PubRank

Naoaki Fujii

Author PubWeight™ 18.82‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 An anti-Wnt-2 monoclonal antibody induces apoptosis in malignant melanoma cells and inhibits tumor growth. Cancer Res 2004 1.64
2 Functional regulation of cystic fibrosis transmembrane conductance regulator-containing macromolecular complexes: a small-molecule inhibitor approach. Biochem J 2011 1.55
3 Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3. Elife 2013 1.27
4 Hedgehog-Gli signaling pathway inhibitors as anticancer agents. J Med Chem 2009 1.14
5 Role of electrostatic interactions in PDZ domain ligand recognition. Biochemistry 2003 1.13
6 Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication. J Biol Chem 2012 1.03
7 Recent advances and new perspectives in targeting CFTR for therapy of cystic fibrosis and enterotoxin-induced secretory diarrheas. Future Med Chem 2012 1.00
8 Rational design of the first small-molecule antagonists of NHERF1/EBP50 PDZ domains. Bioorg Med Chem Lett 2007 1.00
9 Sequence requirement and subtype specificity in the high-affinity interaction between human frizzled and dishevelled proteins. Protein Sci 2009 0.92
10 Partial acetylation of lysine residues improves intraprotein cross-linking. Anal Chem 2008 0.89
11 Amide conjugates of ketoprofen and indole as inhibitors of Gli1-mediated transcription in the Hedgehog pathway. Bioorg Med Chem 2010 0.89
12 A small molecule inhibitor of monoubiquitinated Proliferating Cell Nuclear Antigen (PCNA) inhibits repair of interstrand DNA cross-link, enhances DNA double strand break, and sensitizes cancer cells to cisplatin. J Biol Chem 2014 0.88
13 Indole-2-amide based biochemical antagonist of Dishevelled PDZ domain interaction down-regulates Dishevelled-driven Tcf transcriptional activity. Bioorg Med Chem Lett 2007 0.87
14 Small molecule inhibitors of PCNA/PIP-box interaction suppress translesion DNA synthesis. Bioorg Med Chem 2013 0.86
15 Structure-activity relationships and cancer-cell selective toxicity of novel inhibitors of glioma-associated oncogene homologue 1 (Gli1) mediated transcription. J Med Chem 2009 0.81
16 Evaluation of a chemical library of small-molecule Dishevelled antagonists that suppress tumor growth by down-regulating T-cell factor-mediated transcription. Mol Cancer Ther 2008 0.81
17 Discovery of diphenyloxazole and Ndelta-Z-ornithine derivatives as highly potent and selective human prostaglandin EP(4) receptor antagonists. J Med Chem 2005 0.77
18 Investigation of the PDZ domain ligand binding site using chemically modified peptides. Bioorg Med Chem Lett 2002 0.77
19 A structure-activity relationship study of small-molecule inhibitors of GLI1-mediated transcription. Biopolymers 2011 0.76
20 The hydrophobic amino acid cluster at the cytoplasmic end of transmembrane helix III modulates the coupling of the β(1)-adrenergic receptor to G(s). J Recept Signal Transduct Res 2013 0.75
21 Potential Strategies to Target Protein-Protein Interactions in the DNA Damage Response and Repair Pathways. J Med Chem 2017 0.75