Published in Ann Biomed Eng on April 02, 2009
Role of microRNA-23b in flow-regulation of Rb phosphorylation and endothelial cell growth. Proc Natl Acad Sci U S A (2010) 1.73
Circulating vascular growth factors and central hemodynamic load in the community. Hypertension (2012) 1.56
Pulmonary vascular wall stiffness: An important contributor to the increased right ventricular afterload with pulmonary hypertension. Pulm Circ (2011) 1.53
Role of shear-stress-induced VEGF expression in endothelial cell survival. J Cell Sci (2012) 1.21
Xanthine oxidase-derived ROS upregulate Egr-1 via ERK1/2 in PA smooth muscle cells; model to test impact of extracellular ROS in chronic hypoxia. PLoS One (2011) 1.09
In vivo measurement of proximal pulmonary artery elastic modulus in the neonatal calf model of pulmonary hypertension: development and ex vivo validation. J Appl Physiol (1985) (2010) 1.04
High pulsatility flow stimulates smooth muscle cell hypertrophy and contractile protein expression. Am J Physiol Lung Cell Mol Physiol (2012) 1.00
Wall shear stress measured by phase contrast cardiovascular magnetic resonance in children and adolescents with pulmonary arterial hypertension. J Cardiovasc Magn Reson (2013) 0.97
Clinical trials in neonates and children: Report of the pulmonary hypertension academic research consortium pediatric advisory committee. Pulm Circ (2013) 0.94
The role of inflammation in hypoxic pulmonary hypertension: from cellular mechanisms to clinical phenotypes. Am J Physiol Lung Cell Mol Physiol (2014) 0.94
Changes in large pulmonary arterial viscoelasticity in chronic pulmonary hypertension. PLoS One (2013) 0.92
A new flow co-culture system for studying mechanobiology effects of pulse flow waves. Cytotechnology (2012) 0.91
Boundary conditions of patient-specific fluid dynamics modelling of cavopulmonary connections: possible adaptation of pulmonary resistances results in a critical issue for a virtual surgical planning. Interface Focus (2011) 0.90
Shear stress modulation of IL-1β-induced E-selectin expression in human endothelial cells. PLoS One (2012) 0.89
Stiffening-induced high pulsatility flow activates endothelial inflammation via a TLR2/NF-κB pathway. PLoS One (2014) 0.88
High Pulsatility Flow Induces Acute Endothelial Inflammation through Overpolarizing Cells to Activate NF-κB. Cardiovasc Eng Technol (2013) 0.88
Mechanics and Function of the Pulmonary Vasculature: Implications for Pulmonary Vascular Disease and Right Ventricular Function. Compr Physiol (2012) 0.87
Delineating the angiogenic gene expression profile before pulmonary vascular remodeling in a lamb model of congenital heart disease. Physiol Genomics (2010) 0.87
Vascular stiffening in pulmonary hypertension: cause or consequence? (2013 Grover Conference series). Pulm Circ (2014) 0.87
Adaptation of endothelial cells to physiologically-modeled, variable shear stress. PLoS One (2013) 0.85
The role of pulmonary arterial stiffness in COPD. Respir Med (2015) 0.84
17β-Estradiol Attenuates Conduit Pulmonary Artery Mechanical Property Changes With Pulmonary Arterial Hypertension. Hypertension (2015) 0.82
Chronic intrauterine pulmonary hypertension increases main pulmonary artery stiffness and adventitial remodeling in fetal sheep. Am J Physiol Lung Cell Mol Physiol (2014) 0.80
Heme oxygenase-1 and inflammation in experimental right ventricular failure on prolonged overcirculation-induced pulmonary hypertension. PLoS One (2013) 0.79
Main pulmonary arterial wall shear stress correlates with invasive hemodynamics and stiffness in pulmonary hypertension. Pulm Circ (2016) 0.78
Thoracic and abdominal aortas stiffen through unique extracellular matrix changes in intrauterine growth restricted fetal sheep. Am J Physiol Heart Circ Physiol (2013) 0.77
Carotid calcification in mice: a new model to study the effects of arterial stiffness on the brain. J Am Heart Assoc (2013) 0.76
Pulmonary vascular stiffness: measurement, modeling, and implications in normal and hypertensive pulmonary circulations. Compr Physiol (2011) 0.76
Pulmonary blood flow and pulmonary hypertension: Is the pulmonary circulation flowophobic or flowophilic? Pulm Circ (2012) 0.76
Serum levels of soluble ICAM-1 in children with pulmonary artery hypertension. Tex Heart Inst J (2014) 0.75
A Revised Hemodynamic Theory of Age-Related Macular Degeneration. Trends Mol Med (2016) 0.75
Assessment of proximal pulmonary arterial stiffness using magnetic resonance imaging: effects of technique, age and exercise. BMJ Open Respir Res (2016) 0.75
Sex-specific genetic determinants for arterial stiffness in Dahl salt-sensitive hypertensive rats. BMC Genet (2016) 0.75
Arterial Stiffness Induces Remodeling Phenotypes in Pulmonary Artery Smooth Muscle Cells via YAP/TAZ-Mediated Repression of Cyclooxygenase-2. Am J Physiol Lung Cell Mol Physiol (2017) 0.75
Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc (2008) 62.52
Arterial stiffness and risk of coronary heart disease and stroke: the Rotterdam Study. Circulation (2006) 8.18
Mechanisms, pathophysiology, and therapy of arterial stiffness. Arterioscler Thromb Vasc Biol (2005) 5.39
Distinct endothelial phenotypes evoked by arterial waveforms derived from atherosclerosis-susceptible and -resistant regions of human vasculature. Proc Natl Acad Sci U S A (2004) 4.31
Current perspectives on arterial stiffness and pulse pressure in hypertension and cardiovascular diseases. Circulation (2003) 3.96
Endothelial dysfunction, hemodynamic forces, and atherogenesis. Ann N Y Acad Sci (2000) 3.70
Aortic diameter, wall stiffness, and wave reflection in systolic hypertension. Hypertension (2007) 3.68
Prolonged fluid shear stress induces a distinct set of endothelial cell genes, most specifically lung Krüppel-like factor (KLF2). Blood (2002) 3.38
Cross-sectional relations of peripheral microvascular function, cardiovascular disease risk factors, and aortic stiffness: the Framingham Heart Study. Circulation (2005) 2.49
Mature vascular endothelium can give rise to smooth muscle cells via endothelial-mesenchymal transdifferentiation: in vitro analysis. Circ Res (2002) 2.22
Fluid shear stress induces differentiation of Flk-1-positive embryonic stem cells into vascular endothelial cells in vitro. Am J Physiol Heart Circ Physiol (2004) 2.11
Shear stress biology of the endothelium. Ann Biomed Eng (2005) 1.84
Spatial relationships in early signaling events of flow-mediated endothelial mechanotransduction. Annu Rev Physiol (1997) 1.81
A new in vitro model to evaluate differential responses of endothelial cells to simulated arterial shear stress waveforms. J Biomech Eng (2002) 1.77
Atherosclerosis-prone hemodynamics differentially regulates endothelial and smooth muscle cell phenotypes and promotes pro-inflammatory priming. Am J Physiol Cell Physiol (2007) 1.70
Endothelial cellular response to altered shear stress. Am J Physiol Lung Cell Mol Physiol (2001) 1.68
Frequency-dependent response of the vascular endothelium to pulsatile shear stress. Am J Physiol Heart Circ Physiol (2007) 1.33
Phosphatidylinositol 3-kinase gamma mediates shear stress-dependent activation of JNK in endothelial cells. Am J Physiol (1998) 1.27
Age, hypertension and arterial function. Clin Exp Pharmacol Physiol (2007) 1.26
Wall stiffness suppresses Akt/eNOS and cytoprotection in pulse-perfused endothelium. Hypertension (2003) 1.20
Arterial stiffness, vascular disease, and risk of cardiovascular events. Circulation (2006) 1.15
Measurements of mouse pulmonary artery biomechanics. J Biomech Eng (2004) 1.11
Arterial stiffness and cardiovascular outcome. Clin Exp Pharmacol Physiol (2007) 1.08
Precise quantification of pressure flow waveforms of a pulsatile ventricular assist device. ASAIO J (2005) 1.06
Pulsatile blood flow, shear force, energy dissipation and Murray's Law. Theor Biol Med Model (2006) 1.05
Evaluation of mechanical arterial properties: clinical, experimental and therapeutic aspects. Clin Sci (Lond) (2002) 0.98
Gene expression of endothelial cells under pulsatile non-reversing vs. steady shear stress; comparison of nitric oxide production. Ann Biomed Eng (2008) 0.95
In vitro system to study realistic pulsatile flow and stretch signaling in cultured vascular cells. Am J Physiol Cell Physiol (2000) 0.93
Cells in fluidic environments are sensitive to flow frequency. J Cell Physiol (2005) 0.92
Energy equivalent pressure and total hemodynamic energy associated with the pressure-flow waveforms of a pediatric pulsatile ventricular assist device. ASAIO J (2005) 0.89
Secrets of the code: do vascular endothelial cells use ion channels to decipher complex flow signals? Biomaterials (2005) 0.89
A new echocardiographic approach in assessing pulmonary vascular bed in patients with congenital heart disease: pulmonary artery stiffness. Anadolu Kardiyol Derg (2003) 0.87
Peripheral pulse pressure, large arteries, and microvessels. Hypertension (2004) 0.86
Noninvasive methods for determining pulmonary vascular function in children with pulmonary arterial hypertension: application of a mechanical oscillator model. Congenit Heart Dis (2008) 0.84
Correspondence of low mean shear and high harmonic content in the porcine iliac arteries. J Biomech Eng (2006) 0.84
Arterial pressure waveforms in hypertension. Minerva Med (2003) 0.82
Pulse pressure: an important tool in cardiovascular pharmacology and therapeutics. Drugs (2003) 0.81
Arterial stiffness and coronary ischemic disease. Adv Cardiol (2007) 0.81
Brain microbleeds, amyloid plaques, intellectual deterioration, and arterial stiffness. Hypertension (2008) 0.80
Pathophysiology, genetic, and therapy of arterial stiffness. Biomed Mater Eng (2006) 0.80
How important and how treatable is vascular stiffness as a cardiovascular risk factor in renal failure? Nephrol Dial Transplant (2002) 0.77
Heart repair by reprogramming non-myocytes with cardiac transcription factors. Nature (2012) 6.65
Cellular and molecular pathobiology of pulmonary arterial hypertension. J Am Coll Cardiol (2004) 5.79
Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing Maspin. Nature (2007) 4.00
Inflammation, growth factors, and pulmonary vascular remodeling. J Am Coll Cardiol (2009) 3.75
Cellular and molecular basis of pulmonary arterial hypertension. J Am Coll Cardiol (2009) 3.69
Hippo pathway effector Yap promotes cardiac regeneration. Proc Natl Acad Sci U S A (2013) 2.76
Hypoxia-induced pulmonary vascular remodeling requires recruitment of circulating mesenchymal precursors of a monocyte/macrophage lineage. Am J Pathol (2006) 2.70
Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid. Circulation (2012) 2.54
Perspectives on endothelial-to-mesenchymal transition: potential contribution to vascular remodeling in chronic pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol (2007) 2.46
Stromal cell derived factor-1 alpha confers protection against myocardial ischemia/reperfusion injury: role of the cardiac stromal cell derived factor-1 alpha CXCR4 axis. Circulation (2007) 2.35
Safety of thoracoscopic lobectomy in locally advanced lung cancer. Ann Surg Oncol (2011) 2.34
Mature vascular endothelium can give rise to smooth muscle cells via endothelial-mesenchymal transdifferentiation: in vitro analysis. Circ Res (2002) 2.22
Thermomechanics of the shape memory effect in polymers for biomedical applications. J Biomed Mater Res A (2005) 2.17
IL-6 plays an obligatory role in late preconditioning via JAK-STAT signaling and upregulation of iNOS and COX-2. Cardiovasc Res (2004) 2.12
Histone deacetylase inhibition blunts ischemia/reperfusion injury by inducing cardiomyocyte autophagy. Circulation (2014) 2.07
Unconstrained recovery characterization of shape-memory polymer networks for cardiovascular applications. Biomaterials (2007) 1.96
Rosiglitazone attenuates hypoxia-induced pulmonary arterial remodeling. Am J Physiol Lung Cell Mol Physiol (2006) 1.93
Macrophages are required for neonatal heart regeneration. J Clin Invest (2014) 1.93
Optical coherence elastography of engineered and developing tissue. Tissue Eng (2006) 1.86
Sustained hypoxia leads to the emergence of cells with enhanced growth, migratory, and promitogenic potentials within the distal pulmonary artery wall. Am J Physiol Lung Cell Mol Physiol (2009) 1.81
MicroRNA-124 controls the proliferative, migratory, and inflammatory phenotype of pulmonary vascular fibroblasts. Circ Res (2013) 1.80
Spectroscopic spectral-domain optical coherence microscopy. Opt Lett (2006) 1.77
Strong, Tailored, Biocompatible Shape-Memory Polymer Networks. Adv Funct Mater (2008) 1.77
Hypoxia exposure induces the emergence of fibroblasts lacking replication repressor signals of PKCzeta in the pulmonary artery adventitia. Cardiovasc Res (2008) 1.72
Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa. Proc Natl Acad Sci U S A (2012) 1.70
Hypoxia-induced pulmonary artery adventitial remodeling and neovascularization: contribution of progenitor cells. Am J Physiol Lung Cell Mol Physiol (2003) 1.68
Distensibility of the normal human lung circulation during exercise. Am J Physiol Lung Cell Mol Physiol (2005) 1.62
An artificial right ventricle for failing fontan: in vitro and computational study. Ann Thorac Surg (2009) 1.58
Administration of a CO-releasing molecule at the time of reperfusion reduces infarct size in vivo. Am J Physiol Heart Circ Physiol (2004) 1.56
Embryonic growth-associated protein is one subunit of a novel N-terminal acetyltransferase complex essential for embryonic vascular development. Circ Res (2006) 1.54
Changes in the structure-function relationship of elastin and its impact on the proximal pulmonary arterial mechanics of hypertensive calves. Am J Physiol Heart Circ Physiol (2008) 1.54
Varicella-zoster virus vasculopathy: immune characteristics of virus-infected arteries. Neurology (2012) 1.52
Significant effect of size on the in vivo biodistribution of gold composite nanodevices in mouse tumor models. Nanomedicine (2007) 1.49
Lung EC-SOD overexpression attenuates hypoxic induction of Egr-1 and chronic hypoxic pulmonary vascular remodeling. Am J Physiol Lung Cell Mol Physiol (2008) 1.48
C/EBP transcription factors mediate epicardial activation during heart development and injury. Science (2012) 1.48
Vascular remodeling versus vasoconstriction in chronic hypoxic pulmonary hypertension: a time for reappraisal? Circ Res (2005) 1.48
Retracted Targeting 3-phosphoinoside-dependent kinase-1 to inhibit insulin-like growth factor-I induced AKT and p70 S6 kinase activation in breast cancer cells. PLoS One (2012) 1.41
Emergence of fibroblasts with a proinflammatory epigenetically altered phenotype in severe hypoxic pulmonary hypertension. J Immunol (2011) 1.39
Erythroid dysplasia, megaloblastic anemia, and impaired lymphopoiesis arising from mitochondrial dysfunction. Blood (2009) 1.37
Quantification of hemodynamic wall shear stress in patients with bicuspid aortic valve using phase-contrast MRI. Ann Biomed Eng (2009) 1.37
Selective class I histone deacetylase inhibition suppresses hypoxia-induced cardiopulmonary remodeling through an antiproliferative mechanism. Circ Res (2012) 1.37
Extracellular ATP is an autocrine/paracrine regulator of hypoxia-induced adventitial fibroblast growth. Signaling through extracellular signal-regulated kinase-1/2 and the Egr-1 transcription factor. J Biol Chem (2002) 1.35
Hypoxia induces differentiation of pulmonary artery adventitial fibroblasts into myofibroblasts. Am J Physiol Cell Physiol (2003) 1.34
Sustained hypoxia promotes the development of a pulmonary artery-specific chronic inflammatory microenvironment. Am J Physiol Lung Cell Mol Physiol (2009) 1.32
Pediatric Pulmonary Hypertension: Guidelines From the American Heart Association and American Thoracic Society. Circulation (2015) 1.30
Detection of tissue harmonic motion induced by ultrasonic radiation force using pulse-echo ultrasound and Kalman filter. IEEE Trans Ultrason Ferroelectr Freq Control (2007) 1.22
Renal NF-kappaB activation and TNF-alpha upregulation correlate with salt-sensitive hypertension in Dahl salt-sensitive rats. Am J Physiol Regul Integr Comp Physiol (2006) 1.22
A NIK-IKKα module expands ErbB2-induced tumor-initiating cells by stimulating nuclear export of p27/Kip1. Cancer Cell (2013) 1.21
Is thoracoscopic pneumonectomy safe? Ann Thorac Surg (2009) 1.18
U2AF participates in the binding of TAP (NXF1) to mRNA. J Biol Chem (2001) 1.18
Activation of phosphatidylinositol 3-kinase, Akt, and mammalian target of rapamycin is necessary for hypoxia-induced pulmonary artery adventitial fibroblast proliferation. J Appl Physiol (1985) (2004) 1.17
Pulmonary artery adventitial fibroblasts cooperate with vasa vasorum endothelial cells to regulate vasa vasorum neovascularization: a process mediated by hypoxia and endothelin-1. Am J Pathol (2006) 1.16
Cardioprotection afforded by inducible nitric oxide synthase gene therapy is mediated by cyclooxygenase-2 via a nuclear factor-kappaB dependent pathway. Circulation (2007) 1.15
Gene transfer of inducible nitric oxide synthase affords cardioprotection by upregulating heme oxygenase-1 via a nuclear factor-{kappa}B-dependent pathway. Circulation (2009) 1.15
Administration of a CO-releasing molecule induces late preconditioning against myocardial infarction. J Mol Cell Cardiol (2004) 1.12
Noninvasive Doppler tissue measurement of pulmonary artery compliance in children with pulmonary hypertension. J Am Soc Echocardiogr (2006) 1.11
Semiquantitative visual approach to scoring lung cancer treatment response using computed tomography: a pilot study. J Comput Assist Tomogr (2009) 1.10
Xanthine oxidase-derived ROS upregulate Egr-1 via ERK1/2 in PA smooth muscle cells; model to test impact of extracellular ROS in chronic hypoxia. PLoS One (2011) 1.09
Gene therapy with iNOS provides long-term protection against myocardial infarction without adverse functional consequences. Am J Physiol Heart Circ Physiol (2005) 1.09
Nuclear export factor family protein participates in cytoplasmic mRNA trafficking. J Biol Chem (2005) 1.09
The renin-angiotensin system in pulmonary hypertension. Am J Respir Crit Care Med (2013) 1.08
Phase II study of Dutasteride for recurrent prostate cancer during androgen deprivation therapy. J Urol (2008) 1.08
A microstructural hyperelastic model of pulmonary arteries under normo- and hypertensive conditions. Ann Biomed Eng (2005) 1.06
Lung extracellular superoxide dismutase overexpression lessens bleomycin-induced pulmonary hypertension and vascular remodeling. Am J Respir Cell Mol Biol (2010) 1.05
Egr-1 antisense oligonucleotides inhibit hypoxia-induced proliferation of pulmonary artery adventitial fibroblasts. J Appl Physiol (1985) (2004) 1.04
Numerical modeling of microbubble backscatter to optimize ultrasound particle image velocimetry imaging: initial studies. Ultrasonics (2004) 1.04
In vivo measurement of proximal pulmonary artery elastic modulus in the neonatal calf model of pulmonary hypertension: development and ex vivo validation. J Appl Physiol (1985) (2010) 1.04
Photodynamic therapy (PDT) using HPPH for the treatment of precancerous lesions associated with Barrett's esophagus. Lasers Surg Med (2011) 1.04
Simulations of congenital septal defect closure and reactivity testing in patient-specific models of the pediatric pulmonary vasculature: A 3D numerical study with fluid-structure interaction. J Biomech Eng (2006) 1.03
Physiologic and molecular consequences of endothelial Bmpr2 mutation. Respir Res (2011) 1.03
Noninvasive measurement of steady and pulsating velocity profiles and shear rates in arteries using echo PIV: in vitro validation studies. Ann Biomed Eng (2004) 1.03
Unique, highly proliferative growth phenotype expressed by embryonic and neointimal smooth muscle cells is driven by constitutive Akt, mTOR, and p70S6K signaling and is actively repressed by PTEN. Circulation (2004) 1.02
Oroxylin A inhibits hemolysis via hindering the self-assembly of α-hemolysin heptameric transmembrane pore. PLoS Comput Biol (2013) 1.02
Impact of residual stretch and remodeling on collagen engagement in healthy and pulmonary hypertensive calf pulmonary arteries at physiological pressures. Ann Biomed Eng (2012) 1.02
Extracellular ATP is a pro-angiogenic factor for pulmonary artery vasa vasorum endothelial cells. Angiogenesis (2007) 1.01
High pulsatility flow stimulates smooth muscle cell hypertrophy and contractile protein expression. Am J Physiol Lung Cell Mol Physiol (2012) 1.00
Paclitaxel-liposome-microbubble complexes as ultrasound-triggered therapeutic drug delivery carriers. J Control Release (2013) 0.99
Wall shear stress measured by phase contrast cardiovascular magnetic resonance in children and adolescents with pulmonary arterial hypertension. J Cardiovasc Magn Reson (2013) 0.97
Synthesis and characterization of PAMAM dendrimer-based multifunctional nanodevices for targeting alphavbeta3 integrins. Bioconjug Chem (2007) 0.97
The COX-2/PGI2 receptor axis plays an obligatory role in mediating the cardioprotection conferred by the late phase of ischemic preconditioning. PLoS One (2012) 0.96
Progenitor cells in pulmonary vascular remodeling. Pulm Circ (2011) 0.96
Effects of four Si-Wu-Tang's constituents and their combination on irradiated mice. Biol Pharm Bull (2006) 0.96
Induction of SM-alpha-actin expression by mechanical strain in adult vascular smooth muscle cells is mediated through activation of JNK and p38 MAP kinase. Biochem Biophys Res Commun (2003) 0.96
Lung vascular cell heterogeneity: endothelium, smooth muscle, and fibroblasts. Proc Am Thorac Soc (2008) 0.96
Vitamin D deficiency and insufficiency among patients with prostate cancer. BJU Int (2009) 0.95
The correlations of disease activity, socioeconomic status, quality of life, and depression/anxiety in Chinese patients with systemic lupus erythematosus. Clin Dev Immunol (2013) 0.94
Clinical trials in neonates and children: Report of the pulmonary hypertension academic research consortium pediatric advisory committee. Pulm Circ (2013) 0.94
The lymph node yield during robot-assisted radical cystectomy. BJU Int (2008) 0.94
Late preconditioning induced by NO donors, adenosine A1 receptor agonists, and delta1-opioid receptor agonists is mediated by iNOS. Am J Physiol Heart Circ Physiol (2005) 0.94
Role of reactive oxygen species in chronic hypoxia-induced pulmonary hypertension and vascular remodeling. Adv Exp Med Biol (2007) 0.94
Photopolymerized Thiol-Ene Systems as Shape Memory Polymers. Polymer (Guildf) (2010) 0.94
A microstructurally driven model for pulmonary artery tissue. J Biomech Eng (2011) 0.93