PubRank

D A Lauffenburger

Author PubWeight™ 167.66‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness. Nature 1997 8.52
2 Mathematical model for the effects of adhesion and mechanics on cell migration speed. Biophys J 1991 4.68
3 Cell adhesion and motility depend on nanoscale RGD clustering. J Cell Sci 2000 4.13
4 Maximal migration of human smooth muscle cells on fibronectin and type IV collagen occurs at an intermediate attachment strength. J Cell Biol 1993 3.74
5 Integrin-cytoskeletal interactions in migrating fibroblasts are dynamic, asymmetric, and regulated. J Cell Biol 1993 3.37
6 Regulation of cell migration by the calcium-dependent protease calpain. J Biol Chem 1997 2.52
7 A dynamical model for receptor-mediated cell adhesion to surfaces. Biophys J 1987 2.49
8 Vector unpacking as a potential barrier for receptor-mediated polyplex gene delivery. Biotechnol Bioeng 2000 2.49
9 Migration of individual microvessel endothelial cells: stochastic model and parameter measurement. J Cell Sci 1991 2.49
10 Epidermal growth factor receptor activation of calpain is required for fibroblast motility and occurs via an ERK/MAP kinase signaling pathway. J Biol Chem 2000 2.37
11 Physical and biochemical regulation of integrin release during rear detachment of migrating cells. J Cell Sci 1998 2.23
12 A stochastic model for leukocyte random motility and chemotaxis based on receptor binding fluctuations. J Cell Biol 1988 2.18
13 Membrane proximal ERK signaling is required for M-calpain activation downstream of epidermal growth factor receptor signaling. J Biol Chem 2001 2.16
14 The role of tyrosine kinase activity in endocytosis, compartmentation, and down-regulation of the epidermal growth factor receptor. J Biol Chem 1991 2.15
15 Bioengineering models of cell signaling. Annu Rev Biomed Eng 2000 1.96
16 Metalloprotease-mediated ligand release regulates autocrine signaling through the epidermal growth factor receptor. Proc Natl Acad Sci U S A 1999 1.96
17 Kinetic analysis of F-actin depolymerization in polymorphonuclear leukocyte lysates indicates that chemoattractant stimulation increases actin filament number without altering the filament length distribution. J Cell Biol 1991 1.94
18 Relationship between receptor/ligand binding affinity and adhesion strength. Biophys J 1993 1.92
19 Integrin dynamics on the tail region of migrating fibroblasts. J Cell Sci 1996 1.83
20 Intracellular trafficking of epidermal growth factor family ligands is directly influenced by the pH sensitivity of the receptor/ligand interaction. J Biol Chem 1995 1.72
21 Epidermal growth factor alters fibroblast migration speed and directional persistence reciprocally and in a matrix-dependent manner. J Cell Sci 1998 1.72
22 A computational study of feedback effects on signal dynamics in a mitogen-activated protein kinase (MAPK) pathway model. Biotechnol Prog 2001 1.71
23 Engineering epidermal growth factor for enhanced mitogenic potency. Nat Biotechnol 1996 1.68
24 EGF receptor regulation of cell motility: EGF induces disassembly of focal adhesions independently of the motility-associated PLCgamma signaling pathway. J Cell Sci 1998 1.68
25 Receptor-mediated cell attachment and detachment kinetics. I. Probabilistic model and analysis. Biophys J 1990 1.65
26 Biophysical integration of effects of epidermal growth factor and fibronectin on fibroblast migration. Biophys J 1999 1.58
27 Analysis of the roles of microvessel endothelial cell random motility and chemotaxis in angiogenesis. J Theor Biol 1991 1.57
28 Effect of epidermal growth factor receptor internalization on regulation of the phospholipase C-gamma1 signaling pathway. J Biol Chem 1999 1.57
29 Internalized epidermal growth factor receptors participate in the activation of p21(ras) in fibroblasts. J Biol Chem 1999 1.57
30 Quantitative comparison of polyethylenimine formulations and adenoviral vectors in terms of intracellular gene delivery processes. Gene Ther 2005 1.56
31 Autocrine loops with positive feedback enable context-dependent cell signaling. Am J Physiol Cell Physiol 2002 1.55
32 Self-assembly of a beta-sheet protein governed by relief of electrostatic repulsion relative to van der Waals attraction. Biomacromolecules 2000 1.54
33 Spatial range of autocrine signaling: modeling and computational analysis. Biophys J 2001 1.52
34 Leukemia inhibitory factor (LIF) concentration modulates embryonic stem cell self-renewal and differentiation independently of proliferation. Biotechnol Bioeng 2000 1.50
35 A mathematical model for chemoattractant gradient sensing based on receptor-regulated membrane phospholipid signaling dynamics. Ann Biomed Eng 2001 1.48
36 Kinetic analysis of chemotactic peptide receptor modulation. J Cell Biol 1982 1.45
37 Regulation of postendocytic trafficking of the epidermal growth factor receptor through endosomal retention. J Biol Chem 1994 1.35
38 Quantitative analysis of the EGF receptor autocrine system reveals cryptic regulation of cell response by ligand capture. J Cell Sci 2001 1.35
39 Specific adhesion of glycophorin liposomes to a lectin surface in shear flow. Biophys J 1990 1.34
40 Receptor-mediated cell attachment and detachment kinetics. II. Experimental model studies with the radial-flow detachment assay. Biophys J 1990 1.32
41 Physical modulation of intracellular signaling processes by locational regulation. Biophys J 1997 1.32
42 Deconstructing (and reconstructing) cell migration. Microsc Res Tech 1998 1.32
43 Tumor invasion as dysregulated cell motility. Semin Cancer Biol 2001 1.31
44 Biological surface engineering: a simple system for cell pattern formation. Biomaterials 1999 1.29
45 Shaping up for shipping out: PLCgamma signaling of morphology changes in EGF-stimulated fibroblast migration. Cell Motil Cytoskeleton 1999 1.27
46 Quantitative relationship among integrin-ligand binding, adhesion, and signaling via focal adhesion kinase and extracellular signal-regulated kinase 2. J Biol Chem 1999 1.26
47 Integrin-cytoskeletal interactions in neuronal growth cones. J Neurosci 1995 1.25
48 Quantitative analysis of synthetic gene delivery vector design properties. Mol Ther 2001 1.23
49 Removal of the membrane-anchoring domain of epidermal growth factor leads to intracrine signaling and disruption of mammary epithelial cell organization. J Cell Biol 1998 1.22
50 Overexpression of cellular Src in fibroblasts enhances endocytic internalization of epidermal growth factor receptor. J Biol Chem 1997 1.22
51 Autocrine epidermal growth factor signaling stimulates directionally persistent mammary epithelial cell migration. J Cell Biol 2001 1.22
52 Mathematical modeling of epidermal growth factor receptor signaling through the phospholipase C pathway: mechanistic insights and predictions for molecular interventions. Biotechnol Bioeng 2000 1.21
53 Stochastic model of leukocyte chemosensory movement. J Math Biol 1987 1.19
54 Postendocytic trafficking of epidermal growth factor-receptor complexes is mediated through saturable and specific endosomal interactions. J Biol Chem 1994 1.18
55 Measurement of bacterial random motility and chemotaxis coefficients: I. Stopped-flow diffusion chamber assay. Biotechnol Bioeng 1991 1.17
56 A ligand-receptor signaling threshold model of stem cell differentiation control: a biologically conserved mechanism applicable to hematopoiesis. Blood 2000 1.17
57 Integrin-binding peptide in solution inhibits or enhances endothelial cell migration, predictably from cell adhesion. Ann Biomed Eng 1994 1.17
58 Simulation of detachment of specifically bound particles from surfaces by shear flow. Biophys J 1997 1.15
59 The role of transient ERK2 signals in fibronectin- and insulin-mediated DNA synthesis. J Cell Sci 2000 1.12
60 The role of low-affinity interleukin-2 receptors in autocrine ligand binding: alternative mechanisms for enhanced binding effect. Mol Immunol 1994 1.09
61 Reversible pinocytosis in polymorphonuclear leukocytes. J Cell Biol 1983 1.09
62 Chemotactic factor concentration gradients in chemotaxis assay systems. J Immunol Methods 1981 1.08
63 Analysis of intracellular receptor/ligand sorting in endosomes. J Theor Biol 1988 1.08
64 Analysis of receptor internalization as a mechanism for modulating signal transduction. J Theor Biol 1998 1.07
65 Quantitative relationships between single-cell and cell-population model parameters for chemosensory migration responses of alveolar macrophages to C5a. Cell Motil Cytoskeleton 1990 1.07
66 Autocrine ligand binding to cell receptors. Mathematical analysis of competition by solution "decoys". Biophys J 1992 1.06
67 Direct Lyapunov exponent analysis enables parametric study of transient signalling governing cell behaviour. Syst Biol (Stevenage) 2006 1.06
68 Mathematical model for the effects of epidermal growth factor receptor trafficking dynamics on fibroblast proliferation responses. Biotechnol Prog 1992 1.05
69 Motile chondrocytes from newborn calf: migration properties and synthesis of collagen II. Osteoarthritis Cartilage 2003 1.05
70 Computational model for effects of ligand/receptor binding properties on interleukin-2 trafficking dynamics and T cell proliferation response. Biotechnol Prog 2000 1.04
71 Intracellular receptor/ligand sorting based on endosomal retention components. Biotechnol Bioeng 1996 1.04
72 Receptor-mediated effects on ligand availability influence relative mitogenic potencies of epidermal growth factor and transforming growth factor alpha. J Cell Physiol 1996 1.04
73 Optimization of cell surface binding enhances efficiency and specificity of molecular conjugate gene delivery. J Biol Chem 1998 1.03
74 Controlling receptor/ligand trafficking: effects of cellular and molecular properties on endosomal sorting. Ann Biomed Eng 1997 1.02
75 Methylation of episomal plasmids as a barrier to transient gene expression via a synthetic delivery vector. Biomol Eng 2001 1.01
76 Heterogeneity and probabilistic binding contributions to receptor-mediated cell detachment kinetics. Biophys J 1993 1.01
77 Receptor-mediated targeting of gene delivery vectors: insights from molecular mechanisms for improved vehicle design. Biotechnol Bioeng 2000 1.01
78 Escape of autocrine ligands into extracellular medium: experimental test of theoretical model predictions. Biotechnol Bioeng 1998 1.00
79 Measurement of the chemotaxis coefficient for human neutrophils in the under-agarose migration assay. Cell Motil Cytoskeleton 1988 0.99
80 Proliferative response of fibroblasts expressing internalization-deficient epidermal growth factor (EGF) receptors is altered via differential EGF depletion effect. Biotechnol Prog 1994 0.98
81 Measurement of bacterial random motility and chemotaxis coefficients: II. Application of single-cell-based mathematical model. Biotechnol Bioeng 1991 0.98
82 Effect of bacterial chemotaxis on dynamics of microbial competition. Microb Ecol 1988 0.96
83 Consequences of chemosensory phenomena for leukocyte chemotactic orientation. Cell Biophys 1986 0.96
84 Computational modelling of ErbB family phosphorylation dynamics in response to transforming growth factor alpha and heregulin indicates spatial compartmentation of phosphatase activity. Syst Biol (Stevenage) 2006 0.95
85 Probability of autocrine ligand capture by cell-surface receptors: implications for ligand secretion measurements. J Comput Biol 1994 0.95
86 Kinetic model for integrin-mediated adhesion release during cell migration. Ann Biomed Eng 1999 0.94
87 Measurement of leukocyte motility and chemotaxis parameters with the Millipore filter assay. J Immunol Methods 1989 0.93
88 Molecular properties in cell adhesion: a physical and engineering perspective. Trends Biotechnol 2001 0.92
89 Cell motility. Making connections count. Nature 1996 0.92
90 Analysis of chemotactic bacterial distributions in population migration assays using a mathematical model applicable to steep or shallow attractant gradients. Bull Math Biol 1991 0.92
91 Comparative mitogenic potencies of EGF and TGF alpha and their dependence on receptor-limitation versus ligand-limitation. Med Biol Eng Comput 1998 0.90
92 Mechanical properties of a self-assembling oligopeptide matrix. J Biomater Sci Polym Ed 1998 0.90
93 Transient behavior of a chemotaxis system modelling certain types of tissue inflammation. J Math Biol 1987 0.90
94 Assays of leukocyte chemotaxis. Annu Rev Med 1986 0.90
95 Simulation of integrin-cytoskeletal interactions in migrating fibroblasts. Biophys J 1994 0.89
96 Analysis of intracellular receptor/ligand sorting. Calculation of mean surface and bulk diffusion times within a sphere. Biophys J 1986 0.88
97 Adhesion mediated by bonds in series. Biotechnol Prog 1996 0.87
98 Interrupting autocrine ligand-receptor binding: comparison between receptor blockers and ligand decoys. Biophys J 1992 0.87
99 Increased endosomal sorting of ligand to recycling enhances potency of an interleukin-2 analog. J Biol Chem 2000 0.86
100 Inhibition of microvascular endothelial cell migration by beta-cyclodextrin tetradecasulfate and hydrocortisone. Microvasc Res 1990 0.86
101 Localized bacterial infection in a distributed model for tissue inflammation. J Math Biol 1983 0.83
102 Concentration gradients of chemotactic factors in chemotaxis assays. Methods Enzymol 1988 0.83
103 A dynamical model for receptor-mediated cell adhesion to surfaces in viscous shear flow. Cell Biophys 1989 0.82
104 Quantitative analysis of random motility of human microvessel endothelial cells using a linear under-agarose assay. Lab Invest 1988 0.81
105 The motile response of alveolar macrophages. An experimental study using single-cell and cell population approaches. Am Rev Respir Dis 1989 0.81
106 Chemotaxis of human microvessel endothelial cells in response to acidic fibroblast growth factor. Lab Invest 1990 0.81
107 Use of cell affinity chromatography for separation of lymphocyte subpopulations. Biotechnol Bioeng 1985 0.81
108 Influence of external concentration fluctuations on leukocyte chemotactic orientation. Cell Biophys 1982 0.80
109 Quantification of bacterial chemotaxis by measurement of model parameters using the capillary assay. Biotechnol Bioeng 1986 0.79
110 Endocytic Relay as a Potential Means for Enhancing Ligand Transport through Cellular Tissue Matrices: Analysis and Possible Implications for Drug Delivery. Tissue Eng 1996 0.79
111 Mathematical analysis of cell-target encounter rates in two dimensions. The effect of chemotaxis. Biophys J 1987 0.79
112 The effect of alveolar macrophage chemotaxis on bacterial clearance from the lung surface. Am Rev Respir Dis 1988 0.78
113 A rapid and sensitive quantitative kinase activity assay using a convenient 96-well format. Anal Biochem 1999 0.78
114 Measurement of chemoattractant concentration profiles and diffusion coefficient in agarose. J Immunol Methods 1984 0.78
115 Getting a grip: new insights for cell adhesion and traction. Nat Cell Biol 2001 0.78
116 A simple expression for quantifying bacterial chemotaxis using capillary assay data: application to the analysis of enhanced chemotactic responses from growth-limited cultures. Math Biosci 1992 0.78
117 Targeted synthetic gene delivery vectors. Curr Opin Mol Ther 2000 0.78
118 The multiple dimensions of Integrative Biology. Integr Biol (Camb) 2011 0.78
119 The motile response of lung macrophages: theoretical and experimental approaches using the linear under-agarose assay. J Leukoc Biol 1985 0.77
120 The matrix delivers. Nat Med 1999 0.77
121 Computer simulations of cell-target encounter including biased cell motion toward targets: single and multiple cell-target simulations in two dimensions. Bull Math Biol 1991 0.77
122 Studies on engineered autocrine systems: requirements for ligand release from cells producing an artificial growth factor. Tissue Eng 1995 0.76
123 Mathematical analysis of cell-target encounter rates in three dimensions. Effect of chemotaxis. Biophys J 1990 0.75
124 Analysis of the effects of immune cell motility and chemotaxis on target elimination dynamics. Math Biosci 1990 0.75
125 Stopped-flow chamber and image analysis system for quantitative characterization of bacterial population migration: Motility and chemotaxis ofEscherichia coli K12 to fucose. Microb Ecol 1991 0.75
126 Quantitative assessment of autocrine cell loops. Methods Mol Med 1999 0.75
127 Characterization of cell detachment from hollow fiber affinity membranes. Biomed Sci Instrum 1999 0.75
128 Model for the dynamics of colicin plasmids in continuous culture. Ann N Y Acad Sci 1986 0.75
129 Distinct genital tract HIV-specific antibody profiles associated with tenofovir gel. Mucosal Immunol 2016 0.75
130 Editorial. Microb Ecol 1991 0.75