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Top papers

Rank Title Journal Year PubWeight™‹?›
1 The yield of first-time endoscopic ultrasonography in screening individuals at a high risk of developing pancreatic cancer. Am J Gastroenterol 2009 2.04
2 Inoculation of human interleukin-17 gene-transfected Meth-A fibrosarcoma cells induces T cell-dependent tumor-specific immunity in mice. Oncology 2001 1.68
3 Problems in the definition and treatment of early gastric cancer. Br J Surg 1991 1.19
4 Reduced invasiveness and metastasis of Chinese hamster ovary cells transfected with human interleukin-17 gene. Anticancer Res 2000 1.04
5 Epidermal growth factor and its receptor as prognostic indicators in Chinese patients with pancreatic cancer. Anticancer Res 1999 1.02
6 Clinicopathological significance of epidermal growth factor and its receptor in human pancreatic cancer. Anticancer Res 1998 0.96
7 Differential gene expression and regulation of angiotensin II receptor subtypes in rat cardiac fibroblasts and cardiomyocytes in culture. J Clin Invest 1994 0.95
8 Effects of troglitazone on frequency of coronary vasospastic-induced angina pectoris in patients with diabetes mellitus. Am J Cardiol 1999 0.91
9 The correlation between coronary stenosis index and flow-mediated dilation of the brachial artery. Jpn Circ J 1998 0.89
10 Comparative study of p53 expression in primary invasive ductal carcinoma of the pancreas between Chinese and Japanese. Pancreas 1998 0.89
11 p53 protein expression as prognostic factor in human pancreatic cancer. Anticancer Res 1997 0.88
12 Plant polysaccharide PSK: cytostatic effects on growth and invasion; modulating effect on the expression of HLA and adhesion molecules on human gastric and colonic tumor cell surface. Anticancer Res 2001 0.88
13 Overcoming TNF-alpha and drug resistance of human renal cell carcinoma cells by treatment with pentoxifylline in combination with TNF-alpha or drugs: the role of TNF-alpha mRNA downregulation in tumor cell sensitization. J Urol 1994 0.87
14 Practice and yield of early CT scan in acute pancreatitis: a Dutch Observational Multicenter Study. Pancreatology 2010 0.86
15 Ki-ras point mutation and p53 expression in human pancreatic cancer: a comparative study among Chinese, Japanese, and Western patients. Cancer Epidemiol Biomarkers Prev 2000 0.86
16 Clinicopathological significance of Ki-ras point mutation and p21 expression in benign and malignant exocrine tumors of the human pancreas. Int J Pancreatol 1996 0.83
17 Mechanisms of cytotoxic effects of heavy water (deuterium oxide: D2O) on cancer cells. Anticancer Drugs 1998 0.82
18 Correlation between TGF-beta1 and p21 (WAF1/CIP1) expression and prognosis in resectable invasive ductal carcinoma of the pancreas. Pancreas 2001 0.81
19 Experimental chemotherapy for xenograft cell lines of human bile duct and gall bladder cancers in nude mice. J Surg Oncol 1992 0.81
20 Deuterium oxide (heavy water) accelerates actin assembly in vitro and changes microfilament distribution in cultured cells. Eur J Cell Biol 1997 0.80
21 cAMP responsive element-mediated regulation of the gene transcription of the alpha 1B adrenergic receptor by thyrotropin. J Clin Invest 1994 0.80
22 Enhanced susceptibility of cis-diamminedichloroplatinum-treated K562 cells to lysis by peripheral blood lymphocytes and lymphokine activated killer cells. Cancer 1993 0.79
23 [Abdominal typhus and paratyphoid fever in 2 academic hospitals: 1984-1990]. Ned Tijdschr Geneeskd 1993 0.79
24 Effects of splenectomy on pulmonary metastasis and growth of SC42 carcinoma transplanted into mouse liver. J Surg Oncol 1991 0.79
25 Metabolic bone disease following gastrectomy: assessment by dual energy X-ray absorptiometry. Br J Surg 1992 0.79
26 A splenic-inferior mesenteric venous anastomosis prevents gastric congestion following pylorus preserving pancreatoduodenectomy with extensive portal vein resection for cancer of the head of the pancreas. Int Surg 1997 0.78
27 [Experimental study of oral administration of streptococcal preparation "OK-432". The 6th report: its effect on in vivo anti-tumor immunity of the mice with transplanted cecal tumor]. Nihon Gan Chiryo Gakkai Shi 1985 0.78
28 [The oral administration of OK-432. The 5th report: the effects on the lymphoproliferative response and natural killer cell activity in mice with transplanted cecal tumors]. Nihon Gan Chiryo Gakkai Shi 1985 0.78
29 Modulation by cis-diamminedichloroplatinum (II) of the susceptibilities of human T24 lined and freshly separated autologous urinary bladder transitional carcinoma cells to peripheral blood lymphocytes and lymphokine activated killer cells. J Urol 1992 0.78
30 Comparison of K-ras point mutations at codon 12 and p21 expression in pancreatic cancer between Japanese and Chinese patients. J Surg Oncol 2000 0.78
31 A comparative study on immunosuppressive effects of cyclosporin A and FK 506 on peripheral blood lymphocytes in dogs. Biotherapy 1992 0.78
32 Ten-year follow-up results of a randomised controlled study comparing level-I vs level-III axillary lymph node dissection for primary breast cancer. Br J Cancer 2006 0.78
33 Effects of bacillus Calmette-Guerin on cytotoxic activities of peripheral blood lymphocytes against human T24 lined and freshly isolated autologous urinary bladder transitional carcinoma cells in patients with urinary bladder cancer. Cancer 1992 0.78
34 [Tumor-specific cytotoxicity of tumor infiltrating lymphocytes (TIL) induced with TCGF in murine mammary carcinoma]. Nihon Geka Gakkai Zasshi 1984 0.78
35 [A double blind study to evaluate the optimal dose and its frequency for oral administration of OK-432 (picibanil) by immunological parameters (the 2nd report)]. Nihon Gan Chiryo Gakkai Shi 1990 0.77
36 Effect of PSK and its subfractions on peripheral blood lymphocytes mediated cytotoxicity against urinary bladder tumor cells. J Urol 1992 0.77
37 The streptococcal preparation OK-432 specifically augments the susceptibility of human urinary bladder tumor cells to autologous peripheral blood lymphocytes. Cancer 1992 0.77
38 Role of endogenous hypergastrinemia in regenerating endocrine pancreas after partial pancreatectomy. Dig Dis Sci 1996 0.77
39 [Surgical drainage of the pancreatic duct in patients with chronic pancreatitis is more effective than endoscopic drainage: randomized trial]. Ned Tijdschr Geneeskd 2007 0.77
40 [Oral administration of OK-432 (Picibanil) (7th report). Clinical application: effects on advanced and recurrent cancers]. Nihon Gan Chiryo Gakkai Shi 1987 0.77
41 Intraperitoneally implanted artificial pancrease with transkaryotic beta-cells on microcarrier beads in a diffusion chamber improves hyperglycemia after 90% pancreatectomy in rats. In Vivo 2000 0.77
42 [A double blind study of the evaluation of the optimal dose and its frequency in oral administration of OK-432 (Picibanil) by immunological parameters (the 1st report)]. Nihon Gan Chiryo Gakkai Shi 1990 0.77
43 [Cancer chemotherapy against human tumor cell lines transplanted in nude mice. 1. The effect of a new anti-cancer agent, UFT]. Nihon Gan Chiryo Gakkai Shi 1986 0.77
44 Hepatectomy accelerates the growth of transplanted liver tumor in mice. Cancer Detect Prev 1992 0.76
45 Immunohistochemical studies on vascular endothelial growth factor and platelet endothelial cell adhesion molecule-1/CD-31 in islet transplantation. Pancreas 2000 0.76
46 Comparative study on various combination chemotherapies against human gastric cancer xenograft lines of well- and poorly-differentiated adenocarcinomas transplanted in nude mice. Anticancer Drugs 1991 0.76
47 Characterization of glucocorticoid response element of rat angiotensin II type 1A receptor gene. Biochem Biophys Res Commun 1995 0.76
48 [A new anti-cancer agent K-18 (conjugate of human IgG and melphalan). (I). K-18 accumulates selectively into the tumor]. Nihon Gan Chiryo Gakkai Shi 1986 0.75
49 Clinical assessment of ultrasonography in diagnosis of abdominal tumors. Nihon Geka Hokan 1980 0.75
50 [Clinical application of cefsulodin to Pseudomonas aeruginosa infections in the surgical field (author's transl)]. Jpn J Antibiot 1981 0.75
51 [Clinical evaluation of immunochemotheray on advanced gastric cancer--combination of OK-432 (picibanil), mitomycin C, and 5-fluorouracil (MF-O therapy) (author's transl)]. Nihon Gan Chiryo Gakkai Shi 1980 0.75
52 [Aggressive infantile fibromatosis: case report]. Nihon Geka Hokan 1983 0.75
53 [A case report of testicular torsion (author's transl)]. Nihon Geka Hokan 1978 0.75
54 [Oral administration of OK-432 (picibanil). (8th report) clinical application: its immunomodulatory effects on the patients with gastrointestinal cancers]. Nihon Gan Chiryo Gakkai Shi 1989 0.75
55 Regulation of gene transcription of angiotensin II receptor subtypes in the heart. Adv Exp Med Biol 1996 0.75
56 [Clinical evaluation of immunochemotherapy with streptococcal preparation "OK-432" on inoperable advanced cancers (author's transl)]. Nihon Geka Hokan 1981 0.75
57 [Recurrence of gallstones after lithotomy (author's transl)]. Nihon Geka Hokan 1978 0.75
58 [Clinical evaluation of prostaglandin F2 alpha (PGF2 alpha) for the postoperative ileus after major abdominal surgery (author's transl)]. Nihon Geka Hokan 1980 0.75
59 In vivo inhibitory effect of anticancer agents on human pancreatic cancer xenografts transplanted in nude mice. Anticancer Res 1991 0.75
60 Protective effects of combined therapy with a protease inhibitor, ONO 3307, and a xanthine oxidase inhibitor, allopurinol on temporary ischaemic model of pancreatitis in rats. Nihon Geka Hokan 1992 0.75
61 [A case of multiple early gastric cancers having macroscopically and histologically different types (author's transl)]. Nihon Geka Hokan 1980 0.75
62 [An in vitro sensitivity assay for anti-cancer agents by measuring the inhibition rate of DNA synthesis (3H-thymidine uptake of cancer cells). II. Clinical study of 110 cases of breast cancer]. Nihon Geka Gakkai Zasshi 1986 0.75
63 Inhibitory effects of a cholecystokinin antagonist, loxiglumide (CR-1505), on the growth of freshly separated and xenografted human pancreatic cancer. J Surg Oncol 1993 0.75
64 The role of additional chemotherapy with oral UFT in intravenous combination chemotherapy with cisplatin and 5-fluorouracil for human gastric cancer xenograft lines of well- and poorly- differentiated adenocarcinomas transplanted in nude mice. Anticancer Res 1992 0.75
65 Experimental investigation of the role of the splenic vein in gastric venous obstruction after pylorus-preserving pancreatoduodenectomy in the dog. Int J Pancreatol 1997 0.75
66 In vitro production of an antitumor agent by reticuloendothelial cells. Gan 1968 0.75
67 [Application for therapeutic use of deuterium oxide (D2O) against human pancreatic cancer]. Gan To Kagaku Ryoho 1996 0.75
68 Effects of FK 506 on in vivo immunity in comparison to cyclosporine. Transplant Proc 1991 0.75
69 Cancer immunotherapy by local transfer of autologous T lymphocytes cultured with T cell growth factor and autologous tumor extract: a clinical trial. Nihon Geka Hokan 1983 0.75
70 [Clinical trial of oral immunotherapy with streptococcal preparation OK 432 on gastric cancer]. Nihon Gan Chiryo Gakkai Shi 1982 0.75
71 Basic study on immunologic effects of cyclosporine and FK 506 for application to pancreatic transplantation. Transplant Proc 1992 0.75
72 [A case of lipoma of the terminal ileum showing intussusception and melena (author's transl)]. Nihon Geka Hokan 1981 0.75
73 [Oral administration of streptococcal preparation "OK 432"--the 4th report: augmentation of in vitro anti-tumor immune responses of mice with transplanted cecal tumor]. Nihon Gan Chiryo Gakkai Shi 1984 0.75
74 Specific adoptive immunotherapy by local transfer of cultured syngeneic spleen cells for mammary carcinoma in mice. Nihon Geka Hokan 1983 0.75
75 [Immunotherapy of gastric cancer]. Gan To Kagaku Ryoho 1988 0.75
76 Cis-diamminedichloroplatinum(II) augments expression of tumor-associated antigens on human gastric cancer cell line KATO-3 and increases susceptibility and binding of tumor cells to various cytotoxic effector cells. J Surg Oncol 1996 0.75
77 [A case of recurrent pancreatic cancer brought into a complete response by a multimodal treatment with intraarterial chemotherapy and radiotherapy]. Gan To Kagaku Ryoho 2000 0.75
78 [Oral administration of streptococcal preparation "OK 432 (picibanil)"--the second report: experimental studies on its absorption and the responses of the gut associated lymphoid tissue]. Nihon Gan Chiryo Gakkai Shi 1984 0.75
79 Enhanced antitumor effect of Bacillus Calmette-Guérin in combination with fibrinogen on urinary bladder tumor. J Urol 1994 0.75
80 [Emphysematous cholecystitis]. Ryoikibetsu Shokogun Shirizu 1996 0.75
81 [A case of clinically overt multicentric breast cancers (author's transl)]. Nihon Geka Hokan 1980 0.75
82 [N1-(2-tetrahydrofuryl)-5-fluorouracil (FT-207) is metabolized and converted to 5-fluorouracil in tumor cells]. Nihon Gan Chiryo Gakkai Shi 1987 0.75
83 [Two operated cases of synchronous double cancer of the lung and digestive tract in patients over 80 years old and genetical diagnosis]. Kyobu Geka 1996 0.75
84 Improved survival in mice with diet-induced pancreatitis treated with new potent protease inhibitor, E-3123 and a broad spectrum antibiotic, cefmetazole. Nihon Geka Hokan 1992 0.75
85 Effect of short-termed pancreatico-biliary duct obstruction on lysosomal enzyme in rats: protective effect of a potent new protease inhibitor, E-3123. Nihon Geka Hokan 1992 0.75
86 Anticancer chemosensitivity and growth rate of freshly separated human colorectal cancer cells assessed by in vitro DNA synthesis inhibition assay. Anticancer Res 1998 0.75
87 Immunologic control of ovarian cancer. Nat Immun Cell Growth Regul 1988 0.75
88 [Effects of oral administration of PSK on immune responses. I. Correlation of in vivo effects with in vitro biological activities]. Nihon Gan Chiryo Gakkai Shi 1987 0.75
89 [Action of granulocyte-colony stimulating factor and cisplatin on two models of human digestive, esophageal and colonic, cancers]. Chirurgie 1995 0.75
90 [Immunomodulating effects of oral administration of PSK. II. Its effects on mice with cecal tumors]. Nihon Gan Chiryo Gakkai Shi 1988 0.75
91 Anticancer chemosensitivity profile of freshly separated human pancreatic cancer cells assessed by DNA synthesis inhibition assay. J Surg Oncol 1994 0.75
92 [Evaluation of the amylase creatinine clearance ratio in postoperative patients (author's transl)]. Nihon Geka Hokan 1981 0.75
93 The inhibitory effect of a conjugate of human immunoglobulin G and melphalan, K18, on DNA synthesis of human tumor cells. Anticancer Res 1989 0.75
94 Non-insulin-dependent diabetes mellitus complicated with idiopathic hypoparathyroidism. Intern Med 1995 0.75
95 Malignant duodenocolic fistulae. A report of three cases. Nihon Geka Hokan 1982 0.75
96 Heterogeneic distribution of thymidine phosphorylase between primary tumors and metastatic lesions of human pancreatic ductal carcinoma: implications for the efficacy of chemotherapy with 5-FU or its derivatives. Cancer Chemother Pharmacol 2001 0.75
97 [A case of advanced gallbladder cancer responding to neoadjuvant intra-arterial chemotherapy]. Gan To Kagaku Ryoho 1999 0.75
98 [A new anti-cancer agent K-18 (conjugate of human IgG and melphalan). (II). Its inhibitory effects on in vitro DNA synthesis of human tumor cells]. Nihon Gan Chiryo Gakkai Shi 1986 0.75
99 [Adoptive immunotherapy of murine tumors using cultured syngeneic tumor-bearer-spleen cells. II: Therapeutic effect of cultured lymphocytes against malignant ascites and its augmentation by the streptococcal preparation, OK 432]. Nihon Gan Chiryo Gakkai Shi 1985 0.75
100 Human proinsulin gene-transfected Chinese hamster ovary cells secrete immunoreactive insulin. In Vivo 2000 0.75
101 [Adoptive immunotherapy of murine tumor using cultured syngeneic tumor-bearer-spleen cells. 1: Anti-tumor activity of tumor-bearer-spleen cells cultured with T cell growth factor (TCGF) and soluble tumor extract]. Nihon Gan Chiryo Gakkai Shi 1985 0.75
102 [Chemotherapy with fluoropyrimidines for MOPC-104E plasmacytoma transplanted in mice with CCl4 induced chronic liver dysfunction]. Nihon Gan Chiryo Gakkai Shi 1990 0.75
103 [Experimental study of oral administration of streptococcal preparation "OK-432". The third report: its enhancing effects on natural killer activity and lymphoproliferative response to mitogens of mouse mesenteric lymph node]. Nihon Gan Chiryo Gakkai Shi 1984 0.75
104 Increased number of suppressor T-cells and impaired IL-2 mediated T-cell function in peripheral blood of gastric cancer patients. J Clin Lab Immunol 1990 0.75
105 Plasma endothelin-1 elevation associated with alcohol-induced variant angina. Jpn Circ J 1999 0.75
106 [A new selection system of anti-cancer chemotherapeutic agents in consideration of immunosuppression assay--experimental study]. Nihon Gan Chiryo Gakkai Shi 1984 0.75
107 Relationships for recombinant interleukin-2-stimulated mixed lymphocyte tumor extract reaction between peripheral blood lymphocytes and regional node lymphocytes in gastric cancer patients. Anticancer Res 1992 0.75
108 In vivo kinetics of murine lymphoid cells: in relation to local adoptive cancer immunotherapy. Nihon Geka Hokan 1984 0.75
109 [Augmentation of the anti-tumor activity of regional lymph node lymphocytes and spleen cells of tumor-bearing mice by culture with T cell growth factor in vitro--a comparison of the intestinal cancer model and footpad cancer model]. Nihon Geka Gakkai Zasshi 1986 0.75
110 5-Fluorouracil + cisplatin + mitomycin C is a relatively most effective combination against xenograft lines of human colorectal cancer. Anticancer Drugs 1997 0.75
111 In vivo inhibitory effect of a conjugate of immunoglobulin G and melphalan, K18, on human tumors transplanted in nude mice. Anticancer Res 1989 0.75
112 Low uracil concentration in the liver might be responsible for the decreased antineoplastic activity of fluoropyrimidines in mice with CCl4-induced chronic liver dysfunction. Oncology 1991 0.75
113 Commitment reversion model of unrestricted cell growth. Med Hypotheses 1992 0.75
114 Splenectomy abolishes antitumor effect of immunotherapy with streptococcal preparation, OK-432, on mouse liver tumors. Anticancer Res 1991 0.75
115 [A case of recurrent ampullary carcinoma of the papilla of Vater, in which a complete response was induced by combination therapy using radiotherapy and oral chemotherapy employing UFT and cyclophosphamide]. Gan To Kagaku Ryoho 1999 0.75
116 [The cytotoxic activity of tumor infiltrating lymphocytes (TIL) and its application to adoptive immunotherapy]. Nihon Gan Chiryo Gakkai Shi 1985 0.75
117 [Studies on the cells producing an antitumor agent]. Nihon Igaku Hoshasen Gakkai Zasshi 1970 0.75
118 [An in vitro sensitivity assay of anti-cancer agents by measuring the inhibition rate of DNA synthesis (3H-thymidine uptake) of cancer cells--clinical study]. Nihon Geka Gakkai Zasshi 1985 0.75