.34
Specific gamma-hydroxybutyrate-binding sites but loss of pharmacological effects of gamma-hydroxybutyrate in GABA(B)(1)-deficient mice. Eur J Neurosci (2003) 1.34
Distinct localization of GABA(B) receptors relative to synaptic sites in the rat cerebellum and ventrobasal thalamus. Eur J Neurosci (2002) 1.33
Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEP. Br J Pharmacol (2003) 1.33
Synapse loss in cortex of agrin-deficient mice after genetic rescue of perinatal death. J Neurosci (2007) 1.27
Solid and pseudopapillary tumor of the pancreas--review and new insights into pathogenesis. Am J Surg Pathol (2006) 1.23
Notch2 signaling promotes biliary epithelial cell fate specification and tubulogenesis during bile duct development in mice. Hepatology (2009) 1.22
Quinazolin-4-one derivatives: A novel class of noncompetitive NR2C/D subunit-selective N-methyl-D-aspartate receptor antagonists. J Med Chem (2010) 1.20
DNA gyrase interaction with coumarin-based inhibitors: the role of the hydroxybenzoate isopentenyl moiety and the 5'-methyl group of the noviose. Biochemistry (2002) 1.20
Molecular pharmacology of promiscuous seven transmembrane receptors sensing organic nutrients. Mol Pharmacol (2009) 1.20
Expression of Cre recombinase in dopaminoceptive neurons. BMC Neurosci (2007) 1.19
Heartburn in Belgium: prevalence, impact on daily life, and utilization of medical resources. Eur J Gastroenterol Hepatol (2002) 1.18
GABAB receptors: physiological functions and mechanisms of diversity. Adv Pharmacol (2010) 1.18
Signal transducer and activator of transcription 3 protects from liver injury and fibrosis in a mouse model of sclerosing cholangitis. Gastroenterology (2010) 1.17
GluR7 is an essential subunit of presynaptic kainate autoreceptors at hippocampal mossy fiber synapses. Proc Natl Acad Sci U S A (2007) 1.16
A TNF receptor loop peptide mimic blocks RANK ligand-induced signaling, bone resorption, and bone loss. J Clin Invest (2006) 1.15
Estimation and visualization of sagittal kinematics of lower limbs orientation using body-fixed sensors. IEEE Trans Biomed Eng (2006) 1.15
3B but which 3B and that's just one of the questions: the heterogeneity of human 5-HT3 receptors. Trends Pharmacol Sci (2008) 1.14
(R)-(3-amino-2-fluoropropyl) phosphinic acid (AZD3355), a novel GABAB receptor agonist, inhibits transient lower esophageal sphincter relaxation through a peripheral mode of action. J Pharmacol Exp Ther (2009) 1.13
When reverse genetics meets physiology: the use of site-specific recombinases in mice. FEBS Lett (2002) 1.13
The GABAB1a isoform mediates heterosynaptic depression at hippocampal mossy fiber synapses. J Neurosci (2009) 1.13
Differential effects of GABAB receptor subtypes, {gamma}-hydroxybutyric Acid, and Baclofen on EEG activity and sleep regulation. J Neurosci (2010) 1.11
A new application for therapeutic EUS: main pancreatic duct drainage with a "pancreatic rendezvous technique". Gastrointest Endosc (2002) 1.10
The Sushi domains of GABAB receptors function as axonal targeting signals. J Neurosci (2010) 1.09
High-frequency HTR3B variant associated with major depression dramatically augments the signaling of the human 5-HT3AB receptor. Proc Natl Acad Sci U S A (2008) 1.09
The intracellular loops of the GB2 subunit are crucial for G-protein coupling of the heteromeric gamma-aminobutyrate B receptor. Mol Pharmacol (2002) 1.08
Ca2+ activity at GABAB receptors constitutively promotes metabotropic glutamate signaling in the absence of GABA. Proc Natl Acad Sci U S A (2004) 1.07
NMDA receptor-dependent GABAB receptor internalization via CaMKII phosphorylation of serine 867 in GABAB1. Proc Natl Acad Sci U S A (2010) 1.06
JAK-STAT signaling in hepatic fibrosis. Front Biosci (Landmark Ed) (2011) 1.06
GABA(B(1)) receptor isoforms differentially mediate the acquisition and extinction of aversive taste memories. J Neurosci (2006) 1.05
The oligomeric state sets GABA(B) receptor signalling efficacy. EMBO J (2011) 1.05
Altered anxiety and depression-related behaviour in mice lacking GABAB(2) receptor subunits. Neuroreport (2005) 1.05
Targeting of α(v)-integrins in stem/progenitor cells and supportive microenvironment impairs bone metastasis in human prostate cancer. Neoplasia (2011) 1.04
Complex formation with the Type B gamma-aminobutyric acid receptor affects the expression and signal transduction of the extracellular calcium-sensing receptor. Studies with HEK-293 cells and neurons. J Biol Chem (2007) 1.04
Distribution of the auxiliary GABAB receptor subunits KCTD8, 12, 12b, and 16 in the mouse brain. J Comp Neurol (2011) 1.04
Pharmacological characterization of ligands at recombinant NMDA receptor subtypes by electrophysiological recordings and intracellular calcium measurements. Comb Chem High Throughput Screen (2008) 1.04
Molecular determinants of non-competitive antagonist binding to the mouse GPRC6A receptor. Cell Calcium (2009) 1.03
Bone protection by estrens occurs through non-tissue-selective activation of the androgen receptor. J Clin Invest (2006) 1.01
Computer-aided discovery of aromatic l-α-amino acids as agonists of the orphan G protein-coupled receptor GPR139. J Chem Inf Model (2014) 1.01
Excitatory amino acid transporters as potential drug targets. Expert Opin Ther Targets (2009) 1.00
Disruption of the growth hormone--signal transducer and activator of transcription 5--insulinlike growth factor 1 axis severely aggravates liver fibrosis in a mouse model of cholestasis. Hepatology (2010) 1.00
α4βδ GABA(A) receptors are high-affinity targets for γ-hydroxybutyric acid (GHB). Proc Natl Acad Sci U S A (2012) 0.99
Behavioral evaluation of mice deficient in GABA(B(1)) receptor isoforms in tests of unconditioned anxiety. Psychopharmacology (Berl) (2006) 0.99
Probing intermolecular protein-protein interactions in the calcium-sensing receptor homodimer using bioluminescence resonance energy transfer (BRET). Eur J Biochem (2002) 0.98
Tweaking agonist efficacy at N-methyl-D-aspartate receptors by site-directed mutagenesis. Mol Pharmacol (2005) 0.98