Published in Clin Cancer Res on February 17, 2009
RBD-HPV: Risk-Based De-Intensification for HPV+ HNSCC | NCT04849377
Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med (2010) 22.74
Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1. Science (2011) 11.12
Distinct merkel cell polyomavirus molecular features in tumour and non tumour specimens from patients with merkel cell carcinoma. PLoS Pathog (2010) 1.40
ANO1 amplification and expression in HNSCC with a high propensity for future distant metastasis and its functions in HNSCC cell lines. Br J Cancer (2010) 1.38
Correlation between human papillomavirus and p16 overexpression in oropharyngeal tumours: a systematic review. Br J Cancer (2014) 1.25
Equivocal p16 immunostaining in squamous cell carcinoma of the head and neck: staining patterns are suggestive of HPV status. Head Neck Pathol (2012) 1.04
HPV-related methylation signature predicts survival in oropharyngeal squamous cell carcinomas. J Clin Invest (2013) 1.01
Comprehensive IMRT plus weekly cisplatin for advanced head and neck cancer: the University of Wisconsin experience. Head Neck (2010) 0.98
New Concepts for Translational Head and Neck Oncology: Lessons from HPV-Related Oropharyngeal Squamous Cell Carcinomas. Front Oncol (2012) 0.95
Basics of tumor development and importance of human papilloma virus (HPV) for head and neck cancer. GMS Curr Top Otorhinolaryngol Head Neck Surg (2012) 0.94
Differences in imaging characteristics of HPV-positive and HPV-Negative oropharyngeal cancers: a blinded matched-pair analysis. AJNR Am J Neuroradiol (2013) 0.93
Genomic profiling of advanced-stage oral cancers reveals chromosome 11q alterations as markers of poor clinical outcome. PLoS One (2011) 0.92
Expression of p16 in sinonasal undifferentiated carcinoma (SNUC) without associated human papillomavirus (HPV). Head Neck Pathol (2011) 0.91
A comprehensive evaluation of human papillomavirus positive status and p16INK4a overexpression as a prognostic biomarker in head and neck squamous cell carcinoma. Int J Oncol (2014) 0.88
Comprehensive analysis of HPV16 integration in OSCC reveals no significant impact of physical status on viral oncogene and virally disrupted human gene expression. PLoS One (2014) 0.87
Low risk of second primary malignancies among never smokers with human papillomavirus-associated index oropharyngeal cancers. Head Neck (2012) 0.87
Distinct effects of alcohol consumption and smoking on genetic alterations in head and neck carcinoma. PLoS One (2013) 0.87
Virology and molecular pathogenesis of HPV (human papillomavirus)-associated oropharyngeal squamous cell carcinoma. Biochem J (2012) 0.86
High-resolution genomic profiling of human papillomavirus-associated vulval neoplasia. Br J Cancer (2010) 0.85
HPV in oropharyngeal cancer: the basics to know in clinical practice. Acta Otorhinolaryngol Ital (2014) 0.85
HPV positive tonsillar cancer in two laser surgeons: case reports. J Otolaryngol Head Neck Surg (2013) 0.84
Update of prognostic and predictive biomarkers in oropharyngeal squamous cell carcinoma: a review. Eur Arch Otorhinolaryngol (2010) 0.83
Definitive radiation therapy without chemotherapy for human papillomavirus-positive head and neck cancer. Head Neck (2013) 0.83
Increased sensitivity of HPV-positive head and neck cancer cell lines to x-irradiation ± Cisplatin due to decreased expression of E6 and E7 oncoproteins and enhanced apoptosis. Am J Cancer Res (2015) 0.81
Initial evidence for Sec62 as a prognostic marker in advanced head and neck squamous cell carcinoma. Oncol Lett (2016) 0.81
Clinical relevance of copy number profiling in oral and oropharyngeal squamous cell carcinoma. Cancer Med (2015) 0.80
Human papillomavirus in head and neck tumors: epidemiological, molecular and clinical aspects. Wien Med Wochenschr (2010) 0.80
Human papillomavirus induced transformation in cervical and head and neck cancers. Cancers (Basel) (2014) 0.79
Epigenetics of oropharyngeal squamous cell carcinoma: opportunities for novel chemotherapeutic targets. J Otolaryngol Head Neck Surg (2017) 0.79
Counseling the patient with potentially HPV-related newly diagnosed head and neck cancer. Curr Oncol Rep (2014) 0.78
[HPV-associated oropharyngeal carcinoma. Status quo and relationship with cancer of unknown primary]. Pathologe (2014) 0.77
Absence of high-risk HPV 16 and 18 in Chinese patients with oral squamous cell carcinoma and oral potentially malignant disorders. Virol J (2016) 0.77
The microRNA signatures: aberrantly expressed microRNAs in head and neck squamous cell carcinoma. J Hum Genet (2016) 0.77
Human Papillomavirus and Oropharyngeal Squamous Cell Carcinoma: A Case-Control Study regarding Tobacco and Alcohol Consumption. Patholog Res Int (2011) 0.77
Valosin-containing protein (VCP/p97)-expression correlates with prognosis of HPV- negative oropharyngeal squamous cell carcinoma (OSCC). PLoS One (2014) 0.77
Primary chemotherapy and radiation as a treatment strategy for HPV-positive oropharyngeal cancer. Head Neck Pathol (2012) 0.77
Prognostic factors in oral and oropharyngeal cancer based on ultrastructural analysis and DNA methylation of the tumor and surgical margin. Tumour Biol (2014) 0.77
Clinical features and treatment strategy for HPV-related oropharyngeal cancer. Int J Clin Oncol (2016) 0.77
Subtypes of HPV-Positive Head and Neck Cancers Are Associated with HPV Characteristics, Copy Number Alterations, PIK3CA Mutation, and Pathway Signatures. Clin Cancer Res (2016) 0.75
Hybrid Capture 2 is as effective as PCR testing for high-risk human papillomavirus in head and neck cancers. Appl Immunohistochem Mol Morphol (2015) 0.75
DNA Copy Number Aberrations, and Human Papillomavirus Status in Penile Carcinoma. Clinico-Pathological Correlations and Potential Driver Genes. PLoS One (2016) 0.75
Predictive value of epigenetic alterations in head and neck squamous cell carcinoma. Mol Cell Oncol (2014) 0.75
Genomic Copy Number Variations Characterize the Prognosis of Both P16-Positive and P16-Negative Oropharyngeal Squamous Cell Carcinoma After Curative Resection. Medicine (Baltimore) (2015) 0.75
HPV Infection and Prognostic Factors of Tongue Squamous Cell Carcinoma in Different Ethnic Groups from Geographically Closed Cohort in Xinjiang, China. Biochem Res Int (2016) 0.75
Chromosomal Alterations and Gene Expression Changes Associated with the Progression of Leukoplakia to Advanced Gingivobuccal Cancer. Transl Oncol (2017) 0.75
Human Papilloma Virus in Oral Cavity Cancer and Relation to Change in Quality of Life Following Treatment-a Pilot Study from Northern India. Indian J Surg Oncol (2016) 0.75
Prognostic significance of LINE-1 hypomethylation in oropharyngeal squamous cell carcinoma. Clin Epigenetics (2017) 0.75
Amplification of EGFR and cyclin D1 genes associated with human papillomavirus infection in oral squamous cell carcinoma. Med Oncol (2017) 0.75
A novel algorithm for reliable detection of human papillomavirus in paraffin embedded head and neck cancer specimen. Int J Cancer (2007) 4.29
MicroRNA gene expression profile of hepatitis C virus-associated hepatocellular carcinoma. Hepatology (2008) 3.00
Combined analysis of HPV-DNA, p16 and EGFR expression to predict prognosis in oropharyngeal cancer. Int J Cancer (2007) 2.75
Marked differences in survival rate between smokers and nonsmokers with HPV 16-associated tonsillar carcinomas. Int J Cancer (2008) 2.62
Paragangliomas of the head and neck. Oral Oncol (2004) 2.47
Expression of p16 protein identifies a distinct entity of tonsillar carcinomas associated with human papillomavirus. Am J Pathol (2003) 2.26
A subset of head and neck squamous cell carcinomas exhibits integration of HPV 16/18 DNA and overexpression of p16INK4A and p53 in the absence of mutations in p53 exons 5-8. Int J Cancer (2003) 2.24
A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium. PLoS Genet (2011) 1.68
Clinical predictors for germline mutations in head and neck paraganglioma patients: cost reduction strategy in genetic diagnostic process as fall-out. Cancer Res (2009) 1.53
Podoplanin expression in cutaneous head and neck squamous cell carcinoma--prognostic value and clinicopathologic implications. J Surg Oncol (2012) 1.44
Gene expression profiling of primary canine insulinomas and their metastases. Vet J (2013) 1.43
Transition of high-grade cervical intraepithelial neoplasia to micro-invasive carcinoma is characterized by integration of HPV 16/18 and numerical chromosome abnormalities. J Pathol (2004) 1.41
Hepatic and serum levels of miR-122 after chronic HCV-induced fibrosis. J Hepatol (2012) 1.34
P21 Cip1/WAF1 expression is strongly associated with HPV-positive tonsillar carcinoma and a favorable prognosis. Mod Pathol (2009) 1.29
Molecular and cellular biology of neuroendocrine lung tumors: evidence for separate biological entities. Biochim Biophys Acta (2012) 1.24
Hepatic granulomas: histological and molecular pathological approach to differential diagnosis--a study of 442 cases. Liver Int (2008) 1.18
Expression of p16 protein is associated with human papillomavirus status in tonsillar carcinomas and has implications on survival. Adv Otorhinolaryngol (2005) 1.16
Altered levels of the onco-microRNA 21 and the tumor-supressor microRNAs 143 and 145 in advanced rectal cancer indicate successful neoadjuvant chemoradiotherapy. Int J Oncol (2011) 1.15
Apoptosis is associated with CD36/fatty acid translocase upregulation in non-alcoholic steatohepatitis. Liver Int (2010) 1.12
Supratentorial grade II astrocytoma: biological features and clinical course. Lancet Neurol (2003) 1.10
Glucagon cell adenomatosis: a newly recognized disease of the endocrine pancreas. J Clin Endocrinol Metab (2008) 1.10
Pathogenicity of DNA variants and double mutations in multiple endocrine neoplasia type 2 and von Hippel-Lindau syndrome. J Clin Endocrinol Metab (2009) 1.09
Human papillomavirus-positive tonsillar carcinomas: a different tumor entity? Med Microbiol Immunol (2002) 1.08
Head and neck paragangliomas: clinical and molecular genetic classification. Clinics (Sao Paulo) (2012) 1.07
Major histocompatibility complex class I-related chains A and B (MIC A/B): a novel role in nonalcoholic steatohepatitis. Hepatology (2010) 1.04
Clinical spectrum and virologic characteristics of anal intraepithelial neoplasia in HIV infection. J Am Acad Dermatol (2005) 1.04
Penile intraepithelial neoplasia is frequent in HIV-positive men with anal dysplasia. J Invest Dermatol (2008) 1.00
Next-generation treatment strategies for human papillomavirus-related head and neck squamous cell carcinoma: where do we go? Rev Med Virol (2011) 1.00
HPV in situ hybridization: impact of different protocols on the detection of integrated HPV. Int J Cancer (2005) 1.00
Role of human papillomavirus in the development of head and neck squamous cell carcinomas. Acta Otolaryngol (2004) 0.99
Tyramide signal amplification for DNA and mRNA in situ hybridization. Methods Mol Biol (2006) 0.98
Meta-analysis and pooled analysis of GSTM1 and CYP1A1 polymorphisms and oral and pharyngeal cancers: a HuGE-GSEC review. Genet Med (2008) 0.97
Interobserver variability of laryngeal mucosal premalignant lesions: a histopathological evaluation. Mod Pathol (2011) 0.96
Nuclear translocation of β-catenin and decreased expression of epithelial cadherin in human papillomavirus-positive tonsillar cancer: an early event in human papillomavirus-related tumour progression? Histopathology (2011) 0.96
COX-2 polymorphisms and the risk for head and neck cancer in white patients. Head Neck (2009) 0.95
Imiquimod treatment of anal intraepithelial neoplasia in HIV-positive men. Arch Dermatol (2006) 0.95
p16 INK4A overexpression is frequently detected in tumour-free tonsil tissue without association with HPV. Histopathology (2010) 0.95
Distribution pattern and marker profile show two subpopulations of reserve cells in the endocervical canal. Int J Gynecol Pathol (2009) 0.93
Genetic polymorphisms of smoking-related carcinogen detoxifying enzymes and head and neck cancer susceptibility. Anticancer Res (2009) 0.92
Local thrombolysis for successful treatment of acute stroke in an adolescent with cardiac myxoma. ScientificWorldJournal (2011) 0.92
Podoplanin expression predicts prognosis in patients with oral squamous cell carcinoma treated with neoadjuvant radiochemotherapy. Oral Oncol (2011) 0.91
β-catenin and Her2/neu expression in rectal cancer: association with histomorphological response to neoadjuvant therapy and prognosis. Int J Colorectal Dis (2011) 0.91
Integration of HPV6 and downregulation of AKR1C3 expression mark malignant transformation in a patient with juvenile-onset laryngeal papillomatosis. PLoS One (2013) 0.91
Validation of a gene expression signature for assessment of lymph node metastasis in oral squamous cell carcinoma. J Clin Oncol (2012) 0.90
Deletions of 11q22.3-q25 are associated with atypical lung carcinoids and poor clinical outcome. Am J Pathol (2011) 0.89
Association of metabolic gene polymorphisms with tobacco consumption in healthy controls. Int J Cancer (2004) 0.89
Inflammatory myofibroblastic tumor of the parotid gland: case report and review of the literature. Acta Otolaryngol (2005) 0.89
Potent inhibitory effects of type I interferons on human adrenocortical carcinoma cell growth. J Clin Endocrinol Metab (2006) 0.89
Prognostic index for patients with parotid carcinoma: external validation using the nationwide 1985-1994 Dutch Head and Neck Oncology Cooperative Group database. Cancer (2003) 0.89
Sialoendoscopy: prognostic factors for endoscopic removal of salivary stones. Arch Otolaryngol Head Neck Surg (2011) 0.89
A sex-specific association between a 15q25 variant and upper aerodigestive tract cancers. Cancer Epidemiol Biomarkers Prev (2011) 0.88
Mesenchymal stem cells induce T-cell tolerance and protect the preterm brain after global hypoxia-ischemia. PLoS One (2013) 0.88
Frequent loss of 17p, but no p53 mutations or protein overexpression in benign and malignant pheochromocytomas. Mod Pathol (2008) 0.88
Transcriptomic concentration-response evaluation of valproic acid, cyproconazole, and hexaconazole in the neural embryonic stem cell test (ESTn). Toxicol Sci (2011) 0.88
Fatal course of Wegener's granulomatosis with bilateral otomastoiditis and bilateral facial nerve palsy. Otolaryngol Head Neck Surg (2008) 0.88
Viral load, gene expression and mapping of viral integration sites in HPV16-associated HNSCC cell lines. Int J Cancer (2014) 0.88
Paraneoplastic syndromes in patients with primary head and neck cancer. Eur Arch Otorhinolaryngol (2007) 0.87
Resistance of p53 knockout cells to doxorubicin is related to reduced formation of DNA strand breaks rather than impaired apoptotic signaling. DNA Repair (Amst) (2003) 0.87
p16 expression in carcinoma of unknown primary: diagnostic indicator and prognostic marker. Head Neck (2013) 0.87
NIKEI: a new inexpensive and non-invasive scoring system to exclude advanced fibrosis in patients with NAFLD. PLoS One (2013) 0.86
Increase in viral load, viral integration, and gain of telomerase genes during uterine cervical carcinogenesis can be simultaneously assessed by the HPV 16/18 MLPA-assay. Am J Pathol (2010) 0.86
Predictive value of lymph node metastases and extracapsular extension for the risk of distant metastases in laryngeal carcinoma. Laryngoscope (2006) 0.86
P16(INK4A) immunostaining is a strong indicator for high-risk-HPV-associated oropharyngeal carcinomas and dysplasias, but is unreliable to predict low-risk-HPV-infection in head and neck papillomas and laryngeal dysplasias. Int J Cancer (2013) 0.86
Stepwise combination of simple noninvasive fibrosis scoring systems increases diagnostic accuracy in nonalcoholic fatty liver disease. J Clin Gastroenterol (2013) 0.85
A new multiparameter assay to assess HPV 16/18, viral load and physical status together with gain of telomerase genes in HPV-related cancers. Int J Cancer (2010) 0.85
Interobserver variability for the WHO classification of pulmonary carcinoids. Am J Surg Pathol (2014) 0.85
Survivin and epidermal growth factor receptor expression in surgically treated oropharyngeal squamous cell carcinoma. Head Neck (2008) 0.85
MEN1 gene mutation and reduced expression are associated with poor prognosis in pulmonary carcinoids. J Clin Endocrinol Metab (2013) 0.85
Bone metabolic activity in hyperostosis cranialis interna measured with 18F-fluoride PET. Eur J Nucl Med Mol Imaging (2010) 0.84
Aneurysm of the internal carotid artery in the middle ear. Ear Nose Throat J (2011) 0.84
Sialendoscopy for sialolithiasis: early treatment, better outcome. Head Neck (2011) 0.83
Polymorphisms of the glutathione S-transferase P1 gene and head and neck cancer susceptibility. Head Neck (2003) 0.83
Time-response evaluation by transcriptomics of methylmercury effects on neural differentiation of murine embryonic stem cells. Toxicol Sci (2011) 0.83
Molecular biomarkers in cervical cancer diagnosis: a critical appraisal. Expert Opin Med Diagn (2013) 0.83
Microsomal epoxide hydrolase genotypes and the risk for head and neck cancer. Head Neck (2008) 0.83
Human papillomavirus reduces the prognostic value of nodal involvement in tonsillar squamous cell carcinomas. Laryngoscope (2009) 0.82