Translational nociceptor research as guide to human pain perceptions and pathophysiology.

PubWeight™: 0.84‹?›

🔗 View Article (PMID 19350229)

Published in Exp Brain Res on April 07, 2009

Authors

Barbara Namer1, Hermann Otto Handwerker

Author Affiliations

1: Department of Physiology and Pathophysiology, Institut für Physiologie und Pathophysiologie, University of Erlangen/Nuernberg, Universitätsstr. 17, 91054 Erlangen, Germany.

Articles cited by this

Touch, pain and tickling: an electro-physiological investigation on cutaneous sensory nerves. J Physiol (1939) 13.11

Somatosensory, proprioceptive, and sympathetic activity in human peripheral nerves. Physiol Rev (1979) 7.25

Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): standardized protocol and reference values. Pain (2006) 5.55

Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli. J Neurophysiol (1969) 4.68

Specific C-receptors for itch in human skin. J Neurosci (1997) 3.51

Activity from skin mechanoreceptors recorded percutaneously in awake human subjects. Exp Neurol (1968) 3.41

Epidermal nerve fiber density: normative reference range and diagnostic efficiency. Arch Neurol (1998) 3.39

The electrophysiological identification of single nerve fibres, with particular reference to the slowest-conducting vagal afferent fibres in the cat. J Physiol (1958) 3.22

Animal models and the prediction of efficacy in clinical trials of analgesic drugs: a critical appraisal and call for uniform reporting standards. Pain (2008) 3.08

Effect of age and gender on sudomotor and cardiovagal function and blood pressure response to tilt in normal subjects. Muscle Nerve (1997) 2.86

Cutaneous heat and cold receptors with slowly conducting (C) afferent fibres. Q J Exp Physiol Cogn Med Sci (1959) 2.74

Separate peripheral pathways for pruritus in man. J Neurophysiol (2008) 2.64

The itch-producing agents histamine and cowhage activate separate populations of primate spinothalamic tract neurons. J Neurosci (2007) 2.63

A role for polymodal C-fiber afferents in nonhistaminergic itch. J Neurosci (2008) 2.50

What should we be measuring in behavioral studies of chronic pain in animals? Pain (2004) 2.47

Qualitative and quantitative morphology of human sural nerve at different ages. Brain (1985) 2.47

Cowhage-evoked itch is mediated by a novel cysteine protease: a ligand of protease-activated receptors. J Neurosci (2008) 2.40

Chemical response pattern of different classes of C-nociceptors to pruritogens and algogens. J Neurophysiol (2003) 2.39

Behavioral differentiation between itch and pain in mouse. Pain (2008) 2.37

Microneurography: how the technique developed and its role in the investigation of the sympathetic nervous system. J Appl Physiol (1985) (2004) 2.22

Primary afferent units from the hairy skin of the rat hind limb. Brain Res (1982) 2.14

Psychophysical and physiological evidence for parallel afferent pathways mediating the sensation of itch. J Neurosci (2007) 2.10

The neurohistology and neurophysiology of the itch sensation in man. AMA Arch Derm (1957) 1.99

Novel classes of responsive and unresponsive C nociceptors in human skin. J Neurosci (1995) 1.97

Studies on cowhage (Mucuna pruriens) and its pruritogenic proteinase, mucunain. AMA Arch Derm (1955) 1.85

Neuropathic pain symptoms relative to overall pain rating. J Pain (2004) 1.68

Early onset of spontaneous activity in uninjured C-fiber nociceptors after injury to neighboring nerve fibers. J Neurosci (2001) 1.66

Age effects on pain thresholds, temporal summation and spatial summation of heat and pressure pain. Pain (2005) 1.62

Functional attributes discriminating mechano-insensitive and mechano-responsive C nociceptors in human skin. J Neurosci (1999) 1.61

Which nerve fibers mediate the axon reflex flare in human skin? Neuroreport (2000) 1.60

C nociceptor activity in human nerve during painful and non painful skin stimulation. J Neurol Neurosurg Psychiatry (1981) 1.57

Painful traumatic peripheral partial nerve injury-sensory dysfunction profiles comparing outcomes of bedside examination and quantitative sensory testing. Eur J Pain (2007) 1.53

Firing properties of single vasoconstrictor neurones in human subjects with high levels of muscle sympathetic activity. J Physiol (1999) 1.45

Sweat responses in the aged. Age Ageing (1976) 1.43

Response properties of thin myelinated (A-delta) fibers in human skin nerves. J Neurophysiol (1983) 1.36

Uninjured C-fiber nociceptors develop spontaneous activity and alpha-adrenergic sensitivity following L6 spinal nerve ligation in monkey. J Neurophysiol (1999) 1.36

Degeneration of myelinated efferent fibers induces spontaneous activity in uninjured C-fiber afferents. J Neurosci (2002) 1.36

Chronic pain in elderly people. Pain (1997) 1.35

Morphometric and ultrastructural changes with ageing in mouse peripheral nerve. J Anat (1999) 1.31

Slowly conducting afferents activated by innocuous low temperature in human skin. J Physiol (2001) 1.27

Firing properties of single postganglionic sympathetic neurones recorded in awake human subjects. Auton Neurosci (2002) 1.24

Pathological C-fibres in patients with a chronic painful condition. Brain (2003) 1.23

Time course of post-excitatory effects separates afferent human C fibre classes. J Physiol (2000) 1.22

Microneurography as a tool in clinical neurophysiology to investigate peripheral neural traffic in humans. Clin Neurophysiol (2006) 1.21

Delayed responses to electrical stimuli reflect C-fiber responsiveness in human microneurography. Exp Brain Res (1995) 1.18

Peripheral neural mechanisms of cutaneous hyperalgesia following mild injury by heat. J Neurosci (1982) 1.16

Epidermal innervation: changes with aging, topographic location, and in sensory neuropathy. J Neurol Sci (1999) 1.16

C-fibre units recorded from human sensory nerve fascicles in situ. A preliminary report. Acta Soc Med Ups (1970) 1.12

Velocity recovery cycles of single C fibres innervating rat skin. J Physiol (2006) 1.11

Properties of transdermal histamine iontophoresis: differential effects of season, gender, and body region. J Invest Dermatol (1990) 1.09

Prediction of pain center treatment outcome for geriatric chronic pain patients. Clin J Pain (1994) 1.09

Hyperexcitable polymodal and insensitive nociceptors in painful human neuropathy. Muscle Nerve (2005) 1.08

Multiple interacting sites of ectopic spike electrogenesis in primary sensory neurons. J Neurosci (2005) 1.06

Abnormal function of C-fibers in patients with diabetic neuropathy. J Neurosci (2006) 1.04

Microneurographic assessment of C-fibre function in aged healthy subjects. J Physiol (2008) 1.04

Physiological characteristics of low-threshold mechanoreceptors in joints, muscle and skin in human subjects. Clin Exp Pharmacol Physiol (2005) 1.03

Active "itch fibers" in chronic pruritus. Neurology (2003) 1.02

The relationship between cutaneous C fibre type and antidromic vasodilatation in the rabbit and the rat. J Physiol (1997) 1.02

The effect of aging on cardiac autonomic and postganglionic sudomotor function. Muscle Nerve (1990) 1.00

The ability of humans to localise noxious stimuli. Neurosci Lett (1993) 1.00

Age differences in nociception and pain behaviours in the rat. Neurosci Biobehav Rev (2000) 0.99

Chemically and electrically induced sweating and flare reaction. Auton Neurosci (2004) 0.96

The vasodilator component of neurogenic inflammation is caused by a special subclass of heat-sensitive nociceptors in the skin of the pig. J Physiol (1996) 0.96

Spontaneous activity of primary afferent neurons in diabetic BB/Wistar rats. A possible mechanism of chronic diabetic neuropathic pain. Diabetes (1985) 0.96

The classification and properties of nociceptive afferent units from the skin of the anaesthetized pig. Eur J Neurosci (1995) 0.94

Mechano-insensitive nociceptors encode pain evoked by tonic pressure to human skin. Neuroscience (2000) 0.93

Impact of scratching on itch and sympathetic reflexes induced by cowhage (Mucuna pruriens) and histamine. Acta Derm Venereol (2009) 0.93

Methods of measurement of thermal thresholds. Acta Neurol Scand (1987) 0.92

Microelectrode recordings from transected nerves in amputees with phantom limb pain. Neurosci Lett (1981) 0.92

Injured versus uninjured afferents: Who is to blame for neuropathic pain? Anesthesiology (2005) 0.91

Experimental evidence for an enzymatic basis for itching in man. Nature (1955) 0.91

Effect of chronic inflammation on dorsal horn nociceptive neurons in aged rats. J Neurophysiol (2005) 0.90

Psychophysical detection and pain ratings of incremental thermal stimuli: a comparison with nociceptor responses in humans. Brain Res (1983) 0.90

Morphological changes in unmyelinated nerve fibres in the sural nerve with age. Brain (1991) 0.89

Models of neuropathic pain in the rat. Curr Protoc Neurosci (2003) 0.89

Ectopic impulse generation and autoexcitation in single myelinated afferent fibers in patients with peripheral neuropathy and positive sensory symptoms. Muscle Nerve (1998) 0.89

Neurophysiologic and quantitative sensory testing in the diagnosis of trigeminal neuropathy and neuropathic pain. Pain (2005) 0.88

Plastic changes in nociceptive transmission of the rat spinal cord with advancing age. J Neurophysiol (2002) 0.87

Age-related changes in nociception and effect of morphine in the Lou rat. Eur J Pain (2000) 0.87

Suppression of C-fibre discharges upon repeated heat stimulation may explain characteristics of concomitant pain sensations. Brain Res (1984) 0.87

Catecholamine-induced excitation of nociceptors in sympathetically maintained pain. Pain (2006) 0.86

Temperature-dependent double spikes in C-nociceptors of neuropathic pain patients. Brain (2005) 0.86

Action potential conduction in the terminal arborisation of nociceptive C-fibre afferents. J Physiol (2003) 0.85

Discharge pattern of afferent fibers from a neuroma. Pain (1984) 0.83

Effects of aging on spinal opioid-induced antinociception. Neurobiol Aging (1995) 0.82

Comprehensive assessment of chronic low back pain patients and controls: physical abilities, level of activity, psychological adjustment and pain perception. Pain (1985) 0.81

Effect of age on sensitivity to pain and brain opiate receptors. Neurobiol Aging (1981) 0.80

Brain activation during input from mechanoinsensitive versus polymodal C-nociceptors. J Neurosci (2006) 0.80

Outcomes in treatment of pain in geriatric and younger age groups. Arch Phys Med Rehabil (1994) 0.78

Effects of age on the axon reflex response to noxious chemical stimulation. Clin Exp Neurol (1986) 0.77

Age-specific skin blood flow responses to acute capsaicin. J Gerontol A Biol Sci Med Sci (2003) 0.77