Published in Bone on February 12, 2009
An MMP13-selective inhibitor delays primary tumor growth and the onset of tumor-associated osteolytic lesions in experimental models of breast cancer. PLoS One (2012) 0.93
Chondroclasts are mature osteoclasts which are capable of cartilage matrix resorption. Virchows Arch (2012) 0.91
PTHrP induces autocrine/paracrine proliferation of bone tumor cells through inhibition of apoptosis. PLoS One (2011) 0.85
AP-1 as a Regulator of MMP-13 in the Stromal Cell of Giant Cell Tumor of Bone. Biochem Res Int (2011) 0.82
Downregulation of ERK signaling impairs U2OS osteosarcoma cell migration in collagen matrix by suppressing MMP9 production. Oncol Lett (2013) 0.82
Matrix Metalloproteinase Activity in the Stromal Cell of Giant Cell Tumor of Bone. Open Bone J (2009) 0.78
Titanium particles up-regulate the activity of matrix metalloproteinase-2 in human synovial cells. Int Orthop (2013) 0.76
Giant-cell tumor of bone. J Bone Joint Surg Am (1987) 7.92
Membrane type 1 matrix metalloproteinase digests interstitial collagens and other extracellular matrix macromolecules. J Biol Chem (1997) 3.74
Matrix metalloproteinase-2 is an interstitial collagenase. Inhibitor-free enzyme catalyzes the cleavage of collagen fibrils and soluble native type I collagen generating the specific 3/4- and 1/4-length fragments. J Biol Chem (1995) 3.52
Osteoclastic bone resorption by a polarized vacuolar proton pump. Science (1989) 3.31
Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors. Arthritis Res (2001) 3.24
Cellular mechanisms for human procollagenase-3 (MMP-13) activation. Evidence that MT1-MMP (MMP-14) and gelatinase a (MMP-2) are able to generate active enzyme. J Biol Chem (1996) 3.00
The collagenolytic activity of cathepsin K is unique among mammalian proteinases. J Biol Chem (1998) 2.48
Cathepsin K, but not cathepsins B, L, or S, is abundantly expressed in human osteoclasts. J Biol Chem (1996) 2.33
Gene expression of osteoprotegerin ligand, osteoprotegerin, and receptor activator of NF-kappaB in giant cell tumor of bone: possible involvement in tumor cell-induced osteoclast-like cell formation. Am J Pathol (2000) 1.99
Studies on the skeletal tissues. II. The collagen content of bones from rabbits, oxen and humans. Biochem J (1952) 1.98
Roles of matrix metalloproteinases in tumor metastasis and angiogenesis. J Biochem Mol Biol (2003) 1.56
Characterization of chick bone collagen and compositional changes associated with maturation. J Biol Chem (1967) 1.54
The origin of the neoplastic stromal cell in giant cell tumor of bone. Hum Pathol (2003) 1.27
Activation of progelatinase B (proMMP-9) by active collagenase-3 (MMP-13). Eur J Biochem (1997) 1.26
Gene expression in giant-cell tumors. J Lab Clin Med (2004) 1.26
Molecular profiling of giant cell tumor of bone and the osteoclastic localization of ligand for receptor activator of nuclear factor kappaB. Am J Pathol (2005) 1.26
Human giant cell tumors of bone identification and characterization of cell types. J Clin Invest (1987) 1.24
The effects of calcium regulating hormones on bone resorption by isolated human osteoclastoma cells. J Pathol (1985) 1.23
Initiation of osteoclast bone resorption by interstitial collagenase. J Biol Chem (1997) 1.21
Expression of VEGF and MMP-9 in giant cell tumor of bone and other osteolytic lesions. Life Sci (2003) 1.18
Evidence for an autocrine/paracrine role for interleukin-6 in bone resorption by giant cells from giant cell tumors of bone. Endocrinology (1992) 1.17
Phenotypic and molecular studies of giant-cell tumors of bone and soft tissue. Hum Pathol (2005) 1.15
Interleukin 17 (IL-17) induces collagenase-3 production in human osteoarthritic chondrocytes via AP-1 dependent activation: differential activation of AP-1 members by IL-17 and IL-1beta. J Rheumatol (2002) 1.15
Localization of cathepsin K in human osteoclasts by in situ hybridization and immunohistochemistry. Bone (1997) 1.10
Recruitment of osteoclast precursors by stromal cell derived factor-1 (SDF-1) in giant cell tumor of bone. J Orthop Res (2005) 1.10
Cathepsin K is the principal protease in giant cell tumor of bone. Am J Pathol (2004) 1.10
Characterization of cells from human giant cell tumors of bone. Clin Orthop Relat Res (1986) 1.07
Cytological properties of stromal cells derived from giant cell tumor of bone (GCTSC) which can induce osteoclast formation of human blood monocytes without cell to cell contact. J Orthop Res (2005) 1.06
Ultrastructure of giant cell tumors of bone. Hum Pathol (1972) 1.03
Assay of matrix metalloproteases types 8 and 9 by ELISA in human breast cancer. Br J Cancer (1995) 1.03
Gene expression of transforming growth factor-beta 1 and its type II receptor in giant cell tumors of bone. Possible involvement in osteoclast-like cell migration. Am J Pathol (1994) 1.02
Production of matrix metalloproteinases 2 and 3 (stromelysin) by stromal cells of giant cell tumor of bone. Am J Pathol (1992) 1.00
Expression of preosteoblast markers and Cbfa-1 and Osterix gene transcripts in stromal tumour cells of giant cell tumour of bone. Bone (2004) 1.00
Differential regulation of cytokine-induced MMP-1 and MMP-13 expression by p38 kinase inhibitors in human chondrosarcoma cells: potential role of Runx2 in mediating p38 effects. Osteoarthritis Cartilage (2006) 0.99
Properties of the stromal cell in giant cell tumor of bone. Clin Orthop Relat Res (2007) 0.98
Spindle-shaped cells derived from giant-cell tumor of bone support differentiation of blood monocytes to osteoclast-like cells. J Orthop Res (2000) 0.98
Changes in the composition of the human femur during growth. Biochem J (1962) 0.98
Gene expression of monocyte chemoattractant protein-1 in giant cell tumors of bone osteoclastoma: possible involvement in CD68+ macrophage-like cell migration. J Cell Biochem (1998) 0.96
Immunolocalization of matrix metalloproteinase-13 on bone surface under osteoclasts in rat tibia. Bone (2004) 0.95
Localisation of mRNA for collagenase in osteocytic, bone surface and chondrocytic cells but not osteoclasts. J Cell Sci (1995) 0.95
Osteoblast lineage properties in giant cell tumors of bone. J Orthop Sci (2005) 0.93
(Pro)collagenase (matrix metalloproteinase-1) is present in rodent osteoclasts and in the underlying bone-resorbing compartment. J Cell Sci (1993) 0.92
Detection of mRNA for carbonic anhydrase II in human osteoclast-like cells by in situ hybridization. J Bone Miner Res (1993) 0.90
Interstitial collagenase activity stimulates the formation of actin rings and ruffled membranes in mouse marrow osteoclasts. Calcif Tissue Int (2003) 0.89
MMP-13 is over-expressed in renal cell carcinoma bone metastasis and is induced by TGF-beta1. Clin Exp Metastasis (2008) 0.86
Proteases and interleukin-6 gene analysis in 92 giant cell tumors of bone. Ann Oncol (2004) 0.85
Purification and characterization of fully functional human osteoclast precursors. J Bone Miner Res (1996) 0.84
Giant cell tumor bone. Enzyme histochemical, biochemical and tissue culture studies. Virchows Arch A Pathol Anat Histol (1982) 0.83
Effect of cytokines on in vitro bone resorption by cells isolated from giant cell tumor of bone. Chin Med J (Engl) (1999) 0.81
Expression of 72 kDa and 92 kDa type IV collagenases from human giant-cell tumor of bone. Clin Exp Metastasis (1995) 0.81
In vitro bone resorption by isolated multinucleated giant cells from giant cell tumour of bone: light and electron microscopic study. Virchows Arch A Pathol Anat Histopathol (1991) 0.81
Collagen content and collagen extractability pattern of adult human trabecular bone according to age, sex and amount of bone mass. Biochim Biophys Acta (1971) 0.81
Prognosis of giant cell tumor of bone. Histopathological analysis of 15 cases and review of the literature. Adv Clin Path (2001) 0.80
Characterization of a cell line derived from a human giant cell tumor that stimulates osteoclastic bone resorption. Clin Orthop Relat Res (1993) 0.79
Culturing of cells from giant cell tumour of bone on natural and synthetic calcified substrata: the effect of leukaemia inhibitory factor and vitamin D3 on the resorbing activity of osteoclast-like cells. Virchows Arch (1995) 0.77
A systematic meta-analysis of randomized controlled trials of adjuvant chemotherapy for localized resectable soft-tissue sarcoma. Cancer (2008) 3.85
Lower plasma adiponectin levels are associated with larger tumor size and metastasis in clear-cell carcinoma of the kidney. Eur Urol (2008) 2.42
Ionizing radiation activates AMP-activated kinase (AMPK): a target for radiosensitization of human cancer cells. Int J Radiat Oncol Biol Phys (2010) 1.89
Surgical management of bone metastases: quality of evidence and systematic review. Ann Surg Oncol (2014) 1.58
Is low-level laser therapy in relieving neck pain effective? Systematic review and meta-analysis. Rheumatol Int (2013) 1.39
Sestrin2 modulates AMPK subunit expression and its response to ionizing radiation in breast cancer cells. PLoS One (2012) 1.38
Calculation of singlet oxygen dose from photosensitizer fluorescence and photobleaching during mTHPC photodynamic therapy of MLL cells. Photochem Photobiol (2005) 1.37
Overexpression of vimentin: role in the invasive phenotype in an androgen-independent model of prostate cancer. Cancer Res (2003) 1.32
High infection rate outcomes in long-bone tumor surgery with endoprosthetic reconstruction in adults: a systematic review. Clin Orthop Relat Res (2013) 1.27
ets-1 is transcriptionally up-regulated by H2O2 via an antioxidant response element. FASEB J (2005) 1.18
Doxycycline and other tetracyclines in the treatment of bone metastasis. Anticancer Drugs (2003) 1.13
Giant cell tumor of bone: a basic science perspective. Bone (2012) 1.11
Doxycycline decreases tumor burden in a bone metastasis model of human breast cancer. Cancer Res (2002) 1.10
The use of free vascularized fibular grafts in skeletal reconstruction for bone tumors in children. J Am Acad Orthop Surg (2007) 1.08
Myxoid\round cell liposarcoma (MRCLS) revisited: an analysis of 418 primarily managed cases. Ann Surg Oncol (2011) 1.08
Androgen induces adaptation to oxidative stress in prostate cancer: implications for treatment with radiation therapy. Neoplasia (2007) 1.05
Mechanisms associated with mitochondrial-generated reactive oxygen species in cancer. Can J Physiol Pharmacol (2010) 1.01
Use of a calcium sulfate-calcium phosphate synthetic bone graft composite in the surgical management of primary bone tumors. Orthopedics (2013) 1.01
Cancer cell lines release glutamate into the extracellular environment. Clin Exp Metastasis (2009) 1.00
Cancer cells release glutamate via the cystine/glutamate antiporter. Biochem Biophys Res Commun (2009) 0.99
Properties of the stromal cell in giant cell tumor of bone. Clin Orthop Relat Res (2007) 0.98
What are the levels of evidence on which we base decisions for surgical management of lower extremity bone tumors? Clin Orthop Relat Res (2013) 0.98
A systematic review and meta-analysis of intralesional versus wide resection for intramedullary grade I chondrosarcoma of the extremities. Ann Surg Oncol (2011) 0.97
Regulation of the cell cycle in response to inhibition of mitochondrial generated energy. Biochem Biophys Res Commun (2005) 0.97
Role of IGF-1/IGF-1R in regulation of invasion in DU145 prostate cancer cells. Cancer Cell Int (2008) 0.96
High activity of mitochondrial glycerophosphate dehydrogenase and glycerophosphate-dependent ROS production in prostate cancer cell lines. Biochem Biophys Res Commun (2005) 0.95
Establishing a relationship between prolactin and altered fatty acid β-oxidation via carnitine palmitoyl transferase 1 in breast cancer cells. BMC Cancer (2011) 0.95
A Systematic Review and Meta-Analysis of En-Bloc vs Intralesional Resection for Giant Cell Tumor of Bone of the Distal Radius. Open Orthop J (2013) 0.95
Ionizing radiation regulates the expression of AMP-activated protein kinase (AMPK) in epithelial cancer cells: modulation of cellular signals regulating cell cycle and survival. Radiother Oncol (2012) 0.95
The importance of social and collaborative learning for online continuing medical education (OCME): directions for future development and research. Med Teach (2012) 0.95
Intra-articular nodular fasciitis of the shoulder: a case report and review of the literature. Skeletal Radiol (2011) 0.94
Relationships among tumor burden, tumor size, and the changing concentrations of fibrin degradation products and fibrinolytic factors in the pleural effusions of rabbits with VX2 lung tumors. J Lab Clin Med (2006) 0.94
Chronic hypoxia promotes an aggressive phenotype in rat prostate cancer cells. Free Radic Res (2007) 0.93
Resveratrol enhances prostate cancer cell response to ionizing radiation. Modulation of the AMPK, Akt and mTOR pathways. Radiat Oncol (2011) 0.92
Design, synthesis, and evaluation of novel 6-chloro-/fluorochromone derivatives as potential topoisomerase inhibitor anticancer agents. Bioorg Med Chem Lett (2005) 0.92
A systematic review and meta-analysis of oncologic outcomes of pre- versus postoperative radiation in localized resectable soft-tissue sarcoma. Ann Surg Oncol (2010) 0.90
Sustained activation of the extracellular signal-regulated kinase pathway protects cells from photofrin-mediated photodynamic therapy. Cancer Res (2002) 0.90
Ets-1 global gene expression profile reveals associations with metabolism and oxidative stress in ovarian and breast cancers. Cancer Metab (2013) 0.90
Observations on the use of the avian chorioallantoic membrane (CAM) model in investigations into angiogenesis. Curr Drug Targets Cardiovasc Haematol Disord (2003) 0.90
Upregulation of MMP-13 via Runx2 in the stromal cell of Giant Cell Tumor of bone. Bone (2009) 0.90
Prediction and analysis of paralogous proteins in Trichomonas vaginalis genome. Bioinformation (2011) 0.90
Outcomes of an anatomically based approach to metastatic disease of the acetabulum. Clin Orthop Relat Res (2007) 0.90
Simultaneous determination of (fluoro)quinolone antibiotics in kidney, marine products, eggs, and muscle by enzyme-linked immunosorbent assay (ELISA). J Agric Food Chem (2006) 0.90
Transfusion practices for elective orthopedic surgery. CMAJ (2002) 0.89
Relationship between mTHPC fluorescence photobleaching and cell viability during in vitro photodynamic treatment of DP16 cells. Photochem Photobiol (2002) 0.89
Interactions of doxycycline with chemotherapeutic agents in human breast adenocarcinoma MDA-MB-231 cells. Anticancer Drugs (2009) 0.89
Association of phosphorylated epidermal growth factor receptor with survival in patients with locally advanced non-small cell lung cancer treated with radiotherapy. J Thorac Oncol (2008) 0.89
Ets-1 regulates energy metabolism in cancer cells. PLoS One (2010) 0.89
Lovastatin sensitizes lung cancer cells to ionizing radiation: modulation of molecular pathways of radioresistance and tumor suppression. J Thorac Oncol (2011) 0.88
Glutamate signaling in healthy and diseased bone. Front Endocrinol (Lausanne) (2012) 0.88
Role of the transcription factor Ets-1 in cisplatin resistance. Mol Cancer Ther (2004) 0.88
Liver kinase B1 expression (LKB1) is repressed by estrogen receptor alpha (ERα) in MCF-7 human breast cancer cells. Biochem Biophys Res Commun (2011) 0.88
Pseudotumoral appearance of a ruptured epidermal cyst in the foot. Skeletal Radiol (2006) 0.87
Intrawound vancomycin to prevent infections after spine surgery: a systematic review and meta-analysis. Eur Spine J (2014) 0.86
Increased expression of mitochondrial glycerophosphate dehydrogenase and antioxidant enzymes in prostate cancer cell lines/cancer. Free Radic Res (2007) 0.86
Inter-related in vitro effects of androgens, fatty acids and oxidative stress in prostate cancer: a mechanistic model supporting prevention strategies. Int J Oncol (2010) 0.86
Prophylactic antibiotic regimens in tumor surgery (PARITY) survey. BMC Musculoskelet Disord (2012) 0.85
PTHrP induces autocrine/paracrine proliferation of bone tumor cells through inhibition of apoptosis. PLoS One (2011) 0.85
Role of insulin-like growth factor binding proteins (IGFBPs) in breast cancer proliferation and metastasis. Clin Exp Metastasis (2003) 0.85
Up-regulation of Hsp27 plays a role in the resistance of human colon carcinoma HT29 cells to photooxidative stress. Photochem Photobiol (2002) 0.85
Investigation of FGFR2-IIIC signaling via FGF-2 ligand for advancing GCT stromal cell differentiation. PLoS One (2012) 0.84
ETS proteins and MMPs: partners in invasion and metastasis. Curr Drug Targets (2002) 0.84
Effect of Herceptin on the development and progression of skeletal metastases in a xenograft model of human breast cancer. Oncogene (2005) 0.84
Extracellular glutamate alters mature osteoclast and osteoblast functions. Can J Physiol Pharmacol (2010) 0.84
PTHrP increases RANKL expression by stromal cells from giant cell tumor of bone. J Orthop Res (2011) 0.84
Potential therapeutic drug target identification in Community Acquired-Methicillin Resistant Staphylococcus aureus (CA-MRSA) using computational analysis. Bioinformation (2012) 0.84
Characterization of a rat model of metastatic prostate cancer bone pain. J Pain Res (2010) 0.84
Evidence for the role of matrix metalloproteinase-13 in bone resorption by giant cell tumor of bone. Hum Pathol (2010) 0.83
Inhibition by doxycycline of angiogenesis in the chicken chorioallantoic membrane (CAM). Cancer Chemother Pharmacol (2005) 0.83
The epigenetic regulation of SOX9 by miR-145 in human chondrosarcoma. J Cell Biochem (2015) 0.83
Expression of Ets-related transcription factors and matrix metalloproteinase genes in human breast cancer cells. Breast Cancer Res Treat (2002) 0.82
AP-1 as a Regulator of MMP-13 in the Stromal Cell of Giant Cell Tumor of Bone. Biochem Res Int (2011) 0.82
Evaluation of single amino acid chelate derivatives and regioselective radiolabelling of a cyclic peptide for the urokinase plasminogen activator receptor. Nucl Med Biol (2009) 0.82
Metabolic pathway analysis and molecular docking analysis for identification of putative drug targets in Toxoplasma gondii: novel approach. Bioinformation (2012) 0.81
Chronic modulation of AMP-Kinase, Akt and mTOR pathways by ionizing radiation in human lung cancer xenografts. Radiat Oncol (2012) 0.80
The orthopaedic in-training examination: perspectives of program directors and residents from the United States and Canada. J Surg Educ (2013) 0.80
Examination of the mechanisms of osteolysis in patients with metastatic breast cancer. Oncol Rep (2009) 0.80
Androgen-dependent regulation of medium and long chain fatty acids uptake in prostate cancer. Prostate (2007) 0.80
Fibrinogen catabolism within the procoagulant VX-2 tumor of rabbit lung in vivo: Effluxing fibrin(ogen) fragments contain antiangiogenic activity. J Lab Clin Med (2004) 0.80
Activation of the stress-activated JNK and p38 MAP kinases in human cells by Photofrin-mediated photodynamic therapy. J Photochem Photobiol B (2003) 0.80
Chronology of the radiographic appearances of the calcium sulphate-calcium phosphate synthetic bone graft composite following resection of bone tumours--a preliminary study of the normal post-operative appearances. Skeletal Radiol (2010) 0.80
Parathyroid hormone-related protein (PTHrP) modulates adhesion, migration and invasion in bone tumor cells. Bone (2013) 0.79
JNK1 activity lowers the cellular production of H2O2 and modulates the growth arrest response to scavenging of H2O2 by catalase. Exp Cell Res (2003) 0.79
A novel surgical approach to lipomatous tumours of the deltoid region. Sarcoma (2010) 0.79
ETV5 as a regulator of matrix metalloproteinase 2 in human chondrosarcoma. J Orthop Res (2012) 0.78
Molecular modeling, dynamics studies and virtual screening of Fructose 1, 6 biphosphate aldolase-II in community acquired- methicillin resistant Staphylococcus aureus (CA-MRSA). Bioinformation (2013) 0.78
Gene transfection in primary stem-like cells of giant cell tumor of bone. Stem Cells Cloning (2010) 0.78
Quantification of anti-angiogenesis using the capillaries of the chick chorioallantoic membrane demonstrates that the effect of human angiostatin is age-dependent. Microvasc Res (2004) 0.78