Published in Int J Mol Med on July 01, 2009
Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors: rationale and importance to inhibiting these pathways in human health. Oncotarget (2011) 3.43
Rapid KRAS, EGFR, BRAF and PIK3CA mutation analysis of fine needle aspirates from non-small-cell lung cancer using allele-specific qPCR. PLoS One (2011) 1.78
A Potential Role for the Inhibition of PI3K Signaling in Glioblastoma Therapy. PLoS One (2015) 1.45
Role of mTOR signaling in tumor cell motility, invasion and metastasis. Curr Protein Pept Sci (2011) 1.37
Updates of mTOR inhibitors. Anticancer Agents Med Chem (2010) 1.27
Current development of the second generation of mTOR inhibitors as anticancer agents. Chin J Cancer (2011) 1.10
PI3K-AKT-mTOR-signaling and beyond: the complex network in gastroenteropancreatic neuroendocrine neoplasms. Theranostics (2014) 0.95
Revisiting clinical trials using EGFR inhibitor-based regimens in patients with advanced non-small cell lung cancer: a retrospective analysis of an MD Anderson Cancer Center phase I population. Oncotarget (2013) 0.89
Alternative dosing of dual PI3K and MEK inhibition in cancer therapy. BMC Cancer (2012) 0.86
Molecular profiling of lung adenosquamous carcinoma: hybrid or genuine type? Oncotarget (2015) 0.85
Targeting genomic alterations in squamous cell lung cancer. Front Oncol (2013) 0.85
Autophagy Inhibition with Monensin Enhances Cell Cycle Arrest and Apoptosis Induced by mTOR or Epidermal Growth Factor Receptor Inhibitors in Lung Cancer Cells. Tuberc Respir Dis (Seoul) (2013) 0.82
The Biological Role of PI3K Pathway in Lung Cancer. Pharmaceuticals (Basel) (2012) 0.81
Targetable "driver" mutations in non small cell lung cancer. Indian J Surg Oncol (2011) 0.80
Synergistic inhibition of colon cancer cell growth with nanoemulsion-loaded paclitaxel and PI3K/mTOR dual inhibitor BEZ235 through apoptosis. Int J Nanomedicine (2016) 0.78
Synthesis of Novel 3,5-Disubstituted-2-oxindole Derivatives As Antitumor Agents against Human Nonsmall Cell Lung Cancer. ACS Med Chem Lett (2013) 0.77
Rapamycin, a mTOR inhibitor, induced growth inhibition in retinoblastoma Y79 cell via down-regulation of Bmi-1. Int J Clin Exp Pathol (2015) 0.75
Emerging photoluminescence in monolayer MoS2. Nano Lett (2010) 9.26
Epidemiological serosurvey of hepatitis B in China--declining HBV prevalence due to hepatitis B vaccination. Vaccine (2009) 6.30
Direct observation of a widely tunable bandgap in bilayer graphene. Nature (2009) 5.37
Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis. Nat Genet (2009) 5.31
Coordinated regulation of Arabidopsis thaliana development by light and gibberellins. Nature (2008) 4.71
A graphene-based broadband optical modulator. Nature (2011) 4.21
Graphene plasmonics for tunable terahertz metamaterials. Nat Nanotechnol (2011) 4.20
Rapid growth of a hepatocellular carcinoma and the driving mutations revealed by cell-population genetic analysis of whole-genome data. Proc Natl Acad Sci U S A (2011) 3.80
A novel 5-enolpyruvoylshikimate-3-phosphate (EPSP) synthase transgene for glyphosate resistance stimulates growth and fecundity in weedy rice (Oryza sativa) without herbicide. New Phytol (2013) 3.44
Localization algorithms of Underwater Wireless Sensor Networks: a survey. Sensors (Basel) (2012) 3.26
Evaluation of the impact of hepatitis B vaccination among children born during 1992-2005 in China. J Infect Dis (2009) 2.62
Akt signals through the mammalian target of rapamycin pathway to regulate CNS myelination. J Neurosci (2009) 2.35
Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid. Nat Med (2006) 2.35
Comparative transcriptional profiling of two contrasting rice genotypes under salinity stress during the vegetative growth stage. Plant Physiol (2005) 2.28
Association between vitamin D and risk of colorectal cancer: a systematic review of prospective studies. J Clin Oncol (2011) 2.24
Meta-analysis of B vitamin supplementation on plasma homocysteine, cardiovascular and all-cause mortality. Clin Nutr (2012) 2.17
Polyphenols based on isoflavones as inhibitors of Helicobacter pylori urease. Bioorg Med Chem (2007) 2.13
Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations. Nat Genet (2011) 2.05
Obesity and risk of colorectal cancer: a systematic review of prospective studies. PLoS One (2013) 2.02
A murine model of isolated cardiac steatosis leads to cardiomyopathy. Hypertension (2011) 1.90
Pro12Ala polymorphism in the PPARG gene contributes to the development of diabetic nephropathy in Chinese type 2 diabetic patients. Diabetes Care (2009) 1.82
Crystal structure of human histone lysine-specific demethylase 1 (LSD1). Proc Natl Acad Sci U S A (2006) 1.80
Highly efficient and specific genome editing in silkworm using custom TALENs. PLoS One (2012) 1.80
Detecting single-feature polymorphisms using oligonucleotide arrays and robustified projection pursuit. Bioinformatics (2005) 1.79
Definitive hematopoietic stem/progenitor cells manifest distinct differentiation output in the zebrafish VDA and PBI. Development (2009) 1.79
Migratory path of definitive hematopoietic stem/progenitor cells during zebrafish development. Blood (2007) 1.74
Single-molecule imaging reveals target-search mechanisms during DNA mismatch repair. Proc Natl Acad Sci U S A (2012) 1.72
Histone deacetylases are required for androgen receptor function in hormone-sensitive and castrate-resistant prostate cancer. Cancer Res (2009) 1.68
DJ-1 transcriptionally up-regulates the human tyrosine hydroxylase by inhibiting the sumoylation of pyrimidine tract-binding protein-associated splicing factor. J Biol Chem (2006) 1.68
Influenza H7N9 and H9N2 viruses: coexistence in poultry linked to human H7N9 infection and genome characteristics. J Virol (2014) 1.67
miR-150 as a potential biomarker associated with prognosis and therapeutic outcome in colorectal cancer. Gut (2011) 1.66
Consideration of the role of radiotherapy for unresectable intrahepatic cholangiocarcinoma: a retrospective analysis of 75 patients. Cancer J (2006) 1.65
Human circulating microRNA-1 and microRNA-126 as potential novel indicators for acute myocardial infarction. Int J Biol Sci (2012) 1.63
GCN5 is a required cofactor for a ubiquitin ligase that targets NF-kappaB/RelA. Genes Dev (2009) 1.62
Pancreatic stump-closed pancreaticojejunostomy can be performed safely in normal soft pancreas cases. J Surg Res (2011) 1.61
Maintaining the end: roles of telomere proteins in end-protection, telomere replication and length regulation. Mutat Res (2011) 1.56
A comparison of safety, tolerability and immunogenicity of Oka/Merck varicella vaccine and VARILRIX in healthy children. Vaccine (2002) 1.56
Natural products and anti-inflammatory activity. Asia Pac J Clin Nutr (2006) 1.56
Imaging the homogeneous nucleation during the melting of superheated colloidal crystals. Science (2012) 1.56
Factors contributing to high costs and inequality in China's health care system. JAMA (2007) 1.55
Altered NADH/NAD+ ratio mediates coresistance to isoniazid and ethionamide in mycobacteria. Antimicrob Agents Chemother (2005) 1.53
Double-stranded RNA-dependent protein kinase phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 mediates apoptosis. J Biol Chem (2006) 1.53
Sustained MEK inhibition abrogates myeloproliferative disease in Nf1 mutant mice. J Clin Invest (2012) 1.52
High-resolution functional magnetic resonance imaging mapping of noxious heat and tactile activations along the central sulcus in New World monkeys. Pain (2010) 1.50
Increased dietary fat promotes islet amyloid formation and beta-cell secretory dysfunction in a transgenic mouse model of islet amyloid. Diabetes (2003) 1.49
Probing electronic transitions in individual carbon nanotubes by Rayleigh scattering. Science (2004) 1.49
Locally administered adipose-derived stem cells accelerate wound healing through differentiation and vasculogenesis. Cell Transplant (2010) 1.48
Human CST promotes telomere duplex replication and general replication restart after fork stalling. EMBO J (2012) 1.47
Lead poisoning in China: a nightmare from industrialisation. Lancet (2011) 1.47
Comprehensive molecular diagnosis of 179 Leber congenital amaurosis and juvenile retinitis pigmentosa patients by targeted next generation sequencing. J Med Genet (2013) 1.47
Expression levels of Lyn, Syk, PLCγ2 and ERK in patients with chronic lymphocytic leukemia, and higher levels of Lyn are associated with a shorter treatment-free survival. Leuk Lymphoma (2012) 1.46
Arsenite interacts selectively with zinc finger proteins containing C3H1 or C4 motifs. J Biol Chem (2011) 1.45
Low expression level of phosphatase and tensin homolog deleted on chromosome ten predicts poor prognosis in chronic lymphocytic leukemia. Leuk Lymphoma (2012) 1.45
Hypothalamic gene expression in ω-3 PUFA-deficient male rats before, and following, development of hypertension. Hypertens Res (2011) 1.43
One-step, room temperature, colorimetric detection of mercury (Hg2+) using DNA/nanoparticle conjugates. J Am Chem Soc (2008) 1.43
Safety and immunogenicity profile of the concomitant administration of ZOSTAVAX and inactivated influenza vaccine in adults aged 50 and older. J Am Geriatr Soc (2007) 1.42
Effects of temperature on the development and population growth of the sycamore lace bug, Corythucha ciliata. J Insect Sci (2011) 1.41
gamma-Cyclodextrin: a review on enzymatic production and applications. Appl Microbiol Biotechnol (2007) 1.39
Environmental adaptation: genomic analysis of the piezotolerant and psychrotolerant deep-sea iron reducing bacterium Shewanella piezotolerans WP3. PLoS One (2008) 1.38
HIV-1 Nef disrupts the podocyte actin cytoskeleton by interacting with diaphanous interacting protein. J Biol Chem (2008) 1.38
Does cochlear implantation and electrical stimulation affect residual hair cells and spiral ganglion neurons? Hear Res (2006) 1.37
Extracellular ATP activates c-jun N-terminal kinase signaling and cell cycle progression in hepatocytes. Hepatology (2004) 1.35
Transcript-level annotation of Affymetrix probesets improves the interpretation of gene expression data. BMC Bioinformatics (2007) 1.35
Robot-assisted versus conventional laparoscopic surgery for colorectal disease, focusing on rectal cancer: a meta-analysis. Ann Surg Oncol (2012) 1.35
Nucleosome-free region dominates histone acetylation in targeting SWR1 to promoters for H2A.Z replacement. Cell (2013) 1.35
Involvement of exon 11-associated variants of the mu opioid receptor MOR-1 in heroin, but not morphine, actions. Proc Natl Acad Sci U S A (2009) 1.35
Comparison of round window and cochleostomy approaches with a prototype hearing preservation electrode. Audiol Neurootol (2006) 1.34
The draft genome of the carcinogenic human liver fluke Clonorchis sinensis. Genome Biol (2011) 1.34
Components of the Rb pathway are critical targets of UV mutagenesis in a murine melanoma model. Proc Natl Acad Sci U S A (2003) 1.32
Next-generation sequencing-based molecular diagnosis of a Chinese patient cohort with autosomal recessive retinitis pigmentosa. Invest Ophthalmol Vis Sci (2013) 1.32
Change in hepatitis B virus large surface antigen variant prevalence 13 years after implementation of a universal vaccination program in China. J Virol (2013) 1.31
Solid pseudopapillary tumor of the pancreas: a case series of 26 consecutive patients. Am J Surg (2009) 1.31
Eya1-Six1 interaction is sufficient to induce hair cell fate in the cochlea by activating Atoh1 expression in cooperation with Sox2. Dev Cell (2012) 1.30
Both products of the mouse Ink4a/Arf locus suppress melanoma formation in vivo. Oncogene (2003) 1.29
Distinct functions for different scl isoforms in zebrafish primitive and definitive hematopoiesis. PLoS Biol (2007) 1.29
A proposed OB-fold with a protein-interaction surface in Candida albicans telomerase protein Est3. Nat Struct Mol Biol (2008) 1.29
Association of candidate genetic variations with gastric cardia adenocarcinoma in Chinese population: a multiple interaction analysis. Carcinogenesis (2010) 1.28
Fish consumption and CHD mortality: an updated meta-analysis of seventeen cohort studies. Public Health Nutr (2011) 1.28
Irf8 regulates macrophage versus neutrophil fate during zebrafish primitive myelopoiesis. Blood (2010) 1.28
Transcript profiling and identification of molecular markers for early microspore embryogenesis in Brassica napus. Plant Physiol (2007) 1.27
Controlling inelastic light scattering quantum pathways in graphene. Nature (2011) 1.27
China's engagement with global health diplomacy: was SARS a watershed? PLoS Med (2010) 1.27
Estrogen attenuates left ventricular and cardiomyocyte hypertrophy by an estrogen receptor-dependent pathway that increases calcineurin degradation. Circ Res (2008) 1.26
99mTc-3PRGD2 for integrin receptor imaging of lung cancer: a multicenter study. J Nucl Med (2012) 1.23
Nanofabricated racks of aligned and anchored DNA substrates for single-molecule imaging. Langmuir (2010) 1.23
CHIP functions as a novel suppressor of tumour angiogenesis with prognostic significance in human gastric cancer. Gut (2012) 1.22
An improved multistate empirical valence bond model for aqueous proton solvation and transport. J Phys Chem B (2007) 1.22
Fluorescence turn on of coumarin derivatives by metal cations: a new signaling mechanism based on C=N isomerization. Org Lett (2007) 1.22
Astragaloside IV, a novel antioxidant, prevents glucose-induced podocyte apoptosis in vitro and in vivo. PLoS One (2012) 1.21
Elevated oncofoetal miR-17-5p expression regulates colorectal cancer progression by repressing its target gene P130. Nat Commun (2012) 1.21
Identification of four novel exon 5 splice variants of the mouse mu-opioid receptor gene: functional consequences of C-terminal splicing. Mol Pharmacol (2005) 1.20
Triclosan derivatives: towards potent inhibitors of drug-sensitive and drug-resistant Mycobacterium tuberculosis. ChemMedChem (2009) 1.19
Long-term treatment with rosiglitazone and metformin reduces the extent of, but does not prevent, islet amyloid deposition in mice expressing the gene for human islet amyloid polypeptide. Diabetes (2005) 1.19
Hospital-Based Surveillance of Rotavirus Diarrhea in the People's Republic of China, August 2003-July 2007. J Infect Dis (2009) 1.19
A proposed mechanism for the protective effect of dioxin against breast cancer. Toxicol Sci (2007) 1.17
Single-molecule force spectroscopy of the add adenine riboswitch relates folding to regulatory mechanism. Nucleic Acids Res (2011) 1.17
Identification of microRNA-214 as a negative regulator of colorectal cancer liver metastasis by way of regulation of fibroblast growth factor receptor 1 expression. Hepatology (2014) 1.17