PubRank

Yasuo Uchiyama

Author PubWeight™ 254.09‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature 2006 21.40
2 Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy 2007 20.92
3 Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 2012 20.08
4 Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol 2005 18.60
5 Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell 2007 14.63
6 Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice. Science 2004 6.07
7 Identification of Tim4 as a phosphatidylserine receptor. Nature 2007 6.06
8 Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations. Cell 2010 5.09
9 Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease. J Cell Biol 2005 4.91
10 The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice. Mol Biol Cell 2008 3.72
11 Regulation of autophagy by extracellular signal-regulated protein kinases during 1-methyl-4-phenylpyridinium-induced cell death. Am J Pathol 2007 3.29
12 RNA-binding protein Musashi family: roles for CNS stem cells and a subpopulation of ependymal cells revealed by targeted disruption and antisense ablation. Proc Natl Acad Sci U S A 2002 2.79
13 Inhibition of autophagy prevents hippocampal pyramidal neuron death after hypoxic-ischemic injury. Am J Pathol 2008 2.57
14 Participation of autophagy in storage of lysosomes in neurons from mouse models of neuronal ceroid-lipofuscinoses (Batten disease). Am J Pathol 2005 2.56
15 Phosphatidylserine-dependent engulfment by macrophages of nuclei from erythroid precursor cells. Nature 2005 2.45
16 Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue. Mol Brain 2012 2.18
17 The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK-ERK pathway to late endosomes. EMBO J 2009 2.17
18 New neurons clear the path of astrocytic processes for their rapid migration in the adult brain. Neuron 2010 2.12
19 Grafted human-induced pluripotent stem-cell-derived neurospheres promote motor functional recovery after spinal cord injury in mice. Proc Natl Acad Sci U S A 2011 2.09
20 Visualization of TGN to endosome trafficking through fluorescently labeled MPR and AP-1 in living cells. Mol Biol Cell 2003 1.98
21 Different apoptotic mechanisms are activated in male and female brains after neonatal hypoxia-ischaemia. J Neurochem 2006 1.87
22 Bafilomycin A1 inhibits chloroquine-induced death of cerebellar granule neurons. Mol Pharmacol 2006 1.80
23 The MAP1-LC3 conjugation system is involved in lipid droplet formation. Biochem Biophys Res Commun 2009 1.77
24 Impaired thymic development in mouse embryos deficient in apoptotic DNA degradation. Nat Immunol 2003 1.77
25 Nesfatin-1-regulated oxytocinergic signaling in the paraventricular nucleus causes anorexia through a leptin-independent melanocortin pathway. Cell Metab 2009 1.66
26 Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity. Mol Brain 2008 1.61
27 LC3, an autophagosome marker, is highly expressed in gastrointestinal cancers. Int J Oncol 2008 1.61
28 Nuclear cataract caused by a lack of DNA degradation in the mouse eye lens. Nature 2003 1.55
29 Gene transfer of hepatocyte growth factor gene improves learning and memory in the chronic stage of cerebral infarction. Hypertension 2006 1.54
30 Cathepsin D deficiency induces persistent neurodegeneration in the absence of Bax-dependent apoptosis. J Neurosci 2007 1.52
31 Human CHMP6, a myristoylated ESCRT-III protein, interacts directly with an ESCRT-II component EAP20 and regulates endosomal cargo sorting. Biochem J 2005 1.48
32 Participation of autophagy in renal ischemia/reperfusion injury. Biochem Biophys Res Commun 2008 1.46
33 The protocadherin-alpha family is involved in axonal coalescence of olfactory sensory neurons into glomeruli of the olfactory bulb in mouse. Mol Cell Neurosci 2008 1.42
34 NF-M is an essential target for the myelin-directed "outside-in" signaling cascade that mediates radial axonal growth. J Cell Biol 2003 1.41
35 Discovery of a second form of tripartite complex containing gH-gL of human herpesvirus 6 and observations on CD46. J Virol 2004 1.37
36 Development of the circadian oscillator during differentiation of mouse embryonic stem cells in vitro. Proc Natl Acad Sci U S A 2010 1.34
37 GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus. Nat Cell Biol 2008 1.33
38 Human herpesvirus-6 induces MVB formation, and virus egress occurs by an exosomal release pathway. Traffic 2008 1.31
39 Dominant-negative mutant of BIG2, an ARF-guanine nucleotide exchange factor, specifically affects membrane trafficking from the trans-Golgi network through inhibiting membrane association of AP-1 and GGA coat proteins. Biochem Biophys Res Commun 2002 1.29
40 Free fatty acids stimulate autophagy in pancreatic β-cells via JNK pathway. Biochem Biophys Res Commun 2010 1.21
41 Involvement of two different cell death pathways in retinal atrophy of cathepsin D-deficient mice. Mol Cell Neurosci 2003 1.21
42 CLC-3 deficiency leads to phenotypes similar to human neuronal ceroid lipofuscinosis. Genes Cells 2002 1.20
43 Induction of autophagy by cystatin C: a mechanism that protects murine primary cortical neurons and neuronal cell lines. PLoS One 2010 1.20
44 Conditional ablation of GFRalpha1 in postmigratory enteric neurons triggers unconventional neuronal death in the colon and causes a Hirschsprung's disease phenotype. Development 2007 1.20
45 Human IAPP-induced pancreatic β cell toxicity and its regulation by autophagy. J Clin Invest 2014 1.19
46 LC3, a microtubule-associated protein1A/B light chain3, is involved in cytoplasmic lipid droplet formation. Biochem Biophys Res Commun 2010 1.18
47 Intracellular phosphatidylserine is essential for retrograde membrane traffic through endosomes. Proc Natl Acad Sci U S A 2011 1.16
48 Motor neuron-specific disruption of proteasomes, but not autophagy, replicates amyotrophic lateral sclerosis. J Biol Chem 2012 1.15
49 Participation of autophagy in the degeneration process of rat hepatocytes after transplantation following prolonged cold preservation. Arch Histol Cytol 2005 1.14
50 RANKL-induced expression of tetraspanin CD9 in lipid raft membrane microdomain is essential for cell fusion during osteoclastogenesis. J Bone Miner Res 2006 1.14
51 Ablation of C/EBPbeta alleviates ER stress and pancreatic beta cell failure through the GRP78 chaperone in mice. J Clin Invest 2009 1.13
52 PKClambda regulates glucose-induced insulin secretion through modulation of gene expression in pancreatic beta cells. J Clin Invest 2005 1.12
53 Loss of ALS2/Alsin exacerbates motor dysfunction in a SOD1-expressing mouse ALS model by disturbing endolysosomal trafficking. PLoS One 2010 1.12
54 Gene replacement in mice reveals that the heavily phosphorylated tail of neurofilament heavy subunit does not affect axonal caliber or the transit of cargoes in slow axonal transport. J Cell Biol 2002 1.11
55 Sleeping beauty transposon-based phenotypic analysis of mice: lack of Arpc3 results in defective trophoblast outgrowth. Mol Cell Biol 2006 1.09
56 Degradation of nuclear DNA by DNase II-like acid DNase in cortical fiber cells of mouse eye lens. FEBS J 2007 1.08
57 Kainic acid induces early and transient autophagic stress in mouse hippocampus. Neurosci Lett 2006 1.07
58 Insights into the phosphoregulation of beta-secretase sorting signal by the VHS domain of GGA1. Traffic 2004 1.07
59 The neurofilament middle molecular mass subunit carboxyl-terminal tail domains is essential for the radial growth and cytoskeletal architecture of axons but not for regulating neurofilament transport rate. J Cell Biol 2003 1.07
60 Isolation and transplantation of dopaminergic neurons generated from mouse embryonic stem cells. Neurosci Lett 2004 1.04
61 Effects of RNA interference of Atg4B on the limited proteolysis of LC3 in PC12 cells and expression of Atg4B in various rat tissues. Autophagy 2006 1.04
62 Roles of ARFRP1 (ADP-ribosylation factor-related protein 1) in post-Golgi membrane trafficking. J Cell Sci 2005 1.04
63 Phosphorylation of highly conserved neurofilament medium KSP repeats is not required for myelin-dependent radial axonal growth. J Neurosci 2009 1.04
64 Effect of hyaluronan oligosaccharides on the expression of heat shock protein 72. J Biol Chem 2002 1.02
65 c-FLIP maintains tissue homeostasis by preventing apoptosis and programmed necrosis. Sci Signal 2012 1.01
66 Ammonia-induced apoptosis is accelerated at higher pH in gastric surface mucous cells. Am J Physiol Gastrointest Liver Physiol 2002 1.01
67 Reduction of brain beta-amyloid (Abeta) by fluvastatin, a hydroxymethylglutaryl-CoA reductase inhibitor, through increase in degradation of amyloid precursor protein C-terminal fragments (APP-CTFs) and Abeta clearance. J Biol Chem 2010 1.00
68 C-terminal Src kinase controls development and maintenance of mouse squamous epithelia. EMBO J 2007 0.99
69 Rhomboid protease PARL mediates the mitochondrial membrane potential loss-induced cleavage of PGAM5. J Biol Chem 2012 0.98
70 Identification of phospholipid scramblase 1 as a novel interacting molecule with beta -secretase (beta -site amyloid precursor protein (APP) cleaving enzyme (BACE)). J Biol Chem 2003 0.98
71 Identification of a chromogranin A domain that mediates binding to secretogranin III and targeting to secretory granules in pituitary cells and pancreatic beta-cells. Mol Biol Cell 2002 0.96
72 Characterization of Cln3p, the gene product responsible for juvenile neuronal ceroid lipofuscinosis, as a lysosomal integral membrane glycoprotein. J Neurochem 2003 0.95
73 Human herpesvirus 6 open reading frame U14 protein and cellular p53 interact with each other and are contained in the virion. J Virol 2005 0.95
74 Mammalian Mcm2/4/6/7 complex forms a toroidal structure. Genes Cells 2003 0.94
75 Participation of autophagy in the initiation of graft dysfunction after rat liver transplantation. Autophagy 2009 0.94
76 Involvement of cathepsin B in the processing and secretion of interleukin-1beta in chromogranin A-stimulated microglia. Glia 2010 0.94
77 Caspase-9 activation revealed by semaphorin 7A cleavage is independent of apoptosis in the aged olfactory bulb. J Neurosci 2009 0.93
78 Human RME-8 is involved in membrane trafficking through early endosomes. Cell Struct Funct 2008 0.92
79 Developing postmitotic mammalian neurons in vivo lacking Apaf-1 undergo programmed cell death by a caspase-independent, nonapoptotic pathway involving autophagy. J Neurosci 2008 0.91
80 Predominant expression of the short form of GGA3 in human cell lines and tissues. Biochem Biophys Res Commun 2003 0.90
81 Dissociation and dispersion of claudin-3 from the tight junction could be one of the most sensitive indicators of reflux esophagitis in a rat model of the disease. J Gastroenterol 2011 0.90
82 Acquisition of T regulatory function in cathepsin L-inhibited T cells by eye-derived CTLA-2alpha during inflammatory conditions. J Immunol 2009 0.90
83 RGS18 acts as a negative regulator of osteoclastogenesis by modulating the acid-sensing OGR1/NFAT signaling pathway. J Bone Miner Res 2007 0.90
84 HVJ-envelope vector for gene transfer into central nervous system. Biochem Biophys Res Commun 2003 0.90
85 Ablation of TSC2 enhances insulin secretion by increasing the number of mitochondria through activation of mTORC1. PLoS One 2011 0.89
86 Development of Purkinje cell degeneration in a knockin mouse model reveals lysosomal involvement in the pathogenesis of SCA6. Proc Natl Acad Sci U S A 2012 0.89
87 Novel therapeutic strategy to treat brain ischemia: overexpression of hepatocyte growth factor gene reduced ischemic injury without cerebral edema in rat model. Circulation 2004 0.89
88 Altered regulation of phosphatidylinositol 3-kinase signaling in cathepsin D-deficient brain. Autophagy 2007 0.89
89 Detection of a circadian enhancer in the mDbp promoter using prokaryotic transposon vector-based strategy. Nucleic Acids Res 2008 0.88
90 Exendin-4 improves β-cell function in autophagy-deficient β-cells. Endocrinology 2013 0.88
91 Aggregate formation and phosphorylation of neurofilament-L Pro22 Charcot-Marie-Tooth disease mutants. Hum Mol Genet 2006 0.88
92 Presence of robust circadian clock oscillation under constitutive over-expression of mCry1 in rat-1 fibroblasts. FEBS Lett 2007 0.87
93 Generation of a recombinant Oka varicella vaccine expressing mumps virus hemagglutinin-neuraminidase protein as a polyvalent live vaccine. Vaccine 2007 0.86
94 Gene expression profiling of acute cellular rejection in rat liver transplantation using DNA microarrays. Liver Transpl 2009 0.86
95 Immunohistochemical study of the autophagy marker microtubule-associated protein 1 light chain 3 in normal and steatotic human livers. Hepatol Res 2013 0.86
96 Cathepsin B-dependent motor neuron death after nerve injury in the adult mouse. Biochem Biophys Res Commun 2010 0.85
97 Atg9A protein, an autophagy-related membrane protein, is localized in the neurons of mouse brains. J Histochem Cytochem 2010 0.85
98 Closer association of mitochondria with lipid droplets in hepatocytes and activation of Kupffer cells in resveratrol-treated senescence-accelerated mice. Histochem Cell Biol 2011 0.85
99 Deregulation of pancreas-specific oxidoreductin ERO1β in the pathogenesis of diabetes mellitus. Mol Cell Biol 2014 0.84
100 Ablation of Csk in neural crest lineages causes corneal anomaly by deregulating collagen fibril organization and cell motility. Dev Biol 2008 0.83
101 ATP13A2 deficiency induces a decrease in cathepsin D activity, fingerprint-like inclusion body formation, and selective degeneration of dopaminergic neurons. FEBS Lett 2013 0.83
102 Mini screening of kinase inhibitors affecting period-length of mammalian cellular circadian clock. Acta Histochem Cytochem 2009 0.83
103 Early-phase redistribution of the cation-independent mannose 6-phosphate receptor by U18666A treatment in HeLa cells. Cell Tissue Res 2004 0.82
104 PAC1 gene knockout reveals an essential role of chaperone-mediated 20S proteasome biogenesis and latent 20S proteasomes in cellular homeostasis. Mol Cell Biol 2010 0.82
105 Specific depletion of GGA2 causes cathepsin D missorting in HeLa cells. Arch Histol Cytol 2007 0.81
106 Haematopoietic development and immunological function in the absence of cathepsin D. BMC Immunol 2007 0.81
107 Very-high-dose alpha-tocopherol supplementation increases blood pressure and causes possible adverse central nervous system effects in stroke-prone spontaneously hypertensive rats. J Neurosci Res 2009 0.81
108 Involvement of lysosomal storage-induced p38 MAP kinase activation in the overproduction of nitric oxide by microglia in cathepsin D-deficient mice. Mol Cell Neurosci 2007 0.81
109 Human skeletal muscle calcium channel alpha1S is expressed in the basal ganglia: distinctive expression pattern among L-type Ca2+ channels. Neurosci Res 2003 0.80
110 Cathepsin-L, a key molecule in the pathogenesis of drug-induced and I-cell disease-mediated gingival overgrowth: a study with cathepsin-L-deficient mice. Am J Pathol 2002 0.80
111 Application of fluorophore-assisted carbohydrate electrophoresis to analysis of disaccharides and oligosaccharides derived from glycosaminoglycans. Anal Biochem 2005 0.80
112 Biogenesis and proteolytic processing of lysosomal DNase II. PLoS One 2013 0.79
113 Macroautophagy is essential for killing of intracellular Burkholderia pseudomallei in human neutrophils. Autophagy 2015 0.79
114 Inefficient phagosome maturation in infant macrophages. Biochem Biophys Res Commun 2008 0.79
115 The luminal domain participates in the endosomal trafficking of the cation-independent mannose 6-phosphate receptor. Exp Cell Res 2006 0.79
116 Purification, cDNA cloning, and secretory properties of FLRG protein from PC12 cells and the distribution of FLRG mRNA and protein in rat tissues. Arch Histol Cytol 2003 0.79
117 Differences in expression patterns of cathepsin C/dipeptidyl peptidase I in normal, pathological and aged mouse central nervous system. Eur J Neurosci 2012 0.79
118 Cathepsin L in bone marrow-derived cells is required for retinal and choroidal neovascularization. Am J Pathol 2010 0.79
119 Immunocytochemical localization of secretogranin III in the anterior lobe of male rat pituitary glands. J Histochem Cytochem 2003 0.79
120 The expression of tripeptidyl peptidase I in various tissues of rats and mice. Arch Histol Cytol 2002 0.78
121 Resveratrol affects undifferentiated and differentiated PC12 cells differently, particularly with respect to possible differences in mitochondrial and autophagic functions. Eur J Cell Biol 2012 0.78
122 Proteolytic degradation of glutamate decarboxylase mediates disinhibition of hippocampal CA3 pyramidal cells in cathepsin D-deficient mice. J Neurochem 2005 0.78
123 Nitric oxide-mediated injury of interstitial cells of Cajal and intestinal dysmotility under endotoxemia of mice. Biomed Res 2014 0.78
124 Novel GPR119 agonist AS1669058 potentiates insulin secretion from rat islets and has potent anti-diabetic effects in ICR and diabetic db/db mice. Life Sci 2012 0.78
125 Uncoupling protein 2 negatively regulates neurite extensions in PC12h cells. Neurosci Lett 2006 0.77
126 Lysosomal storage and advanced senescence in the brain of LAMP-2-deficient Danon disease. Acta Neuropathol 2012 0.77
127 Spatiotemporal expression of TRPM4 in the mouse cochlea. J Neurosci Res 2014 0.77
128 Hepatic gap junctions in the hepatocarcinogen-resistant DRH rat. Histochem Cell Biol 2008 0.76
129 Tuberin activates and controls the distribution of Rac1 via association with p62 and ubiquitin through the mTORC1 signaling pathway. Int J Oncol 2013 0.76
130 Alendronate inhibits bone resorption at the bone-screw interface. Clin Orthop Relat Res 2005 0.76
131 Particle size of latex beads dictates IL-1β production mechanism. PLoS One 2013 0.76
132 Generation and analysis of serine protease inhibitor kazal type 3-cre driver mice. Exp Anim 2014 0.75
133 Enrichment of GABARAP relative to LC3 in the axonal initial segments of neurons. PLoS One 2013 0.75
134 [Autophagy and neurodegenerative diseases]. Tanpakushitsu Kakusan Koso 2006 0.75
135 Cathepsin D is specifically inhibited by deoxyribonucleic acids. FEBS Lett 2002 0.75
136 Effects of the dipeptidyl peptidase-IV inhibitor ASP8497 on glucose tolerance in animal models of secondary failure. Eur J Pharmacol 2009 0.75
137 Cellular localization and tissue distribution of endogenous DFCP1 protein. Biomed Res 2015 0.75