Human brain glycogen metabolism during and after hypoglycemia.

PubWeight™: 1.32‹?› | Rank: Top 10%

🔗 View Article (PMC 2731528)

Published in Diabetes on June 05, 2009

Authors

Gülin Oz1, Anjali Kumar, Jyothi P Rao, Christopher T Kodl, Lisa Chow, Lynn E Eberly, Elizabeth R Seaquist

Author Affiliations

1: Center for MR Research, Department of Radiology, Medical School, University of Minnesota, Minneapolis, Minnesota, USA. gulin@cmrr.umn.edu

Articles citing this

Brain fuel metabolism, aging, and Alzheimer's disease. Nutrition (2010) 1.89

13C MRS studies of neuroenergetics and neurotransmitter cycling in humans. NMR Biomed (2011) 1.47

Neuroendocrine responses to hypoglycemia. Ann N Y Acad Sci (2010) 1.10

Fueling and imaging brain activation. ASN Neuro (2012) 1.04

Effect of acute hypoglycemia on human cerebral glucose metabolism measured by ¹³C magnetic resonance spectroscopy. Diabetes (2011) 1.00

Patients with type 1 diabetes exhibit altered cerebral metabolism during hypoglycemia. J Clin Invest (2013) 0.97

Brain glycogen content and metabolism in subjects with type 1 diabetes and hypoglycemia unawareness. J Cereb Blood Flow Metab (2011) 0.95

Obesity and type 2 diabetes in rats are associated with altered brain glycogen and amino-acid homeostasis. J Cereb Blood Flow Metab (2010) 0.93

Defective counterregulation and hypoglycemia unawareness in diabetes: mechanisms and emerging treatments. Endocrinol Metab Clin North Am (2012) 0.93

Simultaneous measurement of glucose transport and utilization in the human brain. Am J Physiol Endocrinol Metab (2011) 0.91

Brain glycogen supercompensation in the mouse after recovery from insulin-induced hypoglycemia. J Neurosci Res (2011) 0.90

Increased brain lactate concentrations without increased lactate oxidation during hypoglycemia in type 1 diabetic individuals. Diabetes (2013) 0.90

Is L-lactate a novel signaling molecule in the brain? J Cereb Blood Flow Metab (2015) 0.87

Changes in human brain glutamate concentration during hypoglycemia: insights into cerebral adaptations in hypoglycemia-associated autonomic failure in type 1 diabetes. J Cereb Blood Flow Metab (2014) 0.86

Optimized [1-(13)C]glucose infusion protocol for 13C magnetic resonance spectroscopy at 3T of human brain glucose metabolism under euglycemic and hypoglycemic conditions. J Neurosci Methods (2009) 0.86

Metabolic Flux and Compartmentation Analysis in the Brain In vivo. Front Endocrinol (Lausanne) (2013) 0.85

Glycogen metabolism as a marker of astrocyte differentiation. J Cereb Blood Flow Metab (2009) 0.85

Effects of hypoglycaemia on neuronal metabolism in the adult brain: role of alternative substrates to glucose. J Inherit Metab Dis (2012) 0.84

Noninvasive measurement of brain glycogen by nuclear magnetic resonance spectroscopy and its application to the study of brain metabolism. J Neurosci Res (2011) 0.83

Energy Metabolism of the Brain, Including the Cooperation between Astrocytes and Neurons, Especially in the Context of Glycogen Metabolism. Int J Mol Sci (2015) 0.82

Kinetic analysis of glycogen turnover: relevance to human brain 13C-NMR spectroscopy. J Cereb Blood Flow Metab (2013) 0.82

Diabetes: Does lactate sustain brain metabolism during hypoglycaemia? Nat Rev Endocrinol (2013) 0.80

The Impact of Diabetes on Cerebral Structure and Function. Psychosom Med (2015) 0.80

Molecular basis of impaired glycogen metabolism during ischemic stroke and hypoxia. PLoS One (2014) 0.79

Linking neuronal brain activity to the glucose metabolism. Theor Biol Med Model (2013) 0.77

In vivo Magnetic Resonance Spectroscopy of cerebral glycogen metabolism in animals and humans. Metab Brain Dis (2014) 0.77

Revisiting Glycogen Content in the Human Brain. Neurochem Res (2015) 0.77

Brain glucose metabolism during hypoglycemia in type 1 diabetes: insights from functional and metabolic neuroimaging studies. Cell Mol Life Sci (2015) 0.76

Insulin neuroprotection and the mechanisms. Chin Med J (Engl) (2015) 0.76

Mechanisms of hypoglycemia unawareness and implications in diabetic patients. World J Diabetes (2015) 0.76

Changes in Cerebral Blood Flow during an Alteration in Glycemic State in a Large Non-human Primate (Papio hamadryas sp.). Front Neurosci (2017) 0.75

In vivo imaging techniques: a new era for histochemical analysis. Eur J Histochem (2016) 0.75

Cerebral glycogen in humans following acute and recurrent hypoglycemia: Implications on a role in hypoglycemia unawareness. J Cereb Blood Flow Metab (2016) 0.75

Relationship between motor corticospinal excitability and ventilatory response during intense exercise. Eur J Appl Physiol (2016) 0.75

Articles cited by this

A mathematical model of compartmentalized neurotransmitter metabolism in the human brain. Am J Physiol Endocrinol Metab (2001) 2.27

Neuroglial metabolism in the awake rat brain: CO2 fixation increases with brain activity. J Neurosci (2004) 2.04

A half-volume coil for efficient proton decoupling in humans at 4 tesla. J Magn Reson (1997) 1.84

Effect of hypoglycemia on brain glycogen metabolism in vivo. J Neurosci Res (2003) 1.64

Brain glycogen decreases with increased periods of wakefulness: implications for homeostatic drive to sleep. J Neurosci (2002) 1.58

Glycogen: the forgotten cerebral energy store. J Neurosci Res (2003) 1.50

Steady-state cerebral glucose concentrations and transport in the human brain. J Neurochem (1998) 1.49

High glycogen levels in brains of rats with minimal environmental stimuli: implications for metabolic contributions of working astrocytes. J Cereb Blood Flow Metab (2002) 1.41

Astrocyte glycogen sustains neuronal activity during hypoglycemia: studies with the glycogen phosphorylase inhibitor CP-316,819 ([R-R*,S*]-5-chloro-N-[2-hydroxy-3-(methoxymethylamino)-3-oxo-1-(phenylmethyl)propyl]-1H-indole-2-carboxamide). J Pharmacol Exp Ther (2007) 1.38

Deposition of glycogen and changes in some enzymes in brain wounds. Nature (1958) 1.35

Absolute quantification of regional cerebral glucose utilization in mice by 18F-FDG small animal PET scanning and 2-14C-DG autoradiography. J Nucl Med (2004) 1.35

Intramuscular glycogen and intramyocellular lipid utilization during prolonged exercise and recovery in man: a 13C and 1H nuclear magnetic resonance spectroscopy study. J Clin Endocrinol Metab (2000) 1.27

Factors affecting the turnover of cerebral glycogen and limit dextrin in vivo. J Neurochem (1973) 1.25

Differentiation of glucose transport in human brain gray and white matter. J Cereb Blood Flow Metab (2001) 1.21

Cerebral metabolic changes in profound, insulin-induced hypoglycemia, and in the recovery period following glucose administration. J Neurochem (1978) 1.21

Direct, noninvasive measurement of brain glycogen metabolism in humans. Neurochem Int (2003) 1.18

Effect of acute and recurrent hypoglycemia on changes in brain glycogen concentration. Endocrinology (2008) 1.18

In vivo 13C NMR assessment of brain glycogen concentration and turnover in the awake rat. Neurochem Int (2003) 1.17

Vasoactive intestinal polypeptide induces glycogenolysis in mouse cortical slices: a possible regulatory mechanism for the local control of energy metabolism. Proc Natl Acad Sci U S A (1981) 1.16

Role of hypothalamic adenosine 5'-monophosphate-activated protein kinase in the impaired counterregulatory response induced by repetitive neuroglucopenia. Endocrinology (2006) 1.14

Noninvasive measurements of [1-(13)C]glycogen concentrations and metabolism in rat brain in vivo. J Neurochem (1999) 1.14

Decreased TCA cycle rate in the rat brain after acute 3-NP treatment measured by in vivo 1H-[13C] NMR spectroscopy. J Neurochem (2002) 1.14

Nuclear magnetic resonance studies of hepatic glucose metabolism in humans. Recent Prog Horm Res (2001) 1.11

Glucose, insulin, and insulin-like growth factor I regulate the glycogen content of astroglia-rich primary cultures. J Neurochem (1992) 1.09

Human brain glycogen content and metabolism: implications on its role in brain energy metabolism. Am J Physiol Endocrinol Metab (2006) 1.08

The regulation of carbohydrate and fat metabolism during and after exercise. Front Biosci (1998) 1.07

High glycogen levels in the hippocampus of patients with epilepsy. J Cereb Blood Flow Metab (2006) 1.03

Hypoxic preconditioning increases brain glycogen and delays energy depletion from hypoxia-ischemia in the immature rat. Dev Neurosci (2002) 0.99

Assessment of insulin action and glucose effectiveness in diabetic and nondiabetic humans. J Clin Invest (1994) 0.98

Regionally selective metabolic effects of hypoglycemia in brain. J Neurochem (1981) 0.97

Neuronal activation of brain vagal-regulatory pathways and upper gut enteric plexuses by insulin hypoglycemia. Am J Physiol Endocrinol Metab (2002) 0.94

Comparison of arterialized venous sampling from the hand and foot in the assessment of in vivo glucose metabolism. Metabolism (1997) 0.93

Glycogen accumulated in the brain following insults is not degraded during a subsequent period of ischemia. J Neurol Sci (1996) 0.93

The effect of volatile anaesthetics on levels of metabolites and on metabolic rate in brain. J Neurochem (1971) 0.89

Non-invasive quantification of brain glycogen absolute concentration. J Neurochem (2008) 0.87

L-Glutamate and insulin enhance glycogen synthesis in cultured astrocytes from the rat brain through different intracellular mechanisms. J Neurochem (1999) 0.87

Effects of physiological manipulations on locus coeruleus neuronal activity in freely moving cats. III. Glucoregulatory challenge. Brain Res (1987) 0.85

Direct validation of in vivo localized 13C MRS measurements of brain glycogen. Magn Reson Med (2007) 0.83

Differential early time course activation of the brainstem catecholaminergic groups in response to various stresses. Neuroendocrinology (1991) 0.78

Articles by these authors

The association between symptomatic, severe hypoglycaemia and mortality in type 2 diabetes: retrospective epidemiological analysis of the ACCORD study. BMJ (2010) 6.11

Evaluation and management of adult hypoglycemic disorders: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab (2008) 4.68

Epidemiologic relationships between A1C and all-cause mortality during a median 3.4-year follow-up of glycemic treatment in the ACCORD trial. Diabetes Care (2010) 4.10

The effects of baseline characteristics, glycaemia treatment approach, and glycated haemoglobin concentration on the risk of severe hypoglycaemia: post hoc epidemiological analysis of the ACCORD study. BMJ (2010) 3.26

Role of HMGB1 in apoptosis-mediated sepsis lethality. J Exp Med (2006) 3.26

Cognitive dysfunction and diabetes mellitus. Endocr Rev (2008) 3.17

Sex differences in learning in chimpanzees. Nature (2004) 2.22

Effect of whole grains on insulin sensitivity in overweight hyperinsulinemic adults. Am J Clin Nutr (2002) 2.21

Race/ethnicity, income, major risk factors, and cardiovascular disease mortality. Am J Public Health (2005) 2.02

Diffusion tensor imaging identifies deficits in white matter microstructure in subjects with type 1 diabetes that correlate with reduced neurocognitive function. Diabetes (2008) 1.74

Depressive symptoms and mortality in men: results from the Multiple Risk Factor Intervention Trial. Stroke (2004) 1.68

Effect of hypoglycemia on brain glycogen metabolism in vivo. J Neurosci Res (2003) 1.64

Smoking and incidence of atrial fibrillation: results from the Atherosclerosis Risk in Communities (ARIC) study. Heart Rhythm (2011) 1.64

P-selectin and leukocyte microparticles are associated with venous thrombogenesis. J Vasc Surg (2003) 1.64

Provider factors associated with intramedullary nail use for intertrochanteric hip fractures. J Bone Joint Surg Am (2010) 1.62

Associations of smoking prevalence with individual and area level social cohesion. J Epidemiol Community Health (2004) 1.53

ZIP-code-based versus tract-based income measures as long-term risk-adjusted mortality predictors. Am J Epidemiol (2006) 1.53

Immunogenicity of a monovalent 2009 influenza A (H1N1) vaccine in an immunocompromised population: a prospective study comparing HIV-infected adults with HIV-uninfected adults. Clin Infect Dis (2010) 1.52

Poor cognitive function and risk of severe hypoglycemia in type 2 diabetes: post hoc epidemiologic analysis of the ACCORD trial. Diabetes Care (2012) 1.51

Non-invasive detection of neurochemical changes prior to overt pathology in a mouse model of spinocerebellar ataxia type 1. J Neurochem (2013) 1.43

Biomarkers related to severe hypoglycaemia and lack of good glycaemic control in ACCORD. Diabetologia (2015) 1.41

Body size and predatory performance in wolves: is bigger better? J Anim Ecol (2009) 1.36

Neurochemical alterations in spinocerebellar ataxia type 1 and their correlations with clinical status. Mov Disord (2010) 1.30

Brain glucose concentrations in patients with type 1 diabetes and hypoglycemia unawareness. J Neurosci Res (2004) 1.27

In vivo 13C NMR spectroscopy and metabolic modeling in the brain: a practical perspective. Magn Reson Imaging (2006) 1.25

Personal, indoor, and outdoor VOC exposures in a probability sample of children. J Expo Anal Environ Epidemiol (2004) 1.19

Direct, noninvasive measurement of brain glycogen metabolism in humans. Neurochem Int (2003) 1.18

Impact of diabetes and previous myocardial infarction on long-term survival: 25-year mortality follow-up of primary screenees of the Multiple Risk Factor Intervention Trial. Arch Intern Med (2004) 1.15

Diagnostic accuracy of an "amended" insulin-glucose ratio for the biochemical diagnosis of insulinomas. Ann Intern Med (2013) 1.15

Obesity among HIV-infected persons: impact of weight on CD4 cell count. AIDS (2010) 1.14

Noninvasive detection of presymptomatic and progressive neurodegeneration in a mouse model of spinocerebellar ataxia type 1. J Neurosci (2010) 1.12

Ninety-day mortality after intertrochanteric hip fracture: does provider volume matter? J Bone Joint Surg Am (2010) 1.12

High connectivity between reduced cortical thickness and disrupted white matter tracts in long-standing type 1 diabetes. Diabetes (2010) 1.11

Long-term CD4+ lymphocyte response following HAART initiation in a U.S. Military prospective cohort. AIDS Res Ther (2011) 1.11

Neuroendocrine responses to hypoglycemia. Ann N Y Acad Sci (2010) 1.10

Human brain glycogen content and metabolism: implications on its role in brain energy metabolism. Am J Physiol Endocrinol Metab (2006) 1.08

Neurochemical changes in the rat prefrontal cortex following acute phencyclidine treatment: an in vivo localized (1)H MRS study. NMR Biomed (2009) 1.08

Postnatal age influences hypoglycemia-induced neuronal injury in the rat brain. Brain Res (2008) 1.07

Prevalence and factors associated with sleep disturbances among early-treated HIV-infected persons. Clin Infect Dis (2012) 1.06

Adaptive control of the false discovery rate in voxel-based morphometry. Hum Brain Mapp (2009) 1.04

Durability of antibody responses after receipt of the monovalent 2009 pandemic influenza A (H1N1) vaccine among HIV-infected and HIV-uninfected adults. Vaccine (2011) 1.04

Brain glucose concentrations in healthy humans subjected to recurrent hypoglycemia. J Neurosci Res (2005) 1.04

Variations in product choices of frequently purchased herbs: caveat emptor. Arch Intern Med (2003) 1.03

Antiepileptic drug use in nursing home admissions. Ann Neurol (2003) 1.00

Relationship between diabetes and obesity 9 to 18 years after hemipancreatectomy and transplantation in donors and recipients. Transplantation (2002) 1.00

Risk of glucose intolerance and diabetes in hemipancreatectomized donors selected for normal preoperative glucose metabolism. Diabetes Care (2008) 0.98

Patterns of functional improvement after revision knee arthroplasty. J Bone Joint Surg Am (2009) 0.97

The association of physical activity with lung cancer incidence in a cohort of older women: the Iowa Women's Health Study. Cancer Epidemiol Biomarkers Prev (2006) 0.95

Oncologic colorectal resection, not advanced endoscopic polypectomy, is the best treatment for large dysplastic adenomas. J Gastrointest Surg (2011) 0.95

Brain glycogen content and metabolism in subjects with type 1 diabetes and hypoglycemia unawareness. J Cereb Blood Flow Metab (2011) 0.95

Measurement of cerebral oxidative glucose consumption in patients with type 1 diabetes mellitus and hypoglycemia unawareness using (13)C nuclear magnetic resonance spectroscopy. Metabolism (2009) 0.94

In vitro activity of the aminoglycoside antibiotic arbekacin against Acinetobacter baumannii-calcoaceticus isolated from war-wounded patients at Walter Reed Army Medical Center. Antimicrob Agents Chemother (2010) 0.94

Agreement of pesticide biomarkers between morning void and 24-h urine samples from farmers and their children. J Expo Sci Environ Epidemiol (2006) 0.94

Prevalence of incontinence by race and ethnicity of older people admitted to nursing homes. J Am Med Dir Assoc (2013) 0.93

GEE estimation of a misspecified time-varying covariate: an example with the effect of alcoholism treatment on medical utilization. Stat Med (2005) 0.92

In vivo monitoring of recovery from neurodegeneration in conditional transgenic SCA1 mice. Exp Neurol (2011) 0.92

Impact of weight on immune cell counts among HIV-infected persons. Clin Vaccine Immunol (2011) 0.92

Simultaneous measurement of glucose transport and utilization in the human brain. Am J Physiol Endocrinol Metab (2011) 0.91

The effects of resident and nursing home characteristics on activities of daily living. J Gerontol A Biol Sci Med Sci (2009) 0.91

Hypoglycemia-induced increases in thalamic cerebral blood flow are blunted in subjects with type 1 diabetes and hypoglycemia unawareness. J Cereb Blood Flow Metab (2012) 0.91

Predicting children's short-term exposure to pesticides: results of a questionnaire screening approach. Environ Health Perspect (2003) 0.90

Identification of an abbreviated test battery for detection of HIV-associated neurocognitive impairment in an early-managed HIV-infected cohort. PLoS One (2012) 0.89

Hypoglycemia as a driver of cardiovascular risk in diabetes. Curr Atheroscler Rep (2013) 0.89

Latino risk-adjusted mortality in the men screened for the Multiple Risk Factor Intervention Trial. Am J Epidemiol (2005) 0.88

Variation in deep brain stimulation electrode impedance over years following electrode implantation. Stereotact Funct Neurosurg (2014) 0.87

Evaluation of cardioprotective effects of recombinant soluble P-selectin glycoprotein ligand-immunoglobulin in myocardial ischemia-reperfusion injury by real-time myocardial contrast echocardiography. J Am Coll Cardiol (2004) 0.86

Acute free fatty acid elevation eliminates endurance training effect on insulin sensitivity. J Clin Endocrinol Metab (2012) 0.85

Use of antiepileptic medications in nursing homes. Int Rev Neurobiol (2007) 0.85

Insulin sensitivity and skeletal muscle glucose transport in horses with equine polysaccharide storage myopathy. Neuromuscul Disord (2004) 0.84

Clinical, demographic and laboratory parameters at HAART initiation associated with decreased post-HAART survival in a U.S. military prospective HIV cohort. AIDS Res Ther (2012) 0.84

Ginkgo biloba use in nursing home elderly with epilepsy or seizure disorder. Epilepsia (2006) 0.83

Noninvasive measurement of brain glycogen by nuclear magnetic resonance spectroscopy and its application to the study of brain metabolism. J Neurosci Res (2011) 0.83

Prevalence of appropriate and problematic antiepileptic combination therapy in older people in the nursing home. J Am Geriatr Soc (2005) 0.83

Effect of insulin sensitizer therapy on atherothrombotic and inflammatory profiles associated with insulin resistance. Mayo Clin Proc (2012) 0.83

Impact of treatment exposures on cardiovascular risk and insulin resistance in childhood cancer survivors. Cancer Epidemiol Biomarkers Prev (2013) 0.83

Uncovering hidden in vivo resonances using editing based on localized TOCSY. Magn Reson Med (2005) 0.83

Mercury accumulation in bats near hydroelectric reservoirs in Peninsular Malaysia. Ecotoxicology (2014) 0.82

Prevention of in-stent restenosis via reduction of thrombo-inflammatory reactions with recombinant P-selectin glycoprotein ligand-1. Thromb Haemost (2004) 0.82

Longitudinal evaluation of allergen and culturable fungal concentrations in inner-city households. J Occup Environ Hyg (2008) 0.82

Recombinant soluble P-selectin glycoprotein ligand-Ig (rPSGL-Ig) attenuates infarct size and myeloperoxidase activity in a canine model of ischemia-reperfusion. Thromb Haemost (2002) 0.82

Blunted response to a growth hormone stimulation test is associated with unfavorable cardiovascular risk factor profile in childhood cancer survivors. Pediatr Blood Cancer (2012) 0.82

In vivo neurometabolic profiling in patients with spinocerebellar ataxia types 1, 2, 3, and 7. Mov Disord (2015) 0.81

Effect of insulin on the brain activity obtained during visual and memory tasks in healthy human subjects. Neuroendocrinology (2006) 0.81

Are HIV-positive persons progressing faster after diagnosis over the epidemic? J Acquir Immune Defic Syndr (2010) 0.80

Diabetes: Does lactate sustain brain metabolism during hypoglycaemia? Nat Rev Endocrinol (2013) 0.80

(1)H MR spectroscopy in Friedreich's ataxia and ataxia with oculomotor apraxia type 2. Brain Res (2010) 0.80

Diabetes: Strategies to prevent the type 2 diabetes mellitus epidemic. Nat Rev Endocrinol (2010) 0.80

Statistical hypothesis testing: associating patient characteristics with an incident condition: Kaplan-Meier curves, hazard ratios, and cox proportional hazards regression. J Wound Ostomy Continence Nurs (2011) 0.80