Published in J Med Chem on May 14, 2009
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Structural and enzymatic analyses reveal the binding mode of a novel series of Francisella tularensis enoyl reductase (FabI) inhibitors. J Med Chem (2012) 0.90
Combined X-ray, NMR, and kinetic analyses reveal uncommon binding characteristics of the hepatitis C virus NS3-NS4A protease inhibitor BI 201335. J Biol Chem (2011) 0.84
Synthesis and biological evaluation of C-2 halogenated analogs of salvinorin A. Bioorg Med Chem Lett (2010) 0.84
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Incorporation of piperazino functionality into 1,3-disubstituted urea as the tertiary pharmacophore affording potent inhibitors of soluble epoxide hydrolase with improved pharmacokinetic properties. J Med Chem (2010) 0.80
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The X∙∙∙Au interactions in the CF₃X (X = Cl, Br)∙∙∙Au(n) (n = 2, 3, and 4) complexes. J Mol Model (2014) 0.76
Substituted Bis-THF Protease Inhibitors with Improved Potency against Highly Resistant Mature HIV-1 Protease PR20. J Med Chem (2015) 0.76
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Interplay between halogen and chalcogen bonding in the XCl∙∙∙OCS∙∙∙NH₃ (X = F, OH, NC, CN, and FCC) complex. J Mol Model (2014) 0.76
A novel halogen bond and a better-known hydrogen bond cooperation of neonicotinoid and insect nicotinic acetylcholine receptor recognition. J Mol Model (2012) 0.76
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Functionalized ferrocenes: The role of the para substituent on the phenoxy pendant group. J Organomet Chem (2014) 0.75
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In Vitro Antitumor Active Gold(I) Triphenylphosphane Complexes Containing 7-Azaindoles. Int J Mol Sci (2016) 0.75
Non-covalent interactions involving halogenated derivatives of capecitabine and thymidylate synthase: a computational approach. Springerplus (2016) 0.75
A Halogen-Bond-Induced Triple Helicate Encapsulates Iodide. Angew Chem Int Ed Engl (2016) 0.75
Halogen-directed drug design for Alzheimer's disease: a combined density functional and molecular docking study. Springerplus (2016) 0.75
Theoretical investigations on the enhancing effect of the cation-π interaction on the halogen bond in the M∙∙∙HCCX∙∙∙NH₃ (M = Li⁺, Na⁺, Cu⁺, Ag⁺, Au⁺; X = Cl, Br) complexes. J Mol Model (2014) 0.75
A systematical comparison of DFT methods in reproducing the interaction energies of halide series with protein moieties. J Mol Model (2011) 0.75
The protonated 2-halogenated imidazolium cation as the noncovalent interaction donor: the σ-hole and π-hole interactions. J Mol Model (2016) 0.75
Anion recognition based on halogen bonding: a case study of macrocyclic imidazoliophane receptors. J Mol Model (2012) 0.75
How do halogen bonds (S-O⋯I, N-O⋯I and C-O⋯I) and halogen-halogen contacts (C-I⋯I-C, C-F⋯F-C) subsist in crystal structures? A quantum chemical insight. J Mol Model (2016) 0.75
Cooperative effects between halogen bonds and pnicogen bonds in XBr∙∙∙OFH2P∙∙∙NH3 (X = F, Cl, CN, NC, OH, and NO2) complexes. J Mol Model (2015) 0.75
Influence of transition metals on halogen-bonded complexes of MCCBr∙∙∙NCH and HCCBr∙∙∙NCM' (M, M' = Cu, Ag, and Au). J Mol Model (2012) 0.75
Rational redesign of a cation···π···π stacking at cardiovascular Fbw7-Skp1 complex interface and its application for deriving self-inhibitory peptides to disrupt the complex interaction. J Mol Model (2017) 0.75
Chalcogen- and halogen-bonds involving SX2 (X = F, Cl, and Br) with formaldehyde. J Mol Model (2016) 0.75
Synergistic and diminutive effects between halogen bond and lithium bond in complexes involving aromatic compounds. J Mol Model (2015) 0.75
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Ancient human genome sequence of an extinct Palaeo-Eskimo. Nature (2010) 7.51
Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras. Nat Biotechnol (2006) 6.30
Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder. Nat Genet (2011) 5.73
Isoprenoid pathway optimization for Taxol precursor overproduction in Escherichia coli. Science (2010) 4.96
An Aboriginal Australian genome reveals separate human dispersals into Asia. Science (2011) 4.84
Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation. Science (2006) 4.71
An index of substitution saturation and its application. Mol Phylogenet Evol (2003) 4.71
Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma. Nat Genet (2011) 3.66
Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2. Nature (2010) 3.59
FoxM1 promotes β-catenin nuclear localization and controls Wnt target-gene expression and glioma tumorigenesis. Cancer Cell (2011) 3.58
Structure of the CCR5 chemokine receptor-HIV entry inhibitor maraviroc complex. Science (2013) 3.17
Adhesive phase separation at the dentin interface under wet bonding conditions. J Biomed Mater Res (2002) 3.08
Predicting protein-protein interactions based only on sequences information. Proc Natl Acad Sci U S A (2007) 3.06
Manipulating surface states in topological insulator nanoribbons. Nat Nanotechnol (2011) 2.70
Large electrocaloric effect in ferroelectric polymers near room temperature. Science (2008) 2.66
Noninvasive characterization of epicardial activation in humans with diverse atrial fibrillation patterns. Circulation (2010) 2.57
Molecular mimicry regulates ABA signaling by SnRK2 kinases and PP2C phosphatases. Science (2011) 2.52
Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA. Nat Chem Biol (2012) 2.45
Autophagic proteins regulate cigarette smoke-induced apoptosis: protective role of heme oxygenase-1. Autophagy (2008) 2.38
PDTD: a web-accessible protein database for drug target identification. BMC Bioinformatics (2008) 2.35
TarFisDock: a web server for identifying drug targets with docking approach. Nucleic Acids Res (2006) 2.26
Relationship of solvent to the photopolymerization process, properties, and structure in model dentin adhesives. J Biomed Mater Res A (2007) 2.26
High operative risk of cool-tip radiofrequency ablation for unresectable pancreatic head cancer. J Surg Oncol (2006) 2.19
Role of hyperphosphatemia and 1,25-dihydroxyvitamin D in vascular calcification and mortality in fibroblastic growth factor 23 null mice. J Am Soc Nephrol (2007) 2.16
Serologic survey of pandemic (H1N1) 2009 virus, Guangxi Province, China. Emerg Infect Dis (2009) 2.13
Overexpression of cyclin D1 promotes tumor cell growth and confers resistance to cisplatin-mediated apoptosis in an elastase-myc transgene-expressing pancreatic tumor cell line. Clin Cancer Res (2005) 2.13
The Arabidopsis NPR1 protein is a receptor for the plant defense hormone salicylic acid. Cell Rep (2012) 2.13
MicroRNA expression signatures of bladder cancer revealed by deep sequencing. PLoS One (2011) 2.10
Newcastle disease virus-based live attenuated vaccine completely protects chickens and mice from lethal challenge of homologous and heterologous H5N1 avian influenza viruses. J Virol (2006) 2.08
Bone marrow graft-versus-host disease: early destruction of hematopoietic niche after MHC-mismatched hematopoietic stem cell transplantation. Blood (2010) 2.04
DNMT1 stability is regulated by proteins coordinating deubiquitination and acetylation-driven ubiquitination. Sci Signal (2010) 2.04
Microfluidic device for multimodal characterization of pancreatic islets. Lab Chip (2008) 1.99
The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active site. Nat Struct Mol Biol (2010) 1.98
Adhesive/Dentin interface: the weak link in the composite restoration. Ann Biomed Eng (2010) 1.96
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Ionizing radiation and busulfan induce premature senescence in murine bone marrow hematopoietic cells. Cancer Res (2003) 1.86
Milnacipran for the treatment of fibromyalgia in adults: a 15-week, multicenter, randomized, double-blind, placebo-controlled, multiple-dose clinical trial. Clin Ther (2008) 1.86
Structural basis for molecular recognition at serotonin receptors. Science (2013) 1.86
Pyrosequencing reveals highly diverse and species-specific microbial communities in sponges from the Red Sea. ISME J (2010) 1.84
Integrated profiling of microRNAs and mRNAs: microRNAs located on Xq27.3 associate with clear cell renal cell carcinoma. PLoS One (2010) 1.82
Storage and uptake of D-serine into astrocytic synaptic-like vesicles specify gliotransmission. J Neurosci (2013) 1.82
Human monoclonal antibodies to a novel cluster of conformational epitopes on HCV E2 with resistance to neutralization escape in a genotype 2a isolate. PLoS Pathog (2012) 1.79
A novel glucokinase activator modulates pancreatic islet and hepatocyte function. Endocrinology (2005) 1.75
Mitigation of hematologic radiation toxicity in mice through pharmacological quiescence induced by CDK4/6 inhibition. J Clin Invest (2010) 1.74
Characterization of photopolymerization of dentin adhesives as a function of light source and irradiance. J Biomed Mater Res B Appl Biomater (2007) 1.73
Plasma microRNAs as novel biomarkers for early detection of lung cancer. Int J Clin Exp Pathol (2011) 1.73
Mechanically induced titin kinase activation studied by force-probe molecular dynamics simulations. Biophys J (2004) 1.70
Bariatric surgery reduces visceral adipose inflammation and improves endothelial function in type 2 diabetic mice. Arterioscler Thromb Vasc Biol (2011) 1.69
N'-[4-(Dimethyl-amino)benzyl-idene]benzohydrazide. Acta Crystallogr Sect E Struct Rep Online (2009) 1.68
Complete biosynthesis of erythromycin A and designed analogs using E. coli as a heterologous host. Chem Biol (2010) 1.68
Transitional cell carcinoma in renal transplant recipients: a single center experience. Int J Urol (2008) 1.67
Antiemetic placebo: reduce adverse drug interactions between chemotherapeutic agents and antiemetic drugs in cancer patients. Med Hypotheses (2007) 1.62
Comprehensive molecular etiology analysis of nonsyndromic hearing impairment from typical areas in China. J Transl Med (2009) 1.62
Alignment of molecular networks by integer quadratic programming. Bioinformatics (2007) 1.61
NOA: a novel Network Ontology Analysis method. Nucleic Acids Res (2011) 1.60
SUMO1 modification of PTEN regulates tumorigenesis by controlling its association with the plasma membrane. Nat Commun (2012) 1.58
Nanophase separation of polymers exposed to simulated bonding conditions. J Biomed Mater Res B Appl Biomater (2009) 1.56
Helix-stabilized cyclic peptides as selective inhibitors of steroid receptor-coactivator interactions. Proc Natl Acad Sci U S A (2003) 1.54
Efficacy, safety and tolerability of bosentan in Chinese patients with pulmonary arterial hypertension. J Heart Lung Transplant (2010) 1.54
Carbon monoxide protects against hyperoxia-induced endothelial cell apoptosis by inhibiting reactive oxygen species formation. J Biol Chem (2006) 1.53
A nonproton ligand sensor in the acid-sensing ion channel. Neuron (2010) 1.52
Prediction of protein-RNA binding sites by a random forest method with combined features. Bioinformatics (2010) 1.52
Altered microRNA expression in patients with non-obstructive azoospermia. Reprod Biol Endocrinol (2009) 1.51
PharmMapper server: a web server for potential drug target identification using pharmacophore mapping approach. Nucleic Acids Res (2010) 1.50
Hedgehog signaling drives cellular survival in human colon carcinoma cells. Cancer Res (2010) 1.50
Composite tissue allograft transplantation of cephalocervical skin flap and two ears. Plast Reconstr Surg (2005) 1.47
The significance of bone marrow cell morphology and its correlation with cytogenetic features in the diagnosis of MDS-RA patients. Leuk Res (2009) 1.46
Structural basis for the regulation of cysteine-protease activity by a new class of protease inhibitors in Plasmodium. Structure (2011) 1.46
Insulin secretory deficiency and glucose intolerance in Rab3A null mice. J Biol Chem (2003) 1.46
Vertical stratification of microbial communities in the Red Sea revealed by 16S rDNA pyrosequencing. ISME J (2010) 1.45
The microtubule stabilizing agent laulimalide does not bind in the taxoid site, kills cells resistant to paclitaxel and epothilones, and may not require its epoxide moiety for activity. Biochemistry (2002) 1.45
Structural basis for processivity and single-strand specificity of RNase II. Mol Cell (2006) 1.44
On the origin of Lake Malawi cichlid species: a population genetic analysis of divergence. Proc Natl Acad Sci U S A (2005) 1.43
Scrub typhus in previously unrecognized areas of endemicity in China. J Clin Microbiol (2010) 1.41
Members of the PHO1 gene family show limited functional redundancy in phosphate transfer to the shoot, and are regulated by phosphate deficiency via distinct pathways. Plant J (2007) 1.39
Clinical significance of IL-18 gene over-expression in AML. Leuk Res (2002) 1.39
Interfacial chemistry of moisture-aged class II composite restorations. J Biomed Mater Res B Appl Biomater (2006) 1.38
Identification of metastasis-associated proteins involved in gallbladder carcinoma metastasis by proteomic analysis and functional exploration of chloride intracellular channel 1. Cancer Lett (2009) 1.38
Crystal structure of HAb18G/CD147: implications for immunoglobulin superfamily homophilic adhesion. J Biol Chem (2008) 1.38
Prediction of the tissue-specificity of selective estrogen receptor modulators by using a single biochemical method. Proc Natl Acad Sci U S A (2008) 1.38
Synthesis and herbicidal activity of novel alpha,alpha,alpha-trifluoro-m-tolyl pyridazinone derivatives. Pest Manag Sci (2006) 1.37
Blocking Hedgehog survival signaling at the level of the GLI genes induces DNA damage and extensive cell death in human colon carcinoma cells. Cancer Res (2011) 1.35
Identification of MCAM/CD146 as the target antigen of a human monoclonal antibody that recognizes both epithelioid and sarcomatoid types of mesothelioma. Cancer Res (2009) 1.34
Kank regulates RhoA-dependent formation of actin stress fibers and cell migration via 14-3-3 in PI3K-Akt signaling. J Cell Biol (2008) 1.32
Disease-aging network reveals significant roles of aging genes in connecting genetic diseases. PLoS Comput Biol (2009) 1.32
The electrophysiological cardiac ventricular substrate in patients after myocardial infarction: noninvasive characterization with electrocardiographic imaging. J Am Coll Cardiol (2011) 1.32
Effects of water content and initiator composition on photopolymerization of a model BisGMA/HEMA resin. Dent Mater (2007) 1.32
Ionizing radiation and busulfan inhibit murine bone marrow cell hematopoietic function via apoptosis-dependent and -independent mechanisms. Exp Hematol (2003) 1.31
A study of cycling induced degradation mechanisms in Si nanocrystal memory devices. Nanotechnology (2011) 1.30
A yeast two-hybrid technology-based system for the discovery of PPARgamma agonist and antagonist. Anal Biochem (2004) 1.29
Preparation and Properties of Novel Dentin Adhesives with Esterase Resistance. J Appl Polym Sci Symp (2007) 1.29
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