Insights into the mechanical properties of epithelial cells: the effects of shear stress on the assembly and remodeling of keratin intermediate filaments.

PubWeight™: 1.00‹?› | Rank: Top 15%

🔗 View Article (PMC 2704593)

Published in FASEB J on February 26, 2009

Authors

Eric W Flitney1, Edward R Kuczmarski, Stephen A Adam, Robert D Goldman

Author Affiliations

1: Department of Cell and Molecular Biology, Feinberg School of Medicine of Northwestern University, 303 E. Chicago Avenue, Chicago, IL 60611, USA.

Articles citing this

Cell mechanics and the cytoskeleton. Nature (2010) 5.24

Vimentin induces changes in cell shape, motility, and adhesion during the epithelial to mesenchymal transition. FASEB J (2010) 3.05

Intermediate filaments take the heat as stress proteins. Trends Cell Biol (2010) 1.44

The expanding significance of keratin intermediate filaments in normal and diseased epithelia. Curr Opin Cell Biol (2012) 1.36

Cytoskeleton in motion: the dynamics of keratin intermediate filaments in epithelia. J Cell Biol (2011) 1.25

Self-organization of keratin intermediate filaments into cross-linked networks. J Cell Biol (2009) 1.12

Inroads into the structure and function of intermediate filament networks. J Struct Biol (2011) 1.09

O-GlcNAcylation determines the solubility, filament organization, and stability of keratins 8 and 18. J Biol Chem (2010) 0.90

Measuring the regulation of keratin filament network dynamics. Proc Natl Acad Sci U S A (2013) 0.87

"Panta rhei": Perpetual cycling of the keratin cytoskeleton. Bioarchitecture (2011) 0.86

Mechanics of individual keratin bundles in living cells. Biophys J (2014) 0.77

Multiciliated cell basal bodies align in stereotypical patterns coordinated by the apical cytoskeleton. J Cell Biol (2016) 0.77

The role of intracellular protein O-glycosylation in cell adhesion and disease. J Biomed Res (2011) 0.77

Three-dimensional Organization of Layered Apical Cytoskeletal Networks Associated with Mouse Airway Tissue Development. Sci Rep (2017) 0.75

Quantitative Proteomic Profiling the Molecular Signatures of Annexin A5 in Lung Squamous Carcinoma Cells. PLoS One (2016) 0.75

Intermediate Filaments at the Junction of Mechanotransduction, Migration, and Development. Front Cell Dev Biol (2017) 0.75

Articles cited by this

In vitro cultivation of human tumors: establishment of cell lines derived from a series of solid tumors. J Natl Cancer Inst (1973) 11.26

Intermediate filaments: structure, dynamics, function, and disease. Annu Rev Biochem (1994) 6.32

Self-assembly of bovine epidermal keratin filaments in vitro. J Mol Biol (1976) 4.43

Point mutations in human keratin 14 genes of epidermolysis bullosa simplex patients: genetic and functional analyses. Cell (1991) 3.49

New consensus nomenclature for mammalian keratins. J Cell Biol (2006) 3.27

A mutation in the conserved helix termination peptide of keratin 5 in hereditary skin blistering. Nature (1992) 2.49

Rapid movements of vimentin on microtubule tracks: kinesin-dependent assembly of intermediate filament networks. J Cell Biol (1998) 2.44

"Heads and tails" of intermediate filament phosphorylation: multiple sites and functional insights. Trends Biochem Sci (2006) 1.97

Shear stress-induced reorganization of the surface topography of living endothelial cells imaged by atomic force microscopy. Circ Res (1994) 1.90

Expression of mutant keratin cDNAs in epithelial cells reveals possible mechanisms for initiation and assembly of intermediate filaments. J Cell Biol (1989) 1.89

Rapid displacement of vimentin intermediate filaments in living endothelial cells exposed to flow. Circ Res (2000) 1.77

A requirement for cytoplasmic dynein and dynactin in intermediate filament network assembly and organization. J Cell Biol (2002) 1.72

Characterization of distinct early assembly units of different intermediate filament proteins. J Mol Biol (1999) 1.69

Identification of novel principles of keratin filament network turnover in living cells. Mol Biol Cell (2004) 1.68

Insights into the dynamic properties of keratin intermediate filaments in living epithelial cells. J Cell Biol (2001) 1.66

Disruption of the keratin filament network during epithelial cell division. EMBO J (1982) 1.61

Apoptosis and keratin intermediate filaments. Cell Death Differ (2002) 1.56

Subcellular distribution of shear stress at the surface of flow-aligned and nonaligned endothelial monolayers. Am J Physiol (1995) 1.55

Spatiotemporal analysis of flow-induced intermediate filament displacement in living endothelial cells. Biophys J (2001) 1.48

Reorganization of arrays of prekeratin filaments during mitosis. Immunofluorescence microscopy with multiclonal and monoclonal prekeratin antibodies. Exp Cell Res (1981) 1.43

Active caspases and cleaved cytokeratins are sequestered into cytoplasmic inclusions in TRAIL-induced apoptosis. J Cell Biol (2000) 1.43

Micromechanical properties of keratin intermediate filament networks. Proc Natl Acad Sci U S A (2008) 1.43

Keratin 8 phosphorylation by protein kinase C delta regulates shear stress-mediated disassembly of keratin intermediate filaments in alveolar epithelial cells. J Biol Chem (2005) 1.38

Phosphorylation and disassembly of intermediate filaments in mitotic cells. Proc Natl Acad Sci U S A (1989) 1.37

Cytoskeletal integrity in interphase cells requires protein phosphatase activity. Proc Natl Acad Sci U S A (1992) 1.36

Novel features of intermediate filament dynamics revealed by green fluorescent protein chimeras. J Cell Sci (1998) 1.30

A significant soluble keratin fraction in 'simple' epithelial cells. Lack of an apparent phosphorylation and glycosylation role in keratin solubility. J Cell Sci (1993) 1.28

Modulation of vimentin containing intermediate filament distribution and phosphorylation in living fibroblasts by the cAMP-dependent protein kinase. J Cell Biol (1989) 1.28

Stress, apoptosis, and mitosis induce phosphorylation of human keratin 8 at Ser-73 in tissues and cultured cells. J Biol Chem (1997) 1.27

Keratin incorporation into intermediate filament networks is a rapid process. J Cell Biol (1991) 1.27

A mechanism for heterogeneous endothelial responses to flow in vivo and in vitro. J Biomech (1995) 1.26

Dynamic properties of intermediate filaments: disassembly and reassembly during mitosis in baby hamster kidney cells. Cell Motil Cytoskeleton (1990) 1.26

Induction of rapid and reversible cytokeratin filament network remodeling by inhibition of tyrosine phosphatases. J Cell Sci (2002) 1.21

Rapid transport of neural intermediate filament protein. J Cell Sci (2003) 1.17

Hepatocyte cytokeratins are hyperphosphorylated at multiple sites in human alcoholic hepatitis and in a mallory body mouse model. Am J Pathol (2000) 1.14

Characterization of early assembly intermediates of recombinant human keratins. J Struct Biol (2002) 1.12

Focal adhesions are hotspots for keratin filament precursor formation. J Cell Biol (2006) 1.11

Dissection of keratin dynamics: different contributions of the actin and microtubule systems. Eur J Cell Biol (2005) 1.10

The motility and dynamic properties of intermediate filaments and their constituent proteins. Exp Cell Res (2007) 1.09

Assembling an intermediate filament network by dynamic cotranslation. J Cell Biol (2006) 1.08

Detection of cytokeratin dynamics by time-lapse fluorescence microscopy in living cells. J Cell Sci (1999) 1.08

Protein phosphatases maintain the organization and structural interactions of hepatic keratin intermediate filaments. J Cell Sci (1997) 1.08

p38 MAPK-dependent shaping of the keratin cytoskeleton in cultured cells. J Cell Biol (2007) 1.06

The quest for the function of simple epithelial keratins. Bioessays (2003) 1.06

Dynamics of keratin assembly: exogenous type I keratin rapidly associates with type II keratin in vivo. J Cell Biol (1993) 1.04

Mechanical stress induces profound remodelling of keratin filaments and cell junctions in epidermolysis bullosa simplex keratinocytes. J Cell Sci (2004) 1.02

Mitotic arrest with anti-microtubule agents or okadaic acid is associated with increased glycoprotein terminal GlcNAc's. J Cell Sci (1994) 1.01

Pervanadate-mediated tyrosine phosphorylation of keratins 8 and 19 via a p38 mitogen-activated protein kinase-dependent pathway. J Cell Sci (1999) 0.93

Observation of keratin particles showing fast bidirectional movement colocalized with microtubules. J Cell Sci (2003) 0.91

Monoclonal cytokeratin antibody recognizing a heterotypic complex: immunological probing of conformational states of cytoskeletal proteins in filaments and in solution. Exp Cell Res (1987) 0.90

Human epidermal keratin filaments: studies on their structure and assembly. Ann N Y Acad Sci (1985) 0.89

Protein phosphatase-2A associates with and dephosphorylates keratin 8 after hyposmotic stress in a site- and cell-specific manner. J Cell Sci (2006) 0.88

Soluble cytokeratins in Xenopus laevis oocytes and eggs. Biol Cell (1987) 0.84

Fluorescence-based methods for studying intermediate filaments. Methods Cell Biol (2004) 0.83

Articles by these authors

The nuclear lamina comes of age. Nat Rev Mol Cell Biol (2005) 6.00

Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin. Genes Dev (2008) 4.69

Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging. Proc Natl Acad Sci U S A (2006) 3.86

Importin alpha: a multipurpose nuclear-transport receptor. Trends Cell Biol (2004) 3.64

The A- and B-type nuclear lamin networks: microdomains involved in chromatin organization and transcription. Genes Dev (2008) 3.23

Vimentin induces changes in cell shape, motility, and adhesion during the epithelial to mesenchymal transition. FASEB J (2010) 3.05

A mitotic lamin B matrix induced by RanGTP required for spindle assembly. Science (2006) 2.87

Actin, microtubules, and vimentin intermediate filaments cooperate for elongation of invadopodia. J Cell Biol (2010) 2.62

The role of nuclear lamin B1 in cell proliferation and senescence. Genes Dev (2011) 2.38

Alterations in mitosis and cell cycle progression caused by a mutant lamin A known to accelerate human aging. Proc Natl Acad Sci U S A (2007) 2.24

Nuclear lamins. Cold Spring Harb Perspect Biol (2010) 2.22

Specific in vivo phosphorylation sites determine the assembly dynamics of vimentin intermediate filaments. J Cell Sci (2004) 2.17

Alteration of nuclear lamin organization inhibits RNA polymerase II-dependent transcription. J Cell Biol (2002) 2.14

Intermediate filaments mediate cytoskeletal crosstalk. Nat Rev Mol Cell Biol (2004) 2.02

Multiple elements regulate nuclear/cytoplasmic shuttling of FOXO1: characterization of phosphorylation- and 14-3-3-dependent and -independent mechanisms. Biochem J (2004) 2.02

The nucleoskeleton: lamins and actin are major players in essential nuclear functions. Curr Opin Cell Biol (2003) 1.97

Introducing intermediate filaments: from discovery to disease. J Clin Invest (2009) 1.96

Giant axonal neuropathy-associated gigaxonin mutations impair intermediate filament protein degradation. J Clin Invest (2013) 1.79

A requirement for cytoplasmic dynein and dynactin in intermediate filament network assembly and organization. J Cell Biol (2002) 1.72

Intermediate filaments are dynamic and motile elements of cellular architecture. J Cell Sci (2004) 1.66

Tracking melanosomes inside a cell to study molecular motors and their interaction. Proc Natl Acad Sci U S A (2007) 1.66

The nuclear lamina and its functions in the nucleus. Int Rev Cytol (2003) 1.60

Vimentin organization modulates the formation of lamellipodia. Mol Biol Cell (2011) 1.60

A progeria mutation reveals functions for lamin A in nuclear assembly, architecture, and chromosome organization. Proc Natl Acad Sci U S A (2009) 1.58

Nuclear lamins, diseases and aging. Curr Opin Cell Biol (2006) 1.55

Nuclear lamin functions and disease. Trends Genet (2012) 1.52

Recruitment of vimentin to the cell surface by beta3 integrin and plectin mediates adhesion strength. J Cell Sci (2009) 1.48

The role of vimentin intermediate filaments in cortical and cytoplasmic mechanics. Biophys J (2013) 1.47

Micromechanical properties of keratin intermediate filament networks. Proc Natl Acad Sci U S A (2008) 1.43

Keratin 8 phosphorylation by protein kinase C delta regulates shear stress-mediated disassembly of keratin intermediate filaments in alveolar epithelial cells. J Biol Chem (2005) 1.38

Nestin promotes the phosphorylation-dependent disassembly of vimentin intermediate filaments during mitosis. Mol Biol Cell (2003) 1.38

A nestin scaffold links Cdk5/p35 signaling to oxidant-induced cell death. EMBO J (2006) 1.37

Desmoplakin assembly dynamics in four dimensions: multiple phases differentially regulated by intermediate filaments and actin. J Cell Biol (2005) 1.35

Microfilament-dependent movement of the beta3 integrin subunit within focal contacts of endothelial cells. FASEB J (2002) 1.34

Intermediate filaments: versatile building blocks of cell structure. Curr Opin Cell Biol (2008) 1.34

A role for intermediate filaments in determining and maintaining the shape of nerve cells. Mol Biol Cell (2003) 1.25

The highly conserved nuclear lamin Ig-fold binds to PCNA: its role in DNA replication. J Cell Biol (2008) 1.24

Nuclear lamins and chromatin: when structure meets function. Adv Enzyme Regul (2008) 1.20

Vimentin intermediate filaments modulate the motility of mitochondria. Mol Biol Cell (2011) 1.18

The dynamic properties of intermediate filaments during organelle transport. J Cell Sci (2009) 1.17

Rapid transport of neural intermediate filament protein. J Cell Sci (2003) 1.17

Intermediate filament proteins participate in signal transduction. Trends Cell Biol (2005) 1.12

Inroads into the structure and function of intermediate filament networks. J Struct Biol (2011) 1.09

The motility and dynamic properties of intermediate filaments and their constituent proteins. Exp Cell Res (2007) 1.09

Assembling an intermediate filament network by dynamic cotranslation. J Cell Biol (2006) 1.08

The dynamic and motile properties of intermediate filaments. Annu Rev Cell Dev Biol (2003) 1.07

Withaferin a alters intermediate filament organization, cell shape and behavior. PLoS One (2012) 1.05

Ubiquitin-proteasome-mediated degradation of keratin intermediate filaments in mechanically stimulated A549 cells. J Biol Chem (2008) 1.05

Cdk5 regulates axonal transport and phosphorylation of neurofilaments in cultured neurons. J Cell Sci (2004) 1.04

Functions and dysfunctions of the nuclear lamin Ig-fold domain in nuclear assembly, growth, and Emery-Dreifuss muscular dystrophy. Proc Natl Acad Sci U S A (2005) 1.04

Shear stress induced reorganization of the keratin intermediate filament network requires phosphorylation by protein kinase C zeta. Mol Biol Cell (2009) 1.02

Mechanical model of blebbing in nuclear lamin meshworks. Proc Natl Acad Sci U S A (2013) 1.00

The functions of the nuclear envelope in mediating the molecular crosstalk between the nucleus and the cytoplasm. Curr Opin Cell Biol (2011) 0.98

A role for Caenorhabditis elegans importin IMA-2 in germ line and embryonic mitosis. Mol Biol Cell (2002) 0.96

Ubiquitin is a novel substrate for human insulin-degrading enzyme. J Mol Biol (2010) 0.94

Concentration-dependent lamin assembly and its roles in the localization of other nuclear proteins. Mol Biol Cell (2014) 0.93

Regulation of nuclear lamin polymerization by importin alpha. J Biol Chem (2008) 0.91

Disruption of lamin B1 and lamin B2 processing and localization by farnesyltransferase inhibitors. Nucleus (2013) 0.90

Loss of adhesion-regulated proteinase production is correlated with invasive activity in oral squamous cell carcinoma. Cancer (2002) 0.89

The Nup153-Nup50 protein interface and its role in nuclear import. J Biol Chem (2012) 0.88

Simian virus 40 induces lamin A/C fluctuations and nuclear envelope deformation during cell entry. Nucleus (2011) 0.85

Vimentin Intermediate Filaments Template Microtubule Networks to Enhance Persistence in Cell Polarity and Directed Migration. Cell Syst (2016) 0.84

Insights into the differences between the A- and B-type nuclear lamins. Adv Biol Regul (2012) 0.84

Structural changes in intermediate filament networks alter the activity of insulin-degrading enzyme. FASEB J (2009) 0.83

Fluorescence-based methods for studying intermediate filaments. Methods Cell Biol (2004) 0.83

Tropomyosins are present in lamellipodia of motile cells. Eur J Cell Biol (2006) 0.82

Regulation of nucleotide excision repair by nuclear lamin b1. PLoS One (2013) 0.81

Tropomyosins regulate the impact of actin binding proteins on actin filaments. Adv Exp Med Biol (2008) 0.80

Emergent properties of composite semiflexible biopolymer networks. Bioarchitecture (2014) 0.78

Gene-rich chromosomal regions are preferentially localized in the lamin B deficient nuclear blebs of atypical progeria cells. Nucleus (2015) 0.77

Nuclear lamins and oxidative stress in cell proliferation and longevity. Adv Exp Med Biol (2014) 0.77

Constructing and expressing fluorescent protein fusions. Cold Spring Harb Protoc (2010) 0.75

Purification of bovine lens and bacterially expressed human vimentin. CSH Protoc (2007) 0.75

Transfection of mammalian cells with fluorescent protein fusions. Cold Spring Harb Protoc (2010) 0.75

Constructing and Expressing GFP Fusion Proteins. CSH Protoc (2006) 0.75

Preparation and Microinjection of x-Rhodamine-Labeled Vimentin. CSH Protoc (2007) 0.75