Published in Planta on March 21, 2009
Low cost tuberculosis vaccine antigens in capsules: expression in chloroplasts, bio-encapsulation, stability and functional evaluation in vitro. PLoS One (2013) 1.10
Chloroplast genomes: diversity, evolution, and applications in genetic engineering. Genome Biol (2016) 0.96
Oral immunogenicity of tomato-derived sDPT polypeptide containing Corynebacterium diphtheriae, Bordetella pertussis and Clostridium tetani exotoxin epitopes. Plant Cell Rep (2010) 0.83
Two decades of plant-based candidate vaccines: a review of the chimeric protein approaches. Plant Cell Rep (2011) 0.83
Chloroplast transformation of rapeseed (Brassica napus) by particle bombardment of cotyledons. Plant Cell Rep (2010) 0.83
Chloroplast localization of Cry1Ac and Cry2A protein--an alternative way of insect control in cotton. Biol Res (2015) 0.82
Expression of the nucleocapsid protein of porcine reproductive and respiratory syndrome virus in soybean seed yields an immunogenic antigenic protein. Planta (2011) 0.77
Expression of the Multimeric and Highly Immunogenic Brucella spp. Lumazine Synthase Fused to Bovine Rotavirus VP8d as a Scaffold for Antigen Production in Tobacco Chloroplasts. Front Plant Sci (2015) 0.75
Plastid genetic engineering in Solanaceae. Protoplasma (2012) 0.75
Expression of a Codon-Optimized dsdA Gene in Tobacco Plastids and Rice Nucleus Confers D-Serine Tolerance. Front Plant Sci (2016) 0.75
High-frequency plastid transformation in tobacco by selection for a chimeric aadA gene. Proc Natl Acad Sci U S A (1993) 4.40
Expression of the native cholera toxin B subunit gene and assembly as functional oligomers in transgenic tobacco chloroplasts. J Mol Biol (2001) 2.44
Expression of hepatitis B surface antigen in transgenic plants. Proc Natl Acad Sci U S A (1992) 2.43
Production of hepatitis B surface antigen in transgenic plants for oral immunization. Nat Biotechnol (2000) 2.23
Immunogenicity in humans of a recombinant bacterial antigen delivered in a transgenic potato. Nat Med (1998) 2.20
Human immune responses to a novel norwalk virus vaccine delivered in transgenic potatoes. J Infect Dis (2000) 2.02
Plastid transformation in higher plants. Annu Rev Plant Biol (2004) 2.01
Expression of Norwalk virus capsid protein in transgenic tobacco and potato and its oral immunogenicity in mice. Proc Natl Acad Sci U S A (1996) 2.00
Epidemiology of pertussis. Pediatr Infect Dis J (2005) 1.84
Plant-derived pharmaceuticals--the road forward. Trends Plant Sci (2005) 1.82
Plastid-expressed betaine aldehyde dehydrogenase gene in carrot cultured cells, roots, and leaves confers enhanced salt tolerance. Plant Physiol (2004) 1.79
Plant-based vaccine: mice immunized with chloroplast-derived anthrax protective antigen survive anthrax lethal toxin challenge. Infect Immun (2005) 1.64
Immunogenicity of transgenic plant-derived hepatitis B surface antigen. Proc Natl Acad Sci U S A (1995) 1.51
Expression of tetanus toxin Fragment C in tobacco chloroplasts. Nucleic Acids Res (2003) 1.40
Transgenic plants as factories for biopharmaceuticals. Nat Biotechnol (2000) 1.39
A plant-derived edible vaccine against hepatitis B virus. FASEB J (1999) 1.31
The use of combination vaccines has improved timeliness of vaccination in children. Pediatr Infect Dis J (2006) 1.30
Complementarity of the 16S rRNA penultimate stem with sequences downstream of the AUG destabilizes the plastid mRNAs. Nucleic Acids Res (2001) 1.23
Sustained efficacy during the first 6 years of life of 3-component acellular pertussis vaccines administered in infancy: the Italian experience. Pediatrics (2001) 1.23
Sequences downstream of the translation initiation codon are important determinants of translation efficiency in chloroplasts. Plant Physiol (2001) 1.19
Chloroplast genetic engineering to improve agronomic traits. Methods Mol Biol (2005) 1.15
Oral immunization of mice with transgenic tomato fruit expressing respiratory syncytial virus-F protein induces a systemic immune response. Transgenic Res (2000) 1.11
Construction of a diphtheria toxin A fragment-C180 peptide fusion protein which elicits a neutralizing antibody response against diphtheria toxin and pertussis toxin. Infect Immun (1992) 1.11
Efficient and stable transformation of Lactuca sativa L. cv. Cisco (lettuce) plastids. Transgenic Res (2006) 1.10
Expression of the rabies virus glycoprotein in transgenic tomatoes. Biotechnology (N Y) (1995) 1.10
The stem-loop region of the tobacco psbA 5'UTR is an important determinant of mRNA stability and translation efficiency. Mol Genet Genomics (2003) 1.08
Progress towards commercialization of plastid transformation technology. Trends Biotechnol (2003) 1.07
Neutralizing antibodies and immunoprotection against pertussis and tetanus obtained by use of a recombinant pertussis toxin-tetanus toxin fusion protein. Infect Immun (1994) 1.02
Expression of the B subunit of E. coli heat-labile enterotoxin in the chloroplasts of plants and its characterization. Transgenic Res (2003) 0.99
The intracellular fate of a recombinant protein is tissue dependent. Plant Physiol (2006) 0.96
Vaccine antigen production in transgenic plants: strategies, gene constructs and perspectives. Vaccine (2003) 0.93
Protection against tetanus toxin using a plant-based vaccine. Eur J Immunol (2005) 0.88
Humoral and cellular immune responses in mice immunized with recombinant Mycobacterium bovis Bacillus Calmette-Guérin producing a pertussis toxin-tetanus toxin hybrid protein. Infect Immun (1999) 0.85
Ingestion of transgenic carrots expressing the Escherichia coli heat-labile enterotoxin B subunit protects mice against cholera toxin challenge. Plant Cell Rep (2007) 0.85
Oral immunization with pBsVP6-transgenic alfalfa protects mice against rotavirus infection. Virology (2005) 0.84
Expression of human papillomavirus type 16 L1 protein in transgenic tobacco plants. Acta Biochim Biophys Sin (Shanghai) (2005) 0.84
DNA vaccine encoding pertussis toxin S1 subunit induces protection against Bordetella pertussis in mice. Vaccine (2003) 0.83
Plant-derived measles virus hemagglutinin protein induces neutralizing antibodies in mice. Vaccine (2001) 0.83
Development of novel types of plastid transformation vectors and evaluation of factors controlling expression. Transgenic Res (2005) 0.83
Transgenic plants for vaccine production: expectations and limitations. Trends Plant Sci (2001) 0.82
Pertussis vaccination: acellular pertussis vaccine for the fourth and fifth doses of the DTP series update to supplementary ACIP statement. Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep (1992) 0.81
Chloroplast targeting of FanC, the major antigenic subunit of Escherichia coli K99 fimbriae, in transgenic soybean. Plant Cell Rep (2007) 0.80
Safety and immunogenicity of a primary course and booster dose of a combined diphtheria, tetanus, acellular pertussis, hepatitis B and inactivated poliovirus vaccine. Scand J Infect Dis (2006) 0.78
Expression of viral capsid protein antigen against Epstein-Barr virus in plastids of Nicotiana tabacum cv. SR1. Biotechnol Bioeng (2006) 0.78
Neutralizing immunogenicity of transgenic carrot (Daucus carota L.)-derived measles virus hemagglutinin. Plant Mol Biol (2003) 0.78
Edible vaccines: current status and future. Indian J Med Microbiol (2007) 0.78
Transgenic tomatoes express an antigenic polypeptide containing epitopes of the diphtheria, pertussis and tetanus exotoxins, encoded by a synthetic gene. Plant Cell Rep (2007) 0.77
Expression and characterization of Helicobacter pylori heat-shock protein A (HspA) protein in transgenic tobacco (Nicotiana tabacum) plants. Biotechnol Appl Biochem (2006) 0.76
Expression of Escherichia coli heat-labile enterotoxin b subunit (LTB) in carrot (Daucus carota L.). Plant Cell Rep (2007) 0.76
Accumulation of recombinant SARS-CoV spike protein in plant cytosol and chloroplasts indicate potential for development of plant-derived oral vaccines. Exp Biol Med (Maywood) (2006) 0.76
Expression and purification of a trivalent pertussis toxin-diphtheria toxin-tetanus toxin fusion protein in Escherichia coli. Protein Expr Purif (2006) 0.76
Foods as production and delivery vehicles for human vaccines. J Am Coll Nutr (2002) 0.75
The genome of woodland strawberry (Fragaria vesca). Nat Genet (2010) 5.86
The genome of the pear (Pyrus bretschneideri Rehd.). Genome Res (2012) 2.55
Multiple models for Rosaceae genomics. Plant Physiol (2008) 2.08
Development of a set of SNP markers present in expressed genes of the apple. Genomics (2008) 1.46
Integration of physical and genetic maps in apple confirms whole-genome and segmental duplications in the apple genome. J Exp Bot (2011) 1.22
A BAC-based physical map of the apple genome. Genomics (2007) 1.19
Overexpression of Arabidopsis phytochelatin synthase paradoxically leads to hypersensitivity to cadmium stress. Plant Physiol (2003) 1.18
Association mapping in forest trees and fruit crops. J Exp Bot (2012) 1.12
An overview of the apple genome through BAC end sequence analysis. Plant Mol Biol (2008) 1.09
A multi-population consensus genetic map reveals inconsistent marker order among maps likely attributed to structural variations in the apple genome. PLoS One (2012) 1.07
Introduction of apple ANR genes into tobacco inhibits expression of both CHI and DFR genes in flowers, leading to loss of anthocyanin. J Exp Bot (2012) 1.04
Transgenic Indian mustard (Brassica juncea) plants expressing an Arabidopsis phytochelatin synthase (AtPCS1) exhibit enhanced As and Cd tolerance. Plant Mol Biol (2007) 1.03
Two receptor-like genes, Vfa1 and Vfa2, confer resistance to the fungal pathogen Venturia inaequalis inciting apple scab disease. Mol Plant Microbe Interact (2008) 1.03
BAC-end sequence-based SNPs and Bin mapping for rapid integration of physical and genetic maps in apple. Genomics (2008) 1.02
Ectopic expression of apple F3'H genes contributes to anthocyanin accumulation in the Arabidopsis tt7 mutant grown under nitrogen stress. Plant Physiol (2010) 1.02
Systems level analysis of two-component signal transduction systems in Erwinia amylovora: role in virulence, regulation of amylovoran biosynthesis and swarming motility. BMC Genomics (2009) 1.01
Variation in nuclear DNA content in Malus species and cultivated apples. Genome (2005) 0.99
A cluster of four receptor-like genes resides in the Vf locus that confers resistance to apple scab disease. Genetics (2002) 0.99
AFLP analysis of genetic variability in New Guinea impatiens. Theor Appl Genet (2003) 0.98
Striking phenotypic and functional differences in lamina propria lymphocytes from the large and small intestine of mice. Life Sci (2005) 0.98
The Rcs phosphorelay system is essential for pathogenicity in Erwinia amylovora. Mol Plant Pathol (2009) 0.97
Human metapneumovirus infections in Mexico: epidemiological and clinical characteristics. J Med Microbiol (2005) 0.95
DNA-methylation alterations and exchanges during in vitro cellular differentiation in rose (Rosa hybrida L.). Theor Appl Genet (2004) 0.94
Identification, characterization, and utilization of genome-wide simple sequence repeats to identify a QTL for acidity in apple. BMC Genomics (2012) 0.92
AFLP-derived SCARs facilitate construction of a 1.1 Mb sequence-ready map of a region that spans the Vf locus in the apple genome. Plant Mol Biol (2002) 0.92
Immunohistochemical characterization of the initial stages of Naegleria fowleri meningoencephalitis in mice. Parasitol Res (2004) 0.90
Diversification of genes encoding granule-bound starch synthase in monocots and dicots is marked by multiple genome-wide duplication events. PLoS One (2012) 0.90
Molecular signature of differential virulence in natural isolates of Erwinia amylovora. Phytopathology (2010) 0.89
Characterization of the RcsC sensor kinase from Erwinia amylovora and other Enterobacteria. Phytopathology (2011) 0.89
Expression profiles of differentially regulated genes during the early stages of apple flower infection with Erwinia amylovora. J Exp Bot (2011) 0.89
Soybean (Glycine max) transformation using immature cotyledon explants. Methods Mol Biol (2006) 0.87
Somatic variation plays a key role in the evolution of the Vf gene family residing in the Vf locus that confers resistance to apple scab disease. Mol Phylogenet Evol (2004) 0.87
AmyR is a novel negative regulator of amylovoran production in Erwinia amylovora. PLoS One (2012) 0.86
The orphan gene ybjN conveys pleiotropic effects on multicellular behavior and survival of Escherichia coli. PLoS One (2011) 0.86
Small-molecule inhibitors suppress the expression of both type III secretion and amylovoran biosynthesis genes in Erwinia amylovora. Mol Plant Pathol (2013) 0.86
Expression of Arabidopsis phytochelatin synthase in Indian mustard (Brassica juncea) plants enhances tolerance for Cd and Zn. Planta (2006) 0.86
Genome-wide identification of genes regulated by the Rcs phosphorelay system in Erwinia amylovora. Mol Plant Microbe Interact (2012) 0.86
Spring: a novel family of miniature inverted-repeat transposable elements is associated with genes in apple. Genomics (2007) 0.85
Ingestion of transgenic carrots expressing the Escherichia coli heat-labile enterotoxin B subunit protects mice against cholera toxin challenge. Plant Cell Rep (2007) 0.85
Multiple-copy cluster-type organization and evolution of genes encoding O-methyltransferases in the apple. Genetics (2007) 0.84
Oral immunogenicity of tomato-derived sDPT polypeptide containing Corynebacterium diphtheriae, Bordetella pertussis and Clostridium tetani exotoxin epitopes. Plant Cell Rep (2010) 0.83
Transcriptome analysis of the exocarp of apple fruit identifies light-induced genes involved in red color pigmentation. Gene (2013) 0.83
Intranasal coadministration of the Cry1Ac protoxin with amoebal lysates increases protection against Naegleria fowleri meningoencephalitis. Infect Immun (2004) 0.83
Expression of toll-like receptor TLR-2, TLR-3, TLR-4 and TLR-9 is increased in placentas from patients with preeclampsia. Arch Med Res (2011) 0.83
Two decades of plant-based candidate vaccines: a review of the chimeric protein approaches. Plant Cell Rep (2011) 0.83
Production of a plant-derived immunogenic protein targeting ApoB100 and CETP: toward a plant-based atherosclerosis vaccine. Mol Biotechnol (2014) 0.82
Transcriptome analysis of resistant and susceptible genotypes of Glycine tomentella during Phakopsora pachyrhizi infection reveals novel rust resistance genes. Theor Appl Genet (2010) 0.82
Identification of genetic loci associated with fire blight resistance in Malus through combined use of QTL and association mapping. Physiol Plant (2013) 0.82
A gene encoding starch branching enzyme I (SBEI) in apple (Malusxdomestica, Rosaceae) and its phylogenetic relationship to Sbe genes from other angiosperms. Mol Phylogenet Evol (2006) 0.82
Current status of viral expression systems in plants and perspectives for oral vaccines development. Plant Mol Biol (2015) 0.82
Expression of an immunogenic F1-V fusion protein in lettuce as a plant-based vaccine against plague. Planta (2010) 0.81
Phenotypic and functional differences between lymphocytes from NALT and nasal passages of mice. Scand J Immunol (2007) 0.81
A high-throughput apple SNP genotyping platform using the GoldenGate™ assay. Gene (2011) 0.81
Controlled release of Pantoea agglomerans E325 for biocontrol of fire blight disease of apple. J Control Release (2012) 0.81
Pretreatment with Cry1Ac protoxin modulates the immune response, and increases the survival of Plasmodium-infected CBA/Ca mice. J Biomed Biotechnol (2010) 0.81
Development and linkage mapping of E-STS and RGA markers for functional gene homologues in apple. Genome (2006) 0.80
Suppression of the death gene BIK is a critical factor for resistance to tamoxifen in MCF-7 breast cancer cells. Int J Oncol (2013) 0.80
Identifying differentially expressed genes in leaves of Glycine tomentella in the presence of the fungal pathogen Phakopsora pachyrhizi. Planta (2010) 0.80
A chloroplast-derived C4V3 polypeptide from the human immunodeficiency virus (HIV) is orally immunogenic in mice. Plant Mol Biol (2012) 0.80
Structural implication of the induced immune response by Bacillus thuringiensis Cry proteins: role of the N-terminal region. Mol Immunol (2004) 0.80
An Env-derived multi-epitope HIV chimeric protein produced in the moss Physcomitrella patens is immunogenic in mice. Plant Cell Rep (2014) 0.80
Transgenic rose lines harboring an antimicrobial protein gene, Ace-AMP1, demonstrate enhanced resistance to powdery mildew ( Sphaerotheca pannosa). Planta (2003) 0.79
Immunogenicity of nuclear-encoded LTB:ST fusion protein from Escherichia coli expressed in tobacco plants. Plant Cell Rep (2011) 0.79
Enhanced resistance to early blight in transgenic tomato lines expressing heterologous plant defense genes. Planta (2005) 0.79
Two critical factors are required for efficient transformation of multiple soybean cultivars: Agrobacterium strain and orientation of immature cotyledonary explant. Theor Appl Genet (2003) 0.79
Overexpression of GmCaM4 in soybean enhances resistance to pathogens and tolerance to salt stress. Mol Plant Pathol (2013) 0.79
Three orthologs in rice, Arabidopsis, and Populus encoding starch branching enzymes (SBEs) are different from other SBE gene families in plants. Gene (2007) 0.79
Plant-based vaccines for Alzheimer's disease: an overview. Expert Rev Vaccines (2014) 0.78
Characterization of sulfate-reducing bacteria dominated surface communities during start-up of a down-flow fluidized bed reactor. J Ind Microbiol Biotechnol (2008) 0.78
Soybean mosaic virus Helper Component-Protease Alters Leaf Morphology and Reduces Seed Production in Transgenic Soybean Plants. Phytopathology (2007) 0.77
Transgenic plants: a 5-year update on oral antipathogen vaccine development. Expert Rev Vaccines (2014) 0.77
Transgenic apple expressing an antigenic protein of the human respiratory syncytial virus. J Plant Physiol (2010) 0.77
A Plant-Derived Multi-HIV Antigen Induces Broad Immune Responses in Orally Immunized Mice. Mol Biotechnol (2015) 0.77
Human metapneumovirus and other respiratory viral infections in children attending a day care center. Pediatr Infect Dis J (2009) 0.77
Expression of the nucleocapsid protein of porcine reproductive and respiratory syndrome virus in soybean seed yields an immunogenic antigenic protein. Planta (2011) 0.77
Transgenic tomatoes express an antigenic polypeptide containing epitopes of the diphtheria, pertussis and tetanus exotoxins, encoded by a synthetic gene. Plant Cell Rep (2007) 0.77
Soybean mosaic virus helper component-protease enhances somatic embryo production and stabilizes transgene expression in soybean. Plant Physiol Biochem (2005) 0.76