Published in Toxicol Appl Pharmacol on May 03, 2009
Preclinical and clinical research on inflammation after intracerebral hemorrhage. Prog Neurobiol (2010) 2.04
Astrogliosis in CNS pathologies: is there a role for microglia? Mol Neurobiol (2010) 1.38
Cyclooxygenase-1 mediates prostaglandin E(2) elevation and contextual memory impairment in a model of sustained hippocampal interleukin-1beta expression. J Neurochem (2010) 0.93
The role of inflammatory processes in Alzheimer's disease. Inflammopharmacology (2012) 0.92
The endotoxin-induced neuroinflammation model of Parkinson's disease. Parkinsons Dis (2011) 0.89
Microglial inhibitory factor (MIF/TKP) mitigates secondary damage following spinal cord injury. Neurobiol Dis (2012) 0.85
Low energy laser light (632.8 nm) suppresses amyloid-β peptide-induced oxidative and inflammatory responses in astrocytes. Neuroscience (2010) 0.84
Acute neuroimmune modulation attenuates the development of anxiety-like freezing behavior in an animal model of traumatic brain injury. J Neurotrauma (2012) 0.81
Augmented expression of TSPO after intracerebral hemorrhage: a role in inflammation? J Neuroinflammation (2016) 0.80
Vascular Dysfunction in Brain Hemorrhage: Translational Pathways to Developing New Treatments from Old Targets. J Neurol Neurophysiol (2011) 0.79
Interactions between prostaglandins, leukotrienes and HIV-1: possible implications for the central nervous system. Retrovirology (2012) 0.77
Increased expression of T cell immunoglobulin and mucin domain 3 aggravates brain inflammation via regulation of the function of microglia/macrophages after intracerebral hemorrhage in mice. J Neuroinflammation (2013) 0.75
Reactive astrocytes: cellular and molecular cues to biological function. Trends Neurosci (1997) 4.92
Pharmacology and signaling of prostaglandin receptors: multiple roles in inflammation and immune modulation. Pharmacol Ther (2004) 3.40
Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol (1997) 2.44
Microglia function in brain tumors. J Neurosci Res (2005) 2.18
A role for astrocytes in motor neuron loss in amyotrophic lateral sclerosis. Brain Res Brain Res Rev (2004) 2.14
Prostaglandin E2 synthesis and secretion: the role of PGE2 synthases. Clin Immunol (2006) 1.96
The role of glial reaction and inflammation in Parkinson's disease. Ann N Y Acad Sci (2003) 1.94
Cyclooxygenase knockout mice: models for elucidating isoform-specific functions. Biochem Pharmacol (1999) 1.65
Recent advances in molecular biology and physiology of the prostaglandin E2-biosynthetic pathway. Prog Lipid Res (2004) 1.60
Trophic actions of extracellular nucleotides and nucleosides on glial and neuronal cells. Trends Neurosci (1996) 1.58
Microglia in brain tumors. Glia (2002) 1.54
The vasodepressor function of the kidney: prostaglandin E2 is not the principal vasodepressor lipid of the renal medulla. Acta Physiol (Oxf) (2006) 1.44
Reactive astrogliosis in the neonatal mouse brain and its modulation by cytokines. J Neurosci (1994) 1.44
Expression of cyclooxygenase 2 (COX-2) in human glioma and in vitro inhibition by a specific COX-2 inhibitor, NS-398. Cancer Res (2000) 1.35
Prostaglandin D2-mediated microglia/astrocyte interaction enhances astrogliosis and demyelination in twitcher. J Neurosci (2006) 1.32
Role of the cell cycle in the pathobiology of central nervous system trauma. Cell Cycle (2005) 1.32
Dextromethorphan protects dopaminergic neurons against inflammation-mediated degeneration through inhibition of microglial activation. J Pharmacol Exp Ther (2003) 1.30
Glial fibrillary acidic protein and related glial proteins as biomarkers of neurotoxicity. Expert Opin Drug Saf (2005) 1.24
Diverse microglial responses after intrahippocampal administration of lipopolysaccharide. Glia (2006) 1.16
Reduction of astrogliosis and microgliosis by cerebrospinal fluid shunting in experimental hydrocephalus. Cerebrospinal Fluid Res (2007) 1.15
Interleukin-1 beta is required for the early evolution of reactive astrogliosis following CNS lesion. J Neuropathol Exp Neurol (2001) 1.15
Constitutive cyclooxygenase (COX-1) and inducible cyclooxygenase (COX-2): rationale for selective inhibition and progress to date. Med Res Rev (1996) 1.13
Genetics of demyelinating diseases. Brain Pathol (1996) 1.07
The acute and the long-term effects of nigral lipopolysaccharide administration on dopaminergic dysfunction and glial cell activation. Eur J Neurosci (2005) 1.07
Attenuation of astrogliosis by suppressing of microglial proliferation with the cell cycle inhibitor olomoucine in rat spinal cord injury model. Brain Res (2007) 1.04
Reduced infarct volume and differential effects on glial cell activation after hyperbaric oxygen treatment in rat permanent focal cerebral ischaemia. Eur J Neurosci (2005) 1.03
The effect of activated microglia on astrogliosis parameters in astrocyte cultures. Brain Res (2006) 0.99
Interleukin-1, nitric oxide and reactive astrocytes. Brain Behav Immun (1995) 0.99
Attenuation of astroglial reactivity by interleukin-10. J Neurosci (1996) 0.98
Roles of prostaglandin synthesis in excitotoxic brain diseases. Neurochem Int (2007) 0.98
Human astrocytes proliferate in response to tumor necrosis factor alpha. J Neuroimmunol (1990) 0.96
Complexity of astrocyte-motor neuron interactions in amyotrophic lateral sclerosis. Neurodegener Dis (2005) 0.92
Growth factors, glia and gliomas. J Neurooncol (1997) 0.91
Induction of astrogliosis by activated microglia is associated with a down-regulation of metabotropic glutamate receptor 5. J Neuroimmunol (2007) 0.91
Pain modulatory actions of cytokines and prostaglandin E2 in the brain. Ann N Y Acad Sci (1998) 0.90
Curcumin protects dopaminergic neuron against LPS induced neurotoxicity in primary rat neuron/glia culture. Neurochem Res (2008) 0.90
Compromised reactive microgliosis in MPTP-lesioned IL-6 KO mice. Brain Res (2003) 0.88
The alteration of prostaglandin E2 levels in patients with brain tumors before and after tumor removal. J Neurooncol (2002) 0.88
Reaction of microglial cells in human astrocytomas (preliminary report). Folia Neuropathol (1994) 0.86
Squamosamide derivative FLZ protects dopaminergic neurons against inflammation-mediated neurodegeneration through the inhibition of NADPH oxidase activity. J Neuroinflammation (2008) 0.86
Tumor necrosis factor-induced proliferation of astrocytes from mature brain is associated with down-regulation of glial fibrillary acidic protein mRNA. J Neurochem (1991) 0.84
Cyclooxygenase in the treatment of glioma: its complex role in signal transduction. Cancer Control (2004) 0.83
Cyclooxygenase-2 inhibitors in glioma therapy. Am J Ther (2004) 0.83
Vascular endothelial growth factor (VEGF), prostaglandin E2(PGE2) and active renin in hypertension of adrenal origin. J Endocrinol Invest (2004) 0.83
Genetics of brain neoplasms. Curr Neurol Neurosci Rep (2001) 0.83
Current status of clinical trials for glioblastoma. Rev Recent Clin Trials (2006) 0.82
High concentrations of cannabinoids activate apoptosis in human U373MG glioma cells. J Neurosci Res (2008) 0.80
Tumor necrosis factor-alpha and basic fibroblast growth factor decrease glial fibrillary acidic protein and its encoding mRNA in astrocyte cultures and glioblastoma cells. J Neurochem (1995) 0.80
Emerging therapies for malignant glioma. Expert Rev Anticancer Ther (2007) 0.79
Retracted M-CSF deficiency leads to reduced metallothioneins I and II expression and increased tissue damage in the brain stem after 6-aminonicotinamide treatment. Exp Neurol (2002) 0.79
Neuronal degeneration and glial cell-responses following trimethyltin intoxication in the rat. Acta Neuropathol (2002) 0.78
[Inducible cyclooxygenase. New relationships between non-steroidal anti-inflammatory agents and inhibition of synthesis of prostaglandins]. Presse Med (1995) 0.77
Differential activation of astrocytes and microglia during post-natal development of dopaminergic neuronal death in the weaver mouse. Brain Res Dev Brain Res (2003) 0.76
A genomic view of alternative splicing. Nat Genet (2002) 12.62
Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat Rev Neurosci (2007) 11.24
Genome-wide detection of tissue-specific alternative splicing in the human transcriptome. Nucleic Acids Res (2002) 6.71
Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration. Glia (2007) 5.67
Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism. Prog Neurobiol (2005) 4.96
Combining partial order alignment and progressive multiple sequence alignment increases alignment speed and scalability to very large alignment problems. Bioinformatics (2004) 3.83
Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease. FASEB J (2005) 3.60
Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention. J Pharmacol Exp Ther (2003) 3.29
Microglial activation-mediated delayed and progressive degeneration of rat nigral dopaminergic neurons: relevance to Parkinson's disease. J Neurochem (2002) 3.14
Alternative splicing and RNA selection pressure--evolutionary consequences for eukaryotic genomes. Nat Rev Genet (2006) 3.00
NADPH oxidase mediates lipopolysaccharide-induced neurotoxicity and proinflammatory gene expression in activated microglia. J Biol Chem (2003) 2.92
Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action. J Pharmacol Exp Ther (2007) 2.90
Integration site preference of xenotropic murine leukemia virus-related virus, a new human retrovirus associated with prostate cancer. J Virol (2008) 2.83
Assessing the impact of alternative splicing on domain interactions in the human proteome. J Proteome Res (2004) 2.71
Discovery of novel splice forms and functional analysis of cancer-specific alternative splicing in human expressed sequences. Nucleic Acids Res (2003) 2.50
Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression. Trends Immunol (2008) 2.46
Clinical correlates in an experimental model of repetitive mild brain injury. Ann Neurol (2013) 2.32
A transcriptional sketch of a primary human breast cancer by 454 deep sequencing. BMC Genomics (2009) 2.27
Increased systemic and brain cytokine production and neuroinflammation by endotoxin following ethanol treatment. J Neuroinflammation (2008) 2.25
Deficiency of either cyclooxygenase (COX)-1 or COX-2 alters epidermal differentiation and reduces mouse skin tumorigenesis. Cancer Res (2002) 2.20
Enhanced oligodendrogenesis and recovery of neurological function by erythropoietin after neonatal hypoxic/ischemic brain injury. Stroke (2010) 2.18
Detecting tissue-specific regulation of alternative splicing as a qualitative change in microarray data. Nucleic Acids Res (2004) 2.17
Antioxidants protect PINK1-dependent dopaminergic neurons in Drosophila. Proc Natl Acad Sci U S A (2006) 2.08
Direct reprogramming of human fibroblasts toward a cardiomyocyte-like state. Stem Cell Reports (2013) 2.05
Global analysis of alternative splicing differences between humans and chimpanzees. Genes Dev (2007) 2.00
Inferring protein domain interactions from databases of interacting proteins. Genome Biol (2005) 1.97
Genetic deletion or pharmacological inhibition of cyclooxygenase-1 attenuate lipopolysaccharide-induced inflammatory response and brain injury. FASEB J (2007) 1.93
Evidence for a subpopulation of conserved alternative splicing events under selection pressure for protein reading frame preservation. Nucleic Acids Res (2004) 1.93
Motor cortex organization after stroke is related to side of stroke and level of recovery. Stroke (2003) 1.91
An expectation-maximization algorithm for probabilistic reconstructions of full-length isoforms from splice graphs. Nucleic Acids Res (2006) 1.90
Evidence of functional selection pressure for alternative splicing events that accelerate evolution of protein subsequences. Proc Natl Acad Sci U S A (2005) 1.88
Distinct role for microglia in rotenone-induced degeneration of dopaminergic neurons. J Neurosci (2002) 1.87
Critical role of microglial NADPH oxidase-derived free radicals in the in vitro MPTP model of Parkinson's disease. FASEB J (2003) 1.81
The ASAP II database: analysis and comparative genomics of alternative splicing in 15 animal species. Nucleic Acids Res (2006) 1.80
Role of nitric oxide in inflammation-mediated neurodegeneration. Ann N Y Acad Sci (2002) 1.75
A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate. Nat Cell Biol (2009) 1.73
Critical role for microglial NADPH oxidase in rotenone-induced degeneration of dopaminergic neurons. J Neurosci (2003) 1.73
The multiassembly problem: reconstructing multiple transcript isoforms from EST fragment mixtures. Genome Res (2004) 1.70
In utero bacterial endotoxin exposure causes loss of tyrosine hydroxylase neurons in the postnatal rat midbrain. Mov Disord (2002) 1.68
Neuroinflammation is a key player in Parkinson's disease and a prime target for therapy. J Neural Transm (Vienna) (2010) 1.66
Microglia/macrophage polarization dynamics in white matter after traumatic brain injury. J Cereb Blood Flow Metab (2013) 1.62
Synergistic dopaminergic neurotoxicity of the pesticide rotenone and inflammogen lipopolysaccharide: relevance to the etiology of Parkinson's disease. J Neurosci (2003) 1.58
The effects of aspirin on gastric mucosal integrity, surface hydrophobicity, and prostaglandin metabolism in cyclooxygenase knockout mice. Gastroenterology (2004) 1.58
Microglia enhance beta-amyloid peptide-induced toxicity in cortical and mesencephalic neurons by producing reactive oxygen species. J Neurochem (2002) 1.58
Activated charcoal decreases the risk of QT prolongation after citalopram overdose. Ann Emerg Med (2007) 1.58
Catechol-O-methyltransferase inhibition increases pain sensitivity through activation of both beta2- and beta3-adrenergic receptors. Pain (2006) 1.57
QPRIMER: a quick web-based application for designing conserved PCR primers from multigenome alignments. Bioinformatics (2007) 1.49
Parkinson's disease and exposure to infectious agents and pesticides and the occurrence of brain injuries: role of neuroinflammation. Environ Health Perspect (2003) 1.47
Flexible, stretchable, transparent carbon nanotube thin film loudspeakers. Nano Lett (2008) 1.47
Mechanism of cyclooxygenase-2 upregulation in late preconditioning. J Mol Cell Cardiol (2003) 1.45
Genetic control of heart function and aging in Drosophila. Trends Cardiovasc Med (2007) 1.43
Neuroprotective effect of dextromethorphan in the MPTP Parkinson's disease model: role of NADPH oxidase. FASEB J (2004) 1.40
Susceptibility of cyclooxygenase-2-deficient mice to pulmonary fibrogenesis. Am J Pathol (2002) 1.39
Diesel exhaust particles induce oxidative stress, proinflammatory signaling, and P-glycoprotein up-regulation at the blood-brain barrier. FASEB J (2008) 1.39
Molecular mechanism of AHSP-mediated stabilization of alpha-hemoglobin. Cell (2004) 1.39
Astrogliosis in CNS pathologies: is there a role for microglia? Mol Neurobiol (2010) 1.38
Histone deacetylase inhibitors up-regulate astrocyte GDNF and BDNF gene transcription and protect dopaminergic neurons. Int J Neuropsychopharmacol (2008) 1.38
HMGB1 acts on microglia Mac1 to mediate chronic neuroinflammation that drives progressive neurodegeneration. J Neurosci (2011) 1.38
Toxoplasmosis in HIV/AIDS patients: a current situation. Jpn J Infect Dis (2004) 1.37
Cardioblast-intrinsic Tinman activity controls proper diversification and differentiation of myocardial cells in Drosophila. Development (2006) 1.36
Neuromelanin activates microglia and induces degeneration of dopaminergic neurons: implications for progression of Parkinson's disease. Neurotox Res (2009) 1.35
The role of microglia in paraquat-induced dopaminergic neurotoxicity. Antioxid Redox Signal (2005) 1.34
Interactive role of the toll-like receptor 4 and reactive oxygen species in LPS-induced microglia activation. Glia (2005) 1.31
Adoptive regulatory T-cell therapy protects against cerebral ischemia. Ann Neurol (2013) 1.30
Neuroinflammation and α-synuclein dysfunction potentiate each other, driving chronic progression of neurodegeneration in a mouse model of Parkinson's disease. Environ Health Perspect (2011) 1.30
Dextromethorphan protects dopaminergic neurons against inflammation-mediated degeneration through inhibition of microglial activation. J Pharmacol Exp Ther (2003) 1.30
Neuroinflammatory response to lipopolysaccharide is exacerbated in mice genetically deficient in cyclooxygenase-2. J Neuroinflammation (2008) 1.30
Contrasting effects of cyclooxygenase-1 (COX-1) and COX-2 deficiency on the host response to influenza A viral infection. J Immunol (2005) 1.30
Widespread production of novel soluble protein isoforms by alternative splicing removal of transmembrane anchoring domains. FEBS Lett (2003) 1.29
Sinomenine, a natural dextrorotatory morphinan analog, is anti-inflammatory and neuroprotective through inhibition of microglial NADPH oxidase. J Neuroinflammation (2007) 1.27
Microglial PHOX and Mac-1 are essential to the enhanced dopaminergic neurodegeneration elicited by A30P and A53T mutant alpha-synuclein. Glia (2007) 1.26
Interleukin-10 protects lipopolysaccharide-induced neurotoxicity in primary midbrain cultures by inhibiting the function of NADPH oxidase. J Pharmacol Exp Ther (2006) 1.25
Role of reactive oxygen species in LPS-induced production of prostaglandin E2 in microglia. J Neurochem (2004) 1.24
Cyclooxygenase-2 expression is critical for chronic UV-induced murine skin carcinogenesis. Mol Carcinog (2007) 1.24
Evidence that public database records for many cancer-associated genes reflect a splice form found in tumors and lack normal splice forms. Nucleic Acids Res (2005) 1.23
Generation of a conditional allele of the mouse prostaglandin EP4 receptor. Genesis (2004) 1.22
A pivotal role of matrix metalloproteinase-3 activity in dopaminergic neuronal degeneration via microglial activation. FASEB J (2006) 1.22
Role of oxidative stress in epileptic seizures. Neurochem Int (2011) 1.20
Accentuated T helper type 2 airway response after allergen challenge in cyclooxygenase-1-/- but not cyclooxygenase-2-/- mice. Am J Respir Crit Care Med (2003) 1.19
The Akt1-eNOS axis illustrates the specificity of kinase-substrate relationships in vivo. Sci Signal (2009) 1.19
Implementing the LIM code: the structural basis for cell type-specific assembly of LIM-homeodomain complexes. EMBO J (2008) 1.19
Macrophage antigen complex-1 mediates reactive microgliosis and progressive dopaminergic neurodegeneration in the MPTP model of Parkinson's disease. J Immunol (2008) 1.18
Valproate pretreatment protects dopaminergic neurons from LPS-induced neurotoxicity in rat primary midbrain cultures: role of microglia. Brain Res Mol Brain Res (2004) 1.18