PubRank

George S Baillie

Author PubWeight™ 81.05‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling. Science 2005 5.20
2 Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins. Science 2002 3.46
3 cAMP-Specific phosphodiesterase-4 enzymes in the cardiovascular system: a molecular toolbox for generating compartmentalized cAMP signaling. Circ Res 2007 2.21
4 RNA silencing identifies PDE4D5 as the functionally relevant cAMP phosphodiesterase interacting with beta arrestin to control the protein kinase A/AKAP79-mediated switching of the beta2-adrenergic receptor to activation of ERK in HEK293B2 cells. J Biol Chem 2005 1.89
5 Long PDE4 cAMP specific phosphodiesterases are activated by protein kinase A-mediated phosphorylation of a single serine residue in Upstream Conserved Region 1 (UCR1). Br J Pharmacol 2002 1.85
6 Sleep deprivation impairs cAMP signalling in the hippocampus. Nature 2009 1.83
7 Mixed species biofilms of Candida albicans and Staphylococcus epidermidis. J Med Microbiol 2002 1.66
8 Mutations of beta-arrestin 2 that limit self-association also interfere with interactions with the beta2-adrenoceptor and the ERK1/2 MAPKs: implications for beta2-adrenoceptor signalling via the ERK1/2 MAPKs. Biochem J 2008 1.62
9 Protein kinase A type I and type II define distinct intracellular signaling compartments. Circ Res 2008 1.62
10 Inferring signaling pathway topologies from multiple perturbation measurements of specific biochemical species. Sci Signal 2010 1.54
11 Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ. Mol Cell 2011 1.52
12 Compartmentalization of cAMP-dependent signaling by phosphodiesterase-4D is involved in the regulation of vasopressin-mediated water reabsorption in renal principal cells. J Am Soc Nephrol 2006 1.50
13 Scanning peptide array analyses identify overlapping binding sites for the signalling scaffold proteins, beta-arrestin and RACK1, in cAMP-specific phosphodiesterase PDE4D5. Biochem J 2006 1.46
14 EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation. Proc Natl Acad Sci U S A 2008 1.43
15 Phosphorylation of RACK1 on tyrosine 52 by c-Abl is required for insulin-like growth factor I-mediated regulation of focal adhesion kinase. J Biol Chem 2009 1.33
16 p75 neurotrophin receptor regulates tissue fibrosis through inhibition of plasminogen activation via a PDE4/cAMP/PKA pathway. J Cell Biol 2007 1.30
17 Attenuation of the activity of the cAMP-specific phosphodiesterase PDE4A5 by interaction with the immunophilin XAP2. J Biol Chem 2003 1.27
18 Structure-function analysis of core STRIPAK Proteins: a signaling complex implicated in Golgi polarization. J Biol Chem 2011 1.26
19 Tyrosine 302 in RACK1 is essential for insulin-like growth factor-I-mediated competitive binding of PP2A and beta1 integrin and for tumor cell proliferation and migration. J Biol Chem 2008 1.19
20 Small molecule AKAP-protein kinase A (PKA) interaction disruptors that activate PKA interfere with compartmentalized cAMP signaling in cardiac myocytes. J Biol Chem 2010 1.18
21 The structure of the human RNase H2 complex defines key interaction interfaces relevant to enzyme function and human disease. J Biol Chem 2010 1.17
22 The unique amino-terminal region of the PDE4D5 cAMP phosphodiesterase isoform confers preferential interaction with beta-arrestins. J Biol Chem 2003 1.17
23 The cardiac IKs potassium channel macromolecular complex includes the phosphodiesterase PDE4D3. J Biol Chem 2009 1.16
24 Cyclic AMP phosphodiesterase 4D (PDE4D) Tethers EPAC1 in a vascular endothelial cadherin (VE-Cad)-based signaling complex and controls cAMP-mediated vascular permeability. J Biol Chem 2010 1.10
25 Mdm2 directs the ubiquitination of beta-arrestin-sequestered cAMP phosphodiesterase-4D5. J Biol Chem 2009 1.09
26 Remodelling of the PDE4 cAMP phosphodiesterase isoform profile upon monocyte-macrophage differentiation of human U937 cells. Br J Pharmacol 2004 1.04
27 MEK1 binds directly to betaarrestin1, influencing both its phosphorylation by ERK and the timing of its isoprenaline-stimulated internalization. J Biol Chem 2009 1.02
28 Cross talk between phosphatidylinositol 3-kinase and cyclic AMP (cAMP)-protein kinase a signaling pathways at the level of a protein kinase B/beta-arrestin/cAMP phosphodiesterase 4 complex. Mol Cell Biol 2010 1.01
29 Differential expression of PDE4 cAMP phosphodiesterase isoforms in inflammatory cells of smokers with COPD, smokers without COPD, and nonsmokers. Am J Physiol Lung Cell Mol Physiol 2004 1.01
30 The A-kinase-anchoring protein AKAP-Lbc facilitates cardioprotective PKA phosphorylation of Hsp20 on Ser(16). Biochem J 2012 1.01
31 Dynamic regulation, desensitization, and cross-talk in discrete subcellular microdomains during beta2-adrenoceptor and prostanoid receptor cAMP signaling. J Biol Chem 2007 1.01
32 cAMP: novel concepts in compartmentalised signalling. Semin Cell Dev Biol 2011 0.99
33 Distinct functional outputs of PTEN signalling are controlled by dynamic association with β-arrestins. EMBO J 2011 0.97
34 Spatial organisation of AKAP18 and PDE4 isoforms in renal collecting duct principal cells. Eur J Cell Biol 2006 0.96
35 Reciprocal regulation of PKA and Rac signaling. Proc Natl Acad Sci U S A 2013 0.95
36 1H NMR structural and functional characterisation of a cAMP-specific phosphodiesterase-4D5 (PDE4D5) N-terminal region peptide that disrupts PDE4D5 interaction with the signalling scaffold proteins, beta-arrestin and RACK1. Cell Signal 2007 0.95
37 PDE4B5, a novel, super-short, brain-specific cAMP phosphodiesterase-4 variant whose isoform-specifying N-terminal region is identical to that of cAMP phosphodiesterase-4D6 (PDE4D6). J Pharmacol Exp Ther 2007 0.95
38 Gravin orchestrates protein kinase A and β2-adrenergic receptor signaling critical for synaptic plasticity and memory. J Neurosci 2012 0.94
39 Phosphodiesterase-8A binds to and regulates Raf-1 kinase. Proc Natl Acad Sci U S A 2013 0.93
40 Ndel1 alters its conformation by sequestering cAMP-specific phosphodiesterase-4D3 (PDE4D3) in a manner that is dynamically regulated through Protein Kinase A (PKA). Cell Signal 2008 0.91
41 Selective SUMO modification of cAMP-specific phosphodiesterase-4D5 (PDE4D5) regulates the functional consequences of phosphorylation by PKA and ERK. Biochem J 2010 0.91
42 Phosphodiesterase-4 influences the PKA phosphorylation status and membrane translocation of G-protein receptor kinase 2 (GRK2) in HEK-293beta2 cells and cardiac myocytes. Biochem J 2006 0.91
43 Inferring signaling pathway topologies from multiple perturbation measurements of specific biochemical species. Sci Signal 2010 0.91
44 A phosphodiesterase 3B-based signaling complex integrates exchange protein activated by cAMP 1 and phosphatidylinositol 3-kinase signals in human arterial endothelial cells. J Biol Chem 2011 0.90
45 Elucidation of a structural basis for the inhibitor-driven, p62 (SQSTM1)-dependent intracellular redistribution of cAMP phosphodiesterase-4A4 (PDE4A4). J Med Chem 2011 0.90
46 PKA phosphorylation of the small heat-shock protein Hsp20 enhances its cardioprotective effects. Biochem Soc Trans 2012 0.90
47 Chemoresistant KM12C colon cancer cells are addicted to low cyclic AMP levels in a phosphodiesterase 4-regulated compartment via effects on phosphoinositide 3-kinase. Cancer Res 2007 0.90
48 RACK1 to the future--a historical perspective. Cell Commun Signal 2013 0.90
49 Occupancy of the catalytic site of the PDE4A4 cyclic AMP phosphodiesterase by rolipram triggers the dynamic redistribution of this specific isoform in living cells through a cyclic AMP independent process. Cell Signal 2003 0.88
50 Reduced PDE4 expression and activity contributes to enhanced catecholamine-induced cAMP accumulation in adipocytes from FOXC2 transgenic mice. FEBS Lett 2006 0.88
51 A scanning peptide array approach uncovers association sites within the JNK/beta arrestin signalling complex. FEBS Lett 2009 0.88
52 Targeting protein-protein interactions within the cyclic AMP signaling system as a therapeutic strategy for cardiovascular disease. Future Med Chem 2013 0.87
53 Phosphorylation of cAMP-specific PDE4A5 (phosphodiesterase-4A5) by MK2 (MAPKAPK2) attenuates its activation through protein kinase A phosphorylation. Biochem J 2011 0.87
54 Cyclic AMP-specific phosphodiesterase, PDE8A1, is activated by protein kinase A-mediated phosphorylation. FEBS Lett 2012 0.85
55 Molecular cloning and subcellular distribution of the novel PDE4B4 cAMP-specific phosphodiesterase isoform. Biochem J 2003 0.85
56 Evolutionarily conserved role of calcineurin in phosphodegron-dependent degradation of phosphodiesterase 4D. Mol Cell Biol 2010 0.84
57 Interaction with receptor for activated C-kinase 1 (RACK1) sensitizes the phosphodiesterase PDE4D5 towards hydrolysis of cAMP and activation by protein kinase C. Biochem J 2010 0.84
58 p62 (SQSTM1) and cyclic AMP phosphodiesterase-4A4 (PDE4A4) locate to a novel, reversible protein aggregate with links to autophagy and proteasome degradation pathways. Cell Signal 2010 0.83
59 Expression, intracellular distribution and basis for lack of catalytic activity of the PDE4A7 isoform encoded by the human PDE4A cAMP-specific phosphodiesterase gene. Biochem J 2004 0.82
60 Real-time probing of β-amyloid self-assembly and inhibition using fluorescence self-quenching between neighbouring dyes. Mol Biosyst 2013 0.82
61 Investigation of extracellular signal-regulated kinase 2 mitogen-activated protein kinase phosphorylation and regulation of activity of PDE4 cyclic adenosine monophosphate-specific phosphodiesterases. Methods Mol Biol 2005 0.81
62 In cardiac myocytes, cAMP elevation triggers the down-regulation of transcripts and promoter activity for cyclic AMP phosphodiesterase-4A10 (PDE4A10). Cell Signal 2008 0.81
63 Human PDE4A8, a novel brain-expressed PDE4 cAMP-specific phosphodiesterase that has undergone rapid evolutionary change. Biochem J 2008 0.79
64 Chemical informatics uncovers a new role for moexipril as a novel inhibitor of cAMP phosphodiesterase-4 (PDE4). Biochem Pharmacol 2013 0.79
65 Can acetylcholinesterase activity be considered as a reliable biomarker for the assessment of cadmium-induced neurotoxicity? Food Chem Toxicol 2013 0.78
66 Identification and characterization of small-molecule ligands that maintain pluripotency of human embryonic stem cells. Biochem Soc Trans 2010 0.77
67 Erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) blocks differentiation and maintains the expression of pluripotency markers in human embryonic stem cells. Biochem J 2010 0.76
68 Protein kinase D in the hypertrophy pathway. Biochem Soc Trans 2012 0.76
69 The extent and the nature of the cholinergic contribution to the hepatic encephalopathy-induced cognitive impairment. Free Radic Biol Med 2013 0.75
70 Evaluating the suitability of postnuclear supernatants as in vitro models for assessing cadmium- and other xenobiotic-induced neurotoxicity on crucial enzymatic parameters. Biol Trace Elem Res 2013 0.75
71 Specific Inhibition of Phosphodiesterase-4B Results in Anxiolysis and Facilitates Memory Acquisition. Neuropsychopharmacology 2017 0.75
72 OS 15-08 Ang(1-7) INFLUENCES ET-1 SIGNALING THROUGH MAS: ETBR INTERACTIONS: IMPLICATIONS IN PULMONARY HYPERTENSION. J Hypertens 2016 0.75
73 Perihaematomal cytokine expression is a crucial component of intracerebral haemorrhage pathophysiology. Neurol Sci 2014 0.75
74 JS ISH-ECCR-2 ANG-(1-7) AND ET-1, A NEW PARTNERSHIP. J Hypertens 2016 0.75
75 Arrestin-dependent localization of phosphodiesterases. Handb Exp Pharmacol 2014 0.75
76 Arrestin regulation of small GTPases. Handb Exp Pharmacol 2014 0.75
77 JS ISH-ECCR-2 ANG-(1-7) AND ET-1, A NEW PARTNERSHIP. J Hypertens 2016 0.75
78 Withdrawal: Mdm2 directs the ubiquitination of β-arrestin-sequestered cAMP phosphodiesterase-4D5. J Biol Chem 2020 0.75
79 OS 15-08 Ang(1-7) INFLUENCES ET-1 SIGNALING THROUGH MAS: ETBR INTERACTIONS: IMPLICATIONS IN PULMONARY HYPERTENSION. J Hypertens 2016 0.75