Published in Mol Endocrinol on April 30, 2009
Nuclear receptor coregulators as a new paradigm for therapeutic targeting. Adv Drug Deliv Rev (2010) 0.98
Alternative mRNA splicing of corepressors generates variants that play opposing roles in adipocyte differentiation. J Biol Chem (2011) 0.93
Thyroid hormone receptor mutants implicated in human hepatocellular carcinoma display an altered target gene repertoire. Oncogene (2009) 0.91
DNA recognition by thyroid hormone and retinoic acid receptors: 3,4,5 rule modified. Mol Cell Endocrinol (2009) 0.89
A mechanism for pituitary-resistance to thyroid hormone (PRTH) syndrome: a loss in cooperative coactivator contacts by thyroid hormone receptor (TR)beta2. Mol Endocrinol (2011) 0.88
Aberrant corepressor interactions implicated in PML-RAR(alpha) and PLZF-RAR(alpha) leukemogenesis reflect an altered recruitment and release of specific NCoR and SMRT splice variants. J Biol Chem (2010) 0.88
Thyroid hormone receptor mutations in cancer and resistance to thyroid hormone: perspective and prognosis. J Thyroid Res (2011) 0.85
Thyroid hormones, t3 and t4, in the brain. Front Endocrinol (Lausanne) (2014) 0.83
NCoR1 regulates thyroid hormone receptor isoform-dependent adipogenesis. J Mol Endocrinol (2011) 0.80
The ability of thyroid hormone receptors to sense t4 as an agonist depends on receptor isoform and on cellular cofactors. Mol Endocrinol (2014) 0.77
Mutant thyroid hormone receptors (TRs) isolated from distinct cancer types display distinct target gene specificities: a unique regulatory repertoire associated with two renal clear cell carcinomas. Mol Endocrinol (2011) 0.77
A conserved lysine in the thyroid hormone receptor-alpha1 DNA-binding domain, mutated in hepatocellular carcinoma, serves as a sensor for transcriptional regulation. Mol Cancer Res (2010) 0.77
Thyroid hormone suppresses expression of stathmin and associated tumor growth in hepatocellular carcinoma. Sci Rep (2016) 0.75
Mutation analysis underlying the downregulation of the thyroid hormone receptor β1 gene in the Chinese breast cancer population. Onco Targets Ther (2015) 0.75
Thyroid Hormones as Renal Cell Cancer Regulators. J Signal Transduct (2016) 0.75
The nuclear receptor superfamily: the second decade. Cell (1995) 24.99
Eukaryotic proteins expressed in Escherichia coli: an improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase. Anal Biochem (1991) 16.18
The c-erb-A gene encodes a thyroid hormone receptor. Nature (1987) 10.53
The c-erb-A protein is a high-affinity receptor for thyroid hormone. Nature (1987) 7.06
Physiological and molecular basis of thyroid hormone action. Physiol Rev (2001) 5.69
The SRC family of nuclear receptor coactivators. Gene (2000) 2.96
Biological roles and mechanistic actions of co-repressor complexes. J Cell Sci (2002) 2.86
The mechanism of action of thyroid hormones. Annu Rev Physiol (2000) 2.80
The role of corepressors in transcriptional regulation by nuclear hormone receptors. Annu Rev Physiol (2004) 2.14
Minireview: nuclear receptor coactivators--an update. Endocrinology (2002) 2.04
Nuclear receptor coactivators: multiple enzymes, multiple complexes, multiple functions. J Steroid Biochem Mol Biol (1999) 2.00
Multiple mechanisms for regulation of the transcriptional activity of thyroid hormone receptors. Rev Endocr Metab Disord (2000) 1.71
Thyroid hormone resistance syndrome manifests as an aberrant interaction between mutant T3 receptors and transcriptional corepressors. Mol Endocrinol (1997) 1.60
Alternative mRNA splicing of SMRT creates functional diversity by generating corepressor isoforms with different affinities for different nuclear receptors. J Biol Chem (2005) 1.46
The nuclear receptor corepressor (N-CoR) contains three isoleucine motifs (I/LXXII) that serve as receptor interaction domains (IDs). Mol Endocrinol (2000) 1.46
Genetic analysis of 29 kindreds with generalized and pituitary resistance to thyroid hormone. Identification of thirteen novel mutations in the thyroid hormone receptor beta gene. J Clin Invest (1994) 1.46
Mechanism of thyroid hormone action. Thyroid (2002) 1.36
The specificity of interactions between nuclear hormone receptors and corepressors is mediated by distinct amino acid sequences within the interacting domains. Mol Endocrinol (2001) 1.35
Molecular basis of resistance to thyroid hormone. Trends Endocrinol Metab (2003) 1.33
SMRT and N-CoR corepressors are regulated by distinct kinase signaling pathways. J Biol Chem (2004) 1.28
Thyroid hormone receptor mutations and disease: beyond thyroid hormone resistance. Trends Endocrinol Metab (2005) 1.27
Thyroid hormone receptors mutated in liver cancer function as distorted antimorphs. Oncogene (2006) 1.26
Functionally impaired TR mutants are present in thyroid papillary cancer. J Clin Endocrinol Metab (2002) 1.23
Expression of mutant thyroid hormone nuclear receptors in human hepatocellular carcinoma cells. Mol Carcinog (1999) 1.21
Expression of mutant thyroid hormone nuclear receptors is associated with human renal clear cell carcinoma. Carcinogenesis (2002) 1.18
Spectrum of transcriptional, dimerization, and dominant negative properties of twenty different mutant thyroid hormone beta-receptors in thyroid hormone resistance syndrome. Mol Endocrinol (1994) 1.17
Thyroid hormone receptors/THR genes in human cancer. Cancer Lett (2003) 1.17
Transcriptional silencing is defined by isoform- and heterodimer-specific interactions between nuclear hormone receptors and corepressors. Mol Cell Biol (1998) 1.16
Determination of nuclear receptor corepressor interactions with the thyroid hormone receptor. Mol Endocrinol (2003) 1.13
The nuclear corepressors recognize distinct nuclear receptor complexes. Mol Endocrinol (2000) 1.13
Corepressors: custom tailoring and alterations while you wait. Nucl Recept Signal (2005) 1.02
A novel thyroid hormone receptor-beta mutation that fails to bind nuclear receptor corepressor in a patient as an apparent cause of severe, predominantly pituitary resistance to thyroid hormone. J Clin Endocrinol Metab (2006) 1.02
Thyroid abnormalities and hepatocellular carcinoma in mice transgenic for v-erbA. EMBO J (1994) 1.02
Heterodimers of retinoic acid receptors and thyroid hormone receptors display unique combinatorial regulatory properties. Mol Endocrinol (2005) 1.00
Leukemic transformation by the v-ErbA oncoprotein entails constitutive binding to and repression of an erythroid enhancer in vivo. EMBO J (1998) 0.97
Retinoic acid receptor-alpha is stabilized in a repressive state by its C-terminal, isotype-specific F domain. Mol Endocrinol (2004) 0.95
Response of SMRT (silencing mediator of retinoic acid and thyroid hormone receptor) and N-CoR (nuclear receptor corepressor) corepressors to mitogen-activated protein kinase kinase kinase cascades is determined by alternative mRNA splicing. Mol Endocrinol (2007) 0.94
Isotype-restricted corepressor recruitment: a constitutively closed helix 12 conformation in retinoic acid receptors beta and gamma interferes with corepressor recruitment and prevents transcriptional repression. Mol Cell Biol (2003) 0.94
Resistance to thyroid hormone (RTH) syndrome reveals novel determinants regulating interaction of T3 receptor with corepressor. Mol Cell Endocrinol (2000) 0.93
Dominant negative activity of mutant thyroid hormone alpha1 receptors from patients with hepatocellular carcinoma. Endocrinology (1997) 0.91
Alterations of thyroid hormone receptor alpha gene: frequency and association with Nm23 protein expression and metastasis in gastric cancer. Cancer Lett (2002) 0.88
Avian erythroleukemia: a model for corepressor function in cancer. Oncogene (2001) 0.88
An improved high throughput protein-protein interaction assay for nuclear hormone receptors. Nucl Recept Signal (2007) 0.88
Resistance to thyroid hormone, and peroxisome-proliferator-activated receptor gamma resistance. Biochem Soc Trans (2001) 0.86
Resistance to thyroid hormone. Clin Lab Med (1993) 0.83
Germline and somatic thyroid hormone receptor mutations in man. J Endocrinol Invest (2003) 0.83
The gene regulating activity of thyroid hormone nuclear receptors is modulated by cell-type specific factors. Biochem Biophys Res Commun (1997) 0.80
Multiple mutations contribute to repression by the v-Erb A oncoprotein. Oncogene (2005) 0.78
Phosphorylation of PML by mitogen-activated protein kinases plays a key role in arsenic trioxide-mediated apoptosis. Cancer Cell (2004) 2.06
Alternative mRNA splicing of SMRT creates functional diversity by generating corepressor isoforms with different affinities for different nuclear receptors. J Biol Chem (2005) 1.46
A cautionary note as to the use of pBi-L and related luciferase/transgenic vectors in the study of thyroid endocrinology. Thyroid (2008) 1.41
Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy. J Clin Invest (2012) 1.29
SMRT and N-CoR corepressors are regulated by distinct kinase signaling pathways. J Biol Chem (2004) 1.28
Temporal comparison of PBDEs, OH-PBDEs, PCBs, and OH-PCBs in the serum of second trimester pregnant women recruited from San Francisco General Hospital, California. Environ Sci Technol (2013) 1.20
Functional regulation of GATA-2 by acetylation. J Leukoc Biol (2004) 1.14
Pituitary resistance to thyroid hormone syndrome is associated with T3 receptor mutants that selectively impair beta2 isoform function. Mol Endocrinol (2005) 1.08
Isoform-specific transcriptional activity of overlapping target genes that respond to thyroid hormone receptors alpha1 and beta1. Mol Endocrinol (2009) 1.06
Retinoic acid receptors beta and gamma do not repress, but instead activate target gene transcription in both the absence and presence of hormone ligand. Mol Endocrinol (2002) 1.01
Heterodimers of retinoic acid receptors and thyroid hormone receptors display unique combinatorial regulatory properties. Mol Endocrinol (2005) 1.00
Nuclear receptor coregulators as a new paradigm for therapeutic targeting. Adv Drug Deliv Rev (2010) 0.98
Retinoic acid receptor-alpha is stabilized in a repressive state by its C-terminal, isotype-specific F domain. Mol Endocrinol (2004) 0.95
Isotype-restricted corepressor recruitment: a constitutively closed helix 12 conformation in retinoic acid receptors beta and gamma interferes with corepressor recruitment and prevents transcriptional repression. Mol Cell Biol (2003) 0.94
Response of SMRT (silencing mediator of retinoic acid and thyroid hormone receptor) and N-CoR (nuclear receptor corepressor) corepressors to mitogen-activated protein kinase kinase kinase cascades is determined by alternative mRNA splicing. Mol Endocrinol (2007) 0.94
Competitive cofactor recruitment by orphan receptor hepatocyte nuclear factor 4alpha1: modulation by the F domain. Mol Cell Biol (2002) 0.93
Alternative mRNA splicing of corepressors generates variants that play opposing roles in adipocyte differentiation. J Biol Chem (2011) 0.93
DNA recognition by thyroid hormone and retinoic acid receptors: 3,4,5 rule modified. Mol Cell Endocrinol (2009) 0.89
A mechanism for pituitary-resistance to thyroid hormone (PRTH) syndrome: a loss in cooperative coactivator contacts by thyroid hormone receptor (TR)beta2. Mol Endocrinol (2011) 0.88
An improved high throughput protein-protein interaction assay for nuclear hormone receptors. Nucl Recept Signal (2007) 0.88
Aberrant corepressor interactions implicated in PML-RAR(alpha) and PLZF-RAR(alpha) leukemogenesis reflect an altered recruitment and release of specific NCoR and SMRT splice variants. J Biol Chem (2010) 0.88
Regulation of SMRT corepressor dimerization and composition by MAP kinase phosphorylation. Mol Cell Endocrinol (2010) 0.87
Novel mode of deoxyribonucleic acid recognition by thyroid hormone receptors: thyroid hormone receptor beta-isoforms can bind as trimers to natural response elements comprised of reiterated half-sites. Mol Endocrinol (2004) 0.86
Estrogen receptors recruit SMRT and N-CoR corepressors through newly recognized contacts between the corepressor N terminus and the receptor DNA binding domain. Mol Cell Biol (2010) 0.86
Thyroid hormone receptor mutations in cancer and resistance to thyroid hormone: perspective and prognosis. J Thyroid Res (2011) 0.85
SMRTε, a corepressor variant, interacts with a restricted subset of nuclear receptors, including the retinoic acid receptors α and β. Mol Cell Endocrinol (2012) 0.82
Coactivator recruitment is enhanced by thyroid hormone receptor trimers. Mol Cell Endocrinol (2007) 0.80
NCoR1 regulates thyroid hormone receptor isoform-dependent adipogenesis. J Mol Endocrinol (2011) 0.80
Molecular analysis of human resistance to thyroid hormone syndrome. Methods Mol Biol (2002) 0.79
Research resource: identification of novel coregulators specific for thyroid hormone receptor-β2. Mol Endocrinol (2013) 0.78
Multiple mutations contribute to repression by the v-Erb A oncoprotein. Oncogene (2005) 0.78
Mutant thyroid hormone receptors (TRs) isolated from distinct cancer types display distinct target gene specificities: a unique regulatory repertoire associated with two renal clear cell carcinomas. Mol Endocrinol (2011) 0.77
The ability of thyroid hormone receptors to sense t4 as an agonist depends on receptor isoform and on cellular cofactors. Mol Endocrinol (2014) 0.77
A conserved lysine in the thyroid hormone receptor-alpha1 DNA-binding domain, mutated in hepatocellular carcinoma, serves as a sensor for transcriptional regulation. Mol Cancer Res (2010) 0.77
High throughput analysis of nuclear receptor-cofactor interactions. Methods Mol Biol (2009) 0.77