Published in J Gerontol A Biol Sci Med Sci on February 17, 2009
Protein homeostasis and aging: taking care of proteins from the cradle to the grave. J Gerontol A Biol Sci Med Sci (2009) 1.84
Biological approaches to mechanistically understand the healthy life span extension achieved by calorie restriction and modulation of hormones. J Gerontol A Biol Sci Med Sci (2009) 1.36
Cell stress and aging: new emphasis on multiplex resistance mechanisms. J Gerontol A Biol Sci Med Sci (2009) 1.24
Methusaleh's Zoo: how nature provides us with clues for extending human health span. J Comp Pathol (2009) 1.21
Trajectories of physiological dysregulation predicts mortality and health outcomes in a consistent manner across three populations. Mech Ageing Dev (2014) 0.92
Whole blood transcriptomics and urinary metabolomics to define adaptive biochemical pathways of high-intensity exercise in 50-60 year old masters athletes. PLoS One (2014) 0.85
Extension of the mitochondria dysfunction hypothesis of metabolic syndrome to atherosclerosis with emphasis on the endocrine-disrupting chemicals and biophysical laws. J Diabetes Investig (2013) 0.84
Complex systems dynamics in aging: new evidence, continuing questions. Biogerontology (2015) 0.83
Rule-based cell systems model of aging using feedback loop motifs mediated by stress responses. PLoS Comput Biol (2010) 0.81
The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models. Bioinformatics (2003) 32.92
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Evolutionary capacitance as a general feature of complex gene networks. Nature (2003) 5.00
The origin of allometric scaling laws in biology from genomes to ecosystems: towards a quantitative unifying theory of biological structure and organization. J Exp Biol (2005) 3.30
A systematic look at an old problem. Nature (2008) 2.84
Allometric scaling of metabolic rate from molecules and mitochondria to cells and mammals. Proc Natl Acad Sci U S A (2002) 2.62
A network theory of ageing: the interactions of defective mitochondria, aberrant proteins, free radicals and scavengers in the ageing process. Mutat Res (1996) 1.76
Genetic determinants of human health span and life span: progress and new opportunities. PLoS Genet (2007) 1.70
Buffering mechanisms in aging: a systems approach toward uncovering the genetic component of aging. PLoS Comput Biol (2007) 1.64
Systems biology: integrating technology, biology, and computation. Mech Ageing Dev (2003) 1.63
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Towards an e-biology of ageing: integrating theory and data. Nat Rev Mol Cell Biol (2003) 1.11
Understanding aging: revealing order out of chaos. Biochim Biophys Acta (2004) 0.97
Programmed ageing: the theory of maximal metabolic scope. How does the biological clock tick? EMBO Rep (2005) 0.97
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Systems approaches to the networks of aging. Ageing Res Rev (2006) 0.90
Reflections on an unsolved problem of biology: the evolution of senescence and death. Adv Gerontol (2004) 0.86
Multi-scale modelling and the IUPS physiome project. J Mol Histol (2004) 0.83
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Evolutionary biology: mortality and lifespan. Nature (2004) 0.81
Waddington's canalization revisited: developmental stability and evolution. Proc Natl Acad Sci U S A (2002) 4.01
Lipoprotein genotype and conserved pathway for exceptional longevity in humans. PLoS Biol (2006) 3.12
Arteriolar niches maintain haematopoietic stem cell quiescence. Nature (2013) 3.07
CD169⁺ macrophages provide a niche promoting erythropoiesis under homeostasis and stress. Nat Med (2013) 2.26
Amino acid runs in eukaryotic proteomes and disease associations. Proc Natl Acad Sci U S A (2002) 2.17
Evolution in health and medicine Sackler colloquium: Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians. Proc Natl Acad Sci U S A (2009) 1.96
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The evolution of the evolvability properties of the yeast prion [PSI+]. Evolution (2003) 1.58
A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. PLoS Genet (2012) 1.52
REST and CoREST modulate neuronal subtype specification, maturation and maintenance. PLoS One (2009) 1.34
Ubiquitylated PCNA plays a role in somatic hypermutation and class-switch recombination and is required for meiotic progression. Proc Natl Acad Sci U S A (2008) 1.32
Functional and evolutionary inference in gene networks: does topology matter? Genetica (2006) 1.29
Differential deployment of REST and CoREST promotes glial subtype specification and oligodendrocyte lineage maturation. PLoS One (2009) 1.20
RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans. PLoS One (2009) 1.16
Genetic studies reveal the role of the endocrine and metabolic systems in aging. J Clin Endocrinol Metab (2010) 1.13
SHMTool: a webserver for comparative analysis of somatic hypermutation datasets. DNA Repair (Amst) (2008) 1.12
A core erythroid transcriptional network is repressed by a master regulator of myelo-lymphoid differentiation. Proc Natl Acad Sci U S A (2012) 1.12
Corepressor for element-1-silencing transcription factor preferentially mediates gene networks underlying neural stem cell fate decisions. Proc Natl Acad Sci U S A (2010) 1.12
V-region mutation in vitro, in vivo, and in silico reveal the importance of the enzymatic properties of AID and the sequence environment. Proc Natl Acad Sci U S A (2009) 1.05
The limits of subfunctionalization. BMC Evol Biol (2007) 1.03
Coevolution of robustness, epistasis, and recombination favors asexual reproduction. Proc Natl Acad Sci U S A (2007) 0.97
Distinguishing between longevity and buffered-deleterious genotypes for exceptional human longevity: the case of the MTP gene. J Gerontol A Biol Sci Med Sci (2012) 0.97
Fungal virulence in a lepidopteran model is an emergent property with deterministic features. MBio (2013) 0.90
Disease-enhancing antibodies improve the efficacy of bacterial toxin-neutralizing antibodies. Cell Host Microbe (2013) 0.90
Old Cryptococcus neoformans cells contribute to virulence in chronic cryptococcosis. MBio (2013) 0.85
Site-specific molecular signatures predict aggressive disease in HNSCC. Head Neck Pathol (2008) 0.84
Socially stable territories: the negotiation of space by interacting foragers. Am Nat (2002) 0.84
Gene size matters. PLoS One (2012) 0.84
The underlying molecular and network level mechanisms in the evolution of robustness in gene regulatory networks. PLoS Comput Biol (2013) 0.83
Recombinase-mediated cassette exchange as a novel method to study somatic hypermutation in Ramos cells. MBio (2011) 0.81
A general model for ontogenetic growth under food restriction. Proc Biol Sci (2011) 0.80
Energetic basis of correlation between catch-up growth, health maintenance, and aging. J Gerontol A Biol Sci Med Sci (2011) 0.79
Temporal behavior of capsule enlargement by Cryptococcus neoformans. Eukaryot Cell (2013) 0.77
A general life history theory for effects of caloric restriction on health maintenance. BMC Syst Biol (2011) 0.76
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