Postnatal neurogenesis as a therapeutic target in temporal lobe epilepsy.

PubWeight™: 0.98‹?› | Rank: Top 15%

🔗 View Article (PMC 2713813)

Published in Epilepsy Res on April 14, 2009

Authors

Helen E Scharfman1, Daniel P McCloskey

Author Affiliations

1: Center for Dementia Research, The Nathan Kline Institute, 140 Old Orangeburg Rd., Bldg. 35, Orangeburg, NY 10962, United States. hscharfman@nki.rfmh.org

Articles citing this

Heterogeneous integration of adult-generated granule cells into the epileptic brain. J Neurosci (2011) 1.26

New insights into the role of hilar ectopic granule cells in the dentate gyrus based on quantitative anatomic analysis and three-dimensional reconstruction. Epilepsia (2012) 1.01

Finding a better drug for epilepsy: antiepileptogenesis targets. Epilepsia (2012) 0.99

Shared cognitive and behavioral impairments in epilepsy and Alzheimer's disease and potential underlying mechanisms. Epilepsy Behav (2013) 0.98

Mechanisms regulating neuronal excitability and seizure development following mTOR pathway hyperactivation. Front Mol Neurosci (2014) 0.95

Morphometry of hilar ectopic granule cells in the rat. J Comp Neurol (2011) 0.92

The endogenous regenerative capacity of the damaged newborn brain: boosting neurogenesis with mesenchymal stem cell treatment. J Cereb Blood Flow Metab (2013) 0.87

MicroRNA-124 and -137 cooperativity controls caspase-3 activity through BCL2L13 in hippocampal neural stem cells. Sci Rep (2015) 0.86

Stress, glucocorticoid receptors, and adult neurogenesis: a balance between excitation and inhibition? Cell Mol Life Sci (2014) 0.86

Prospects of levetiracetam as a neuroprotective drug against status epilepticus, traumatic brain injury, and stroke. Front Neurol (2013) 0.86

The influence of ectopic migration of granule cells into the hilus on dentate gyrus-CA3 function. PLoS One (2013) 0.86

Epileptogenesis: can the science of epigenetics give us answers? Epilepsy Curr (2012) 0.85

Mitogen- and stress-activated kinases regulate progenitor cell proliferation and neuron development in the adult dentate gyrus. J Neurochem (2012) 0.85

Hippocampal injury-induced cognitive and mood dysfunction, altered neurogenesis, and epilepsy: can early neural stem cell grafting intervention provide protection? Epilepsy Behav (2014) 0.84

Seizure evoked regulation of LIM-HD genes and co-factors in the postnatal and adult hippocampus. F1000Res (2013) 0.82

Using sex differences in the developing brain to identify nodes of influence for seizure susceptibility and epileptogenesis. Neurobiol Dis (2014) 0.81

Methylmercury: a potential environmental risk factor contributing to epileptogenesis. Neurotoxicology (2011) 0.79

Caspase 3 involves in neuroplasticity, microglial activation and neurogenesis in the mice hippocampus after intracerebral injection of kainic acid. J Biomed Sci (2013) 0.79

Potential implications of a monosynaptic pathway from mossy cells to adult-born granule cells of the dentate gyrus. Front Syst Neurosci (2015) 0.78

Elucidating the Complex Interactions between Stress and Epileptogenic Pathways. Cardiovasc Psychiatry Neurol (2011) 0.77

Corruption of the dentate gyrus by "dominant" granule cells: Implications for dentate gyrus function in health and disease. Neurobiol Learn Mem (2015) 0.76

Neurogenic function in rats with unilateral hippocampal sclerosis that experienced early-life status epilepticus. Int J Physiol Pathophysiol Pharmacol (2014) 0.75

Neuroblast Distribution after Cortical Impact Is Influenced by White Matter Injury in the Immature Gyrencephalic Brain. Front Neurosci (2016) 0.75

Is plasticity of GABAergic mechanisms relevant to epileptogenesis? Adv Exp Med Biol (2014) 0.75

Mice with conditional NeuroD1 knockout display reduced aberrant hippocampal neurogenesis but no change in epileptic seizures. Exp Neurol (2017) 0.75

Articles cited by this

Multimodal fast optical interrogation of neural circuitry. Nature (2007) 14.68

Mechanisms and functional implications of adult neurogenesis. Cell (2008) 14.50

Functional neurogenesis in the adult hippocampus. Nature (2002) 11.17

GABA regulates synaptic integration of newly generated neurons in the adult brain. Nature (2005) 7.04

Enhanced synaptic plasticity in newly generated granule cells of the adult hippocampus. Nature (2004) 6.15

Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus. Proc Natl Acad Sci U S A (2006) 5.83

Milestones of neuronal development in the adult hippocampus. Trends Neurosci (2004) 5.80

Dentate granule cell neurogenesis is increased by seizures and contributes to aberrant network reorganization in the adult rat hippocampus. J Neurosci (1997) 5.78

Reactive astrocytes protect tissue and preserve function after spinal cord injury. J Neurosci (2004) 5.70

Astrocytes give rise to new neurons in the adult mammalian hippocampus. J Neurosci (2001) 5.66

PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice. Nat Neurosci (2008) 5.25

Early determination and long-term persistence of adult-generated new neurons in the hippocampus of mice. Development (2003) 4.49

Neurons born in the adult dentate gyrus form functional synapses with target cells. Nat Neurosci (2008) 4.01

Functional convergence of neurons generated in the developing and adult hippocampus. PLoS Biol (2006) 3.16

Outcomes of epilepsy surgery in adults and children. Lancet Neurol (2008) 2.67

Nonrandom connectivity of the epileptic dentate gyrus predicts a major role for neuronal hubs in seizures. Proc Natl Acad Sci U S A (2008) 2.56

Granule-like neurons at the hilar/CA3 border after status epilepticus and their synchrony with area CA3 pyramidal cells: functional implications of seizure-induced neurogenesis. J Neurosci (2000) 2.52

The dentate gyrus: fundamental neuroanatomical organization (dentate gyrus for dummies). Prog Brain Res (2007) 2.52

Is epilepsy a progressive disorder? Prospects for new therapeutic approaches in temporal-lobe epilepsy. Lancet Neurol (2002) 2.43

Environment matters: synaptic properties of neurons born in the epileptic adult brain develop to reduce excitability. Neuron (2006) 2.38

The chemokine SDF1 regulates migration of dentate granule cells. Development (2002) 2.34

GABA sets the tempo for activity-dependent adult neurogenesis. Trends Neurosci (2006) 2.23

Aberrant seizure-induced neurogenesis in experimental temporal lobe epilepsy. Ann Neurol (2006) 2.22

Apoptosis and proliferation of dentate gyrus neurons after single and intermittent limbic seizures. Proc Natl Acad Sci U S A (1997) 2.16

Seizure-associated, aberrant neurogenesis in adult rats characterized with retrovirus-mediated cell labeling. J Neurosci (2007) 2.09

Cortical inhibition modified by embryonic neural precursors grafted into the postnatal brain. J Neurosci (2006) 2.08

Unmasking recurrent excitation generated by mossy fiber sprouting in the epileptic dentate gyrus: an emergent property of a complex system. Prog Brain Res (2007) 2.04

Seizures accelerate functional integration of adult-generated granule cells. J Neurosci (2006) 1.96

Reversible silencing of neuronal excitability in behaving mice by a genetically targeted, ivermectin-gated Cl- channel. Neuron (2007) 1.95

Learning enhances the survival of new neurons beyond the time when the hippocampus is required for memory. J Neurosci (2004) 1.90

Traumatic brain injury-induced hippocampal neurogenesis requires activation of early nestin-expressing progenitors. J Neurosci (2008) 1.90

Development of hippocampal mossy fiber synaptic outputs by new neurons in the adult brain. Proc Natl Acad Sci U S A (2008) 1.90

Synaptic integration and plasticity of new neurons in the adult hippocampus. J Physiol (2008) 1.82

Epigenetic modulation of seizure-induced neurogenesis and cognitive decline. J Neurosci (2007) 1.77

Selective electrical silencing of mammalian neurons in vitro by the use of invertebrate ligand-gated chloride channels. J Neurosci (2002) 1.71

Pilocarpine-induced seizures cause selective time-dependent changes to adult-generated hippocampal dentate granule cells. J Neurosci (2007) 1.69

Status epilepticus-induced hilar basal dendrites on rodent granule cells contribute to recurrent excitatory circuitry. J Comp Neurol (2000) 1.55

Seizures induce proliferation and dispersion of doublecortin-positive hippocampal progenitor cells. Exp Neurol (2005) 1.47

Cyclooxygenase-2 inhibitor, celecoxib, inhibits the altered hippocampal neurogenesis with attenuation of spontaneous recurrent seizures following pilocarpine-induced status epilepticus. Neurobiol Dis (2006) 1.43

Inhibition of dentate granule cell neurogenesis with brain irradiation does not prevent seizure-induced mossy fiber synaptic reorganization in the rat. J Neurosci (1999) 1.42

Mossy fiber plasticity and enhanced hippocampal excitability, without hippocampal cell loss or altered neurogenesis, in an animal model of prolonged febrile seizures. Hippocampus (2003) 1.41

Seizure-induced neurogenesis: are more new neurons good for an adult brain? Prog Brain Res (2002) 1.41

Radiation response of neural precursor cells. Neurosurg Clin N Am (2007) 1.36

The role of the piriform cortex in kindling. Prog Neurobiol (1996) 1.35

Continuous cytosine-b-D-arabinofuranoside infusion reduces ectopic granule cells in adult rat hippocampus with attenuation of spontaneous recurrent seizures following pilocarpine-induced status epilepticus. Eur J Neurosci (2004) 1.34

Chronic temporal lobe epilepsy is associated with severely declined dentate neurogenesis in the adult hippocampus. Neurobiol Dis (2004) 1.33

In vivo intracellular analysis of granule cell axon reorganization in epileptic rats. J Neurophysiol (1999) 1.33

Stereological methods reveal the robust size and stability of ectopic hilar granule cells after pilocarpine-induced status epilepticus in the adult rat. Eur J Neurosci (2006) 1.32

Dentate granule cells form novel basal dendrites in a rat model of temporal lobe epilepsy. Neuroscience (1998) 1.30

Subcortical structures and pathways involved in convulsive seizure generation. J Clin Neurophysiol (1992) 1.29

Reelin regulates neuronal progenitor migration in intact and epileptic hippocampus. J Neurosci (2007) 1.27

Spontaneous recurrent seizures after pilocarpine-induced status epilepticus activate calbindin-immunoreactive hilar cells of the rat dentate gyrus. Neuroscience (2002) 1.25

Neurogenesis in the dentate gyrus of the rat following electroconvulsive shock seizures. Exp Neurol (2000) 1.24

Integration of newly born dentate granule cells into adult brains: hypotheses based on normal and epileptic rodents. Brain Res Brain Res Rev (2005) 1.24

Ectopic granule cells of the rat dentate gyrus. Dev Neurosci (2007) 1.23

Surviving granule cells of the sclerotic human hippocampus have reduced Ca(2+) influx because of a loss of calbindin-D(28k) in temporal lobe epilepsy. J Neurosci (2000) 1.22

Increased dentate granule cell neurogenesis following amygdala kindling in the adult rat. Neurosci Lett (1998) 1.22

Kainic acid increases the proliferation of granule cell progenitors in the dentate gyrus of the adult rat. Brain Res (1998) 1.18

Neuropeptide Y is neuroproliferative for post-natal hippocampal precursor cells. J Neurochem (2003) 1.18

Progression in mesial temporal lobe epilepsy. Ann Neurol (1999) 1.15

Mechanisms of epilepsy progression: current theories and perspectives from neuroplasticity in adulthood and development. Epilepsy Res (2004) 1.15

Relevance of seizure-induced neurogenesis in animal models of epilepsy to the etiology of temporal lobe epilepsy. Epilepsia (2007) 1.15

Hippocampal neurogenesis and neural stem cells in temporal lobe epilepsy. Epilepsy Behav (2008) 1.14

Mechanisms and functional significance of aberrant seizure-induced hippocampal neurogenesis. Epilepsia (2008) 1.13

Synaptic input to dentate granule cell basal dendrites in a rat model of temporal lobe epilepsy. J Comp Neurol (2008) 1.11

Functional implications of seizure-induced neurogenesis. Adv Exp Med Biol (2004) 1.09

Region-specific differentiation of embryonic stem cell-derived neural progenitor transplants into the adult mouse hippocampus following seizures. J Neurosci Res (2008) 1.07

Structural changes for adult-born dentate granule cells after status epilepticus. Epilepsia (2008) 1.04

Gene therapy in epilepsy: the focus on NPY. Peptides (2006) 1.04

Developing cell transplantation for temporal lobe epilepsy. Neurosurg Focus (2008) 1.03

Kindling-induced neurogenesis in the dentate gyrus of the rat. Neurosci Lett (1998) 1.01

Mapping seizure pathways in the temporal lobe. Epilepsia (2008) 1.00

Suppression of hippocampal neurogenesis is associated with developmental stage, number of perinatal seizure episodes, and glucocorticosteroid level. Exp Neurol (2003) 0.99

Newly generated dentate granule cells from epileptic rats exhibit elongated hilar basal dendrites that align along GFAP-immunolabeled processes. Neuroscience (2005) 0.99

Nestin promoter/enhancer directs transgene expression to precursors of adult generated periglomerular neurons. J Comp Neurol (2004) 0.99

The bumetanide-sensitive Na-K-2Cl cotransporter NKCC1 as a potential target of a novel mechanism-based treatment strategy for neonatal seizures. Neurosurg Focus (2008) 0.99

Newly generated granule cells show rapid neuroplastic changes in the adult rat dentate gyrus during the first five days following pilocarpine-induced seizures. Eur J Neurosci (2007) 0.97

Postnatal and adult neurogenesis in the development of human disease. Neuroscientist (2008) 0.96

Subventricular zone-derived, newly generated neurons populate several olfactory and limbic forebrain regions. Epilepsy Behav (2008) 0.95

GABAergic signalling to adult-generated neurons. J Physiol (2008) 0.95

Long-term decrease in calbindin-D28K expression in the hippocampus of epileptic rats following pilocarpine-induced status epilepticus. Epilepsy Res (2008) 0.95

The promise of gene therapy for the treatment of epilepsy. Expert Rev Neurother (2007) 0.94

Brain-derived neurotrophic factor and epilepsy--a missing link? Epilepsy Curr (2005) 0.94

Region-specific plasticity in the epileptic rat brain: a hippocampal and extrahippocampal analysis. Epilepsia (2008) 0.93

Targeting epileptogenesis-associated induction of neurogenesis by enzymatic depolysialylation of NCAM counteracts spatial learning dysfunction but fails to impact epilepsy development. J Neurochem (2008) 0.93

Dual role of Cajal-Retzius cells and reelin in cortical development. Cell Tissue Res (1997) 0.93

Calbindin-D28k immunoreactivity and selective vulnerability to ischemia in the dentate gyrus of the developing rat. Brain Res (1993) 0.87

Plasticity of neuropeptide Y in the dentate gyrus after seizures, and its relevance to seizure-induced neurogenesis. EXS (2006) 0.86

Ultrastructure and synaptic connectivity of cell types in the adult rat dentate gyrus. Prog Brain Res (2007) 0.85

Neurotrophins in the dentate gyrus. Prog Brain Res (2007) 0.85

Age-related naturally occurring depression of hippocampal neurogenesis does not affect trace fear conditioning. Hippocampus (2006) 0.84

Neuroplasticity in the damaged dentate gyrus of the epileptic brain. Prog Brain Res (2002) 0.84

Radiation of the rat brain suppresses seizure-induced neurogenesis and transiently enhances excitability during kindling acquisition. Epilepsia (2007) 0.82

Temporal profile of hilar basal dendrite formation on dentate granule cells after status epilepticus. Epilepsy Res (2003) 0.80

Could hippocampal neurogenesis be a future drug target for treating temporal lobe epilepsy? CNS Neurol Disord Drug Targets (2007) 0.79

Potential consequences of altered neurogenesis on learning and memory in the epileptic brain. Epilepsia (2008) 0.79

Influence of ionizing radiation on the course of kindled epileptogenesis. Brain Res (2006) 0.77

When newborn neurons stray. Epilepsy Curr (2005) 0.76