Cyclic GMP signaling is involved in the luteinizing hormone-dependent meiotic maturation of mouse oocytes.

PubWeight™: 1.59‹?› | Rank: Top 4%

🔗 View Article (PMC 2731981)

Published in Biol Reprod on May 27, 2009

Authors

Sergio Vaccari1, James L Weeks, Minnie Hsieh, Frank S Menniti, Marco Conti

Author Affiliations

1: Center for Reproductive Sciences, University of California, San Francisco, California 94143-0556, USA.

Associated clinical trials:

Serum Levels of C Type Natriuretic Peptide in Different Reproductive Periods (CO) | NCT04000815

Comparison of Serum C Type Natriuretic Peptide Levels Between Polycystic Ovary Syndrome Patients and Healthy Women (CNP) | NCT04006171

Articles citing this

The mammalian ovary from genesis to revelation. Endocr Rev (2009) 2.31

Granulosa cell ligand NPPC and its receptor NPR2 maintain meiotic arrest in mouse oocytes. Science (2010) 1.83

Absence of MSY2 in mouse oocytes perturbs oocyte growth and maturation, RNA stability, and the transcriptome. Biol Reprod (2011) 1.58

Dephosphorylation and inactivation of NPR2 guanylyl cyclase in granulosa cells contributes to the LH-induced decrease in cGMP that causes resumption of meiosis in rat oocytes. Development (2014) 1.54

Novel signaling mechanisms in the ovary during oocyte maturation and ovulation. Mol Cell Endocrinol (2011) 1.35

Bidirectional communication between oocytes and ovarian follicular somatic cells is required for meiotic arrest of mammalian oocytes. Proc Natl Acad Sci U S A (2013) 1.14

Luteinizing hormone reduces the activity of the NPR2 guanylyl cyclase in mouse ovarian follicles, contributing to the cyclic GMP decrease that promotes resumption of meiosis in oocytes. Dev Biol (2012) 1.13

Developmental control of oocyte maturation and egg activation in metazoan models. Cold Spring Harb Perspect Biol (2011) 1.09

Prophase I arrest and progression to metaphase I in mouse oocytes: comparison of resumption of meiosis and recovery from G2-arrest in somatic cells. Mol Hum Reprod (2010) 1.06

Epidermal growth factor receptor kinase activity is required for gap junction closure and for part of the decrease in ovarian follicle cGMP in response to LH. Reproduction (2010) 1.05

Estradiol promotes and maintains cumulus cell expression of natriuretic peptide receptor 2 (NPR2) and meiotic arrest in mouse oocytes in vitro. Endocrinology (2011) 1.05

Genetic dissection of epidermal growth factor receptor signaling during luteinizing hormone-induced oocyte maturation. PLoS One (2011) 1.04

Ontogeny of the ovary in polycystic ovary syndrome. Fertil Steril (2013) 0.92

Ovulation involves the luteinizing hormone-dependent activation of G(q/11) in granulosa cells. Mol Endocrinol (2013) 0.92

A novel loss-of-function mutation in Npr2 clarifies primary role in female reproduction and reveals a potential therapy for acromesomelic dysplasia, Maroteaux type. Hum Mol Genet (2012) 0.92

Zinc depletion causes multiple defects in ovarian function during the periovulatory period in mice. Endocrinology (2011) 0.92

Proteomic analysis of human follicular fluid from fertile women. Clin Proteomics (2015) 0.91

Regulation of the G2/M transition in rodent oocytes. Mol Reprod Dev (2010) 0.90

LH-induced neuregulin 1 (NRG1) type III transcripts control granulosa cell differentiation and oocyte maturation. Mol Endocrinol (2010) 0.89

Clinical and molecular genetics of the phosphodiesterases (PDEs). Endocr Rev (2013) 0.89

Multiple pathways mediate luteinizing hormone regulation of cGMP signaling in the mouse ovarian follicle. Biol Reprod (2014) 0.87

Consequences of RAS and MAPK activation in the ovary: the good, the bad and the ugly. Mol Cell Endocrinol (2011) 0.86

Intercellular signaling via cyclic GMP diffusion through gap junctions restarts meiosis in mouse ovarian follicles. Proc Natl Acad Sci U S A (2015) 0.86

Hormonal coordination of natriuretic peptide type C and natriuretic peptide receptor 3 expression in mouse granulosa cells. Biol Reprod (2013) 0.85

Mouse versus rat: Profound differences in meiotic regulation at the level of the isolated oocyte. Mol Reprod Dev (2011) 0.82

Female infertility in PDE3A(-/-) mice: polo-like kinase 1 (Plk1) may be a target of protein kinase A (PKA) and involved in meiotic arrest of oocytes from PDE3A(-/-) mice. Cell Cycle (2010) 0.80

Cooperative effects of 17β-estradiol and oocyte-derived paracrine factors on the transcriptome of mouse cumulus cells. Endocrinology (2013) 0.80

Meiotic and developmental competence in mice are compromised following follicle development in vitro using an alginate-based culture system. Biol Reprod (2011) 0.80

Follicle-stimulating hormone regulates expression and activity of epidermal growth factor receptor in the murine ovarian follicle. Proc Natl Acad Sci U S A (2014) 0.80

A moderate increase of hydrogen peroxide level is beneficial for spontaneous resumption of meiosis from diplotene arrest in rat oocytes cultured in vitro. Biores Open Access (2014) 0.80

Biobanking of different body fluids within the frame of IVF-a standard operating procedure to improve reproductive biology research. J Assist Reprod Genet (2016) 0.80

Dephosphorylation of juxtamembrane serines and threonines of the NPR2 guanylyl cyclase is required for rapid resumption of oocyte meiosis in response to luteinizing hormone. Dev Biol (2015) 0.79

Cyclic guanosine monophosphate does not inhibit gonadotropin-induced activation of mitogen-activated protein kinase 3/1 in pig cumulus-oocyte complexes. Reprod Biol Endocrinol (2015) 0.79

Role of PDE3A in regulation of cell cycle progression in mouse vascular smooth muscle cells and oocytes: implications in cardiovascular diseases and infertility. Curr Opin Pharmacol (2011) 0.78

Targeted disruption of Nrg1 in granulosa cells alters the temporal progression of oocyte maturation. Mol Endocrinol (2014) 0.78

Luteinizing Hormone Causes Phosphorylation and Activation of the cGMP Phosphodiesterase PDE5 in Rat Ovarian Follicles, Contributing, Together with PDE1 Activity, to the Resumption of Meiosis. Biol Reprod (2016) 0.78

Identification of phosphodiesterase 9A as a cyclic guanosine monophosphate-specific phosphodiesterase in germinal vesicle oocytes: a proposed role in the resumption of meiosis. Fertil Steril (2012) 0.78

Forkhead box O member FOXO1 regulates the majority of follicle-stimulating hormone responsive genes in ovarian granulosa cells. Mol Cell Endocrinol (2016) 0.77

Morphological, cellular and molecular changes during postovulatory egg aging in mammals. J Biomed Sci (2015) 0.77

Reduction of nitric oxide level leads to spontaneous resumption of meiosis in diplotene-arrested rat oocytes cultured in vitro. Exp Biol Med (Maywood) (2014) 0.77

Porcine oocyte maturation in vitro: role of cAMP and oocyte-secreted factors - A practical approach. J Reprod Dev (2016) 0.75

Selective Regulation of Oocyte Meiotic Events Enhances Progress in Fertility Preservation Methods. Biochem Insights (2015) 0.75

Estrogen receptors in granulosa cells govern meiotic resumption of pre-ovulatory oocytes in mammals. Cell Death Dis (2017) 0.75

Aversive Behavior in the Nematode C. elegans Is Modulated by cGMP and a Neuronal Gap Junction Network. PLoS Genet (2016) 0.75

Levels of cyclic-AMP and cyclic-GMP in porcine oocyte-cumulus complexes and cumulus-free oocytes derived from small and middle follicles during the first 24-hour period of in vitro maturation. J Reprod Dev (2017) 0.75

Protein kinase C isoforms α, δ and ε are differentially expressed in mouse ovaries at different stages of postnatal development. J Ovarian Res (2014) 0.75

The dynamics of connexin expression, degradation and localisation are regulated by gonadotropins during the early stages of in vitro maturation of swine oocytes. PLoS One (2013) 0.75

Epidermal growth factor-mediated mitogen-activated protein kinase3/1 pathway is conducive to in vitro maturation of sheep oocytes. PLoS One (2015) 0.75

MAPK3/1 is conducive to luteinizing hormone-mediated C-type natriuretic peptide decrease in bovine granulosa cells. J Reprod Dev (2015) 0.75

Regulation of mitogen-activated protein kinase 3/1 activity during meiosis resumption in mammals. J Reprod Dev (2015) 0.75

The Effect of Chronic Activation of the Novel Endocannabinoid Receptor GPR18 on Myocardial Function and Blood Pressure in Conscious Rats. J Cardiovasc Pharmacol (2016) 0.75

Regulation of Mammalian Oocyte Meiosis by Intercellular Communication Within the Ovarian Follicle. Annu Rev Physiol (2016) 0.75

cyclic GMP Mediated Inhibition of Spontaneous Germinal Vesicle Breakdown Both with and without Cumulus in Mouse Oocyte. Balsaenggwa Saengsig (2016) 0.75

Beneficial Effects of Melatonin on the In Vitro Maturation of Sheep Oocytes and Its Relation to Melatonin Receptors. Int J Mol Sci (2017) 0.75

Quadrupling efficiency in production of genetically modified pigs through improved oocyte maturation. Proc Natl Acad Sci U S A (2017) 0.75

Macrophage colony-stimulating factor (M-CSF) is an intermediate in the process of luteinizing hormone-induced decrease in natriuretic peptide receptor 2 (NPR2) and resumption of oocyte meiosis. J Ovarian Res (2017) 0.75

Articles cited by this

EGF-like growth factors as mediators of LH action in the ovulatory follicle. Science (2004) 3.66

Effects of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes. J Urol (1998) 2.49

The Gs-linked receptor GPR3 maintains meiotic arrest in mammalian oocytes. Science (2004) 2.32

Cyclic nucleotide phosphodiesterases: relating structure and function. Prog Nucleic Acid Res Mol Biol (2001) 2.30

Luteinizing hormone-dependent activation of the epidermal growth factor network is essential for ovulation. Mol Cell Biol (2006) 2.12

Molecular basis of the synergistic inhibition of platelet function by nitrovasodilators and activators of adenylate cyclase: inhibition of cyclic AMP breakdown by cyclic GMP. Mol Pharmacol (1990) 1.88

Oocyte maturation involves compartmentalization and opposing changes of cAMP levels in follicular somatic and germ cells: studies using selective phosphodiesterase inhibitors. Dev Biol (1996) 1.75

Luteinizing hormone signaling in preovulatory follicles involves early activation of the epidermal growth factor receptor pathway. Mol Endocrinol (2008) 1.71

Cyclic nucleotide phosphodiesterase 3A-deficient mice as a model of female infertility. J Clin Invest (2004) 1.68

The G-protein-coupled receptors GPR3 and GPR12 are involved in cAMP signaling and maintenance of meiotic arrest in rodent oocytes. Dev Biol (2005) 1.63

Role of cyclic nucleotide signaling in oocyte maturation. Mol Cell Endocrinol (2002) 1.55

Inhibitory effect of dibutyryl cAMP on mouse oocyte maturation in vitro. J Exp Zool (1974) 1.54

Rodent oocytes express an active adenylyl cyclase required for meiotic arrest. Dev Biol (2003) 1.44

Luteinizing hormone causes MAP kinase-dependent phosphorylation and closure of connexin 43 gap junctions in mouse ovarian follicles: one of two paths to meiotic resumption. Development (2008) 1.44

Regulation and function of the cyclic nucleotide phosphodiesterase (PDE3) gene family. Prog Nucleic Acid Res Mol Biol (2001) 1.35

Mitogen-activated protein kinase mediates luteinizing hormone-induced breakdown of communication and oocyte maturation in rat ovarian follicles. Endocrinology (2004) 1.32

Disruption of gap junctional communication within the ovarian follicle induces oocyte maturation. Endocrinology (2006) 1.27

Role of phosphodiesterase type 3A in rat oocyte maturation. Biol Reprod (2001) 1.25

Induction of maturation in cumulus cell-enclosed mouse oocytes by follicle-stimulating hormone and epidermal growth factor: evidence for a positive stimulus of somatic cell origin. J Exp Zool (1988) 1.24

Protein kinase B/Akt phosphorylation of PDE3A and its role in mammalian oocyte maturation. EMBO J (2006) 1.17

Meiotic resumption and intracellular cAMP levels in mouse oocytes treated with compounds which act on cAMP metabolism. Cell Differ (1983) 1.07

[3H]sildenafil binding to phosphodiesterase-5 is specific, kinetically heterogeneous, and stimulated by cGMP. Mol Pharmacol (2003) 1.05

Efficacy and selectivity of phosphodiesterase-targeted drugs in inhibiting photoreceptor phosphodiesterase (PDE6) in retinal photoreceptors. Invest Ophthalmol Vis Sci (2005) 1.03

A dramatic loss of cumulus cell gap junctions is correlated with germinal vesicle breakdown in rat oocytes. Dev Biol (1986) 1.03

Resumption of rat oocyte meiosis is paralleled by a decrease in guanosine 3',5'-cyclic monophosphate (cGMP) and is inhibited by microinjection of cGMP. Acta Physiol Scand (1990) 1.00

Generation of mouse oocytes defective in cAMP synthesis and degradation: endogenous cyclic AMP is essential for meiotic arrest. Dev Biol (2008) 1.00

Modulation of cell-to-cell communication in the cumulus-oocyte complex and the regulation of oocyte maturation by LH. Dev Biol (1981) 0.99

Hormonal regulation of 3',5'-adenosine monophosphate phosphodiesterases in cultured rat granulosa cells. Endocrinology (1984) 0.97

Inhibition of rat oocyte maturation and ovulation by nitric oxide: mechanism of action. Biol Reprod (2008) 0.97

Regulation of oocyte maturation by changes in ovarian levels of cyclic nucleotides. Hum Reprod (1991) 0.93

Inhibition of maturation and metabolism in rat oocytes by cyclic amp. J Exp Zool (1977) 0.91

Inhibition of oocyte maturation in the mouse: participation of cAMP, steroid hormones, and a putative maturation-inhibitory factor. Dev Biol (1983) 0.91

N-Terminal domain of phosphodiesterase-11A4 (PDE11A4) decreases affinity of the catalytic site for substrates and tadalafil, and is involved in oligomerization. Biochemistry (2007) 0.90

Modulation of rat thymocyte proliferative response through the inhibition of different cyclic nucleotide phosphodiesterase isoforms by means of selective inhibitors and cGMP-elevating agents. Mol Pharmacol (1993) 0.88

Induction of mouse oocyte maturation in vivo by perturbants of purine metabolism. Biol Reprod (1987) 0.88

Nitric oxide inhibits oocyte meiotic maturation. Biol Reprod (2002) 0.88

Inhibitory action of cyclic guanosine 5'-phosphoric acid (GMP) on oocyte maturation: dependence on an intact cumulus. Biol Reprod (1982) 0.87

Conserved amino acids in metal-binding motifs of PDE3A are involved in substrate and inhibitor binding. Blood (2000) 0.87

Different effects of cyclic nucleotide derivatives upon the rat oocyte-cumulus complex in vitro. Acta Physiol Scand (1984) 0.84

Effects of manipulating the nitric oxide/cyclic GMP pathway on bovine oocyte meiotic resumption in vitro. Theriogenology (2007) 0.84

Nitric oxide influences the maturation of cumulus cell-enclosed mouse oocytes cultured in spontaneous maturation medium and hypoxanthine-supplemented medium through different signaling pathways. Mol Cell Endocrinol (2004) 0.84

Up-regulation of 3'5'-cyclic guanosine monophosphate-specific phosphodiesterase in the porcine cumulus-oocyte complex affects steroidogenesis during in vitro maturation. Endocrinology (2008) 0.82

PDE5 modulates oocyte spontaneous maturation via cGMP-cAMP but not cGMP-PKG signaling. Front Biosci (2008) 0.82

Alterations in nitrate/nitrite and nitric oxide synthase in preovulatory follicles in gonadotropin-primed immature rat. Endocr J (2002) 0.81

Cyclic GMP phosphodiesterase and guanylate cyclase activities in rabbit ovaries and the effect of in-vivo stimulation with LH. J Endocrinol (1984) 0.81

Effects of a nitric oxide donor and nitric oxide synthase inhibitors on luteinizing hormone-induced ovulation in the ex-vivo perfused rat ovary. Hum Reprod (1999) 0.80

Effects of follicle stimulating hormone and luteinizing hormone upon cyclic AMP and cyclic GMP levels in rat ovaries in vitro. Endocrinology (1976) 0.80

Role of cyclic AMP in oocyte maturation and glycolysis in the pre-ovulatory rat follicle. Acta Endocrinol (Copenh) (1978) 0.79

Cyclic nucleotides, DNA, and steroid levels in ovarian follicles and corpora lutea of the cyclic hamster. Biol Reprod (1982) 0.79

Oocyte-somatic cell interactions during oocyte growth and maturation in the mammal. Dev Biol (N Y 1985) (1985) 0.77

Articles by these authors

Glutamate receptor ion channels: structure, regulation, and function. Pharmacol Rev (2010) 11.25

An innovative design to establish proof of concept of the antidepressant effects of the NR2B subunit selective N-methyl-D-aspartate antagonist, CP-101,606, in patients with treatment-refractory major depressive disorder. J Clin Psychopharmacol (2008) 3.90

EGF-like growth factors as mediators of LH action in the ovulatory follicle. Science (2004) 3.66

Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins. Science (2002) 3.46

Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias. Cell (2005) 3.01

Mice deficient for soluble adenylyl cyclase are infertile because of a severe sperm-motility defect. Proc Natl Acad Sci U S A (2004) 2.62

Luteinizing hormone-dependent activation of the epidermal growth factor network is essential for ovulation. Mol Cell Biol (2006) 2.12

Calcium regulation of the soluble adenylyl cyclase expressed in mammalian spermatozoa. Proc Natl Acad Sci U S A (2003) 1.99

Novel signaling pathways that control ovarian follicular development, ovulation, and luteinization. Recent Prog Horm Res (2002) 1.92

Induction of the cyclic nucleotide phosphodiesterase PDE4B is essential for LPS-activated TNF-alpha responses. Proc Natl Acad Sci U S A (2002) 1.83

Role of the epidermal growth factor network in ovarian follicles. Mol Endocrinol (2005) 1.74

Soluble adenylyl cyclase (sAC) is indispensable for sperm function and fertilization. Dev Biol (2006) 1.74

Phosphodiesterase 4D forms a cAMP diffusion barrier at the apical membrane of the airway epithelium. J Biol Chem (2004) 1.73

Luteinizing hormone signaling in preovulatory follicles involves early activation of the epidermal growth factor receptor pathway. Mol Endocrinol (2008) 1.71

Cyclic nucleotide phosphodiesterase 3A-deficient mice as a model of female infertility. J Clin Invest (2004) 1.68

Phosphodiesterase 4D is required for beta2 adrenoceptor subtype-specific signaling in cardiac myocytes. Proc Natl Acad Sci U S A (2005) 1.65

Somatic cells regulate maternal mRNA translation and developmental competence of mouse oocytes. Nat Cell Biol (2013) 1.65

The G-protein-coupled receptors GPR3 and GPR12 are involved in cAMP signaling and maintenance of meiotic arrest in rodent oocytes. Dev Biol (2005) 1.63

Deletion of phosphodiesterase 4D in mice shortens alpha(2)-adrenoceptor-mediated anesthesia, a behavioral correlate of emesis. J Clin Invest (2002) 1.62

Specific role of phosphodiesterase 4B in lipopolysaccharide-induced signaling in mouse macrophages. J Immunol (2005) 1.62

Immunohistochemical localization of PDE10A in the rat brain. Brain Res (2003) 1.61

Variations of the intra-articular portion of the long head of the biceps tendon: a classification of embryologically explained variations. J Shoulder Elbow Surg (2009) 1.60

Immunohistochemical localization of phosphodiesterase 10A in multiple mammalian species. J Histochem Cytochem (2006) 1.60

A specific pattern of phosphodiesterases controls the cAMP signals generated by different Gs-coupled receptors in adult rat ventricular myocytes. Circ Res (2006) 1.57

Phosphodiesterase-4D knock-out and RNA interference-mediated knock-down enhance memory and increase hippocampal neurogenesis via increased cAMP signaling. J Neurosci (2011) 1.55

Genetic deletion of the striatum-enriched phosphodiesterase PDE10A: evidence for altered striatal function. Neuropharmacology (2006) 1.53

Molecular mechanism of AMPA receptor noncompetitive antagonism. Neuron (2005) 1.51

Misregulated Wnt/beta-catenin signaling leads to ovarian granulosa cell tumor development. Cancer Res (2005) 1.51

Spatiotemporal dynamics of beta-adrenergic cAMP signals and L-type Ca2+ channel regulation in adult rat ventricular myocytes: role of phosphodiesterases. Circ Res (2008) 1.50

Signaling from beta1- and beta2-adrenergic receptors is defined by differential interactions with PDE4. EMBO J (2008) 1.50

Genome-wide analysis of translation reveals a critical role for deleted in azoospermia-like (Dazl) at the oocyte-to-zygote transition. Genes Dev (2011) 1.47

Cyclic nucleotide phosphodiesterases and their role in endocrine cell signaling. Trends Endocrinol Metab (2001) 1.47

Wee1B is an oocyte-specific kinase involved in the control of meiotic arrest in the mouse. Curr Biol (2005) 1.46

Antidepressant-like profile and reduced sensitivity to rolipram in mice deficient in the PDE4D phosphodiesterase enzyme. Neuropsychopharmacology (2002) 1.45

Inhibition of the striatum-enriched phosphodiesterase PDE10A: a novel approach to the treatment of psychosis. Neuropharmacology (2006) 1.44

Rodent oocytes express an active adenylyl cyclase required for meiotic arrest. Dev Biol (2003) 1.44

Splice variants of the cyclic nucleotide phosphodiesterase PDE4D are differentially expressed and regulated in rat tissue. Biochem J (2005) 1.43

Dynamic regulation of cystic fibrosis transmembrane conductance regulator by competitive interactions of molecular adaptors. J Biol Chem (2007) 1.41

Novel signaling mechanisms in the ovary during oocyte maturation and ovulation. Mol Cell Endocrinol (2011) 1.35

PDE4B polymorphisms and decreased PDE4B expression are associated with schizophrenia. Schizophr Res (2008) 1.32

Mechanism for the allosteric regulation of phosphodiesterase 2A deduced from the X-ray structure of a near full-length construct. Proc Natl Acad Sci U S A (2009) 1.30

Nonredundant function of phosphodiesterases 4D and 4B in neutrophil recruitment to the site of inflammation. J Immunol (2004) 1.29

Anxiogenic-like behavioral phenotype of mice deficient in phosphodiesterase 4B (PDE4B). Neuropsychopharmacology (2007) 1.29

PDE4D plays a critical role in the control of airway smooth muscle contraction. FASEB J (2003) 1.22

Wee1B, Myt1, and Cdc25 function in distinct compartments of the mouse oocyte to control meiotic resumption. J Cell Biol (2010) 1.21

Conserved expression and functions of PDE4 in rodent and human heart. Basic Res Cardiol (2010) 1.19

Discovery of a novel class of phosphodiesterase 10A inhibitors and identification of clinical candidate 2-[4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the treatment of schizophrenia. J Med Chem (2009) 1.19

Cellular mechanisms underlying prostaglandin-induced transient cAMP signals near the plasma membrane of HEK-293 cells. Am J Physiol Cell Physiol (2006) 1.17

Protein kinase B/Akt phosphorylation of PDE3A and its role in mammalian oocyte maturation. EMBO J (2006) 1.17

Dimerization of the type 4 cAMP-specific phosphodiesterases is mediated by the upstream conserved regions (UCRs). J Biol Chem (2002) 1.17

The protein kinase A pathway-regulated transcriptome of endometrial stromal fibroblasts reveals compromised differentiation and persistent proliferative potential in endometriosis. Endocrinology (2010) 1.15

New pathways from PKA to the Cdc2/cyclin B complex in oocytes: Wee1B as a potential PKA substrate. Cell Cycle (2006) 1.15

Histone variant H3.3 maintains a decondensed chromatin state essential for mouse preimplantation development. Development (2013) 1.14

PDE4D and PDE4B function in distinct subcellular compartments in mouse embryonic fibroblasts. J Biol Chem (2011) 1.13

Cyclic adenosine monophosphate phosphodiesterase type 4 protects against atrial arrhythmias. J Am Coll Cardiol (2012) 1.12

Inhibition of the striatal specific phosphodiesterase PDE10A ameliorates striatal and cortical pathology in R6/2 mouse model of Huntington's disease. PLoS One (2010) 1.11

Arthroscopic bankart suture-anchor repair: radiological and clinical outcome at minimum 10 years of follow-up. Am J Sports Med (2010) 1.10

The mouse polyubiquitin gene Ubb is essential for meiotic progression. Mol Cell Biol (2007) 1.10

The long head of biceps as a source of pain in active population: tenotomy or tenodesis? A comparison of 2 case series with isolated lesions. Musculoskelet Surg (2012) 1.10

Phosphodiesterase 4B in the cardiac L-type Ca²⁺ channel complex regulates Ca²⁺ current and protects against ventricular arrhythmias in mice. J Clin Invest (2011) 1.09

Inhibition of Phosphodiesterase 10A Increases the Responsiveness of Striatal Projection Neurons to Cortical Stimulation. J Pharmacol Exp Ther (2008) 1.09

Effects of a NR2B selective NMDA glutamate antagonist, CP-101,606, on dyskinesia and Parkinsonism. Mov Disord (2008) 1.08

Male infertility, impaired spermatogenesis, and azoospermia in mice deficient for the pseudophosphatase Sbf1. J Clin Invest (2002) 1.07

Discovery of a series of 6,7-dimethoxy-4-pyrrolidylquinazoline PDE10A inhibitors. J Med Chem (2007) 1.06

Early effects of exercise training on on- and off-kinetics in 50-year-old subjects. Pflugers Arch (2001) 1.06

[3H]sildenafil binding to phosphodiesterase-5 is specific, kinetically heterogeneous, and stimulated by cGMP. Mol Pharmacol (2003) 1.05

Genetic dissection of epidermal growth factor receptor signaling during luteinizing hormone-induced oocyte maturation. PLoS One (2011) 1.04

The oligomerization state determines regulatory properties and inhibitor sensitivity of type 4 cAMP-specific phosphodiesterases. J Biol Chem (2004) 1.04

Discovery and SAR of 2-aminothiazole inhibitors of cyclin-dependent kinase 5/p25 as a potential treatment for Alzheimer's disease. Bioorg Med Chem Lett (2004) 1.03

Decreased expression and activity of cAMP phosphodiesterases in cardiac hypertrophy and its impact on beta-adrenergic cAMP signals. Circ Res (2009) 1.03

G-protein-coupled receptor signaling and the EGF network in endocrine systems. Trends Endocrinol Metab (2005) 1.02

Role of estrogen receptors in neuroprotection by estradiol against MPTP toxicity. Neuropharmacology (2007) 1.02

Protein tyrosine kinase Wee1B is essential for metaphase II exit in mouse oocytes. Science (2011) 1.02

Differential expression and function of phosphodiesterase 4 (PDE4) subtypes in human primary CD4+ T cells: predominant role of PDE4D. J Immunol (2007) 1.02

Epidermal growth factor-like growth factors in the follicular fluid: role in oocyte development and maturation. Semin Reprod Med (2009) 1.01

Generation of mouse oocytes defective in cAMP synthesis and degradation: endogenous cyclic AMP is essential for meiotic arrest. Dev Biol (2008) 1.00

Regulation of cAMP-specific phosphodiesterases type 4B and 4D (PDE4) splice variants by cAMP signaling in primary cortical neurons. J Neurochem (2002) 1.00

Blockade of cannabinoid type 1 receptors augments the antiparkinsonian action of levodopa without affecting dyskinesias in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated rhesus monkeys. J Pharmacol Exp Ther (2007) 0.99

Soluble adenylyl cyclase is not required for axon guidance to netrin-1. J Neurosci (2008) 0.99

Structural basis for the catalytic mechanism of human phosphodiesterase 9. Proc Natl Acad Sci U S A (2008) 0.99

Signaling pathways for modulation of mouse sperm motility by adenosine and catecholamine agonists. Biol Reprod (2005) 0.97

Lack of functional pregnancy-associated plasma protein-A (PAPPA) compromises mouse ovarian steroidogenesis and female fertility. Biol Reprod (2010) 0.97

Deep partial rotator cuff tear: transtendon repair or tear completion and repair? A randomized clinical trial. Knee Surg Sports Traumatol Arthrosc (2013) 0.97

Posterior humeral avulsion of the glenohumeral ligament: a clinical review of 9 cases. Arthroscopy (2007) 0.97

Predictive factors of subtle residual shoulder symptoms after transtendinous arthroscopic cuff repair: a clinical study. Am J Sports Med (2008) 0.96

Arthroscopic stabilization of the shoulder in adolescent athletes participating in overhead or contact sports. Arthroscopy (2011) 0.96

Phosphodiesterase 9A regulates central cGMP and modulates responses to cholinergic and monoaminergic perturbation in vivo. J Pharmacol Exp Ther (2012) 0.96

Amphiregulin promotes the maturation of oocytes isolated from the small antral follicles of the rhesus macaque. Hum Reprod (2012) 0.96

Critical role of PDE4D in beta2-adrenoceptor-dependent cAMP signaling in mouse embryonic fibroblasts. J Biol Chem (2008) 0.95

Inactivation of multidrug resistance proteins disrupts both cellular extrusion and intracellular degradation of cAMP. Mol Pharmacol (2011) 0.95

Is musculoskeletal pain a consequence or a cause of occupational stress? A longitudinal study. Int Arch Occup Environ Health (2014) 0.94

Hormone-regulated expression and localization of versican in the rodent ovary. Endocrinology (2003) 0.94

Phosphodiesterase inhibitors: factors that influence potency, selectivity, and action. Handb Exp Pharmacol (2011) 0.93

Immunohistochemical localization of phosphodiesterase 2A in multiple mammalian species. J Histochem Cytochem (2009) 0.93

Phosphodiesterase 4B is essential for T(H)2-cell function and development of airway hyperresponsiveness in allergic asthma. J Allergy Clin Immunol (2010) 0.93

Expression of the soluble adenylyl cyclase during rat spermatogenesis: evidence for cytoplasmic sites of cAMP production in germ cells. Dev Biol (2004) 0.92