PubRank

S Higashiyama

Author PubWeight™ 96.77‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Appearance of heparin-binding EGF-like growth factor in wound fluid as a response to injury. Proc Natl Acad Sci U S A 1993 2.51
2 Ectodomain shedding of epidermal growth factor receptor ligands is required for keratinocyte migration in cutaneous wound healing. J Cell Biol 2000 2.14
3 Diphtheria toxin binds to the epidermal growth factor (EGF)-like domain of human heparin-binding EGF-like growth factor/diphtheria toxin receptor and inhibits specifically its mitogenic activity. J Biol Chem 1995 2.09
4 The integrin alpha(9)beta(1) binds to a novel recognition sequence (SVVYGLR) in the thrombin-cleaved amino-terminal fragment of osteopontin. J Biol Chem 1999 1.97
5 Isolation and characterization of a macrophage-derived heparin-binding growth factor. Cell Regul 1990 1.96
6 Phorbol ester induces the rapid processing of cell surface heparin-binding EGF-like growth factor: conversion from juxtacrine to paracrine growth factor activity. Mol Biol Cell 1995 1.96
7 Heparin-binding epidermal growth factor-like growth factor is an autocrine growth factor for human keratinocytes. J Biol Chem 1994 1.76
8 Heparin-binding EGF-like growth factor, which acts as the diphtheria toxin receptor, forms a complex with membrane protein DRAP27/CD9, which up-regulates functional receptors and diphtheria toxin sensitivity. EMBO J 1994 1.69
9 Retracted Angiotensin AT(1) and AT(2) receptors differentially regulate angiopoietin-2 and vascular endothelial growth factor expression and angiogenesis by modulating heparin binding-epidermal growth factor (EGF)-mediated EGF receptor transactivation. Circ Res 2001 1.64
10 Expression and clinical significance of erb-B receptor family in hepatocellular carcinoma. Br J Cancer 2001 1.51
11 Identification of the ligand binding site for the integrin alpha9 beta1 in the third fibronectin type III repeat of tenascin-C. J Biol Chem 1998 1.46
12 Characterization of sequences within heparin-binding EGF-like growth factor that mediate interaction with heparin. J Biol Chem 1994 1.30
13 Localization of heparin-binding EGF-like growth factor in the smooth muscle cells and macrophages of human atherosclerotic plaques. J Clin Invest 1995 1.28
14 Expression and clinical significance of the erbB family in intrahepatic cholangiocellular carcinoma. Pathol Res Pract 2001 1.23
15 Biosynthesis and processing by phorbol ester of the cells surface-associated precursor form of heparin-binding EGF-like growth factor. Biochem Biophys Res Commun 1994 1.20
16 Upregulation of endogenous heparin-binding EGF-like growth factor and its role as a survival factor in skeletal myotubes. FEBS Lett 1999 1.09
17 Pre-B-cell leukemia transcription factor 1 is a major target of promyelocytic leukemia zinc-finger-mediated melanoma cell growth suppression. Oncogene 2006 1.09
18 Human high molecular weight kininogen as a thiol proteinase inhibitor: presence of the entire inhibition capacity in the native form of heavy chain. Biochemistry 1986 1.09
19 Localization of heparin-binding epidermal growth factor-like growth factor in human gastric mucosa. Gastroenterology 1995 1.08
20 Heparin-binding epidermal growth factor-like growth factor expression in cultured fetal human vascular smooth muscle cells. Induction of mRNA levels and secretion of active mitogen. J Biol Chem 1993 1.07
21 Angiotensin II signaling and HB-EGF shedding via metalloproteinase in glomerular mesangial cells. Kidney Int 2001 1.05
22 Heparin-binding epidermal growth factor-like growth factor stimulates mitogenic signaling and is highly expressed in human malignant gliomas. Acta Neuropathol 1998 1.04
23 Membrane-anchored heparin-binding epidermal growth factor-like growth factor acts as a tumor survival factor in a hepatoma cell line. J Biol Chem 1997 1.03
24 Role of heparin-binding epidermal growth factor-like growth factor as a hepatotrophic factor in rat liver regeneration after partial hepatectomy. Hepatology 1995 1.01
25 Glucocorticoid inhibits thrombin-induced expression of platelet-derived growth factor A-chain and heparin-binding epidermal growth factor-like growth factor in human aortic smooth muscle cells. J Biol Chem 1993 1.01
26 BCL6 degradation caused by the interaction with the C-terminus of pro-HB-EGF induces cyclin D2 expression in gastric cancers. Br J Cancer 2009 0.98
27 Selective induction of heparin-binding epidermal growth factor-like growth factor by methylglyoxal and 3-deoxyglucosone in rat aortic smooth muscle cells. The involvement of reactive oxygen species formation and a possible implication for atherogenesis in diabetes. J Biol Chem 1997 0.96
28 Gastrin induces heparin-binding epidermal growth factor-like growth factor in rat gastric epithelial cells transfected with gastrin receptor. Gastroenterology 1999 0.96
29 Expression of heparin-binding epidermal growth factor in human hepatocellular carcinoma. Gastroenterology 1994 0.95
30 Regulation of neuregulin expression in the injured rat brain and cultured astrocytes. J Neurosci 2001 0.94
31 Heparin-like molecules on the cell surface potentiate binding of diphtheria toxin to the diphtheria toxin receptor/membrane-anchored heparin-binding epidermal growth factor-like growth factor. J Biol Chem 1995 0.94
32 Expression of heparin binding epidermal growth factor-like growth factor in hepatocellular carcinoma: an immunohistochemical study. Oncol Rep 2001 0.94
33 Possible role of coexpression of CD9 with membrane-anchored heparin-binding EGF-like growth factor and amphiregulin in cultured human keratinocyte growth. J Cell Physiol 1997 0.93
34 Distribution of heparin-binding EGF-like growth factor protein and mRNA in the normal rat kidneys. Kidney Int 1997 0.93
35 Localization of heparin-binding epidermal growth factor-like growth factor in human coronary arteries. Possible roles of HB-EGF in the formation of coronary atherosclerosis. Circulation 1996 0.92
36 Expression of heparin-binding epidermal growth factor-like growth factor during pancreas development. A potential role of PDX-1 in transcriptional activation. J Biol Chem 1997 0.90
37 Neuronal and glial expression of heparin-binding EGF-like growth factor in central nervous system of prenatal and early-postnatal rat. Brain Res Dev Brain Res 1998 0.90
38 Expression level of integrin alpha 5 on tumour cells affects the rate of metastasis to the kidney. Br J Cancer 2003 0.89
39 Attenuation of Notch signaling promotes the differentiation of neural progenitors into neurons in the hippocampal CA1 region after ischemic injury. Neuroscience 2008 0.89
40 Suppression of tumorigenicity, but not anchorage independence, of human cancer cells by new candidate tumor suppressor gene CapG. Oncogene 2006 0.88
41 The addition of bisecting N-acetylglucosamine residues to E-cadherin down-regulates the tyrosine phosphorylation of beta-catenin. J Biol Chem 2001 0.88
42 Heparin-binding EGF-like growth factor is a potent mitogen for rat hepatocytes. Biochem Biophys Res Commun 1994 0.88
43 Heparin-binding epidermal growth factor-like growth factor mRNA expression in neonatal rat brain with hypoxic/ischemic injury. Brain Res 1999 0.88
44 Involvement of glycation and oxidative stress in diabetic macroangiopathy. Diabetes 1996 0.88
45 Induction of heparin binding epidermal growth factor-like growth factor and amphiregulin mRNAs by gastrin in the rat stomach. Biochem Biophys Res Commun 1997 0.88
46 Regulation of heparin-binding epidermal growth factor-like growth factor mRNA levels by hypertrophic stimuli in neonatal and adult rat cardiac myocytes. J Biol Chem 1994 0.88
47 Amino-terminal processing of cell surface heparin-binding epidermal growth factor-like growth factor up-regulates its juxtacrine but not its paracrine growth factor activity. J Biol Chem 1996 0.88
48 Involvement of heparin-binding EGF-like growth factor and its processing by metalloproteinases in early epithelial morphogenesis of the submandibular gland. Dev Biol 2001 0.87
49 Expression of heparin-binding epidermal growth factor-like growth factor in neointimal cells induced by balloon injury in rat carotid arteries. Arterioscler Thromb Vasc Biol 1996 0.87
50 Increased mitogenic response to heparin-binding epidermal growth factor-like growth factor in vascular smooth muscle cells of diabetic rats. Arterioscler Thromb Vasc Biol 1995 0.86
51 Human liver manganese superoxide dismutase. Purification and crystallization, subunit association and sulfhydryl reactivity. Eur J Biochem 1990 0.86
52 CD9 antigen interacts with heparin-binding EGF-like growth factor through its heparin-binding domain. J Biochem 1997 0.86
53 Effectiveness of fructose-modified chitosan as a scaffold for hepatocyte attachment. Biol Pharm Bull 1997 0.86
54 Fragmentation of ceruloplasmin following non-enzymatic glycation reaction. J Biochem 1995 0.85
55 Alteration of integrins by heparin-binding EGF-like growth factor in human breast cancer cells. Oncology 1996 0.84
56 The requirement of both intracellular reactive oxygen species and intracellular calcium elevation for the induction of heparin-binding EGF-like growth factor in vascular endothelial cells and smooth muscle cells. Biochem Biophys Res Commun 1999 0.84
57 Osmotic stress induces HB-EGF gene expression via Ca(2+)/Pyk2/JNK signal cascades in rat aortic smooth muscle cells. J Biochem 2001 0.83
58 Calcium dependent cysteine proteinase is a precursor of a chemotactic factor for neutrophils. Biochem Biophys Res Commun 1989 0.83
59 Expression of heparin-binding epidermal growth factor-like growth factor in the hepatocytes of fibrotic rat liver during hepatocarcinogenesis. J Gastroenterol Hepatol 1999 0.82
60 Three new mutations in the hepatocyte nuclear factor-1alpha gene in Japanese subjects with diabetes mellitus: clinical features and functional characterization. Diabetologia 1999 0.82
61 Identification of a phosphopeptide in bovine alpha s1-casein digest as a factor influencing proliferation and immunoglobulin production in lymphocyte cultures. J Dairy Res 1998 0.82
62 Inactivation of glutathione peroxidase by NO leads to the accumulation of H2O2 and the induction of HB-EGF via c-Jun NH2-terminal kinase in rat aortic smooth muscle cells. FASEB J 2001 0.82
63 High glucose and hyperosmolarity increase heparin-binding epidermal growth factor-like growth factor (HB-EGF) production in cultured human aortic endothelial cells. Cell Biochem Funct 1996 0.81
64 Kinin release from kininogens by calpains. Life Sci 1986 0.81
65 Expression of heparin-binding epidermal growth factor-like growth factor in rat brain. Brain Res 1998 0.81
66 The gene for heparin-binding epidermal growth factor-like growth factor is stress-inducible: its role in cerebral ischemia. J Cereb Blood Flow Metab 1999 0.81
67 Expression of heparin-binding EGF-like growth factor in rat liver injured by carbon tetrachloride or D-galactosamine. Biochem Biophys Res Commun 1996 0.81
68 Plasma heparin-binding EGF-like growth factor levels in patients after partial hepatectomy as determined with an enzyme-linked immunosorbent assay. Biochem Biophys Res Commun 1998 0.80
69 Heparin-binding EGF-like growth factor is an autocrine growth factor for rat gastric epithelial cells. Biochem Biophys Res Commun 1996 0.80
70 Induction of heparin-binding epidermal growth factor-like growth factor mRNA by protein kinase C activators. Kidney Int 1994 0.80
71 Elevation of immunoreactive serum Mn-superoxide dismutase in patients with acute myocardial infarction. Free Radic Res Commun 1992 0.80
72 Regional distribution of heparin-binding epidermal growth factor-like growth factor mRNA and protein in adult rat forebrain. Neurosci Lett 1996 0.80
73 Characterization of the human NTAK gene structure and distribution of the isoforms for rat NTAK mRNA. Gene 2000 0.80
74 Expression of heparin-binding epidermal growth factor-like growth factor in breast carcinoma. Breast Cancer Res Treat 2001 0.80
75 Effects of nifedipine on left ventricular diastolic function in patients with asymptomatic or minimally symptomatic hypertrophic cardiomyopathy. Circulation 1990 0.79
76 High concentration of glucose increases mitogenic responsiveness to heparin-binding epidermal growth factor-like growth factor in rat vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 1997 0.79
77 Carboxyl-terminal truncation of leucine76 converts heparin-binding EGF-like growth factor from a heparin-enhancible to a heparin-suppressible growth factor. J Cell Physiol 1995 0.79
78 Increased expression of integrins by heparin-binding EGF like growth factor in human esophageal cancer cells. Cancer Lett 1996 0.79
79 Mapping of functional domains of human high molecular weight and low molecular weight kininogens using murine monoclonal antibodies. Biochemistry 1987 0.79
80 Lysophosphatidylcholine increases expression of heparin-binding epidermal growth factor-like growth factor in human T lymphocytes. Circ Res 1997 0.78
81 Physiological FDG uptake in the palatine tonsils. Ann Nucl Med 2001 0.78
82 Interaction of human calpains I and II with high molecular weight and low molecular weight kininogens and their heavy chain: mechanism of interaction and the role of divalent cations. Biochemistry 1987 0.78
83 Enhanced expression of heparin-binding EGF-like growth factor and its receptor in hypertrophied left ventricle of spontaneously hypertensive rats. Cardiovasc Res 1998 0.78
84 High expression of heparin-binding EGF-like growth factor in rat hepatocarcinogenesis. Int J Cancer 1996 0.78
85 Oxidative stress increases gene expression of heparin-binding EGF-like growth factor and amphiregulin in cultured rat gastric epithelial cells. Biochem Biophys Res Commun 1996 0.78
86 Heparin-binding epidermal growth factor-like growth factor: p91 activation induction of plasminogen activator/inhibitor, and tubular morphogenesis in human microvascular endothelial cells. Jpn J Cancer Res 1996 0.78
87 Cutaneous symptoms in a patient with cardiofaciocutaneous syndrome and increased ERK phosphorylation in skin fibroblasts. Br J Dermatol 2010 0.78
88 NTAKalpha and beta isoforms stimulate breast tumor cell growth by means of different receptor combinations. J Biochem 2000 0.78
89 Expression of heparin-binding epidermal growth factor-like growth factor in pancreatic adenocarcinoma. Int J Pancreatol 2001 0.78
90 [Effects of nitroglycerin on left ventricular systolic, diastolic and regional myocardial function in patients with coronary artery disease]. J Cardiogr 1985 0.77
91 Purification and characterization of alpha 1-thiol proteinase inhibitor and its identity with kinin- and fragment 1.2-free high molecular weight kininogen. Int J Biochem 1988 0.77
92 Bimodal expression of heparin-binding EGF-like growth factor in colonic neoplasms. Anticancer Res 2001 0.77
93 Induction of macrophage colony-stimulating factor receptor (c-fms) expression in vascular medial smooth muscle cells treated with heparin binding epidermal growth factor-like growth factor. J Biol Chem 1996 0.77
94 Localization of CD9, an enhancer protein for proheparin-binding epidermal growth factor-like growth factor, in human atherosclerotic plaques: possible involvement of juxtacrine growth mechanism on smooth muscle cell proliferation. Arterioscler Thromb Vasc Biol 2000 0.76
95 Regulation of heparin-binding EGF-like growth factor expression by phorbol ester in a human hepatoma-derived cell line. Biochim Biophys Acta 1996 0.76
96 Immobilization of tripeptide growth factor glycyl-L-histidyl-L-lysine on poly(vinylalcohol)-quarternized stilbazole (PVA-SbQ) and its use as a ligand for hepatocyte attachment. Biol Pharm Bull 1999 0.76
97 Purification and characterization of a novel vascular endothelial cell growth inhibitor secreted by macrophage-like U-937 cells. J Biochem 1999 0.76
98 [Structure and function of a novel ErbB ligand, NTAK]. Nihon Shinkei Seishin Yakurigaku Zasshi 1998 0.76
99 Effects of exogenous human heparin-binding epidermal growth factor-like growth factor on DNA synthesis of hepatocytes in normal mouse liver. Biochem Biophys Res Commun 1999 0.76
100 Lysophosphatidylcholine induces heparin-binding epidermal growth factor-like growth factor and interferon-gamma in human T-lymphocytes. Ann N Y Acad Sci 1997 0.75
101 Role of membrane-anchored heparin-binding epidermal growth factor-like growth factor and CD9 on macrophages. Biochem J 1997 0.75
102 Clinical implication of hyperprolactinemias, especially with prolactinoma and luteal insufficiency. Asia Oceania J Obstet Gynaecol 1983 0.75
103 [Pregnancy following HCG therapy after clomiphene-induced ovulation (author's transl)]. Nihon Funin Gakkai Zasshi 1975 0.75
104 [Prognostic value of treadmill exercise testing early after acute myocardial infarction]. Kokyu To Junkan 1985 0.75
105 [Case of hepatoblastoma in an infant with ectopic gonadotropin production]. Horumon To Rinsho 1972 0.75
106 [Clinical study of S-3800E tablets, a combination of norethindrone and mestranol in a small dosage]. Saishin Igaku 1969 0.75
107 Suppression of apoptosis in hepatocytes by fructose-modified dendrimers. J Biomed Mater Res 2001 0.75
108 [Clinical significance of septal Q wave response on exercise testing in coronary artery disease]. Kokyu To Junkan 1986 0.75
109 Monoclonal antibodies against the complex between HMW kininogen and calpain I. Adv Exp Med Biol 1989 0.75
110 [Effects of synthetic sex steroids on the pituitary responsiveness to luteinizing hormone releasing hormone (LH-RH) (author's transl)]. Nihon Naibunpi Gakkai Zasshi 1976 0.75
111 Nitroblue tetrazolium reduction by neutrophils of newborn foals, adult horses, and a foal infected with Rhodococcus (Corynebacterium) equi. Nihon Juigaku Zasshi 1986 0.75
112 [Effect of Copper-IUD on the human endometrium (author's transl)]. Nihon Funin Gakkai Zasshi 1978 0.75
113 [Effects of a reduction or deviation of metastasis inhibitory factor MRP-1/CD9 on postoperative follow-up results in patients with lung cancer]. Nihon Kyobu Geka Gakkai Zasshi 1996 0.75
114 Increased Tl-201 uptake by a contusion on the left lateral aspect of the face and head. Clin Nucl Med 2001 0.75
115 Zn-alpha 2-glycoprotein is a novel adhesive protein. Biochem Biophys Res Commun 1994 0.75
116 [Biological effects of 17-alpha-ethynyl-4-estrene-3-beta, 17-beta-diol-diacetate]. Nihon Naibunpi Gakkai Zasshi 1967 0.75
117 [Effect of copper-IUD on the human endometrium (author's transl)]. Nihon Funin Gakkai Zasshi 1978 0.75
118 The effect of cilostazol, a cyclic nucleotide phosphodiesterase III inhibitor, on heparin-binding EGF-like growth factor expression in macrophages and vascular smooth muscle cells. Biochem Biophys Res Commun 1997 0.75
119 [Smooth muscle cell remodeling in diabetes]. Nihon Ronen Igakkai Zasshi 2000 0.75
120 Effectiveness of polyamidoamine dendrimers modified with tripeptide growth factor, glycyl-L-histidyl-L-lysine, for enhancement of function of hepatoma cells. J Biosci Bioeng 1999 0.75
121 [KAI1/CD82 and ME491/CD63 expression in non-small-cell carcinoma of the lung and prognosis]. Nihon Kyobu Geka Gakkai Zasshi 1997 0.75
122 [Left ventricular systolic and diastolic functions in hypertrophic cardiomyopathy: with special reference to clinical symptom and the effects of calcium blocking agent (nifedipine)]. J Cardiol Suppl 1987 0.75
123 Porcine high molecular weight kininogen: its purification and properties as a thiol proteinase inhibitor as compared to human high molecular weight kininogen. Comp Biochem Physiol B 1987 0.75
124 [Clinical studies on the low-dosage norgestrel-ethinylestradiol combination as a long term oral contraception (author's transl)]. Nihon Funin Gakkai Zasshi 1974 0.75
125 [Biological activities of 3 different types of ethynodiol diacetate-ethynyl estradiol combinations (author's transl)]. Nihon Funin Gakkai Zasshi 1978 0.75
126 Immobilization of ligand-modified polyamidoamine dendrimer for cultivation of hepatoma cells. Artif Organs 2000 0.75
127 [Proceedings: Response of patients with amenorrhea to LH-RH]. Nihon Naibunpi Gakkai Zasshi 1974 0.75