PubRank

David C Chan

Author PubWeight™ 121.20‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 2012 20.08
2 Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development. J Cell Biol 2003 10.10
3 Disruption of fusion results in mitochondrial heterogeneity and dysfunction. J Biol Chem 2005 7.30
4 Functions and dysfunctions of mitochondrial dynamics. Nat Rev Mol Cell Biol 2007 6.33
5 Mitochondrial dynamics--fusion, fission, movement, and mitophagy--in neurodegenerative diseases. Hum Mol Genet 2009 5.15
6 Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations. Cell 2010 5.14
7 Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy. Hum Mol Genet 2011 4.41
8 Mitochondrial fusion protects against neurodegeneration in the cerebellum. Cell 2007 4.30
9 OPA1 processing controls mitochondrial fusion and is regulated by mRNA splicing, membrane potential, and Yme1L. J Cell Biol 2007 4.28
10 Structural basis of mitochondrial tethering by mitofusin complexes. Science 2004 4.21
11 SLP-2 is required for stress-induced mitochondrial hyperfusion. EMBO J 2009 3.61
12 A common lipid links Mfn-mediated mitochondrial fusion and SNARE-regulated exocytosis. Nat Cell Biol 2006 3.56
13 Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosis. J Cell Biol 2004 3.55
14 Emerging functions of mammalian mitochondrial fusion and fission. Hum Mol Genet 2005 2.84
15 Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine. Nat Med 2012 2.51
16 Mitofusins and OPA1 mediate sequential steps in mitochondrial membrane fusion. Mol Biol Cell 2009 2.49
17 The WD40 protein Caf4p is a component of the mitochondrial fission machinery and recruits Dnm1p to mitochondria. J Cell Biol 2005 2.33
18 Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission. Mol Biol Cell 2013 2.21
19 Evidence for a mitochondrial regulatory pathway defined by peroxisome proliferator-activated receptor-gamma coactivator-1 alpha, estrogen-related receptor-alpha, and mitofusin 2. Diabetes 2006 1.91
20 The mitochondrial transcription and packaging factor Tfam imposes a U-turn on mitochondrial DNA. Nat Struct Mol Biol 2011 1.68
21 Critical dependence of neurons on mitochondrial dynamics. Curr Opin Cell Biol 2006 1.67
22 Physiological functions of mitochondrial fusion. Ann N Y Acad Sci 2010 1.66
23 Structural basis for recruitment of mitochondrial fission complexes by Fis1. Proc Natl Acad Sci U S A 2007 1.58
24 The prefusogenic intermediate of HIV-1 gp41 contains exposed C-peptide regions. J Biol Chem 2002 1.58
25 Mitochondrial dynamics in mammals. Curr Top Dev Biol 2004 1.53
26 Complementation between mouse Mfn1 and Mfn2 protects mitochondrial fusion defects caused by CMT2A disease mutations. J Cell Biol 2007 1.51
27 Improving safety and eliminating redundant tests: cutting costs in U.S. hospitals. Health Aff (Millwood) 2009 1.37
28 OPA1 disease alleles causing dominant optic atrophy have defects in cardiolipin-stimulated GTP hydrolysis and membrane tubulation. Hum Mol Genet 2010 1.30
29 Domain interactions within Fzo1 oligomers are essential for mitochondrial fusion. J Biol Chem 2006 1.21
30 Hindlimb gait defects due to motor axon loss and reduced distal muscles in a transgenic mouse model of Charcot-Marie-Tooth type 2A. Hum Mol Genet 2007 1.16
31 SIRT3 deacetylates and activates OPA1 to regulate mitochondrial dynamics during stress. Mol Cell Biol 2013 1.15
32 Loss of Mfn2 results in progressive, retrograde degeneration of dopaminergic neurons in the nigrostriatal circuit. Hum Mol Genet 2012 1.13
33 Mouse lines with photo-activatable mitochondria to study mitochondrial dynamics. Genesis 2012 1.07
34 New insights into mitochondrial fusion. FEBS Lett 2007 1.05
35 Molecular mechanism of mitochondrial membrane fusion. Biochim Biophys Acta 2006 1.02
36 Lysocardiolipin acyltransferase 1 (ALCAT1) controls mitochondrial DNA fidelity and biogenesis through modulation of MFN2 expression. Proc Natl Acad Sci U S A 2012 0.92
37 The fusion activity of HIV-1 gp41 depends on interhelical interactions. J Biol Chem 2005 0.90
38 Crystal structure of mitochondrial fission complex reveals scaffolding function for mitochondrial division 1 (Mdv1) coiled coil. J Biol Chem 2012 0.89
39 The impact of Massachusetts health care reform on access, quality, and costs of care for the already-insured. Health Serv Res 2014 0.89
40 Parkin uses the UPS to ship off dysfunctional mitochondria. Autophagy 2011 0.84
41 Genome-wide analysis reveals coating of the mitochondrial genome by TFAM. PLoS One 2013 0.83
42 piRNAs meet mitochondria. Dev Cell 2011 0.80
43 Crystal structure and functional analysis of MiD49, a receptor for the mitochondrial fission protein Drp1. Protein Sci 2015 0.77
44 Methods in Enzymology. Mitochondrial function. Preface. Methods Enzymol 2014 0.75