Published in Biochim Biophys Acta on May 13, 2009
TrkB phosphorylation by Cdk5 is required for activity-dependent structural plasticity and spatial memory. Nat Neurosci (2012) 1.82
A 24-residue peptide (p5), derived from p35, the Cdk5 neuronal activator, specifically inhibits Cdk5-p25 hyperactivity and tau hyperphosphorylation. J Biol Chem (2010) 1.11
CYY-1/cyclin Y and CDK-5 differentially regulate synapse elimination and formation for rewiring neural circuits. Neuron (2011) 1.11
Heterogeneous reallocation of presynaptic efficacy in recurrent excitatory circuits adapting to inactivity. Nat Neurosci (2011) 1.10
Quantitative measurement of in vivo phosphorylation states of Cdk5 activator p35 by Phos-tag SDS-PAGE. Mol Cell Proteomics (2010) 1.03
Activity-dependent phosphorylation of neuronal Kv2.1 potassium channels by CDK5. J Biol Chem (2011) 0.99
Sex differences and effects of cocaine on excitatory synapses in the nucleus accumbens. Neuropharmacology (2011) 0.97
Protection after stroke: cellular effectors of neurovascular unit integrity. Front Cell Neurosci (2014) 0.97
Cyclin-dependent kinase 5 regulates PSD-95 ubiquitination in neurons. J Neurosci (2011) 0.94
Schizophrenia is associated with dysregulation of a Cdk5 activator that regulates synaptic protein expression and cognition. Brain (2011) 0.93
Kalirin, a key player in synapse formation, is implicated in human diseases. Neural Plast (2012) 0.90
Phosphorylation of drebrin by cyclin-dependent kinase 5 and its role in neuronal migration. PLoS One (2014) 0.86
Phosphorylation of gephyrin in hippocampal neurons by cyclin-dependent kinase CDK5 at Ser-270 is dependent on collybistin. J Biol Chem (2012) 0.86
Cocaine- and morphine-induced synaptic plasticity in the nucleus accumbens. Synapse (2010) 0.86
Gephyrin phosphorylation in the functional organization and plasticity of GABAergic synapses. Front Cell Neurosci (2014) 0.85
CDK5 is essential for soluble amyloid β-induced degradation of GKAP and remodeling of the synaptic actin cytoskeleton. PLoS One (2011) 0.84
Phosphorylation of AATYK1 by Cdk5 suppresses its tyrosine phosphorylation. PLoS One (2010) 0.84
Acute and chronic stress differentially regulate cyclin-dependent kinase 5 in mouse brain: implications to glucocorticoid actions and major depression. Transl Psychiatry (2015) 0.83
Actin interaction and regulation of cyclin-dependent kinase 5/p35 complex activity. J Neurochem (2011) 0.81
Cdk5: mediator of neuronal development, death and the response to DNA damage. Mech Ageing Dev (2011) 0.80
Anti-diabetes drug pioglitazone ameliorates synaptic defects in AD transgenic mice by inhibiting cyclin-dependent kinase5 activity. PLoS One (2015) 0.79
Cyclin-dependent Kinase 5 (Cdk5)-dependent Phosphorylation of p70 Ribosomal S6 Kinase 1 (S6K) Is Required for Dendritic Spine Morphogenesis. J Biol Chem (2015) 0.79
S-nitrosylation-dependent proteasomal degradation restrains Cdk5 activity to regulate hippocampal synaptic strength. Nat Commun (2015) 0.79
Adolescent Alcohol Exposure: Burden of Epigenetic Reprogramming, Synaptic Remodeling, and Adult Psychopathology. Front Neurosci (2016) 0.77
Synaptic Plasticity and Signal Transduction Gene Polymorphisms and Vulnerability to Drug Addictions in Populations of European or African Ancestry. CNS Neurosci Ther (2015) 0.77
Regulation of neuronal cav3.1 channels by cyclin-dependent kinase 5 (Cdk5). PLoS One (2015) 0.75
Cdk5 regulates developmental remodeling of mushroom body neurons in Drosophila. Dev Dyn (2015) 0.75
Phosphorylation of CRMP2 by Cdk5 Regulates Dendritic Spine Development of Cortical Neuron in the Mouse Hippocampus. Neural Plast (2015) 0.75
Quantitative and combinatory determination of in situ phosphorylation of tau and its FTDP-17 mutants. Sci Rep (2016) 0.75
Estrogen administration modulates hippocampal GABAergic subpopulations in the hippocampus of trimethyltin-treated rats. Front Cell Neurosci (2015) 0.75
p47Phox/CDK5/DRP1-Mediated Mitochondrial Fission Evokes PV Cell Degeneration in the Rat Dentate Gyrus Following Status Epilepticus. Front Cell Neurosci (2017) 0.75
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Two cyclin-dependent kinase pathways are essential for polarized trafficking of presynaptic components. Cell (2010) 2.32
Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism. Nat Neurosci (2006) 2.30
Regulation of NMDA receptors by neuregulin signaling in prefrontal cortex. J Neurosci (2005) 2.01
TrkB phosphorylation by Cdk5 is required for activity-dependent structural plasticity and spatial memory. Nat Neurosci (2012) 1.82
Synapse development and plasticity: roles of ephrin/Eph receptor signaling. Curr Opin Neurobiol (2009) 1.69
Systems-level comparison of host-responses elicited by avian H5N1 and seasonal H1N1 influenza viruses in primary human macrophages. PLoS One (2009) 1.61
Synaptic roles of Cdk5: implications in higher cognitive functions and neurodegenerative diseases. Neuron (2006) 1.57
Hyperinduction of cyclooxygenase-2-mediated proinflammatory cascade: a mechanism for the pathogenesis of avian influenza H5N1 infection. J Infect Dis (2008) 1.46
APC(Cdh1) mediates EphA4-dependent downregulation of AMPA receptors in homeostatic plasticity. Nat Neurosci (2010) 1.43
Alpha2-chimaerin interacts with EphA4 and regulates EphA4-dependent growth cone collapse. Proc Natl Acad Sci U S A (2007) 1.32
Cdk5 is involved in BDNF-stimulated dendritic growth in hippocampal neurons. PLoS Biol (2007) 1.28
Cdk5: a multifaceted kinase in neurodegenerative diseases. Trends Cell Biol (2011) 1.27
Cyclin-dependent kinase 5 phosphorylates signal transducer and activator of transcription 3 and regulates its transcriptional activity. Proc Natl Acad Sci U S A (2004) 1.27
Aberrant motor axon projection, acetylcholine receptor clustering, and neurotransmission in cyclin-dependent kinase 5 null mice. Proc Natl Acad Sci U S A (2005) 1.26
Cdk5-mediated phosphorylation of endophilin B1 is required for induced autophagy in models of Parkinson's disease. Nat Cell Biol (2011) 1.25
STAT3 as a downstream mediator of Trk signaling and functions. J Biol Chem (2006) 1.22
Integration of signals from receptor tyrosine kinases and g protein-coupled receptors. Neurosignals (2002) 1.22
Endophilin B1 as a novel regulator of nerve growth factor/ TrkA trafficking and neurite outgrowth. J Neurosci (2008) 1.20
Pctaire1 phosphorylates N-ethylmaleimide-sensitive fusion protein: implications in the regulation of its hexamerization and exocytosis. J Biol Chem (2006) 1.15
Molecular mechanisms underlying maturation and maintenance of the vertebrate neuromuscular junction. Trends Neurosci (2012) 1.14
Cyclin-dependent kinase 5 supports neuronal survival through phosphorylation of Bcl-2. J Neurosci (2008) 1.11
Pctaire1 interacts with p35 and is a novel substrate for Cdk5/p35. J Biol Chem (2002) 1.09
Autoinhibition of X11/Mint scaffold proteins revealed by the closed conformation of the PDZ tandem. Nat Struct Mol Biol (2005) 1.07
The roles of cyclin-dependent kinase 5 in dendrite and synapse development. Biotechnol J (2007) 1.06
Autophagy deregulation in neurodegenerative diseases - recent advances and future perspectives. J Neurochem (2011) 1.06
Cdk5: mediator of neuronal death and survival. Neurosci Lett (2004) 1.05
Structural plasticity of dendritic spines: the underlying mechanisms and its dysregulation in brain disorders. Biochim Biophys Acta (2013) 1.02
Identification of the Jak/Stat proteins as novel downstream targets of EphA4 signaling in muscle: implications in the regulation of acetylcholinesterase expression. J Biol Chem (2004) 1.01
Tyk2/STAT3 signaling mediates beta-amyloid-induced neuronal cell death: implications in Alzheimer's disease. J Neurosci (2010) 1.00
α2-chimaerin controls neuronal migration and functioning of the cerebral cortex through CRMP-2. Nat Neurosci (2011) 1.00
Ephrin-B1 reverse signaling activates JNK through a novel mechanism that is independent of tyrosine phosphorylation. J Biol Chem (2003) 0.99
Melanocortin-4 receptor regulates hippocampal synaptic plasticity through a protein kinase A-dependent mechanism. J Neurosci (2013) 0.99
The emerging role of autophagy in Parkinson's disease. Mol Brain (2009) 0.97
Cdk5: a new player at synapses. Neurosignals (2003) 0.97
{alpha}-Syntrophin regulates ARMS localization at the neuromuscular junction and enhances EphA4 signaling in an ARMS-dependent manner. J Cell Biol (2005) 0.94
Ephexin1 is required for structural maturation and neurotransmission at the neuromuscular junction. Neuron (2010) 0.94
Cdk5-mediated phosphorylation of Axin directs axon formation during cerebral cortex development. J Neurosci (2011) 0.93
S-nitrosylation of cyclin-dependent kinase 5 (cdk5) regulates its kinase activity and dendrite growth during neuronal development. J Neurosci (2010) 0.91
Bidirectional signaling of ErbB and Eph receptors at synapses. Neuron Glia Biol (2009) 0.90
Eph receptors at synapses: implications in neurodegenerative diseases. Cell Signal (2011) 0.89
Axin directs the amplification and differentiation of intermediate progenitors in the developing cerebral cortex. Neuron (2013) 0.88
Leukemia inhibitory factor receptor signaling negatively modulates nerve growth factor-induced neurite outgrowth in PC12 cells and sympathetic neurons. J Biol Chem (2003) 0.87
Induction of Cdk5 activity in rat skeletal muscle after nerve injury. Neuroreport (2002) 0.87
Cyclin-dependent kinase 5 links extracellular cues to actin cytoskeleton during dendritic spine development. Cell Adh Migr (2007) 0.87
Ankyrin repeat-rich membrane spanning protein (kidins220) is required for neurotrophin and ephrin receptor-dependent dendrite development. J Neurosci (2012) 0.86
Activity of macrocyclic jatrophane diterpenes from Euphorbia kansui in a TrkA fibroblast survival assay. J Nat Prod (2004) 0.86
Molecular machinery of macroautophagy and its deregulation in diseases. Biochim Biophys Acta (2011) 0.86
Scapinin-induced inhibition of axon elongation is attenuated by phosphorylation and translocation to the cytoplasm. J Biol Chem (2011) 0.86
Coronin 6 regulates acetylcholine receptor clustering through modulating receptor anchorage to actin cytoskeleton. J Neurosci (2014) 0.85
Beta-catenin in reverse action. Nat Neurosci (2008) 0.84
Solution structure of the C-terminal domain of the ciliary neurotrophic factor (CNTF) receptor and ligand free associations among components of the CNTF receptor complex. J Biol Chem (2003) 0.83
Axin: an emerging key scaffold at the synapse. IUBMB Life (2013) 0.83
Multiple Gi proteins participate in nerve growth factor-induced activation of c-Jun N-terminal kinases in PC12 cells. Neurochem Res (2008) 0.83
Multiple roles of the Rho GEF ephexin1 in synapse remodeling. Commun Integr Biol (2010) 0.83
Postsynaptic signaling of new players at the neuromuscular junction. J Neurocytol (2004) 0.82
Cdk5/p35 phosphorylates mSds3 and regulates mSds3-mediated repression of transcription. J Biol Chem (2004) 0.82
A DNA microarray for the authentication of toxic traditional Chinese medicinal plants. Planta Med (2005) 0.82
Central synapse and neuromuscular junction: same players, different roles. Trends Genet (2003) 0.81
Cdk5-mediated phosphorylation of delta-catenin regulates its localization and GluR2-mediated synaptic activity. J Neurosci (2010) 0.80
Differential regulation of the Cdk5-dependent phosphorylation sites of inhibitor-1 and DARPP-32 by depolarization. J Neurochem (2007) 0.80
SLAM-associated protein as a potential negative regulator in Trk signaling. J Biol Chem (2005) 0.80
Nerve growth factor-induced stimulation of p38 mitogen-activated protein kinase in PC12 cells is partially mediated via G(i/o) proteins. Cell Signal (2008) 0.80
Endophilin B1: Guarding the gate to destruction. Commun Integr Biol (2009) 0.80
CDK5 activator p35 downregulates E-cadherin precursor independently of CDK5. FEBS Lett (2008) 0.79
Genotyping on a complementary metal oxide semiconductor silicon polymerase chain reaction chip with integrated DNA microarray. Anal Chem (2002) 0.79
Triterpenoids with neurotrophic activity from Ganoderma lucidum. Nat Prod Res (2011) 0.79
A new carotenoid glycoside from Rehmannia glutinosa. Nat Prod Res (2011) 0.79
Dual actions of brain-derived neurotrophic factor on GABAergic transmission in cerebellar Purkinje neurons. Exp Neurol (2011) 0.79
ent-rosane and labdane diterpenoids from Sagittaria sagittifolia and their antibacterial activity against three oral pathogens. J Nat Prod (2006) 0.78
New secoiridoid glucosides from Ligustrum lucidum induce ERK and CREB phosphorylation in cultured cortical neurons. Planta Med (2010) 0.78
Expression of Cdk5 and its activators in NT2 cells during neuronal differentiation. J Neurochem (2002) 0.78
Agrin regulates growth cone turning of Xenopus spinal motoneurons. Development (2005) 0.78
The N-terminal cytokine binding domain of LIFR is required for CNTF binding and signaling. FEBS Lett (2005) 0.78
Design, synthesis and evaluation of novel heterodimers of donepezil and huperzine fragments as acetylcholinesterase inhibitors. Bioorg Med Chem (2012) 0.78
Cdk5 phosphorylates a component of the HDAC complex and regulates histone acetylation during neuronal cell death. Neurosignals (2012) 0.78
Trophic factors: 50 years of growth. Dev Neurobiol (2010) 0.78
Astragaloside IV and cycloastragenol stimulate the phosphorylation of extracellular signal-regulated protein kinase in multiple cell types. Planta Med (2011) 0.78
The atypical guanine nucleotide exchange factor Dock4 regulates neurite differentiation through modulation of Rac1 GTPase and actin dynamics. J Biol Chem (2013) 0.78
Expression of Gα(z) in C2C12 cells restrains myogenic differentiation. Cell Signal (2010) 0.77
Cdk5: a key player at neuronal synapse with diverse functions. Mini Rev Med Chem (2015) 0.77
Intestinal transport of bis(12)-hupyridone in Caco-2 cells and its improved permeability by the surfactant Brij-35. Biopharm Drug Dispos (2011) 0.77
Minor limonoids from Melia toosendan and their antibacterial activity. Planta Med (2007) 0.77
Antibacterial diterpenoids from Sagittaria pygmaea. Planta Med (2007) 0.77
Melia toosendan regulates PC12 Cell differentiation via the activation of protein kinase A and extracellular signal-regulated kinases. Neurosignals (2004) 0.77
Dammarane saponins from Gynostemma pentaphyllum. Phytochemistry (2010) 0.76
In vitro intestinal absorption and first-pass intestinal and hepatic metabolism of cycloastragenol, a potent small molecule telomerase activator. Drug Metab Pharmacokinet (2010) 0.76
Differential and synergistic effect of nerve growth factor and cAMP on the regulation of early response genes during neuronal differentiation. Neurosignals (2009) 0.76
Cyclin-dependent kinase 5 in axon growth and regeneration. Int Rev Neurobiol (2012) 0.76
Cytotoxic diterpenoids from the roots of Euphorbia ebracteolata. Planta Med (2005) 0.76
Olean-12-eno[2,3-c] [1,2,5]oxadiazol-28-oic acid (OEOA) induces G1 cell cycle arrest and differentiation in human leukemia cell lines. PLoS One (2013) 0.75
Cycloastragenol is a potent telomerase activator in neuronal cells: implications for depression management. Neurosignals (2014) 0.75
Complete 1H, 15N and 13C assignments of the carboxyl terminal domain of the ciliary neurotrophic factor receptor (CNTFR). J Biomol NMR (2002) 0.75
NRG induces membrane targeting of Galphaz in muscle: implication in myogenesis. Neuroreport (2007) 0.75
From understanding synaptic plasticity to the development of cognitive enhancers. Int J Neuropsychopharmacol (2011) 0.75
Membrane distal cytokine binding domain of LIFR interacts with soluble CNTFR in vitro. FEBS Lett (2002) 0.75