The relationship between aberrant neuronal activation in the pregenual anterior cingulate, altered glutamatergic metabolism, and anhedonia in major depression.

PubWeight™: 1.61‹?› | Rank: Top 4%

🔗 View Article (PMID 19414707)

Published in Arch Gen Psychiatry on May 01, 2009

Authors

Martin Walter1, Anke Henning, Simone Grimm, Rolf F Schulte, Johannes Beck, Ulrike Dydak, Betina Schnepf, Heinz Boeker, Peter Boesiger, Georg Northoff

Author Affiliations

1: Department of Psychiatry, Ottovon-Guericke University of Magdeburg, Magdeburg, Germany.

Articles citing this

Reconsidering anhedonia in depression: lessons from translational neuroscience. Neurosci Biobehav Rev (2010) 3.46

Frontocingulate dysfunction in depression: toward biomarkers of treatment response. Neuropsychopharmacology (2010) 2.97

Magnetic resonance spectroscopy studies of glutamate-related abnormalities in mood disorders. Biol Psychiatry (2010) 2.08

In vivo magnetic resonance spectroscopy of GABA: a methodological review. Prog Nucl Magn Reson Spectrosc (2011) 1.91

Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: evidence for an immune-modulated glutamatergic neurotransmission? J Neuroinflammation (2011) 1.56

Glutamatergic and resting-state functional connectivity correlates of severity in major depression - the role of pregenual anterior cingulate cortex and anterior insula. Front Syst Neurosci (2010) 1.54

Prefrontal cortical GABA abnormalities are associated with reduced hippocampal volume in major depressive disorder. Eur Neuropsychopharmacol (2015) 1.45

Ketamine decreases resting state functional network connectivity in healthy subjects: implications for antidepressant drug action. PLoS One (2012) 1.27

Striatum-based circuitry of adolescent depression and anhedonia. J Am Acad Child Adolesc Psychiatry (2013) 1.24

Anterior cingulate cortex γ-aminobutyric acid in depressed adolescents: relationship to anhedonia. Arch Gen Psychiatry (2011) 1.23

Anti-anhedonic effect of ketamine and its neural correlates in treatment-resistant bipolar depression. Transl Psychiatry (2014) 1.14

Regional decoupling of N-acetyl-aspartate and glutamate in schizophrenia. Neuropsychopharmacology (2012) 1.02

Mood-congruent amygdala responses to subliminally presented facial expressions in major depression: associations with anhedonia. J Psychiatry Neurosci (2013) 0.98

High field FMRI reveals thalamocortical integration of segregated cognitive and emotional processing in mediodorsal and intralaminar thalamic nuclei. Front Neuroanat (2010) 0.97

The association of interoceptive awareness and alexithymia with neurotransmitter concentrations in insula and anterior cingulate. Soc Cogn Affect Neurosci (2013) 0.97

An investigation of amino-acid neurotransmitters as potential predictors of clinical improvement to ketamine in depression. Int J Neuropsychopharmacol (2011) 0.97

A neurobiological approach to the cognitive deficits of psychiatric disorders. Dialogues Clin Neurosci (2013) 0.97

Glutamate concentration in the medial prefrontal cortex predicts resting-state cortical-subcortical functional connectivity in humans. PLoS One (2013) 0.96

Reduced frontal glutamate + glutamine and N-acetylaspartate levels in patients with chronic schizophrenia but not in those at clinical high risk for psychosis or with first-episode schizophrenia. Schizophr Bull (2013) 0.94

Relationship between genetic variation in the glutaminase gene GLS1 and brain glutamine/glutamate ratio measured in vivo. Biol Psychiatry (2011) 0.91

Neural correlates of change in major depressive disorder anhedonia following open-label ketamine. J Psychopharmacol (2015) 0.91

Functional mapping of thalamic nuclei and their integration into cortico-striatal-thalamo-cortical loops via ultra-high resolution imaging-from animal anatomy to in vivo imaging in humans. Front Neurosci (2013) 0.89

Multimodal analysis of the hippocampus in schizophrenia using proton magnetic resonance spectroscopy and functional magnetic resonance imaging. Schizophr Res (2012) 0.89

Neurochemistry of major depression: a study using magnetic resonance spectroscopy. Psychopharmacology (Berl) (2014) 0.84

Why are cortical GABA neurons relevant to internal focus in depression? A cross-level model linking cellular, biochemical and neural network findings. Mol Psychiatry (2014) 0.84

Differential levels of brain amino acids in rat models presenting learned helplessness or non-learned helplessness. Psychopharmacology (Berl) (2013) 0.83

Multistage drug effects of ketamine in the treatment of major depression. Eur Arch Psychiatry Clin Neurosci (2014) 0.82

Glutamine deficiency in the prefrontal cortex increases depressive-like behaviours in male mice. J Psychiatry Neurosci (2013) 0.82

Magnetic resonance spectroscopy studies of the glutamatergic system in mood disorders: a pathway to diagnosis, novel therapeutics, and personalized medicine? Biol Psychiatry (2010) 0.81

Neural response to eye contact and paroxetine treatment in generalized social anxiety disorder. Psychiatry Res (2011) 0.81

Reduced density of glutamine synthetase immunoreactive astrocytes in different cortical areas in major depression but not in bipolar I disorder. Front Cell Neurosci (2015) 0.80

Disturbance of the glutamatergic system in mood disorders. Exp Neurobiol (2014) 0.80

Selective GABA release as a mechanistic basis of high-frequency stimulation used for the treatment of neuropsychiatric diseases. Naunyn Schmiedebergs Arch Pharmacol (2011) 0.79

Reliability of 7T (1) H-MRS measured human prefrontal cortex glutamate, glutamine, and glutathione signals using an adapted echo time optimized PRESS sequence: A between- and within-sessions investigation. J Magn Reson Imaging (2015) 0.79

Self-referential processing influences functional activation during cognitive control: an fMRI study. Soc Cogn Affect Neurosci (2012) 0.79

GABA System in Schizophrenia and Mood Disorders: A Mini Review on Third-Generation Imaging Studies. Front Psychiatry (2016) 0.79

Vulnerability for new episodes in recurrent major depressive disorder: protocol for the longitudinal DELTA-neuroimaging cohort study. BMJ Open (2016) 0.78

Prefrontal cortex glutamate and extraversion. Soc Cogn Affect Neurosci (2011) 0.78

Mapping anhedonia-specific dysfunction in a transdiagnostic approach: an ALE meta-analysis. Brain Imaging Behav (2016) 0.78

Out-of-sync: disrupted neural activity in emotional circuitry during film viewing in melancholic depression. Sci Rep (2015) 0.78

Baseline effects of transcranial direct current stimulation on glutamatergic neurotransmission and large-scale network connectivity. Brain Res (2014) 0.78

Glutamate and Gamma-Aminobutyric Acid Systems in the Pathophysiology of Major Depression and Antidepressant Response to Ketamine. Biol Psychiatry (2016) 0.77

Decoupling of N-acetyl-aspartate and glutamate within the dorsolateral prefrontal cortex in schizophrenia. Curr Mol Med (2015) 0.77

Asymmetry of the endogenous opioid system in the human anterior cingulate: a putative molecular basis for lateralization of emotions and pain. Cereb Cortex (2013) 0.76

Dysfunctional Connectivity in the Depressed Adolescent Brain. Biol Psychiatry (2015) 0.76

A spectroscopic approach toward depression diagnosis: local metabolism meets functional connectivity. Eur Arch Psychiatry Clin Neurosci (2016) 0.76

Abnormal Anterior Cingulate N-Acetylaspartate and Executive Functioning in Treatment-Resistant Depression After rTMS Therapy. Int J Neuropsychopharmacol (2015) 0.76

Cocaine dependence and thalamic functional connectivity: a multivariate pattern analysis. Neuroimage Clin (2016) 0.76

Temporal Dynamics of Antidepressant Ketamine Effects on Glutamine Cycling Follow Regional Fingerprints of AMPA and NMDA Receptor Densities. Neuropsychopharmacology (2016) 0.76

State and Training Effects of Mindfulness Meditation on Brain Networks Reflect Neuronal Mechanisms of Its Antidepressant Effect. Neural Plast (2016) 0.75

Altered Effective Connectivity among Core Neurocognitive Networks in Idiopathic Generalized Epilepsy: An fMRI Evidence. Front Hum Neurosci (2016) 0.75

The value of success: acquiring gains, avoiding losses, and simply being successful. PLoS One (2011) 0.75

Differential effects of rumination and distraction on ketamine induced modulation of resting state functional connectivity and reactivity of regions within the default-mode network. Soc Cogn Affect Neurosci (2016) 0.75

Large-Scale Brain Network Coupling Predicts Total Sleep Deprivation Effects on Cognitive Capacity. PLoS One (2015) 0.75

Metabolic mapping reveals sex-dependent involvement of default mode and salience network in alexithymia. Soc Cogn Affect Neurosci (2015) 0.75

The separation of Gln and Glu in STEAM: a comparison study using short and long TEs/TMs at 3 and 7 T. MAGMA (2015) 0.75

Recent Advances in Translational Magnetic Resonance Imaging in Animal Models of Stress and Depression. Front Cell Neurosci (2017) 0.75

Adaptive metabolic changes in CADASIL white matter. J Neurol (2009) 0.75

Activation volume vs BOLD signal change as measures of fMRI activation - Its impact on GABA - fMRI activation correlation. Magn Reson Imaging (2017) 0.75

Metabotropic Glutamate Receptor 5 and Glutamate Involvement in Major Depressive Disorder: A Multimodal Imaging Study. Biol Psychiatry Cogn Neurosci Neuroimaging (2017) 0.75

Articles by these authors

k-t BLAST and k-t SENSE: dynamic MRI with high frame rate exploiting spatiotemporal correlations. Magn Reson Med (2003) 5.81

Structure of PTB bound to RNA: specific binding and implications for splicing regulation. Science (2005) 5.14

Ultralong spin coherence time in isotopically engineered diamond. Nat Mater (2009) 4.70

Transmit and receive transmission line arrays for 7 Tesla parallel imaging. Magn Reson Med (2005) 4.25

Compressed sensing in dynamic MRI. Magn Reson Med (2008) 3.65

In vivo heating of pacemaker leads during magnetic resonance imaging. Eur Heart J (2004) 3.38

Single-shot readout of a single nuclear spin. Science (2010) 2.79

Culture-sensitive neural substrates of human cognition: a transcultural neuroimaging approach. Nat Rev Neurosci (2008) 2.73

2D SENSE for faster 3D MRI. MAGMA (2002) 2.46

How is our self related to midline regions and the default-mode network? Neuroimage (2011) 2.41

Cardiac SSFP imaging at 3 Tesla. Magn Reson Med (2004) 2.33

GABA concentrations in the human anterior cingulate cortex predict negative BOLD responses in fMRI. Nat Neurosci (2007) 2.22

Dynamic contrast-enhanced myocardial perfusion MRI accelerated with k-t sense. Magn Reson Med (2007) 2.18

Electrodynamics and ultimate SNR in parallel MR imaging. Magn Reson Med (2004) 2.11

Face perception is mediated by a distributed cortical network. Brain Res Bull (2005) 2.10

"Soap-Bubble" visualization and quantitative analysis of 3D coronary magnetic resonance angiograms. Magn Reson Med (2002) 2.09

Is there a core neural network in empathy? An fMRI based quantitative meta-analysis. Neurosci Biobehav Rev (2010) 1.99

Metabolic modulator perhexiline corrects energy deficiency and improves exercise capacity in symptomatic hypertrophic cardiomyopathy. Circulation (2010) 1.96

Facing depression with botulinum toxin: a randomized controlled trial. J Psychiatr Res (2012) 1.90

Better memory and neural efficiency in young apolipoprotein E epsilon4 carriers. Cereb Cortex (2006) 1.87

Array compression for MRI with large coil arrays. Magn Reson Med (2007) 1.81

Imbalance between left and right dorsolateral prefrontal cortex in major depression is linked to negative emotional judgment: an fMRI study in severe major depressive disorder. Biol Psychiatry (2007) 1.78

Altered negative BOLD responses in the default-mode network during emotion processing in depressed subjects. Neuropsychopharmacology (2008) 1.69

ProFit: two-dimensional prior-knowledge fitting of J-resolved spectra. NMR Biomed (2006) 1.67

Heart failure with preserved ejection fraction is characterized by dynamic impairment of active relaxation and contraction of the left ventricle on exercise and associated with myocardial energy deficiency. J Am Coll Cardiol (2009) 1.67

Clinical feasibility of accelerated, high spatial resolution myocardial perfusion imaging. JACC Cardiovasc Imaging (2010) 1.56

Ventricular myocardial architecture as visualised in postmortem swine hearts using magnetic resonance diffusion tensor imaging. Eur J Cardiothorac Surg (2005) 1.56

Clinical proton MR spectroscopy in central nervous system disorders. Radiology (2014) 1.53

Accelerating cine phase-contrast flow measurements using k-t BLAST and k-t SENSE. Magn Reson Med (2005) 1.50

Optimized and combined T1 and B1 mapping technique for fast and accurate T1 quantification in contrast-enhanced abdominal MRI. Magn Reson Med (2007) 1.48

Local deformation of extraocular muscles during eye movement. Invest Ophthalmol Vis Sci (2009) 1.48

IDEAL spiral CSI for dynamic metabolic MR imaging of hyperpolarized [1-13C]pyruvate. Magn Reson Med (2011) 1.41

Increased self-focus in major depressive disorder is related to neural abnormalities in subcortical-cortical midline structures. Hum Brain Mapp (2009) 1.40

Diffusion imaging of the in vivo heart using spin echoes--considerations on bulk motion sensitivity. Magn Reson Med (2007) 1.36

Accelerated whole-heart 3D CSPAMM for myocardial motion quantification. Magn Reson Med (2008) 1.31

Prospective self-gating for simultaneous compensation of cardiac and respiratory motion. Magn Reson Med (2008) 1.31

Accelerating cardiac cine 3D imaging using k-t BLAST. Magn Reson Med (2004) 1.28

Ketamine decreases resting state functional network connectivity in healthy subjects: implications for antidepressant drug action. PLoS One (2012) 1.27

Enhanced brain activity may precede the diagnosis of Alzheimer's disease by 30 years. Brain (2006) 1.27

Slice-selective FID acquisition, localized by outer volume suppression (FIDLOVS) for (1)H-MRSI of the human brain at 7 T with minimal signal loss. NMR Biomed (2009) 1.27

Segregated neural representation of distinct emotion dimensions in the prefrontal cortex-an fMRI study. Neuroimage (2005) 1.25

Abnormal activity in hypothalamus and amygdala during humour processing in human narcolepsy with cataplexy. Brain (2007) 1.24

Distinction between Externally vs. Internally Guided Decision-Making: Operational Differences, Meta-Analytical Comparisons and Their Theoretical Implications. Front Neurosci (2012) 1.24

Bone metastases from prostate cancer: assessing treatment response by using diffusion-weighted imaging and functional diffusion maps--initial observations. Radiology (2010) 1.23

Three-dimensional fiber architecture of the nonpregnant human uterus determined ex vivo using magnetic resonance diffusion tensor imaging. Anat Rec A Discov Mol Cell Evol Biol (2006) 1.22

A cultural neuroscience approach to the biosocial nature of the human brain. Annu Rev Psychol (2012) 1.22

Myocardial tagging with 3D-CSPAMM. J Magn Reson Imaging (2002) 1.22

Sensitivity encoding as a means of enhancing the SNR efficiency in steady-state MRI. Magn Reson Med (2005) 1.22

Sensitivity-encoded single-shot spiral imaging for reduced susceptibility artifacts in BOLD fMRI. Magn Reson Med (2002) 1.21

Optimizing spatiotemporal sampling for k-t BLAST and k-t SENSE: application to high-resolution real-time cardiac steady-state free precession. Magn Reson Med (2005) 1.20

High exercise levels are related to favorable sleep patterns and psychological functioning in adolescents: a comparison of athletes and controls. J Adolesc Health (2009) 1.19

The neuroanatomy of asomatognosia and somatoparaphrenia. J Neurol Neurosurg Psychiatry (2009) 1.18

Structure of the two most C-terminal RNA recognition motifs of PTB using segmental isotope labeling. EMBO J (2005) 1.18

Implicit associative learning engages the hippocampus and interacts with explicit associative learning. Neuron (2005) 1.18

Distinguishing specific sexual and general emotional effects in fMRI-subcortical and cortical arousal during erotic picture viewing. Neuroimage (2008) 1.17

High resolution three-dimensional cardiac perfusion imaging using compartment-based k-t principal component analysis. Magn Reson Med (2010) 1.16

High spatial resolution myocardial perfusion cardiac magnetic resonance for the detection of coronary artery disease. Eur Heart J (2008) 1.14

Dissociation between anterior and posterior cortical regions during self-specificity and familiarity: a combined fMRI-meta-analytic study. Hum Brain Mapp (2011) 1.14

Affective judgment and beneficial decision making: ventromedial prefrontal activity correlates with performance in the Iowa Gambling Task. Hum Brain Mapp (2006) 1.13

Sensitivity-encoded coronary MRA at 3T. Magn Reson Med (2004) 1.11

Deficit in decision making in catatonic schizophrenia: an exploratory study. Psychiatry Res (2005) 1.10

Dissociable networks for the expectancy and perception of emotional stimuli in the human brain. Neuroimage (2005) 1.10

Attentional modulation of emotional stimulus processing: an fMRI study using emotional expectancy. Hum Brain Mapp (2006) 1.09

The effect of macronutrients on gastric volume responses and gastric emptying in humans: A magnetic resonance imaging study. Am J Physiol Gastrointest Liver Physiol (2006) 1.09

Biomarkers of manganese intoxication. Neurotoxicology (2010) 1.09

Hypoxia-induced acute mountain sickness is associated with intracellular cerebral edema: a 3 T magnetic resonance imaging study. J Cereb Blood Flow Metab (2007) 1.08

Nonrigid retrospective respiratory motion correction in whole-heart coronary MRA. Magn Reson Med (2011) 1.08

Delineating self-referential processing from episodic memory retrieval: common and dissociable networks. Neuroimage (2010) 1.08

Reduced negative BOLD responses in the default-mode network and increased self-focus in depression. World J Biol Psychiatry (2011) 1.08

k-Space and time sensitivity encoding-accelerated myocardial perfusion MR imaging at 3.0 T: comparison with 1.5 T. Radiology (2008) 1.07

Abnormal activity in reward brain circuits in human narcolepsy with cataplexy. Ann Neurol (2010) 1.07

Is subcortical-cortical midline activity in depression mediated by glutamate and GABA? A cross-species translational approach. Neurosci Biobehav Rev (2009) 1.06

Is our self nothing but reward? Neuronal overlap and distinction between reward and personal relevance and its relation to human personality. PLoS One (2009) 1.06

Pathophysiology of manganese-associated neurotoxicity. Neurotoxicology (2011) 1.06

Whole-heart dynamic three-dimensional magnetic resonance perfusion imaging for the detection of coronary artery disease defined by fractional flow reserve: determination of volumetric myocardial ischaemic burden and coronary lesion location. Eur Heart J (2012) 1.06