Serotonin transporter polymorphisms, microstructural white matter abnormalities and remission of geriatric depression.

PubWeight™: 0.93‹?›

🔗 View Article (PMC 2796561)

Published in J Affect Disord on April 17, 2009

Authors

George S Alexopoulos1, Christopher F Murphy, Faith M Gunning-Dixon, Charles E Glatt, Vassilios Latoussakis, Robert E Kelly, Dora Kanellopoulos, Sibel Klimstra, Kelvin O Lim, Robert C Young, Matthew J Hoptman

Author Affiliations

1: Weill Cornell Medical College, Weill-Cornell Institute of Geriatric Psychiatry, United States. gsalexop@med.cornell.edu

Articles citing this

The vascular depression hypothesis: mechanisms linking vascular disease with depression. Mol Psychiatry (2013) 2.17

Functional connectivity in the cognitive control network and the default mode network in late-life depression. J Affect Disord (2012) 1.48

Functional connectivity in apathy of late-life depression: a preliminary study. J Affect Disord (2012) 1.17

Biomarkers to predict antidepressant response. Curr Psychiatry Rep (2010) 1.14

Research advances in geriatric depression. World Psychiatry (2009) 1.03

One-year change in anterior cingulate cortex white matter microstructure: relationship with late-life depression outcomes. Am J Geriatr Psychiatry (2011) 0.95

Mechanisms of antidepressant resistance. Front Pharmacol (2013) 0.92

Effects of the BDNF Val66Met polymorphism on white matter microstructure in healthy adults. Neuropsychopharmacology (2012) 0.90

Subcortical biophysical abnormalities in patients with mood disorders. Mol Psychiatry (2013) 0.84

Cognitive deficits in geriatric depression: clinical correlates and implications for current and future treatment. Psychiatr Clin North Am (2013) 0.83

Delineation of early and later adult onset depression by diffusion tensor imaging. PLoS One (2014) 0.80

Social subordination stress and serotonin transporter polymorphisms: associations with brain white matter tract integrity and behavior in juvenile female macaques. Cereb Cortex (2013) 0.79

Gene-environment interactions in geriatric depression. Psychiatr Clin North Am (2011) 0.79

Biological predictors of pharmacological therapy in anxiety disorders. Dialogues Clin Neurosci (2015) 0.76

SLC6A4 polymorphisms and age of onset in late-life depression on treatment outcomes with citalopram: a Sequenced Treatment Alternatives to Relieve Depression (STAR*D) report. Am J Geriatr Psychiatry (2013) 0.75

White matter abnormalities: Insights into the pathophysiology of major affective disorders. World J Radiol (2014) 0.75

Articles cited by this

"Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res (1975) 301.74

A rating scale for depression. J Neurol Neurosurg Psychiatry (1960) 90.89

Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science (2003) 28.61

Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data. Neuroimage (2006) 23.57

Controlling the false discovery rate in behavior genetics research. Behav Brain Res (2001) 21.82

Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science (1996) 16.04

Probability of stroke: a risk profile from the Framingham Study. Stroke (1991) 10.14

5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression. Nat Neurosci (2005) 10.13

A probabilistic atlas of the human brain: theory and rationale for its development. The International Consortium for Brain Mapping (ICBM). Neuroimage (1995) 8.46

Reciprocal limbic-cortical function and negative mood: converging PET findings in depression and normal sadness. Am J Psychiatry (1999) 7.87

Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. Am J Hum Genet (2006) 6.27

Escitalopram and problem-solving therapy for prevention of poststroke depression: a randomized controlled trial. JAMA (2008) 5.96

Depression in the elderly. Lancet (2005) 5.78

Serotonin transporter (5-HTTLPR) genotype and amygdala activation: a meta-analysis. Biol Psychiatry (2007) 4.71

Cingulate function in depression: a potential predictor of treatment response. Neuroreport (1997) 4.48

An expanded evaluation of the relationship of four alleles to the level of response to alcohol and the alcoholism risk. Alcohol Clin Exp Res (2005) 3.94

Neuroimaging studies of mood disorders. Biol Psychiatry (2000) 3.92

Simultaneous genotyping of four functional loci of human SLC6A4, with a reappraisal of 5-HTTLPR and rs25531. Mol Psychiatry (2006) 3.73

Association of a triallelic serotonin transporter gene promoter region (5-HTTLPR) polymorphism with stressful life events and severity of depression. Am J Psychiatry (2006) 3.44

Modulation of cortical-limbic pathways in major depression: treatment-specific effects of cognitive behavior therapy. Arch Gen Psychiatry (2004) 3.33

Polymorphism in serotonin transporter gene associated with susceptibility to major depression. Lancet (1996) 2.92

Major depressive disorder: a prospective study of residual subthreshold depressive symptoms as predictor of rapid relapse. J Affect Disord (1998) 2.75

Estimated 10-year stroke risk by region and race in the United States: geographic and racial differences in stroke risk. Ann Neurol (2008) 2.68

Microstructural white matter abnormalities and remission of geriatric depression. Am J Psychiatry (2008) 2.53

The human serotonin transporter gene linked polymorphism (5-HTTLPR) shows ten novel allelic variants. Mol Psychiatry (2000) 2.46

Imaging genetics: perspectives from studies of genetically driven variation in serotonin function and corticolimbic affective processing. Biol Psychiatry (2006) 2.29

Applications of diffusion-weighted and diffusion tensor MRI to white matter diseases - a review. NMR Biomed (2002) 2.27

Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets. Am J Med Genet (1999) 2.16

Relationship between white matter fractional anisotropy and other indices of cerebral health in normal aging: tract-based spatial statistics study of aging. Neuroimage (2006) 2.09

Frontal white matter microstructure and treatment response of late-life depression: a preliminary study. Am J Psychiatry (2002) 2.00

Serotonin-related gene polymorphisms and central nervous system serotonin function. Neuropsychopharmacology (2002) 1.96

Lower serotonin transporter binding potential in the human brain during major depressive episodes. Am J Psychiatry (2006) 1.96

Influence of serotonin transporter gene polymorphism on depressive symptoms and new cardiac events after acute myocardial infarction. Am Heart J (2005) 1.86

Role of the serotonergic system in the pathogenesis of major depression and suicidal behavior. Neuropsychopharmacology (1999) 1.61

How the serotonin story is being rewritten by new gene-based discoveries principally related to SLC6A4, the serotonin transporter gene, which functions to influence all cellular serotonin systems. Neuropharmacology (2008) 1.56

Analysis of association between the serotonin transporter and antidepressant response in a large clinical sample. Biol Psychiatry (2006) 1.49

Allelic variation in the serotonin transporter promoter affects onset of paroxetine treatment response in late-life depression. Neuropsychopharmacology (2000) 1.45

Serotonin transporter polymorphism, memory and hippocampal volume in the elderly: association and interaction with cortisol. Mol Psychiatry (2007) 1.40

Serotonin and hippocampal neurogenesis. Neuropsychopharmacology (1999) 1.36

Is subcortical disease associated with a poor response to antidepressants? Neurological, neuropsychological and neuroradiological findings in late-life depression. Psychol Med (1998) 1.35

Frontal white matter anisotropy and symptom severity of late-life depression: a magnetic resonance diffusion tensor imaging study. J Neurol Neurosurg Psychiatry (2006) 1.34

Decreased regional brain metabolism after ect. Am J Psychiatry (2001) 1.33

Effects of serotonin transporter promoter polymorphisms on serotonin function. Neuropsychopharmacology (2004) 1.21

Serotonin transporter gene status predicts caudate nucleus but not amygdala or hippocampal volumes in older persons with major depression. J Affect Disord (2006) 1.13

Thresholding in correlation analyses of magnetic resonance functional neuroimaging. Magn Reson Imaging (2003) 1.13

Macromolecular white matter abnormalities in geriatric depression: a magnetization transfer imaging study. Am J Geriatr Psychiatry (2008) 1.13

Evaluation of platelet activation in depressed patients with ischemic heart disease after paroxetine or nortriptyline treatment. J Clin Psychopharmacol (2000) 1.09

Cerebral glucose metabolic response to combined total sleep deprivation and antidepressant treatment in geriatric depression. Am J Psychiatry (1999) 1.08

Brain morphometry using diffusion-weighted magnetic resonance imaging: application to schizophrenia. Neuroreport (2005) 1.08

Serotonin transporter promoter polymorphism in African Americans : allele frequencies and implications for treatment. Am J Pharmacogenomics (2003) 1.05

5-HTTLPR polymorphism of the serotonin transporter gene predicts non-remission in major depression patients treated with citalopram in a 12-weeks follow up study. J Clin Psychopharmacol (2003) 1.03

Biophysical changes in normal-appearing white matter and subcortical nuclei in late-life major depression detected using magnetization transfer. Psychiatry Res (2004) 1.01

Acute and chronic effects of citalopram on cerebral glucose metabolism in geriatric depression. Am J Geriatr Psychiatry (2002) 0.99

Biological and social predictors of long-term geriatric depression outcome. Int Psychogeriatr (2005) 0.95

Serotonin transporter promoter polymorphism is associated with attenuated prolactin response to fenfluramine. Am J Med Genet (2001) 0.95

Short/long heterozygotes at 5HTTLPR and white matter lesions in geriatric depression. Int J Geriatr Psychiatry (2008) 0.94

Virchow-Robin space dilatation may predict resistance to antidepressant monotherapy in elderly patients with depression. J Affect Disord (2006) 0.91

The relationship of MRI subcortical hyperintensities to treatment response in a trial of sertraline in geriatric depressed outpatients. Am J Geriatr Psychiatry (2002) 0.91

Selective serotonin reuptake inhibitors for late-life depression: a comparative review. Drugs Aging (2001) 0.89

Antidepressant therapy in post-stroke depression. Expert Opin Pharmacother (2008) 0.87

Effect of the selective serotonin reuptake inhibitor paroxetine on platelet function is modified by a SLC6A4 serotonin transporter polymorphism. J Thromb Haemost (2008) 0.86

Association of the serotonin transporter gene with serum cholesterol levels and heart disease. Mol Genet Metab (1999) 0.84

The serotonin transporter gene and effectiveness of SSRIs. Expert Rev Neurother (2008) 0.82

Antidepressant treatment and worsening white matter on serial cranial magnetic resonance imaging in the elderly: the Cardiovascular Health Study. Stroke (2008) 0.78

Articles by these authors

Toward discovery science of human brain function. Proc Natl Acad Sci U S A (2010) 15.22

A genetic variant BDNF polymorphism alters extinction learning in both mouse and human. Science (2010) 3.61

Randomized phase III trial of three versus six cycles of adjuvant carboplatin and paclitaxel in early stage epithelial ovarian carcinoma: a Gynecologic Oncology Group study. Gynecol Oncol (2006) 3.39

Quantitative comparison of algorithms for inter-subject registration of 3D volumetric brain MRI scans. J Neurosci Methods (2005) 3.32

Depression and Bipolar Support Alliance consensus statement on the unmet needs in diagnosis and treatment of mood disorders in late life. Arch Gen Psychiatry (2003) 2.70

Test-retest and between-site reliability in a multicenter fMRI study. Hum Brain Mapp (2008) 2.63

Executive dysfunction and the course of geriatric depression. Biol Psychiatry (2005) 2.56

Microstructural white matter abnormalities and remission of geriatric depression. Am J Psychiatry (2008) 2.53

Dysregulation of working memory and default-mode networks in schizophrenia using independent component analysis, an fBIRN and MCIC study. Hum Brain Mapp (2009) 2.28

Early-stage visual processing and cortical amplification deficits in schizophrenia. Arch Gen Psychiatry (2005) 2.25

The NKI-Rockland Sample: A Model for Accelerating the Pace of Discovery Science in Psychiatry. Front Neurosci (2012) 2.12

MRI study of white matter diffusion anisotropy in schizophrenia. Neuroreport (2003) 2.04

Problem-solving therapy and supportive therapy in older adults with major depression and executive dysfunction: effect on disability. Arch Gen Psychiatry (2011) 2.00

Frontal white matter microstructure and treatment response of late-life depression: a preliminary study. Am J Psychiatry (2002) 2.00

Function biomedical informatics research network recommendations for prospective multicenter functional MRI studies. J Magn Reson Imaging (2012) 1.86

Visual inspection of independent components: defining a procedure for artifact removal from fMRI data. J Neurosci Methods (2010) 1.84

Experience and modification update for the minimally invasive Nuss technique for pectus excavatum repair in 303 patients. J Pediatr Surg (2002) 1.82

Altered resting state complexity in schizophrenia. Neuroimage (2011) 1.81

Altered functional and anatomical connectivity in schizophrenia. Schizophr Bull (2009) 1.79

Advances in white matter imaging: a review of in vivo magnetic resonance methodologies and their applicability to the study of development and aging. Neurosci Biobehav Rev (2006) 1.77

Altered fear learning across development in both mouse and human. Proc Natl Acad Sci U S A (2012) 1.77

Problem-solving therapy and supportive therapy in older adults with major depression and executive dysfunction. Am J Psychiatry (2010) 1.76

A preliminary study of functional connectivity in comorbid adolescent depression. Neurosci Lett (2009) 1.74

Diffusion tensor imaging identifies deficits in white matter microstructure in subjects with type 1 diabetes that correlate with reduced neurocognitive function. Diabetes (2008) 1.74

Clinical presentation of the "depression-executive dysfunction syndrome" of late life. Am J Geriatr Psychiatry (2002) 1.73

White matter integrity predicts delay discounting behavior in 9- to 23-year-olds: a diffusion tensor imaging study. J Cogn Neurosci (2009) 1.72

Clinical and neuropsychological correlates of white matter abnormalities in recent onset schizophrenia. Neuropsychopharmacology (2007) 1.70

Patients' depression treatment preferences and initiation, adherence, and outcome: a randomized primary care study. Psychiatr Serv (2009) 1.70

Neurocognitive correlates of the COMT Val(158)Met polymorphism in chronic schizophrenia. Biol Psychiatry (2002) 1.66

Frontal white matter microstructure, aggression, and impulsivity in men with schizophrenia: a preliminary study. Biol Psychiatry (2002) 1.62

Chest wall anomalies: pectus excavatum and pectus carinatum. Adolesc Med Clin (2004) 1.62

The neural substrates of impaired prosodic detection in schizophrenia and its sensorial antecedents. Am J Psychiatry (2007) 1.61

Diffusion tensor imaging in psychiatric disorders. Top Magn Reson Imaging (2008) 1.60

White matter abnormalities in first-episode schizophrenia or schizoaffective disorder: a diffusion tensor imaging study. Am J Psychiatry (2005) 1.56

Diffusion tensor imaging of frontal white matter microstructure in early Alzheimer's disease: a preliminary study. J Geriatr Psychiatry Neurol (2005) 1.54

Proton echo-planar spectroscopic imaging of J-coupled resonances in human brain at 3 and 4 Tesla. Magn Reson Med (2007) 1.53

Altered white matter microstructure in adolescents with major depression: a preliminary study. J Am Acad Child Adolesc Psychiatry (2010) 1.52

White matter abnormalities in obsessive-compulsive disorder: a diffusion tensor imaging study. Arch Gen Psychiatry (2005) 1.49

Functional connectivity in the cognitive control network and the default mode network in late-life depression. J Affect Disord (2012) 1.48

Toward individualized post-electroconvulsive therapy care: piloting the Symptom-Titrated, Algorithm-Based Longitudinal ECT (STABLE) intervention. J ECT (2008) 1.47

Neurocognitive and neuroimaging correlates of pediatric traumatic brain injury: a diffusion tensor imaging (DTI) study. Arch Clin Neuropsychol (2007) 1.47

The development of corpus callosum microstructure and associations with bimanual task performance in healthy adolescents. Neuroimage (2007) 1.43

DTI and impulsivity in schizophrenia: a first voxelwise correlational analysis. Neuroreport (2004) 1.38

Tuning in to the voices: a multisite FMRI study of auditory hallucinations. Schizophr Bull (2008) 1.38

Diffusion tensor imaging in fixed brain tissue at 7.0 T. NMR Biomed (2003) 1.38

Brain structural abnormalities in psychotropic drug-naive pediatric patients with obsessive-compulsive disorder. Am J Psychiatry (2004) 1.35

White-matter integrity predicts stroop performance in patients with geriatric depression. Biol Psychiatry (2006) 1.32

Prognostic factors for high-risk early-stage epithelial ovarian cancer: a Gynecologic Oncology Group study. Cancer (2008) 1.30

Prefrontal cortical changes following cognitive training in patients with chronic schizophrenia: effects of practice, generalization, and specificity. Neuropsychopharmacology (2010) 1.30

Inferior frontal white matter anisotropy and negative symptoms of schizophrenia: a diffusion tensor imaging study. Am J Psychiatry (2003) 1.28

Differential fractional anisotropy abnormalities in adolescents with ADHD or schizophrenia. Psychiatry Res (2010) 1.27

Diffusion tensor imaging in children with fetal alcohol spectrum disorders. Alcohol Clin Exp Res (2006) 1.27

Early sensory contributions to contextual encoding deficits in schizophrenia. Arch Gen Psychiatry (2011) 1.26

Frontal hyperconnectivity related to discounting and reversal learning in cocaine subjects. Biol Psychiatry (2011) 1.26

Global white matter abnormalities in schizophrenia: a multisite diffusion tensor imaging study. Schizophr Bull (2009) 1.25

Evidence of disrupted functional connectivity in the brain after combat-related blast injury. Neuroimage (2010) 1.24

Abnormal white matter integrity in healthy apolipoprotein E epsilon4 carriers. Neuroreport (2005) 1.21

Brain region and sex differences in age association with brain volume: a quantitative MRI study of healthy young adults. Am J Geriatr Psychiatry (2002) 1.21

Family study of the inheritance of pectus excavatum. J Pediatr Surg (2006) 1.19

Functional connectivity in apathy of late-life depression: a preliminary study. J Affect Disord (2012) 1.17

Functional magnetic resonance imaging of brain activity in the visual oddball task. Brain Res Cogn Brain Res (2002) 1.17

Diffuse and spatially variable white matter disruptions are associated with blast-related mild traumatic brain injury. Neuroimage (2011) 1.17

Magnetic resonance field strength effects on diffusion measures and brain connectivity networks. Brain Connect (2013) 1.16

Disruption of hippocampal connectivity in children and adolescents with schizophrenia--a voxel-based diffusion tensor imaging study. Schizophr Res (2006) 1.15

The MCIC collection: a shared repository of multi-modal, multi-site brain image data from a clinical investigation of schizophrenia. Neuroinformatics (2013) 1.14

Macromolecular white matter abnormalities in geriatric depression: a magnetization transfer imaging study. Am J Geriatr Psychiatry (2008) 1.13

Serotonin transporter polyadenylation polymorphism modulates the retention of fear extinction memory. Proc Natl Acad Sci U S A (2012) 1.12

Classification of the dysmorphology of pectus excavatum. J Pediatr Surg (2006) 1.12

High connectivity between reduced cortical thickness and disrupted white matter tracts in long-standing type 1 diabetes. Diabetes (2010) 1.11

A comparison of clinical ratings with vocal acoustic measures of flat affect and alogia. J Psychiatr Res (2002) 1.11

Problem solving therapy for the depression-executive dysfunction syndrome of late life. Int J Geriatr Psychiatry (2008) 1.10

Impact of pectus excavatum on pulmonary function before and after repair with the Nuss procedure. J Pediatr Surg (2005) 1.09

Associations between p53 overexpression and multiple measures of clinical outcome in high-risk, early stage or suboptimally-resected, advanced stage epithelial ovarian cancers A Gynecologic Oncology Group study. Gynecol Oncol (2008) 1.09

Cerebral and muscle MRI abnormalities in myotonic dystrophy. Neuromuscul Disord (2012) 1.08