Propofol: neuroprotection in an in vitro model of traumatic brain injury.

Argon: neuroprotection in in vitro models of cerebral ischemia and traumatic brain injury. Crit Care (2009) 1.40

The spectrum of neurobehavioral sequelae after repetitive mild traumatic brain injury: a novel mouse model of chronic traumatic encephalopathy. J Neurotrauma (2014) 1.12

Dexmedetomidine is neuroprotective in an in vitro model for traumatic brain injury. BMC Neurol (2012) 1.05

Anesthetic propofol attenuates the isoflurane-induced caspase-3 activation and Aβ oligomerization. PLoS One (2011) 0.98

Neuroprotective properties of levosimendan in an in vitro model of traumatic brain injury. BMC Neurol (2010) 0.86

Therapeutic hypothermia as a neuroprotective strategy in neonatal hypoxic-ischemic brain injury and traumatic brain injury. Curr Mol Med (2012) 0.86

Dexmedetomidine attenuates repeated propofol exposure-induced hippocampal apoptosis, PI3K/Akt/Gsk-3β signaling disruption, and juvenile cognitive deficits in neonatal rats. Mol Med Rep (2016) 0.82

Expression analysis of the early chemokine response 4 h after in vitro traumatic brain injury. Inflamm Res (2010) 0.82

Propofol and magnesium attenuate isoflurane-induced caspase-3 activation via inhibiting mitochondrial permeability transition pore. Med Gas Res (2012) 0.82

Chronic treatment with anesthetic propofol improves cognitive function and attenuates caspase activation in both aged and Alzheimer's disease transgenic mice. J Alzheimers Dis (2014) 0.80

Anesthetic Propofol Attenuates Apoptosis, Aβ Accumulation, and Inflammation Induced by Sevoflurane Through NF-κB Pathway in Human Neuroglioma Cells. Cell Mol Neurobiol (2015) 0.78

Propofol Decreases Endoplasmic Reticulum Stress-Mediated Apoptosis in Retinal Pigment Epithelial Cells. PLoS One (2016) 0.78

Effects of blast overpressure on neurons and glial cells in rat organotypic hippocampal slice cultures. Front Neurol (2015) 0.77

Chronic treatment with anesthetic propofol attenuates β-amyloid protein levels in brain tissues of aged mice. Transl Neurodegener (2014) 0.77

Desflurane impairs outcome of organotypic hippocampal slices in an in vitro model of traumatic brain injury. Med Gas Res (2016) 0.75

A simple method for organotypic cultures of nervous tissue. J Neurosci Methods (1991) 14.18

The neuroprotective effects of xenon and helium in an in vitro model of traumatic brain injury. Crit Care Med (2008) 1.81

Propofol in anesthesia. Mechanism of action, structure-activity relationships, and drug delivery. Curr Med Chem (2000) 1.78

Molecular targets underlying general anaesthesia. Br J Pharmacol (2006) 1.74

Organotypic hippocampal slice cultures for studies of brain damage, neuroprotection and neurorepair. Curr Drug Targets CNS Neurol Disord (2005) 1.64

Cerebral ischemia and trauma-different etiologies yet similar mechanisms: neuroprotective opportunities. Brain Res Brain Res Rev (2002) 1.61

Correlating in vivo anaesthetic effects with ex vivo receptor density data supports a GABAergic mechanism of action for propofol, but not for isoflurane. Br J Anaesth (2001) 1.57

Comparison of the effects of propofol and pentobarbital on neurologic outcome and cerebral infarct size after temporary focal ischemia in the rat. Anesthesiology (1997) 1.50

Traumatic brain injury: assessment, resuscitation and early management. Br J Anaesth (2007) 1.49

Apoptosis after traumatic brain injury. J Neurotrauma (2000) 1.45

Time course of synaptic development in hippocampal organotypic cultures. Brain Res Dev Brain Res (1993) 1.45

Determination of diffusion and partition coefficients of propofol in rat brain tissue: implications for studies of drug action in vitro. Br J Anaesth (2004) 1.36

Propofol neuroprotection in cerebral ischemia and its effects on low-molecular-weight antioxidants and skilled motor tasks. Anesthesiology (2004) 1.29

In vitro central nervous system models of mechanically induced trauma: a review. J Neurotrauma (1998) 1.27

Free radicals, antioxidants, and neurologic injury: possible relationship to cerebral protection by anesthetics. J Neurosurg Anesthesiol (2002) 1.27

Ischemia-induced brain damage depends on specific gap-junctional coupling. J Cereb Blood Flow Metab (2002) 1.24

Organotypic cultures as tools for functional screening in the CNS. Drug Discov Today (2005) 1.23

Long-term hippocampal slices: a model system for investigating synaptic mechanisms and pathologic processes. J Neurosci Res (1995) 1.23

Biochemical, cellular, and molecular mechanisms in the evolution of secondary damage after severe traumatic brain injury in infants and children: Lessons learned from the bedside. Pediatr Crit Care Med (2000) 1.23

The general anesthetic propofol increases brain N-arachidonylethanolamine (anandamide) content and inhibits fatty acid amide hydrolase. Br J Pharmacol (2003) 1.22

The regional vulnerability to hypoglycemia-induced neurotoxicity in organotypic hippocampal culture: protection by early tetrodotoxin or delayed MK-801. J Neurosci (1992) 1.19

Comparison of seven anesthetic agents on outcome after experimental traumatic brain injury in adult, male rats. J Neurotrauma (2006) 1.16

Progressive incorporation of propidium iodide in cultured mouse neurons correlates with declining electrophysiological status: a fluorescence scale of membrane integrity. J Neurosci Methods (1990) 1.11

Methods to induce primary and secondary traumatic damage in organotypic hippocampal slice cultures. Brain Res Brain Res Protoc (2000) 1.08

Mechanisms and effects of intracellular calcium buffering on neuronal survival in organotypic hippocampal cultures exposed to anoxia/aglycemia or to excitotoxins. J Neurosci (1997) 1.06

Direct observation of the agonist-specific regional vulnerability to glutamate, NMDA, and kainate neurotoxicity in organotypic hippocampal cultures. Exp Neurol (1991) 1.04

Cerebrospinal fluid concentrations of propofol during anaesthesia in humans. Br J Anaesth (1998) 1.02

Traumatic injury induces differential expression of cell death genes in organotypic brain slice cultures determined by complementary DNA array hybridization. Neuroscience (2000) 1.02

Carbamylated erythropoietin is neuroprotective in an experimental model of traumatic brain injury. Crit Care Med (2008) 1.01

Propofol: relation between brain concentrations, electroencephalogram, middle cerebral artery blood flow velocity, and cerebral oxygen extraction during induction of anesthesia. Anesthesiology (2002) 0.99

Neuroprotection by propofol in acute mechanical injury: role of GABAergic inhibition. J Neurophysiol (1996) 0.98

Functional validation of adult hippocampal organotypic cultures as an in vitro model of brain injury. Brain Res (2004) 0.98

Mild hypothermia, but not propofol, is neuroprotective in organotypic hippocampal cultures. Anesth Analg (2005) 0.96

1-Aminoindan-1,5-dicarboxylic acid and (S)-(+)-2-(3'-carboxybicyclo[1.1.1] pentyl)-glycine, two mGlu1 receptor-preferring antagonists, reduce neuronal death in in vitro and in vivo models of cerebral ischaemia. Eur J Neurosci (1999) 0.95

Disposition of propofol between red blood cells, plasma, brain and cerebrospinal fluid in rabbits. Eur J Anaesthesiol (2000) 0.94

Induction and mechanism of apoptotic cell death by propofol in HL-60 cells. Acta Anaesthesiol Scand (2002) 0.93

Neuroprotective effects of propofol in models of cerebral ischemia: inhibition of mitochondrial swelling as a possible mechanism. Anesthesiology (2006) 0.92

Neuroprotective effects of propofol in acute cerebral injury. CNS Drug Rev (2007) 0.92

Concentration and regional distribution of propofol in brain and spinal cord during propofol anesthesia in the rat. Neurosci Lett (1995) 0.91

Post-insult activity is a major cause of delayed neuronal death in organotypic hippocampal slices exposed to glutamate. Neuroscience (2001) 0.88

Propofol anesthesia compared to awake reduces infarct size in rats. Anesthesiology (2002) 0.88

Combined mechanical trauma and metabolic impairment in vitro induces NMDA receptor-dependent neuronal cell death and caspase-3-dependent apoptosis. FASEB J (1999) 0.86

Possible involvement of the endocannabinoid system in the actions of three clinically used drugs. Trends Pharmacol Sci (2004) 0.86

Anesthetic concentrations of propofol protect against oxidative stress in primary astrocyte cultures: comparison with hypothermia. Anesthesiology (2001) 0.85

Neuroprotective effects of propofol in a model of ischemic cortical cell cultures: role of glutamate and its transporters. Anesthesiology (2003) 0.85

The effects of propofol on brain electrical activity, neurologic outcome, and neuronal damage following incomplete ischemia in rats. Anesthesiology (1992) 0.85

Hypothermia and injury. Curr Opin Crit Care (2004) 0.84

Propofol prevents peroxide-induced inhibition of glutamate transport in cultured astrocytes. Anesthesiology (1999) 0.81

Propofol protection of sodium-hydrogen exchange activity sustains glutamate uptake during oxidative stress. Anesth Analg (2001) 0.81

Erythropoietin attenuates post-traumatic injury in organotypic hippocampal slices. J Neurotrauma (2004) 0.81

The effect of electroencephalogram-targeted high- and low-dose propofol infusion on histopathological damage after traumatic brain injury in the rat. Anesth Analg (2006) 0.80

The effect of thiopental and propofol on NMDA- and AMPA-mediated glutamate excitotoxicity. Anesthesiology (1997) 0.80

Comparative effects of propofol and halothane on outcome from temporary middle cerebral artery occlusion in the rat. Anesthesiology (1992) 0.79

The effects of thiopental and propofol on cell swelling induced by oxygen/glucose deprivation in the CA1 pyramidal cell layer of rat hippocampal slices. Anesth Analg (2002) 0.78

Development of specific synaptic network functions in organotypic central nervous system (CNS) cultures: implications for transplantation of CNS neural cells in vivo. Methods (1998) 0.78

Propofol does not reduce infarct volume in rats undergoing permanent middle cerebral artery occlusion. Acta Anaesthesiol Sin (1994) 0.77

Intensive insulin therapy and pentastarch resuscitation in severe sepsis. N Engl J Med (2008) 19.93

Drotrecogin alfa (activated) for adults with severe sepsis and a low risk of death. N Engl J Med (2005) 8.55

A Multicenter Trial of Remote Ischemic Preconditioning for Heart Surgery. N Engl J Med (2015) 4.22

PML in a patient treated with fumaric acid. N Engl J Med (2013) 3.87

Management of bleeding and coagulopathy following major trauma: an updated European guideline. Crit Care (2013) 3.65

Recombinant factor VIIa as adjunctive therapy for bleeding control in severely injured trauma patients: two parallel randomized, placebo-controlled, double-blind clinical trials. J Trauma (2005) 3.22

Epidemiology of sepsis in Germany: results from a national prospective multicenter study. Intensive Care Med (2007) 2.97

Nonmalignant late effects after allogeneic stem cell transplantation. Blood (2003) 2.95

MFN2 mutation distribution and genotype/phenotype correlation in Charcot-Marie-Tooth type 2. Brain (2006) 2.77

Patient self-reports of symptoms and clinician ratings as predictors of overall cancer survival. J Natl Cancer Inst (2011) 2.56

Practice and perception--a nationwide survey of therapy habits in sepsis. Crit Care Med (2008) 2.43

Management of bleeding following major trauma: a European guideline. Crit Care (2007) 2.40

Mutations in SIL1 cause Marinesco-Sjögren syndrome, a cerebellar ataxia with cataract and myopathy. Nat Genet (2005) 2.38

Gene expression profile of glioblastoma multiforme invasive phenotype points to new therapeutic targets. Neoplasia (2005) 2.37

Axonal prion protein is required for peripheral myelin maintenance. Nat Neurosci (2010) 2.25

The intraoperative decrease of selenium is associated with the postoperative development of multiorgan dysfunction in cardiac surgical patients. Crit Care Med (2011) 2.21

Evidence-based medicine in the therapy of the acute respiratory distress syndrome. Intensive Care Med (2002) 2.16

Continuous right ventricular volumetry by fast-response thermodilution during right ventricular ischemia: head-to-head comparison with conductance catheter measurements. Crit Care Med (2009) 1.96

Activation of STAT3 by IL-6 and IL-10 in primary human macrophages is differentially modulated by suppressor of cytokine signaling 3. J Immunol (2003) 1.92

Effects of psycho-oncologic interventions on emotional distress and quality of life in adult patients with cancer: systematic review and meta-analysis. J Clin Oncol (2013) 1.87

Neuroprotective effects of argon in an in vivo model of transient middle cerebral artery occlusion in rats. Crit Care Med (2011) 1.85

Airway reactions and emergence times in general laryngeal mask airway anaesthesia: a meta-analysis. Eur J Anaesthesiol (2015) 1.83

Repairing injured peripheral nerves: Bridging the gap. Prog Neurobiol (2010) 1.77

IL-6 is required for glioma development in a mouse model. Oncogene (2004) 1.74

Dynamic preload indicators fail to predict fluid responsiveness in open-chest conditions. Crit Care Med (2009) 1.72

Xenon reduces neurohistopathological damage and improves the early neurological deficit after cardiac arrest in pigs. Crit Care Med (2008) 1.70

The small GTPase Rab7 controls the endosomal trafficking and neuritogenic signaling of the nerve growth factor receptor TrkA. J Neurosci (2005) 1.69

Interleukin-6 induces transcriptional activation of vascular endothelial growth factor (VEGF) in astrocytes in vivo and regulates VEGF promoter activity in glioblastoma cells via direct interaction between STAT3 and Sp1. Int J Cancer (2005) 1.67

Pumpless extracorporeal lung assist for protective mechanical ventilation in experimental lung injury. Crit Care Med (2007) 1.66

International study on microcirculatory shock occurrence in acutely ill patients. Crit Care Med (2015) 1.64

A de novo gain-of-function mutation in SCN11A causes loss of pain perception. Nat Genet (2013) 1.61

Effects of partial ventilatory support modalities on respiratory function in severe hypoxemic lung injury. Crit Care Med (2006) 1.60

Recommendations on the use of recombinant activated factor VII as an adjunctive treatment for massive bleeding--a European perspective. Crit Care (2006) 1.58

Levosimendan but not norepinephrine improves microvascular oxygenation during experimental septic shock. Crit Care Med (2008) 1.57

Postresuscitation treatment with argon improves early neurological recovery in a porcine model of cardiac arrest. Shock (2014) 1.56

Combining xenon and mild therapeutic hypothermia preserves neurological function after prolonged cardiac arrest in pigs. Crit Care Med (2012) 1.53

Chronic augmentation of the parasympathetic tone to the atrioventricular node: a nonthoracotomy neurostimulation technique for ventricular rate control during atrial fibrillation. J Cardiovasc Electrophysiol (2009) 1.51

Ventilation with biphasic positive airway pressure in experimental lung injury. Influence of transpulmonary pressure on gas exchange and haemodynamics. Intensive Care Med (2004) 1.50

Peripheral nerve demyelination caused by a mutant Rho GTPase guanine nucleotide exchange factor, frabin/FGD4. Am J Hum Genet (2007) 1.50

S-100 protein and neurohistopathologic changes in a porcine model of acute lung injury. Anesthesiology (2005) 1.50

Prothrombin complex concentrates and a specific antidote to dabigatran are effective ex-vivo in reversing the effects of dabigatran in an anticoagulation/liver trauma experimental model. Crit Care (2014) 1.49

Repeated generation of the pulmonary pressure-volume curve may lead to derecruitment in experimental lung injury. Intensive Care Med (2004) 1.48

Levosimendan improves right ventriculovascular coupling in a porcine model of right ventricular dysfunction. Crit Care Med (2007) 1.48

Reducing the duration of 100% oxygen ventilation in the early reperfusion period after cardiopulmonary resuscitation decreases striatal brain damage. Resuscitation (2010) 1.44

Genes for hereditary sensory and autonomic neuropathies: a genotype-phenotype correlation. Brain (2009) 1.44

Early modifiable factors associated with fatal outcome in patients with severe traumatic brain injury: a case control study. Crit Care Med (2007) 1.43

Anesthesia and neurotoxicity in the developing brain: A non-systematic review. Acta Anaesthesiol Belg (2015) 1.43

Targeted high-throughput sequencing identifies mutations in atlastin-1 as a cause of hereditary sensory neuropathy type I. Am J Hum Genet (2010) 1.42

High-frequency oscillatory ventilation in experimental lung injury: effects on gas exchange. Intensive Care Med (2002) 1.41

Resistance to antiangiogenic therapy is directed by vascular phenotype, vessel stabilization, and maturation in malignant melanoma. J Exp Med (2010) 1.41

Clinical review: Prothrombin complex concentrates--evaluation of safety and thrombogenicity. Crit Care (2011) 1.40

Argon: neuroprotection in in vitro models of cerebral ischemia and traumatic brain injury. Crit Care (2009) 1.40

SH3TC2/KIAA1985 protein is required for proper myelination and the integrity of the node of Ranvier in the peripheral nervous system. Proc Natl Acad Sci U S A (2009) 1.39

Neurological emergencies as causes of accidents. Eur J Emerg Med (2005) 1.38

Sevoflurane exposure prevents diaphragmatic oxidative stress during mechanical ventilation but reduces force and affects protein metabolism even during spontaneous breathing in a rat model. Anesth Analg (2015) 1.38

SIL1 mutations and clinical spectrum in patients with Marinesco-Sjogren syndrome. Brain (2013) 1.29

Endosomal transport of neurotrophins: roles in signaling and neurodegenerative diseases. Dev Neurobiol (2007) 1.29

Validation of a new arterial pulse contour-based cardiac output device. Crit Care Med (2007) 1.25

Implantation and explantation of a wireless epiretinal retina implant device: observations during the EPIRET3 prospective clinical trial. Invest Ophthalmol Vis Sci (2009) 1.21

Loss of heterozygosity 1p36 and 19q13 is a prognostic factor for overall survival in patients with diffuse WHO grade 2 gliomas treated without chemotherapy. J Clin Oncol (2006) 1.20

New visual feedback device improves performance of chest compressions by professionals in simulated cardiac arrest. Resuscitation (2009) 1.18

Subacute axonal neuropathy in Parkinson's disease with cobalamin and vitamin B6 deficiency under duodopa therapy. Mov Disord (2010) 1.17

Autosomal-dominant distal myopathy associated with a recurrent missense mutation in the gene encoding the nuclear matrix protein, matrin 3. Am J Hum Genet (2009) 1.16

Axonopathy in an APP/PS1 transgenic mouse model of Alzheimer's disease. Acta Neuropathol (2006) 1.16

Minimal important differences for interpreting health-related quality of life scores from the EORTC QLQ-C30 in lung cancer patients participating in randomized controlled trials. Support Care Cancer (2010) 1.15

Diagnostic hallmarks and pitfalls in late-onset progressive transthyretin-related amyloid-neuropathy. J Neurol (2013) 1.14

Augmentation of left ventricular contractility by cardiac sympathetic neural stimulation. Circulation (2010) 1.12

Feasibility of prehospital teleconsultation in acute stroke--a pilot study in clinical routine. PLoS One (2012) 1.12

Post-mortem forensic neuroimaging: correlation of MSCT and MRI findings with autopsy results. Forensic Sci Int (2007) 1.11

Age-dependent axonal degeneration in an Alzheimer mouse model. Neurobiol Aging (2006) 1.10

A global analysis of multitrial data investigating quality of life and symptoms as prognostic factors for survival in different tumor sites. Cancer (2013) 1.10

Neurodevelopmental deficits in Pierson (microcoria-congenital nephrosis) syndrome. Am J Med Genet A (2007) 1.09

The noble gas argon modifies extracellular signal-regulated kinase 1/2 signaling in neurons and glial cells. Eur J Pharmacol (2011) 1.08

Long-term course and mutational spectrum of spatacsin-linked spastic paraplegia. Ann Neurol (2007) 1.08

In vitro assessment of axonal growth using dorsal root ganglia explants in a novel three-dimensional collagen matrix. Tissue Eng (2007) 1.07

Multicenter randomized comparison of xenon and isoflurane on left ventricular function in patients undergoing elective surgery. Anesthesiology (2007) 1.07

Ablation of Dicer from murine Schwann cells increases their proliferation while blocking myelination. PLoS One (2010) 1.07

Major confounders may influence multivariate analysis in a single-center observational study. Crit Care Med (2014) 1.06

Dexmedetomidine is neuroprotective in an in vitro model for traumatic brain injury. BMC Neurol (2012) 1.05

Changes in S-100 protein serum levels in survivors of out-of-hospital cardiac arrest treated with mild therapeutic hypothermia: a prospective, observational study. Crit Care (2009) 1.05