Immunoglobulin gene transcription.

Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms. Mol Cell Biol (2000) 8.89

Different activation domains stimulate transcription from remote ('enhancer') and proximal ('promoter') positions. EMBO J (1992) 4.05

Cloning, functional characterization, and mechanism of action of the B-cell-specific transcriptional coactivator OCA-B. Mol Cell Biol (1995) 2.74

Regulation of the expression of cyclin-dependent kinase inhibitor p21 by E2A and Id proteins. Mol Cell Biol (1997) 2.71

Displacement of an E-box-binding repressor by basic helix-loop-helix proteins: implications for B-cell specificity of the immunoglobulin heavy-chain enhancer. Mol Cell Biol (1994) 2.15

PU.1 is a component of a multiprotein complex which binds an essential site in the murine immunoglobulin lambda 2-4 enhancer. Mol Cell Biol (1993) 2.08

Qualitative changes in the subunit composition of kappa B-binding complexes during murine B-cell differentiation. Proc Natl Acad Sci U S A (1994) 1.89

Mutations of the intronic IgH enhancer and its flanking sequences differentially affect accessibility of the JH locus. EMBO J (1993) 1.80

A novel lineage-specific nuclear factor regulates mb-1 gene transcription at the early stages of B cell differentiation. EMBO J (1991) 1.65

The B cell coactivator Bob1 shows DNA sequence-dependent complex formation with Oct-1/Oct-2 factors, leading to differential promoter activation. EMBO J (1996) 1.63

Indistinguishable nuclear factor binding to functional core sites of the T-cell receptor delta and murine leukemia virus enhancers. Mol Cell Biol (1992) 1.51

The matrix attachment region-binding protein SATB1 participates in negative regulation of tissue-specific gene expression. Mol Cell Biol (1997) 1.50

Identification and characterization of a T-cell-specific enhancer adjacent to the murine CD4 gene. Mol Cell Biol (1991) 1.50

Characterization of a negative retinoic acid response element in the murine Oct4 promoter. Mol Cell Biol (1994) 1.45

Recombination and transcription of the endogenous Ig heavy chain locus is effected by the Ig heavy chain intronic enhancer core region in the absence of the matrix attachment regions. Proc Natl Acad Sci U S A (1999) 1.44

TCR beta and TCR alpha gene enhancers confer tissue- and stage-specificity on V(D)J recombination events. EMBO J (1993) 1.39

Differential activation of transcription versus recombination of transgenic T cell receptor beta variable region gene segments in B and T lineage cells. J Exp Med (1994) 1.26

OCA-B integrates B cell antigen receptor-, CD40L- and IL 4-mediated signals for the germinal center pathway of B cell development. EMBO J (1998) 1.25

The POU homeodomain transcription factor Oct-1 is essential for activity of the gonadotropin-releasing hormone neuron-specific enhancer. Mol Cell Biol (1995) 1.24

Cux/CDP homeoprotein is a component of NF-muNR and represses the immunoglobulin heavy chain intronic enhancer by antagonizing the bright transcription activator. Mol Cell Biol (1999) 1.21

Identification of Ets-like lymphoid specific elements within the immunoglobulin heavy chain 3' enhancer. Nucleic Acids Res (1992) 1.17

Gene structure and characterization of the murine homologue of the B cell-specific transcriptional coactivator OBF-1. Nucleic Acids Res (1996) 1.13

The basic helix-loop-helix-zipper domain of TFE3 mediates enhancer-promoter interaction. Mol Cell Biol (1994) 1.12

STAT5 and Oct-1 form a stable complex that modulates cyclin D1 expression. Mol Cell Biol (2003) 1.12

Both LyF-1 and an Ets protein interact with a critical promoter element in the murine terminal transferase gene. Mol Cell Biol (1993) 1.10

Switch recombination breakpoints are strictly correlated with DNA recognition motifs for immunoglobulin S gamma 3 DNA-binding proteins. J Exp Med (1992) 1.10

BOB.1/OBF.1 controls the balance of TH1 and TH2 immune responses. EMBO J (2007) 1.10

The V(D)J recombinational and transcriptional activities of the immunoglobulin heavy-chain intronic enhancer can be mediated through distinct protein-binding sites in a transgenic substrate. Mol Cell Biol (1995) 1.09

Targeted disruption of the Oct-2 locus in a B cell provides genetic evidence for two distinct cell type-specific pathways of octamer element-mediated gene activation. EMBO J (1993) 1.07

Characterization of ABF-1, a novel basic helix-loop-helix transcription factor expressed in activated B lymphocytes. Mol Cell Biol (1998) 1.07

Immunoglobulin heavy chain enhancer is located near or in an initiation zone of chromosomal DNA replication. Proc Natl Acad Sci U S A (1993) 1.06

Direct interactions of OCA-B and TFII-I regulate immunoglobulin heavy-chain gene transcription by facilitating enhancer-promoter communication. Mol Cell (2011) 1.04

An AP1 binding site upstream of the kappa immunoglobulin intron enhancer binds inducible factors and contributes to expression. Nucleic Acids Res (1994) 1.04

Oct-1 counteracts autoinhibition of Runx2 DNA binding to form a novel Runx2/Oct-1 complex on the promoter of the mammary gland-specific gene beta-casein. Mol Cell Biol (2005) 1.03

A developmentally modulated chromatin structure at the mouse immunoglobulin kappa 3' enhancer. Mol Cell Biol (1996) 1.01

Up-regulation of BOB.1/OBF.1 expression in normal germinal center B cells and germinal center-derived lymphomas. Am J Pathol (2000) 1.01

Activation of the immunoglobulin kappa 3' enhancer in pre-B cells correlates with the suppression of a nuclear factor binding to a sequence flanking the active core. Nucleic Acids Res (1994) 1.00

Multiple proteins interact with the fushi tarazu proximal enhancer. Mol Cell Biol (1993) 0.99

Differential in vivo activation of the class II and class III snRNA genes by the POU-specific domain of Oct-1. Nucleic Acids Res (1997) 0.98

Coactivation by OCA-B: definition of critical regions and synergism with general cofactors. Mol Cell Biol (1998) 0.97

Differential transactivation potential of Oct1 and Oct2 is determined by additional B cell-specific activities. EMBO J (1994) 0.95

The Ets factor Spi-B is a direct critical target of the coactivator OBF-1. Proc Natl Acad Sci U S A (2006) 0.94

Targeting of transgene expression to monocyte/macrophages by the gp91-phox promoter and consequent histiocytic malignancies. Proc Natl Acad Sci U S A (1991) 0.94

Induction of the POU domain transcription factor Oct-2 during T-cell activation by cognate antigen. Mol Cell Biol (1992) 0.93

CRISP-3, a protein with homology to plant defense proteins, is expressed in mouse B cells under the control of Oct2. Mol Cell Biol (1996) 0.93

LMP1-augmented kappa intron enhancer activity contributes to upregulation expression of Ig kappa light chain via NF-kappaB and AP-1 pathways in nasopharyngeal carcinoma cells. Mol Cancer (2009) 0.93

Coordinate transcription and V(D)J recombination of the kappa immunoglobulin light-chain locus: NF-kappaB-dependent and -independent pathways of activation. Mol Cell Biol (1997) 0.91

The number of vitamin D receptor binding sites defines the different vitamin D responsiveness of the CYP24 gene in malignant and normal mammary cells. J Biol Chem (2010) 0.91

Sequences affecting the V(D)J recombinational activity of the IgH intronic enhancer in a transgenic substrate. Nucleic Acids Res (1994) 0.90

Expression of B-lymphocyte-associated transcription factors in human T-cell neoplasms. Am J Pathol (2003) 0.89

Octamer-binding transcription factors: genomics and functions. Front Biosci (Landmark Ed) (2013) 0.88

Oct-2 regulates CD36 gene expression via a consensus octamer, which excludes the co-activator OBF-1. Nucleic Acids Res (2002) 0.88

Regulation of T cell receptor delta gene rearrangement by CBF/PEBP2. J Exp Med (1997) 0.87

Characterization of an Oct1 orthologue in the channel catfish, Ictalurus punctatus: a negative regulator of immunoglobulin gene transcription? BMC Mol Biol (2007) 0.86

A binding site for multiple transcriptional activators in the fushi tarazu proximal enhancer is essential for gene expression in vivo. Mol Cell Biol (1998) 0.85

AID targeting: old mysteries and new challenges. Trends Immunol (2015) 0.84

Diphosphoryl lipid A from Rhodobacter sphaeroides transiently activates NF-kappa B but inhibits lipopolysaccharide induction of kappa light chain and Oct-2 in the B-cell lymphoma line 70Z/3. Infect Immun (1995) 0.84

Selective synergy of immunoglobulin enhancer elements in B-cell development: a characteristic of kappa light chain enhancers, but not heavy chain enhancers. Nucleic Acids Res (1994) 0.83

B cell receptor light chain repertoires show signs of selection with differences between groups of healthy individuals and SLE patients. Mol Immunol (2012) 0.83

Efficient transcription of an immunoglobulin kappa promoter requires specific sequence elements overlapping with and downstream of the transcriptional start site. Nucleic Acids Res (1997) 0.81

EBV-encoded LMP1 upregulates Igκ 3'enhancer activity and Igκ expression in nasopharyngeal cancer cells by activating the Ets-1 through ERKs signaling. PLoS One (2012) 0.81

Novel salivary gland specific binding elements located in the PSP proximal enhancer core. Nucleic Acids Res (1998) 0.79

Gene Conversion-Like Events in the Diversification of Human Rearranged IGHV3-23*01 Gene Sequences. Front Immunol (2012) 0.79

V(D)J recombination frequency is affected by the sequence interposed between a pair of recombination signals: sequence comparison reveals a putative recombinational enhancer element. Nucleic Acids Res (1997) 0.79

Elements in the immunoglobulin heavy-chain enhancer directly regulate simian virus 40 ori-dependent DNA replication. Mol Cell Biol (1993) 0.78

Lipopolysaccharide regulation of lipoprotein lipase expression in murine macrophages. Infect Immun (1995) 0.78

Yeast artificial chromosome contigs reveal that distal variable-region genes reside at least 3 megabases from the joining regions in the murine immunoglobulin kappa locus. Proc Natl Acad Sci U S A (1995) 0.78

Cis-acting regulatory sequences promote high-frequency gene conversion between repeated sequences in mammalian cells. Nucleic Acids Res (2004) 0.77

Activation of c-myc promoter P1 by immunoglobulin kappa gene enhancers in Burkitt lymphoma: functional characterization of the intron enhancer motifs kappaB, E box 1 and E box 2, and of the 3' enhancer motif PU. Nucleic Acids Res (2000) 0.77

Myosin light chain 1 atrial isoform (MLC1A) is expressed in pre-B cells under control of the BOB.1/OBF.1 coactivator. Nucleic Acids Res (2004) 0.76

Stabilised DNA secondary structures with increasing transcription localise hypermutable bases for somatic hypermutation in IGHV3-23. Immunogenetics (2012) 0.76

Octamer independent activation of transcription from the kappa immunoglobulin germline promoter. Nucleic Acids Res (1996) 0.76

Transcriptional regulation of the HMGA1 gene by octamer-binding proteins Oct-1 and Oct-2. PLoS One (2013) 0.76

Production of recombinant granulocyte colony-stimulating factor by knocking into the active immunoglobulin heavy chain gene locus in the hybridoma cell line. Cytotechnology (2001) 0.75

The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell (2001) 12.59

NF-kappa B and Rel: participants in a multiform transcriptional regulatory system. Int Rev Cytol (1993) 7.42

Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations. Science (2000) 6.98

Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome. Cell (1995) 5.64

Induction of apoptosis in mature T cells by tumour necrosis factor. Nature (1995) 5.26

A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling. Science (2000) 3.72

T cell deletion in high antigen dose therapy of autoimmune encephalomyelitis. Science (1994) 3.00

Inherited human Caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II. Cell (1999) 2.74

Functionally distinct NF-kappa B binding sites in the immunoglobulin kappa and IL-2 receptor alpha chain genes. Science (1989) 2.71

NF-kappa B subunit regulation in nontransformed CD4+ T lymphocytes. Science (1992) 2.69

The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity. Nat Immunol (2000) 2.57

Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis. Proc Natl Acad Sci U S A (1997) 2.50

Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity. Science (1999) 2.45

Reversal of in vitro T cell clonal anergy by IL-2 stimulation. Int Immunol (1992) 2.39

Transactivation by AP-1 is a molecular target of T cell clonal anergy. Science (1992) 2.25

An inherited disorder of lymphocyte apoptosis: the autoimmune lymphoproliferative syndrome. Ann Intern Med (1999) 2.20

The development of lymphomas in families with autoimmune lymphoproliferative syndrome with germline Fas mutations and defective lymphocyte apoptosis. Blood (2001) 2.15

Clincal, immunologic, and genetic features of an autoimmune lymphoproliferative syndrome associated with abnormal lymphocyte apoptosis. Blood (1997) 2.10

Membrane oligomerization and cleavage activates the caspase-8 (FLICE/MACHalpha1) death signal. J Biol Chem (1998) 2.06

Measurement of molecular interactions in living cells by fluorescence resonance energy transfer between variants of the green fluorescent protein. Sci STKE (2000) 1.96

Caspase-10 is an initiator caspase in death receptor signaling. Proc Natl Acad Sci U S A (2001) 1.90

A crucial role for p80 TNF-R2 in amplifying p60 TNF-R1 apoptosis signals in T lymphocytes. Eur J Immunol (2000) 1.89

Death-effector filaments: novel cytoplasmic structures that recruit caspases and trigger apoptosis. J Cell Biol (1998) 1.85

Cell death attenuation by 'Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex. Cell Death Differ (1998) 1.76

Autoimmune lymphoproliferative syndrome with defective Fas: genotype influences penetrance. Am J Hum Genet (1999) 1.74

HIV-1 directly kills CD4+ T cells by a Fas-independent mechanism. J Exp Med (1998) 1.66

NMR structure and mutagenesis of the FADD (Mort1) death-effector domain. Nature (1998) 1.65

Generation of an apoptotic intracellular peptide by gamma-secretase cleavage of Alzheimer's amyloid beta protein precursor. J Alzheimers Dis (2000) 1.61

Defective CD95/APO-1/Fas signal complex formation in the human autoimmune lymphoproliferative syndrome, type Ia. Proc Natl Acad Sci U S A (1999) 1.56

Immunophenotypic profiles in families with autoimmune lymphoproliferative syndrome. Blood (2001) 1.55

Propriocidal apoptosis of mature T lymphocytes occurs at S phase of the cell cycle. Eur J Immunol (1993) 1.51

Characterization of the Trypanosoma brucei 5S ribosomal RNA gene and transcript: the 5S rRNA is a spliced-leader-independent species. Gene (1985) 1.42

Pathological findings in human autoimmune lymphoproliferative syndrome. Am J Pathol (1998) 1.41

Roles of caspases in apoptosis, development, and cytokine maturation revealed by homozygous gene deficiencies. J Cell Sci (2000) 1.38

p53 prevents maturation to the CD4+CD8+ stage of thymocyte differentiation in the absence of T cell receptor rearrangement. J Exp Med (1996) 1.31

Lymphotoxin activation by human T-cell leukemia virus type I-infected cell lines: role for NF-kappa B. J Virol (1990) 1.30

Fluorescence resonance energy transfer analysis of cell surface receptor interactions and signaling using spectral variants of the green fluorescent protein. Cytometry (2001) 1.28

Characteristic T helper 2 T cell cytokine abnormalities in autoimmune lymphoproliferative syndrome, a syndrome marked by defective apoptosis and humoral autoimmunity. J Immunol (1997) 1.27

Requirement for TNF-alpha and IL-1 alpha in fetal thymocyte commitment and differentiation. Science (1995) 1.25

Regulation of thymocyte development from immature progenitors. Curr Opin Immunol (1996) 1.22

Identification of a novel developmental stage marking lineage commitment of progenitor thymocytes. J Exp Med (1997) 1.21

Inhibition of Fas-mediated apoptosis by the B cell antigen receptor through c-FLIP. Eur J Immunol (2000) 1.21

TcR-alpha/beta(+) CD4(-)CD8(-) T cells in humans with the autoimmune lymphoproliferative syndrome express a novel CD45 isoform that is analogous to murine B220 and represents a marker of altered O-glycan biosynthesis. Clin Immunol (2001) 1.20

T cell growth cytokines cause the superinduction of molecules mediating antigen-induced T lymphocyte death. J Immunol (1998) 1.19

The death effector domain-associated factor plays distinct regulatory roles in the nucleus and cytoplasm. J Biol Chem (2001) 1.18

Characterization of the genes specifying two metacyclic variable antigen types in Trypanosoma brucei rhodesiense. Proc Natl Acad Sci U S A (1984) 1.18

The spliced leader sequence of Trypanosoma brucei has a potential role as a cap donor structure. Mol Cell Biol (1985) 1.15

Sublethal gamma-radiation induces differentiation of CD4-/CD8- into CD4+/CD8+ thymocytes without T cell receptor beta rearrangement in recombinase activation gene 2-/- mice. J Exp Med (1994) 1.11

Qualitative and quantitative contributions of the T cell receptor zeta chain to mature T cell apoptosis. J Exp Med (1996) 1.10

Interaction between NF-kappa B- and serum response factor-binding elements activates an interleukin-2 receptor alpha-chain enhancer specifically in T lymphocytes. Mol Cell Biol (1993) 1.09

A novel tumor necrosis factor-responsive transcription factor which recognizes a regulatory element in hemopoietic growth factor genes. Mol Cell Biol (1990) 1.06

The 5.8S ribosomal RNA gene of Trypanosoma brucei: structural and transcriptional studies. Nucleic Acids Res (1985) 1.05

Molecular dissection of the mouse interleukin-4 promoter. Proc Natl Acad Sci U S A (1993) 1.04

To B or not to B: TNF family signaling in lymphocytes. Nat Immunol (2001) 1.04

Gene transcription in differentiating immature T cell receptor(neg) thymocytes resembles antigen-activated mature T cells. J Exp Med (1993) 1.03

Identification of Rlk, a novel protein tyrosine kinase with predominant expression in the T cell lineage. J Biol Chem (1995) 1.01

rlk/TXK encodes two forms of a novel cysteine string tyrosine kinase activated by Src family kinases. Mol Cell Biol (1999) 1.00

Molecules involved in cell death and peripheral tolerance. Curr Opin Immunol (1997) 0.98

Maintenance of clonotype specificity in CD95/Apo-1/Fas-mediated apoptosis of mature T lymphocytes. J Immunol (1997) 0.96

The clinical spectrum in a large kindred with autoimmune lymphoproliferative syndrome caused by a Fas mutation that impairs lymphocyte apoptosis. J Pediatr (1998) 0.96

Antigen-induced programmed T cell death as a new approach to immune therapy. Clin Immunol Immunopathol (1995) 0.95

TNF-alpha-induced secretion of C-C chemokines modulates C-C chemokine receptor 5 expression on peripheral blood lymphocytes. J Immunol (2000) 0.95

Metacyclic variant surface glycoprotein genes of Trypanosoma brucei subsp. rhodesiense are activated in situ, and their expression is transcriptionally regulated. Mol Cell Biol (1986) 0.94

Induction of the POU domain transcription factor Oct-2 during T-cell activation by cognate antigen. Mol Cell Biol (1992) 0.93

Two mechanisms of antigen-specific apoptosis of myelin basic protein (MBP)-specific T lymphocytes derived from multiple sclerosis patients and normal individuals. J Immunol (1995) 0.90

Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk. BMC Immunol (2001) 0.89

TCR-mediated death of mature T lymphocytes occurs in the absence of p53. J Immunol (1996) 0.89

Differential TCR signaling regulates apoptosis and immunopathology during antigen responses in vivo. Immunity (1998) 0.89

Essential lymphocyte function associated 1 (LFA-1): intercellular adhesion molecule interactions for T cell-mediated B cell apoptosis by Fas/APO-1/CD95. J Exp Med (1997) 0.86

Caspases in T-cell receptor-induced thymocyte apoptosis. Cell Death Differ (1999) 0.85

Parameters controlling the programmed death of mature mouse T lymphocytes in high-dose suppression. Cell Immunol (1995) 0.84

Selective induction of apoptosis in mature T lymphocytes by variant T cell receptor ligands. J Exp Med (1998) 0.84

Determinant spreading associated with demyelination in a nonhuman primate model of multiple sclerosis. J Immunol (1999) 0.83

The autoimmune lymphoproliferative syndrome. A disorder of human lymphocyte apoptosis. Clin Rev Allergy Immunol (2001) 0.82

Intravenous antigen administration as a therapy for autoimmune demyelinating disease. Ann Neurol (1996) 0.82

Amelioration of autoimmune reactions by antigen-induced apoptosis of T cells. Adv Exp Med Biol (1995) 0.82

Synergy between T cell Receptor and Fas (CD95/APO-1) signaling in mouse thymocyte death. Cell Immunol (1996) 0.81

Analysis of the CD4 coreceptor and activation-induced costimulatory molecules in antigen-mediated mature T lymphocyte death. J Immunol (1995) 0.81

Tumor necrosis factor alpha mediates a T cell receptor-independent induction of the gene regulatory factor NF-kappa B in T lymphocytes. Mol Immunol (1993) 0.80

Immunological tolerance by antigen-induced apoptosis of mature T lymphocytes. Adv Exp Med Biol (1994) 0.80

Autoimmune lymphoproliferative syndrome: types I, II and beyond. Adv Exp Med Biol (2001) 0.78

Effective antigen-specific immunotherapy in the marmoset model of multiple sclerosis. J Immunol (2001) 0.78

Purification of immunologically active recombinant 21.5 kDa isoform of human myelin basic protein. Mol Immunol (1995) 0.78

Ligand-induced apoptosis of mature T lymphocytes (propriocidal regulation) occurs at distinct stages of the cell cycle. Leukemia (1993) 0.76

Expression of antigenic regions of a trypanosome variable surface glycoprotein in E. coli using Bal-31 nuclease digestion. Nucleic Acids Res (1984) 0.75

Molecular genetic studies in lymphocyte apoptosis and human autoimmunity. Novartis Found Symp (1998) 0.75