Transmission and spreading of tauopathy in transgenic mouse brain.

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Published in Nat Cell Biol on June 07, 2009

Authors

Florence Clavaguera1, Tristan Bolmont, R Anthony Crowther, Dorothee Abramowski, Stephan Frank, Alphonse Probst, Graham Fraser, Anna K Stalder, Martin Beibel, Matthias Staufenbiel, Mathias Jucker, Michel Goedert, Markus Tolnay

Author Affiliations

1: Department of Neuropathology, Institute of Pathology, University of Basel, Switzerland.

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Neurodegenerative tauopathies. Annu Rev Neurosci (2001) 9.53

Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease. Neuron (1989) 8.04

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A century of Alzheimer's disease. Science (2006) 5.84

Tau is a candidate gene for chromosome 17 frontotemporal dementia. Ann Neurol (1998) 5.42

Human spongiform encephalopathy: the National Institutes of Health series of 300 cases of experimentally transmitted disease. Ann Neurol (1994) 5.20

Tau proteins of Alzheimer paired helical filaments: abnormal phosphorylation of all six brain isoforms. Neuron (1992) 4.22

Silver staining of Alzheimer's neurofibrillary changes by means of physical development. Acta Morphol Acad Sci Hung (1971) 3.71

Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis. Nat Neurosci (2005) 3.69

Epitopes that span the tau molecule are shared with paired helical filaments. Neuron (1988) 3.28

Monoclonal antibody AT8 recognises tau protein phosphorylated at both serine 202 and threonine 205. Neurosci Lett (1995) 3.15

Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements. J Neurosci (2007) 3.10

Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein. J Neurosci (2002) 2.80

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Research in motion: the enigma of Parkinson's disease pathology spread. Nat Rev Neurosci (2008) 2.51

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Affinity purification of human tau proteins and the construction of a sensitive sandwich enzyme-linked immunosorbent assay for human tau detection. J Neurochem (1992) 1.17

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Global democratic consensus on neuropathological disease criteria. Lancet Neurol (2002) 1.44