ETS gene fusions in prostate cancer: from discovery to daily clinical practice.

PubWeight™: 2.91‹?› | Rank: Top 1%

🔗 View Article (PMID 19409690)

Published in Eur Urol on April 24, 2009

Authors

Scott A Tomlins1, Anders Bjartell, Arul M Chinnaiyan, Guido Jenster, Robert K Nam, Mark A Rubin, Jack A Schalken

Author Affiliations

1: Michigan Center for Translational Pathology, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA. tomlinss@med.umich.edu

Articles citing this

(truncated to the top 100)

Antibody-based detection of ERG rearrangement-positive prostate cancer. Neoplasia (2010) 3.66

The Molecular Taxonomy of Primary Prostate Cancer. Cell (2015) 3.29

Therapeutic targeting of SPINK1-positive prostate cancer. Sci Transl Med (2011) 2.83

FusionSeq: a modular framework for finding gene fusions by analyzing paired-end RNA-sequencing data. Genome Biol (2010) 2.79

Urinary TMPRSS2:ERG and PCA3 in an active surveillance cohort: results from a baseline analysis in the Canary Prostate Active Surveillance Study. Clin Cancer Res (2013) 2.70

Urine TMPRSS2:ERG fusion transcript stratifies prostate cancer risk in men with elevated serum PSA. Sci Transl Med (2011) 2.62

ETS gene fusions in prostate cancer. Nat Rev Urol (2009) 2.43

Tumor-associated copy number changes in the circulation of patients with prostate cancer identified through whole-genome sequencing. Genome Med (2013) 2.28

The mutational landscape of prostate cancer. Eur Urol (2013) 2.14

The TMPRSS2:ERG rearrangement, ERG expression, and prostate cancer outcomes: a cohort study and meta-analysis. Cancer Epidemiol Biomarkers Prev (2012) 2.13

Zbtb7a suppresses prostate cancer through repression of a Sox9-dependent pathway for cellular senescence bypass and tumor invasion. Nat Genet (2013) 2.11

Characterization of 1577 primary prostate cancers reveals novel biological and clinicopathologic insights into molecular subtypes. Eur Urol (2015) 1.80

Immunohistochemistry for ERG expression as a surrogate for TMPRSS2-ERG fusion detection in prostatic adenocarcinomas. Am J Surg Pathol (2011) 1.58

Prevalence of TMPRSS2-ERG and SLC45A3-ERG gene fusions in a large prostatectomy cohort. Mod Pathol (2010) 1.55

Testing for the recurrent HOXB13 G84E germline mutation in men with clinical indications for prostate biopsy. J Urol (2012) 1.52

Testing mutual exclusivity of ETS rearranged prostate cancer. Lab Invest (2010) 1.48

Combining urinary detection of TMPRSS2:ERG and PCA3 with serum PSA to predict diagnosis of prostate cancer. Urol Oncol (2011) 1.36

ERG rearrangement is specific to prostate cancer and does not occur in any other common tumor. Mod Pathol (2010) 1.33

Alternative splicing and biological heterogeneity in prostate cancer. Nat Rev Urol (2009) 1.33

Clinical potential of the ERG oncoprotein in prostate cancer. Nat Rev Urol (2012) 1.17

TMPRSS2/ERG promotes epithelial to mesenchymal transition through the ZEB1/ZEB2 axis in a prostate cancer model. PLoS One (2011) 1.15

ERG cooperates with androgen receptor in regulating trefoil factor 3 in prostate cancer disease progression. Neoplasia (2010) 1.14

New strategies in prostate cancer: translating genomics into the clinic. Clin Cancer Res (2012) 1.09

Antibody-based detection of ERG rearrangements in prostate core biopsies, including diagnostically challenging cases: ERG staining in prostate core biopsies. Arch Pathol Lab Med (2012) 1.06

Correlation of urine TMPRSS2:ERG and PCA3 to ERG+ and total prostate cancer burden. Am J Clin Pathol (2012) 1.05

Genetic and molecular differences in prostate carcinogenesis between African American and Caucasian American men. Int J Mol Sci (2013) 1.03

Mechanisms of persistent activation of the androgen receptor in CRPC: recent advances and future perspectives. World J Urol (2011) 0.99

TMPRSS2 is a host factor that is essential for pneumotropism and pathogenicity of H7N9 influenza A virus in mice. J Virol (2014) 0.99

A Prospective Investigation of PTEN Loss and ERG Expression in Lethal Prostate Cancer. J Natl Cancer Inst (2015) 0.99

Integrin-linked kinase as a target for ERG-mediated invasive properties in prostate cancer models. Carcinogenesis (2012) 0.98

Regulators of gene expression as biomarkers for prostate cancer. Am J Cancer Res (2012) 0.98

Novel dual-color immunohistochemical methods for detecting ERG-PTEN and ERG-SPINK1 status in prostate carcinoma. Mod Pathol (2013) 0.97

Emergence of ETS transcription factors as diagnostic tools and therapeutic targets in prostate cancer. Am J Transl Res (2013) 0.96

Analysis of serum total and free PSA using immunoaffinity depletion coupled to SRM: correlation with clinical immunoassay tests. J Proteomics (2012) 0.96

Challenges to improved therapeutics for metastatic castrate resistant prostate cancer: from recent successes and failures. J Hematol Oncol (2012) 0.93

HOXB13 G84E-related familial prostate cancers: a clinical, histologic, and molecular survey. Am J Surg Pathol (2014) 0.92

AR function in promoting metastatic prostate cancer. Cancer Metastasis Rev (2014) 0.91

A novel four-color fluorescence in situ hybridization assay for the detection of TMPRSS2 and ERG rearrangements in prostate cancer. Cancer Genet (2013) 0.91

Evaluation of tissue PCA3 expression in prostate cancer by RNA in situ hybridization--a correlative study with urine PCA3 and TMPRSS2-ERG. Mod Pathol (2013) 0.90

A model for the design and construction of a resource for the validation of prognostic prostate cancer biomarkers: the Canary Prostate Cancer Tissue Microarray. Adv Anat Pathol (2013) 0.90

Disruption of prostate epithelial differentiation pathways and prostate cancer development. Front Oncol (2013) 0.89

Changes in cortical cytoskeletal and extracellular matrix gene expression in prostate cancer are related to oncogenic ERG deregulation. BMC Cancer (2010) 0.88

The TMPRSS2:ERG fusion and response to androgen deprivation therapy for prostate cancer. Prostate (2015) 0.88

Characterization of transcriptional changes in ERG rearrangement-positive prostate cancer identifies the regulation of metabolic sensors such as neuropeptide Y. PLoS One (2013) 0.88

Molecular evidence that invasive adenocarcinoma can mimic prostatic intraepithelial neoplasia (PIN) and intraductal carcinoma through retrograde glandular colonization. J Pathol (2015) 0.87

Expression changes in the stroma of prostate cancer predict subsequent relapse. PLoS One (2012) 0.87

The genomic evolution of human prostate cancer. Br J Cancer (2015) 0.86

Comparative evaluation of urinary PCA3 and TMPRSS2: ERG scores and serum PHI in predicting prostate cancer aggressiveness. Int J Mol Sci (2014) 0.86

Application of a Clinical Whole-Transcriptome Assay for Staging and Prognosis of Prostate Cancer Diagnosed in Needle Core Biopsy Specimens. J Mol Diagn (2016) 0.85

ERG rearrangement and protein expression in the progression to castration-resistant prostate cancer. Prostate Cancer Prostatic Dis (2014) 0.85

Cancer-associated changes in the expression of TMPRSS2-ERG, PCA3, and SPINK1 in histologically benign tissue from cancerous vs noncancerous prostatectomy specimens. Urology (2014) 0.84

Modulation of androgen receptor signaling in hormonal therapy-resistant prostate cancer cell lines. PLoS One (2011) 0.84

Evolving Personalized Therapy for Castration-Resistant Prostate Cancer. Biomedicine (Taipei) (2014) 0.84

Nuclear targeting of dystroglycan promotes the expression of androgen regulated transcription factors in prostate cancer. Sci Rep (2013) 0.84

Gene signatures ESC, MYC and ERG-fusion are early markers of a potentially dangerous subtype of prostate cancer. BMC Med Genomics (2014) 0.83

Detection of TMPRSS2-ETS fusions by a multiprobe fluorescence in situ hybridization assay for the early diagnosis of prostate cancer: a pilot study. J Mol Diagn (2010) 0.82

Molecular characterization and clinical impact of TMPRSS2-ERG rearrangement on prostate cancer: comparison between FISH and RT-PCR. Biomed Res Int (2013) 0.82

Markers for detection of prostate cancer. Cancers (Basel) (2010) 0.82

Personalized management in low-risk prostate cancer: the role of biomarkers. Prostate Cancer (2012) 0.82

Bellerophon: a hybrid method for detecting interchromosomal rearrangements at base pair resolution using next-generation sequencing data. BMC Bioinformatics (2013) 0.81

Clinical variability and molecular heterogeneity in prostate cancer. Asian J Androl (2016) 0.81

Obesity and Prostate Cancer Risk According to Tumor TMPRSS2:ERG Gene Fusion Status. Am J Epidemiol (2015) 0.81

Antibody-independent targeted quantification of TMPRSS2-ERG fusion protein products in prostate cancer. Mol Oncol (2014) 0.80

Specific and redundant activities of ETV1 and ETV4 in prostate cancer aggressiveness revealed by co-overexpression cellular contexts. Oncotarget (2015) 0.80

Hypothesis: Artifacts, Including Spurious Chimeric RNAs with a Short Homologous Sequence, Caused by Consecutive Reverse Transcriptions and Endogenous Random Primers. J Cancer (2015) 0.80

Genomic rearrangements in prostate cancer. Curr Opin Urol (2015) 0.80

ETS gene fusions and prostate cancer. Am J Transl Res (2009) 0.80

Altered PCA3 and TMPRSS2-ERG expression in histologically benign regions of cancerous prostates: a systematic, quantitative mRNA analysis in five prostates. BMC Urol (2015) 0.79

Androgen receptor genomic regulation. Transl Androl Urol (2013) 0.79

ERG rearrangement in local recurrences compared to distant metastases of castration-resistant prostate cancer. Virchows Arch (2012) 0.78

Urine markers and prostate cancer. Cent European J Urol (2011) 0.78

Molecular assays for the detection of prostate tumor derived nucleic acids in peripheral blood. Mol Cancer (2010) 0.78

Fluorescence in situ hybridization in surgical pathology: principles and applications. J Pathol Clin Res (2017) 0.78

Presence of TMPRSS2-ERG is associated with alterations of the metabolic profile in human prostate cancer. Oncotarget (2016) 0.77

ERG is specifically associated with ETS-2 and ETV-4, but not with ETS-1, in prostate cancer. Int J Mol Med (2012) 0.77

The prognostic significance of combined ERG and androgen receptor expression in patients with prostate cancer managed by androgen deprivation therapy. Cancer Biol Ther (2014) 0.77

Novel biomarkers for the detection of prostate cancer. J Clin Urol (2016) 0.77

Pre-diagnostic circulating sex hormone levels and risk of prostate cancer by ERG tumour protein expression. Br J Cancer (2016) 0.76

Molecular subtyping of prostate cancer. Curr Opin Urol (2016) 0.76

Usefulness of a monoclonal ERG/FLI1 antibody for immunohistochemical discrimination of Ewing family tumors. Am J Clin Pathol (2013) 0.76

Function of PCA3 in prostate tissue and clinical research progress on developing a PCA3 score. Chin J Cancer Res (2014) 0.76

PCA3 and TMPRSS2-ERG gene fusions as diagnostic biomarkers for prostate cancer. Chin J Cancer Res (2016) 0.76

[Dangerous liaisons in prostate cancer. Clinical and biological implications of recurrent gene fusions]. Pathologe (2010) 0.76

Early detection of clinically significant prostate cancer at diagnosis: a prospective study using a novel panel of TMPRSS2:ETS fusion gene markers. Cancer Med (2013) 0.76

ERG rearrangement as a novel marker for predicting the extra-prostatic extension of clinically localised prostate cancer. Oncol Lett (2016) 0.75

Association of Prostate Cancer Risk Variants with TMPRSS2:ERG Status: Evidence for Distinct Molecular Subtypes. Cancer Epidemiol Biomarkers Prev (2016) 0.75

A simple, rapid, low-cost technique for naked-eye detection of urine-isolated TMPRSS2:ERG gene fusion RNA. Sci Rep (2016) 0.75

Imaging and Markers as Novel Diagnostic Tools in Detecting Insignificant Prostate Cancer: A Critical Overview. Int Sch Res Notices (2014) 0.75

Potential for targeted therapy in prostate cancers with ERG abnormalities. Asian J Androl (2011) 0.75

Expression of ERG Protein and TMRPSS2-ERG Fusion in Prostatic Carcinoma in Egyptian Patients. Open Access Maced J Med Sci (2017) 0.75

The ubiquitin ligase TRIM25 targets ERG for degradation in prostate cancer. Oncotarget (2016) 0.75

Tumour biomarkers: homeostasis as a novel prognostic indicator. Open Biol (2016) 0.75

Colorimetric TMPRSS2-ERG Gene Fusion Detection in Prostate Cancer Urinary Samples via Recombinase Polymerase Amplification. Theranostics (2016) 0.75

Clinically relevant genetic characterization of prostate tumors: how close are we to the goal? Korean J Urol (2015) 0.75

TMPRSS2:ERG gene aberrations may provide insight into pT stage in prostate cancer. BMC Urol (2016) 0.75

TMPRSS2-ERG gene fusion in Turkish patients with localized prostate cancer: results of radical prostatectomy specimens. Turk J Urol (2016) 0.75

Identification of a novel germline SPOP mutation in a family with hereditary prostate cancer. Prostate (2014) 0.75

The role of prostate cancer biomarkers in undiagnosed men. Curr Opin Urol (2017) 0.75

[High-grade prostatic intraepithelial neoplasia: the only accepted prostate cancer precursor lesion]. Pathologe (2011) 0.75

Prostate cancer risk regions at 8q24 and 17q24 are differentially associated with somatic TMPRSS2:ERG fusion status. Hum Mol Genet (2016) 0.75

Articles by these authors

Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer. Science (2005) 39.06

The landscape of somatic copy-number alteration across human cancers. Nature (2010) 31.88

Assessing the significance of chromosomal aberrations in cancer: methodology and application to glioma. Proc Natl Acad Sci U S A (2007) 18.83

The polycomb group protein EZH2 is involved in progression of prostate cancer. Nature (2002) 18.30

ONCOMINE: a cancer microarray database and integrated data-mining platform. Neoplasia (2004) 17.08

Characterizing the cancer genome in lung adenocarcinoma. Nature (2007) 16.48

Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma. Nature (2005) 15.28

Development of human protein reference database as an initial platform for approaching systems biology in humans. Genome Res (2003) 14.79

The genomic complexity of primary human prostate cancer. Nature (2011) 14.06

EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells. Proc Natl Acad Sci U S A (2003) 13.68

ProbeMatch: rapid alignment of oligonucleotides to genome allowing both gaps and mismatches. Bioinformatics (2009) 13.34

High-throughput oncogene mutation profiling in human cancer. Nat Genet (2007) 12.68

Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature (2009) 12.58

The mutational landscape of lethal castration-resistant prostate cancer. Nature (2012) 11.82

Transcriptome sequencing to detect gene fusions in cancer. Nature (2009) 11.63

Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancer. Nature (2007) 10.94

Oncomine 3.0: genes, pathways, and networks in a collection of 18,000 cancer gene expression profiles. Neoplasia (2007) 10.74

Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer. Nat Genet (2012) 9.93

TEAD mediates YAP-dependent gene induction and growth control. Genes Dev (2008) 9.88

Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer. Cancer Res (2006) 9.87

Large-scale meta-analysis of cancer microarray data identifies common transcriptional profiles of neoplastic transformation and progression. Proc Natl Acad Sci U S A (2004) 9.42

Integrative molecular concept modeling of prostate cancer progression. Nat Genet (2006) 8.49

Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing. Nat Biotechnol (2013) 7.97

TMPRSS2:ERG fusion-associated deletions provide insight into the heterogeneity of prostate cancer. Cancer Res (2006) 7.61

Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer. Science (2008) 7.59

Autoantibody signatures in prostate cancer. N Engl J Med (2005) 7.56

SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas. Nat Genet (2009) 7.48

Meta-analysis of microarrays: interstudy validation of gene expression profiles reveals pathway dysregulation in prostate cancer. Cancer Res (2002) 7.29

Punctuated evolution of prostate cancer genomes. Cell (2013) 7.23

Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer. Cell (2009) 7.09

Homozygous deletions and chromosome amplifications in human lung carcinomas revealed by single nucleotide polymorphism array analysis. Cancer Res (2005) 6.93

Sequence variants at the TERT-CLPTM1L locus associate with many cancer types. Nat Genet (2009) 6.91

An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression. Cancer Cell (2010) 6.76

Transcriptome sequencing across a prostate cancer cohort identifies PCAT-1, an unannotated lincRNA implicated in disease progression. Nat Biotechnol (2011) 6.54

The emergence of lncRNAs in cancer biology. Cancer Discov (2011) 6.32

TMPRSS2-ERG fusion prostate cancer: an early molecular event associated with invasion. Am J Surg Pathol (2007) 6.09

Recurrent gene fusions in prostate cancer. Nat Rev Cancer (2008) 6.08

Integrative genomic and proteomic analysis of prostate cancer reveals signatures of metastatic progression. Cancer Cell (2005) 6.04

A hierarchical network of transcription factors governs androgen receptor-dependent prostate cancer growth. Mol Cell (2007) 5.99

Role of the TMPRSS2-ERG gene fusion in prostate cancer. Neoplasia (2008) 5.92

Androgen-independent prostate cancer is a heterogeneous group of diseases: lessons from a rapid autopsy program. Cancer Res (2004) 5.88

Personalized oncology through integrative high-throughput sequencing: a pilot study. Sci Transl Med (2011) 5.82

Profiling critical cancer gene mutations in clinical tumor samples. PLoS One (2009) 5.63

DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer. N Engl J Med (2015) 5.39

Chimeric transcript discovery by paired-end transcriptome sequencing. Proc Natl Acad Sci U S A (2009) 5.30

EML4-ALK fusion lung cancer: a rare acquired event. Neoplasia (2008) 5.22

Prostate pathology of genetically engineered mice: definitions and classification. The consensus report from the Bar Harbor meeting of the Mouse Models of Human Cancer Consortium Prostate Pathology Committee. Cancer Res (2004) 5.13

alpha-Methylacyl coenzyme A racemase as a tissue biomarker for prostate cancer. JAMA (2002) 5.07

TMPRSS2:ETV4 gene fusions define a third molecular subtype of prostate cancer. Cancer Res (2006) 4.99

Rearrangements of the RAF kinase pathway in prostate cancer, gastric cancer and melanoma. Nat Med (2010) 4.81

Active surveillance for low-risk prostate cancer worldwide: the PRIAS study. Eur Urol (2012) 4.48

Integrative analysis of the cancer transcriptome. Nat Genet (2005) 4.44

Integrative genomics analysis reveals silencing of beta-adrenergic signaling by polycomb in prostate cancer. Cancer Cell (2007) 4.43

Prostate specific antigen concentration at age 60 and death or metastasis from prostate cancer: case-control study. BMJ (2010) 4.42

Expressed pseudogenes in the transcriptional landscape of human cancers. Cell (2012) 4.22

Probabilistic model of the human protein-protein interaction network. Nat Biotechnol (2005) 3.99

Activating ESR1 mutations in hormone-resistant metastatic breast cancer. Nat Genet (2013) 3.96

A polycomb repression signature in metastatic prostate cancer predicts cancer outcome. Cancer Res (2007) 3.82

DD3(PCA3), a very sensitive and specific marker to detect prostate tumors. Cancer Res (2002) 3.78

Multiplex biomarker approach for determining risk of prostate-specific antigen-defined recurrence of prostate cancer. J Natl Cancer Inst (2003) 3.73

Antibody-based detection of ERG rearrangement-positive prostate cancer. Neoplasia (2010) 3.66

Characterization of TMPRSS2:ETV5 and SLC45A3:ETV5 gene fusions in prostate cancer. Cancer Res (2008) 3.59

Estrogen-dependent signaling in a molecularly distinct subclass of aggressive prostate cancer. J Natl Cancer Inst (2008) 3.55

Mechanistic rationale for inhibition of poly(ADP-ribose) polymerase in ETS gene fusion-positive prostate cancer. Cancer Cell (2011) 3.53

DD3(PCA3)-based molecular urine analysis for the diagnosis of prostate cancer. Eur Urol (2003) 3.52

Strategy for detection of prostate cancer based on relation between prostate specific antigen at age 40-55 and long term risk of metastasis: case-control study. BMJ (2013) 3.51

Molecular characterization of neuroendocrine prostate cancer and identification of new drug targets. Cancer Discov (2011) 3.43

Inferring loss-of-heterozygosity from unpaired tumors using high-density oligonucleotide SNP arrays. PLoS Comput Biol (2006) 3.39

The long noncoding RNA SChLAP1 promotes aggressive prostate cancer and antagonizes the SWI/SNF complex. Nat Genet (2013) 3.39

Comprehensive assessment of TMPRSS2 and ETS family gene aberrations in clinically localized prostate cancer. Mod Pathol (2007) 3.37

A first-generation multiplex biomarker analysis of urine for the early detection of prostate cancer. Cancer Res (2008) 3.35

Induced chromosomal proximity and gene fusions in prostate cancer. Science (2009) 3.31

Stem cell characteristics in prostate cancer cell lines. Eur Urol (2009) 3.21

Effects of raf kinase inhibitor protein expression on suppression of prostate cancer metastasis. J Natl Cancer Inst (2003) 3.19

Vesiclepedia: a compendium for extracellular vesicles with continuous community annotation. PLoS Biol (2012) 3.18

Patterns of gene expression and copy-number alterations in von-hippel lindau disease-associated and sporadic clear cell carcinoma of the kidney. Cancer Res (2009) 3.17

Identification of targetable FGFR gene fusions in diverse cancers. Cancer Discov (2013) 3.13

Molecular concepts analysis links tumors, pathways, mechanisms, and drugs. Neoplasia (2007) 3.06