A cross-study transcriptional analysis of Parkinson's disease.

PubWeight™: 1.19‹?› | Rank: Top 10%

🔗 View Article (PMC 2654916)

Published in PLoS One on March 23, 2009

Authors

Greg T Sutherland1, Nicholas A Matigian, Alistair M Chalk, Matthew J Anderson, Peter A Silburn, Alan Mackay-Sim, Christine A Wells, George D Mellick

Author Affiliations

1: National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland, Australia.

Articles citing this

Gene expression profiling in human neurodegenerative disease. Nat Rev Neurol (2012) 1.59

DEGAS: de novo discovery of dysregulated pathways in human diseases. PLoS One (2010) 1.59

Evidence for gender-specific transcriptional profiles of nigral dopamine neurons in Parkinson disease. PLoS One (2010) 1.18

Significant effects of antiretroviral therapy on global gene expression in brain tissues of patients with HIV-1-associated neurocognitive disorders. PLoS Pathog (2011) 1.14

MicroRNAs and deregulated gene expression networks in neurodegeneration. Brain Res (2010) 1.11

Identifying consensus disease pathways in Parkinson's disease using an integrative systems biology approach. PLoS One (2011) 1.02

Using 'omics' to define pathogenesis and biomarkers of Parkinson's disease. Expert Rev Neurother (2010) 1.01

Gene expression profiles in Parkinson disease prefrontal cortex implicate FOXO1 and genes under its transcriptional regulation. PLoS Genet (2012) 0.94

Abnormal gene expression in cerebellum of Npc1-/- mice during postnatal development. Brain Res (2010) 0.90

Transcription factors Foxa1 and Foxa2 are required for adult dopamine neurons maintenance. Front Cell Neurosci (2014) 0.87

Aging--RNA in development and disease. Wiley Interdiscip Rev RNA (2011) 0.87

Inflammatory Pathways in Parkinson's Disease; A BNE Microarray Study. Parkinsons Dis (2012) 0.86

Current status and future directions of gene expression profiling in Parkinson's disease. Neurobiol Dis (2010) 0.86

Insulin-like growth factor-1 and progression of motor symptoms in early, drug-naïve Parkinson's disease. J Neurol (2013) 0.85

Concordant signaling pathways produced by pesticide exposure in mice correspond to pathways identified in human Parkinson's disease. PLoS One (2012) 0.85

Increased Rate of Sporadic and Recurrent Rare Genic Copy Number Variants in Parkinson's Disease Among Ashkenazi Jews. Mol Genet Genomic Med (2013) 0.84

Rare variants in PLXNA4 and Parkinson's disease. PLoS One (2013) 0.83

Upregulation of a small vault RNA (svtRNA2-1a) is an early event in Parkinson disease and induces neuronal dysfunction. RNA Biol (2013) 0.83

α-Synuclein overexpression represses 14-3-3θ transcription. J Mol Neurosci (2013) 0.81

Age-mediated transcriptomic changes in adult mouse substantia nigra. PLoS One (2013) 0.80

Does α-synuclein have a dual and opposing effect in preclinical vs. clinical Parkinson's disease? Parkinsonism Relat Disord (2014) 0.80

Concise review: new paradigms for Down syndrome research using induced pluripotent stem cells: tackling complex human genetic disease. Stem Cells Transl Med (2013) 0.80

Integrative analysis of common neurodegenerative diseases using gene association, interaction networks and mRNA expression data. AMIA Jt Summits Transl Sci Proc (2012) 0.79

Differential Co-Expression between α-Synuclein and IFN-γ Signaling Genes across Development and in Parkinson's Disease. PLoS One (2014) 0.79

Systems-based analyses of brain regions functionally impacted in Parkinson's disease reveals underlying causal mechanisms. PLoS One (2014) 0.78

Studying the system-level involvement of microRNAs in Parkinson's disease. PLoS One (2014) 0.78

Evidence for Immune Response, Axonal Dysfunction and Reduced Endocytosis in the Substantia Nigra in Early Stage Parkinson's Disease. PLoS One (2015) 0.76

Identification of NURR1 (Exon 4) and FOXA1 (Exon 3) Haplotypes Associated with mRNA Expression Levels in Peripheral Blood Lymphocytes of Parkinson's Patients in Small Indian Population. Parkinsons Dis (2017) 0.75

Meta-Analysis of Parkinson's Disease Transcriptome Data Using TRAM Software: Whole Substantia Nigra Tissue and Single Dopamine Neuron Differential Gene Expression. PLoS One (2016) 0.75

Concordance analysis of microarray studies identifies representative gene expression changes in Parkinson's disease: a comparison of 33 human and animal studies. BMC Neurol (2017) 0.75

Copy number variability in Parkinson's disease: assembling the puzzle through a systems biology approach. Hum Genet (2016) 0.75

Computational Prediction of Alzheimer's and Parkinson's Disease MicroRNAs in Domestic Animals. Asian-Australas J Anim Sci (2015) 0.75

A micro-silicon chip for in vivo cerebral imprint in monkey. ACS Chem Neurosci (2013) 0.75

Decreased parvalbumin mRNA expression in dorsolateral prefrontal cortex in Parkinson's disease. Brain Res (2013) 0.75

Single-cell and regional gene expression analysis in Alzheimer's disease. Cell Mol Neurobiol (2012) 0.75

Articles cited by this

Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res (2002) 76.95

Summaries of Affymetrix GeneChip probe level data. Nucleic Acids Res (2003) 52.74

Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry (1992) 33.67

Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol Aging (2002) 22.40

Diagnostic criteria for Parkinson disease. Arch Neurol (1999) 11.65

ArrayExpress--a public database of microarray experiments and gene expression profiles. Nucleic Acids Res (2006) 8.92

Ageing and Parkinson's disease: substantia nigra regional selectivity. Brain (1991) 8.16

Molecular mechanisms of axon guidance. Science (2002) 6.49

The substantia nigra of the human brain. II. Patterns of loss of dopamine-containing neurons in Parkinson's disease. Brain (1999) 4.25

A genomic pathway approach to a complex disease: axon guidance and Parkinson disease. PLoS Genet (2007) 3.28

Molecular markers of early Parkinson's disease based on gene expression in blood. Proc Natl Acad Sci U S A (2007) 3.03

Glial reactions in Parkinson's disease. Mov Disord (2008) 2.62

Cell type-specific gene expression of midbrain dopaminergic neurons reveals molecules involved in their vulnerability and protection. Hum Mol Genet (2005) 2.28

The insulin paradox: aging, proteotoxicity and neurodegeneration. Nat Rev Neurosci (2008) 2.10

Gene expression profiling of parkinsonian substantia nigra pars compacta; alterations in ubiquitin-proteasome, heat shock protein, iron and oxidative stress regulated proteins, cell adhesion/cellular matrix and vesicle trafficking genes. J Neural Transm (Vienna) (2004) 1.89

Whole genome expression profiling of the medial and lateral substantia nigra in Parkinson's disease. Neurogenetics (2006) 1.79

Transcriptional analysis of multiple brain regions in Parkinson's disease supports the involvement of specific protein processing, energy metabolism, and signaling pathways, and suggests novel disease mechanisms. Am J Med Genet B Neuropsychiatr Genet (2005) 1.77

Methodological considerations for gene expression profiling of human brain. J Neurosci Methods (2007) 1.59

Combining gene expression data from different generations of oligonucleotide arrays. BMC Bioinformatics (2004) 1.53

Effects of gender on nigral gene expression and parkinson disease. Neurobiol Dis (2007) 1.53

Expression profiling of substantia nigra in Parkinson disease, progressive supranuclear palsy, and frontotemporal dementia with parkinsonism. Arch Neurol (2005) 1.49

Vascular, glial and neuronal effects of vascular endothelial growth factor in mesencephalic explant cultures. Neuroscience (1999) 1.47

Quantifying mRNA in postmortem human brain: influence of gender, age at death, postmortem interval, brain pH, agonal state and inter-lobe mRNA variance. Brain Res Mol Brain Res (2003) 1.44

An inflammatory review of Parkinson's disease. Prog Neurobiol (2002) 1.39

Sleep disorders in Parkinson's disease: an overview. Mov Disord (2007) 1.35

Non-motor dysfunction in Parkinson's disease. Parkinsonism Relat Disord (2007) 1.35

Olfaction in neurodegenerative disorder. Adv Otorhinolaryngol (2006) 1.35

Analysis of gene expression in Parkinson's disease: possible involvement of neurotrophic support and axon guidance in dopaminergic cell death. Brain Pathol (2008) 1.32

Pathology associated with sporadic Parkinson's disease--where does it end? J Neural Transm Suppl (2006) 1.31

Insulin and insulin-like growth factor-I induce vascular endothelial growth factor mRNA expression via different signaling pathways. J Biol Chem (2000) 1.30

The absence of reactive astrocytosis is indicative of a unique inflammatory process in Parkinson's disease. Neuroscience (2000) 1.27

Multiregional gene expression profiling identifies MRPS6 as a possible candidate gene for Parkinson's disease. Gene Expr (2006) 1.21

Transcriptional changes in multiple system atrophy and Parkinson's disease putamen. Exp Neurol (2006) 1.20

Glial degeneration and reactive gliosis in alpha-synucleinopathies: the emerging concept of primary gliodegeneration. Acta Neuropathol (2006) 1.16

Olfactory mucosa is a potential source for autologous stem cell therapy for Parkinson's disease. Stem Cells (2008) 1.15

Cell cycle alterations in biopsied olfactory neuroepithelium in schizophrenia and bipolar I disorder using cell culture and gene expression analyses. Schizophr Res (2006) 1.13

Robust dysregulation of gene expression in substantia nigra and striatum in Parkinson's disease. Neurobiol Dis (2005) 1.12

Protective effect of insulin-like-growth-factor-1 against dopamine-induced neurotoxicity in human and rodent neuronal cultures: possible implications for Parkinson's disease. Neurosci Lett (2001) 1.10

Alpha-synuclein pathology in the olfactory pathways of dementia patients. J Anat (2007) 1.08

Fibroblast and lymphoblast gene expression profiles in schizophrenia: are non-neural cells informative? PLoS One (2008) 1.02

cDNA microarray and proteomic approaches in the study of brain diseases: focus on schizophrenia and Alzheimer's disease. Pharmacol Ther (2003) 0.97

An optimistic view for quantifying mRNA in post-mortem human brain. Brain Res Mol Brain Res (2003) 0.93

Altered gene expression profiles reveal similarities and differences between Parkinson disease and model systems. Neuroscientist (2005) 0.93

Changes in vascularization in substantia nigra pars compacta of monkeys rendered parkinsonian. J Neural Transm (Vienna) (2005) 0.93

Neurorescue effects of VEGF on a rat model of Parkinson's disease. Brain Res (2005) 0.89

IGF-I-induced VEGF expression in HUVEC involves phosphorylation and inhibition of poly(ADP-ribose)polymerase. Biochem Biophys Res Commun (2006) 0.89

Controversies over the staging of alpha-synuclein pathology in Parkinson's disease. Acta Neuropathol (2008) 0.88

Neuropathology of the substantia nigra. Eur Neurol (1991) 0.81

Clinicopathological aspects of Parkinson's disease. Eur Neurol (1997) 0.81

Autonomic dysfunction in Parkinson's disease. Dis Mon (2007) 0.81

Haplotype analysis of the IGF2-INS-TH gene cluster in Parkinson's disease. Am J Med Genet B Neuropsychiatr Genet (2008) 0.80

Articles by these authors

Genome-wide analysis of mammalian promoter architecture and evolution. Nat Genet (2006) 17.19

A promoter-level mammalian expression atlas. Nature (2014) 6.25

The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line. Nat Genet (2009) 6.02

Collaborative analysis of alpha-synuclein gene promoter variability and Parkinson disease. JAMA (2006) 4.26

Association of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case-control study. Lancet Neurol (2011) 3.36

A rescue strategy for multimapping short sequence tags refines surveys of transcriptional activity by CAGE. Genomics (2008) 3.19

The mononuclear phagocyte system revisited. J Leukoc Biol (2002) 3.01

Transcript annotation in FANTOM3: mouse gene catalog based on physical cDNAs. PLoS Genet (2006) 2.48

Nasal-associated lymphoid tissue and olfactory epithelium as portals of entry for Burkholderia pseudomallei in murine melioidosis. J Infect Dis (2009) 2.23

Genome-wide association study confirms BST1 and suggests a locus on 12q24 as the risk loci for Parkinson's disease in the European population. Hum Mol Genet (2010) 2.21

Large-scale replication and heterogeneity in Parkinson disease genetic loci. Neurology (2012) 2.18

MicroRNAs and their isomiRs function cooperatively to target common biological pathways. Genome Biol (2011) 2.15

GSK3B polymorphisms alter transcription and splicing in Parkinson's disease. Ann Neurol (2005) 2.14

Olfactory ensheathing cells promote locomotor recovery after delayed transplantation into transected spinal cord. Brain (2002) 2.04

Lack of replication of thirteen single-nucleotide polymorphisms implicated in Parkinson's disease: a large-scale international study. Lancet Neurol (2006) 1.92

EdU, a new thymidine analogue for labelling proliferating cells in the nervous system. J Neurosci Methods (2008) 1.91

Focal adhesion dynamics are altered in schizophrenia. Biol Psychiatry (2013) 1.61

A novel cell transplantation protocol and its application to an ALS mouse model. Exp Neurol (2008) 1.61

Tau haplotypes regulate transcription and are associated with Parkinson's disease. Ann Neurol (2004) 1.61

Mincle polarizes human monocyte and neutrophil responses to Candida albicans. Immunol Cell Biol (2012) 1.59

Disease-specific, neurosphere-derived cells as models for brain disorders. Dis Model Mech (2010) 1.57

Long-term administration of AMD3100, an antagonist of SDF-1/CXCR4 signaling, alters fracture repair. J Orthop Res (2012) 1.56

UCHL1 is a Parkinson's disease susceptibility gene. Ann Neurol (2004) 1.54

Variance of gene expression identifies altered network constraints in neurological disease. PLoS Genet (2011) 1.53

Multipotent stem cells from adult olfactory mucosa. Dev Dyn (2005) 1.53

A conserved Pbx-Wnt-p63-Irf6 regulatory module controls face morphogenesis by promoting epithelial apoptosis. Dev Cell (2011) 1.43

Independent and joint effects of the MAPT and SNCA genes in Parkinson disease. Ann Neurol (2011) 1.40

Colony-stimulating factor-1 promotes kidney growth and repair via alteration of macrophage responses. Am J Pathol (2011) 1.37

Sexual selection, seminal coagulation and copulatory plug formation in primates. Folia Primatol (Basel) (2002) 1.33

Vitamin D3-implications for brain development. J Steroid Biochem Mol Biol (2004) 1.33

A double-blind, randomized, placebo-controlled trial of macrolide in the treatment of chronic rhinosinusitis. Laryngoscope (2006) 1.31

Human and mouse macrophage-inducible C-type lectin (Mincle) bind Candida albicans. Glycobiology (2008) 1.30

Timing of de novo mutagenesis--a twin study of sodium-channel mutations. N Engl J Med (2010) 1.28

The Vps35 D620N mutation linked to Parkinson's disease disrupts the cargo sorting function of retromer. Traffic (2013) 1.23

Pathogenic effects of novel mutations in the P-type ATPase ATP13A2 (PARK9) causing Kufor-Rakeb syndrome, a form of early-onset parkinsonism. Hum Mutat (2011) 1.19

Defining an informativeness metric for clustering gene expression data. Bioinformatics (2011) 1.17

Pedunculopontine nucleus stimulation improves gait freezing in Parkinson disease. Neurosurgery (2011) 1.16

Olfactory mucosa is a potential source for autologous stem cell therapy for Parkinson's disease. Stem Cells (2008) 1.15

Concordant epigenetic silencing of transforming growth factor-beta signaling pathway genes occurs early in breast carcinogenesis. Cancer Res (2007) 1.15

Anxiety disorders in Parkinson's disease: prevalence and risk factors. Mov Disord (2010) 1.14

Predictors of driving assessment outcome in Parkinson's disease. Mov Disord (2006) 1.14

Stemformatics: visualisation and sharing of stem cell gene expression. Stem Cell Res (2012) 1.13

Cell cycle alterations in biopsied olfactory neuroepithelium in schizophrenia and bipolar I disorder using cell culture and gene expression analyses. Schizophr Res (2006) 1.13

Developmental vitamin D deficiency alters brain protein expression in the adult rat: implications for neuropsychiatric disorders. Proteomics (2007) 1.13

Genome-wide review of transcriptional complexity in mouse protein kinases and phosphatases. Genome Biol (2006) 1.13

Factors associated with depression in Parkinson's disease. J Affect Disord (2011) 1.13

An inflammatory role for the mammalian carboxypeptidase inhibitor latexin: relationship to cystatins and the tumor suppressor TIG1. Structure (2005) 1.11

Behavioural characterization of vitamin D receptor knockout mice. Behav Brain Res (2005) 1.10

Parkinson's disease and family history. Parkinsonism Relat Disord (2006) 1.09

Alternate transcription of the Toll-like receptor signaling cascade. Genome Biol (2006) 1.08

Neurotrophin 3 promotes purification and proliferation of olfactory ensheathing cells from human nose. Glia (2004) 1.06

Sexual behavior, reproductive physiology and sperm competition in male mammals. Physiol Behav (2004) 1.06

Replicated effects of sex and genotype on gene expression in human lymphoblastoid cell lines. Hum Mol Genet (2006) 1.03

Systems biology of transcription control in macrophages. Bioessays (2007) 1.03

NRF2 activation restores disease related metabolic deficiencies in olfactory neurosphere-derived cells from patients with sporadic Parkinson's disease. PLoS One (2011) 1.02

Maternal vitamin D depletion alters neurogenesis in the developing rat brain. Int J Dev Neurosci (2007) 1.02

The neurodevelopmental hypothesis of schizophrenia: a review of recent developments. Ann Med (2003) 1.02

Transient prenatal Vitamin D deficiency is associated with hyperlocomotion in adult rats. Behav Brain Res (2004) 1.02

Fibroblast and lymphoblast gene expression profiles in schizophrenia: are non-neural cells informative? PLoS One (2008) 1.02

Tourette syndrome deep brain stimulation: a review and updated recommendations. Mov Disord (2014) 1.02

Falls in Parkinson's disease: kinematic evidence for impaired head and trunk control. Mov Disord (2010) 1.02

Parkinson's disease-associated human ATP13A2 (PARK9) deficiency causes zinc dyshomeostasis and mitochondrial dysfunction. Hum Mol Genet (2014) 1.01

Modeling distinct osteosarcoma subtypes in vivo using Cre:lox and lineage-restricted transgenic shRNA. Bone (2013) 1.01

Adult vitamin D deficiency leads to behavioural and brain neurochemical alterations in C57BL/6J and BALB/c mice. Behav Brain Res (2012) 1.01

A spatiotemporal analysis of gait freezing and the impact of pedunculopontine nucleus stimulation. Brain (2012) 1.00

Passive smoking and Parkinson disease. Neurology (2006) 1.00

Developmental vitamin D deficiency alters adult behaviour in 129/SvJ and C57BL/6J mice. Behav Brain Res (2007) 0.99

Altered cell cycle dynamics in schizophrenia. Biol Psychiatry (2011) 0.99

Non-replication of association for six polymorphisms from meta-analysis of genome-wide association studies of Parkinson's disease: large-scale collaborative study. Am J Med Genet B Neuropsychiatr Genet (2010) 0.99

attract: A method for identifying core pathways that define cellular phenotypes. PLoS One (2011) 0.99

OMP-ZsGreen fluorescent protein transgenic mice for visualisation of olfactory sensory neurons in vivo and in vitro. J Neurosci Methods (2011) 0.98

Do polymorphisms in the familial Parkinsonism genes contribute to risk for sporadic Parkinson's disease? Mov Disord (2009) 0.97

Dopamine and semantic activation: an investigation of masked direct and indirect priming. J Int Neuropsychol Soc (2004) 0.96