On the biomechanics of heart valve function.

PubWeight™: 1.69‹?› | Rank: Top 3%

🔗 View Article (PMC 2746960)

Published in J Biomech on June 21, 2009

Authors

Michael S Sacks1, W David Merryman, David E Schmidt

Author Affiliations

1: Department of Bioengineering, Engineered Tissue Mechanics and Mechanobiology Laboratory, The McGowan Institute, University of Pittsburgh, Pittsburgh, PA, United States. msacks@pitt.edu

Articles citing this

Heart valve structure and function in development and disease. Annu Rev Physiol (2011) 1.80

The role of organ level conditioning on the promotion of engineered heart valve tissue development in-vitro using mesenchymal stem cells. Biomaterials (2009) 1.19

On the in vivo deformation of the mitral valve anterior leaflet: effects of annular geometry and referential configuration. Ann Biomed Eng (2012) 1.13

Cyclic strain induces dual-mode endothelial-mesenchymal transformation of the cardiac valve. Proc Natl Acad Sci U S A (2011) 1.11

Elastin haploinsufficiency results in progressive aortic valve malformation and latent valve disease in a mouse model. Circ Res (2010) 1.02

Design and demonstration of a microbiaxial optomechanical device for multiscale characterization of soft biological tissues with two-photon microscopy. Microsc Microanal (2011) 0.99

On the biomechanical role of glycosaminoglycans in the aortic heart valve leaflet. Acta Biomater (2012) 0.98

Cyclic strain anisotropy regulates valvular interstitial cell phenotype and tissue remodeling in three-dimensional culture. Acta Biomater (2012) 0.97

Electrospun PGS:PCL microfibers align human valvular interstitial cells and provide tunable scaffold anisotropy. Adv Healthc Mater (2014) 0.96

An inverse modeling approach for stress estimation in mitral valve anterior leaflet valvuloplasty for in-vivo valvular biomaterial assessment. J Biomech (2013) 0.95

Role of cell-matrix interactions on VIC phenotype and tissue deposition in 3D PEG hydrogels. J Tissue Eng Regen Med (2013) 0.93

Regional analysis of dynamic deformation characteristics of native aortic valve leaflets. J Biomech (2011) 0.92

Regional structure-function relationships in mouse aortic valve tissue. J Biomech (2010) 0.91

EMT-inducing biomaterials for heart valve engineering: taking cues from developmental biology. J Cardiovasc Transl Res (2011) 0.91

Revisiting the simplified bernoulli equation. Open Biomed Eng J (2010) 0.91

Noggin attenuates the osteogenic activation of human valve interstitial cells in aortic valve sclerosis. Cardiovasc Res (2013) 0.91

Viscoelastic properties of the aortic valve interstitial cell. J Biomech Eng (2009) 0.91

Three-dimensional printed trileaflet valve conduits using biological hydrogels and human valve interstitial cells. Acta Biomater (2013) 0.90

Quantification and simulation of layer-specific mitral valve interstitial cells deformation under physiological loading. J Theor Biol (2015) 0.90

A generalized method for the analysis of planar biaxial mechanical data using tethered testing configurations. J Biomech Eng (2015) 0.89

Architectural trends in the human normal and bicuspid aortic valve leaflet and its relevance to valve disease. Ann Biomed Eng (2014) 0.87

On the presence of affine fibril and fiber kinematics in the mitral valve anterior leaflet. Biophys J (2015) 0.85

Optimal elastomeric scaffold leaflet shape for pulmonary heart valve leaflet replacement. J Biomech (2013) 0.85

Interlayer micromechanics of the aortic heart valve leaflet. Biomech Model Mechanobiol (2013) 0.83

Role of Computational Simulations in Heart Valve Dynamics and Design of Valvular Prostheses. Cardiovasc Eng Technol (2010) 0.83

Tri-layered elastomeric scaffolds for engineering heart valve leaflets. Biomaterials (2014) 0.83

Complex collagen fiber and membrane morphologies of the whole porcine aortic valve. PLoS One (2014) 0.82

A meso-scale layer-specific structural constitutive model of the mitral heart valve leaflets. Acta Biomater (2015) 0.82

A novel fibre-ensemble level constitutive model for exogenous cross-linked collagenous tissues. Interface Focus (2016) 0.81

Form Follows Function: Advances in Trilayered Structure Replication for Aortic Heart Valve Tissue Engineering. J Healthc Eng (2012) 0.81

GENE EXPRESSION AND COLLAGEN FIBER MICROMECHANICAL INTERACTIONS OF THE SEMILUNAR HEART VALVE INTERSTITIAL CELL. Cell Mol Bioeng (2012) 0.80

Measurements of the effects of decellularization on viscoelastic properties of tissues in ovine, baboon, and human heart valves. Tissue Eng Part A (2011) 0.80

A combined experimental and modelling approach to aortic valve viscoelasticity in tensile deformation. J Mater Sci Mater Med (2011) 0.79

Mechanisms of calcification in aortic valve disease: role of mechanokinetics and mechanodynamics. Curr Cardiol Rep (2013) 0.79

A Computational Tool for the Microstructure Optimization of a Polymeric Heart Valve Prosthesis. J Biomech Eng (2016) 0.78

Fibrous scaffolds for building hearts and heart parts. Adv Drug Deliv Rev (2015) 0.78

Evaluation of bioprosthetic heart valve failure using a matrix-fibril shear stress transfer approach. J Mater Sci Mater Med (2015) 0.77

Porcine vena cava as an alternative to bovine pericardium in bioprosthetic percutaneous heart valves. Biomaterials (2011) 0.77

Large strain stimulation promotes extracellular matrix production and stiffness in an elastomeric scaffold model. J Mech Behav Biomed Mater (2016) 0.77

A finite strain nonlinear human mitral valve model with fluid-structure interaction. Int J Numer Method Biomed Eng (2014) 0.77

Micro-poromechanics model of fluid-saturated chemically active fibrous media. Z Angew Math Mech (2015) 0.77

A novel bioreactor for mechanobiological studies of engineered heart valve tissue formation under pulmonary arterial physiological flow conditions. J Biomech Eng (2014) 0.77

Multiple-Step Injection Molding for Fibrin-Based Tissue-Engineered Heart Valves. Tissue Eng Part C Methods (2015) 0.76

On intrinsic stress fiber contractile forces in semilunar heart valve interstitial cells using a continuum mixture model. J Mech Behav Biomed Mater (2015) 0.76

Neomycin and pentagalloyl glucose enhanced cross-linking for elastin and glycosaminoglycans preservation in bioprosthetic heart valves. J Biomater Appl (2014) 0.76

Age-Dependent Changes in Geometry, Tissue Composition and Mechanical Properties of Fetal to Adult Cryopreserved Human Heart Valves. PLoS One (2016) 0.75

Valve interstitial cell contractile strength and metabolic state are dependent on its shape. Integr Biol (Camb) (2016) 0.75

Structural and Histochemical Alterations in the Aortic Valves of Elderly Patients: A Comparative Study of Aortic Stenosis, Aortic Regurgitation, and Normal Valves. Biomed Res Int (2016) 0.75

Biomechanics of Cardiac Function. Compr Physiol (2015) 0.75

A correlation between long-term in vitro dynamic calcification and abnormal flow patterns past bioprosthetic heart valves. J Biol Phys (2017) 0.75

MODELING THE FUNCTIONAL ROLE OF VALVE INTERSTITIAL CELL STRESS FIBERS. J Biomech Eng (2016) 0.75

A transverse isotropic viscoelastic constitutive model for aortic valve tissue. R Soc Open Sci (2017) 0.75

In-vivo heterogeneous functional and residual strains in human aortic valve leaflets. J Biomech (2016) 0.75

Optical-Based Analysis of Soft Tissue Structures. Annu Rev Biomed Eng (2016) 0.75

Heart Valve Biomechanics and Underlying Mechanobiology. Compr Physiol (2016) 0.75

Characterization of mechanical properties of pericardium tissue using planar biaxial tension and flexural deformation. J Mech Behav Biomed Mater (2017) 0.75

Recellularization of a novel off-the-shelf valve following xenogenic implantation into the right ventricular outflow tract. PLoS One (2017) 0.75

Articles cited by this

(truncated to the top 100)

Heart disease and stroke statistics--2006 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation (2006) 14.72

Constitutive equations for fibrous connective tissues. J Biomech (1983) 2.74

Human semilunar cardiac valve remodeling by activated cells from fetus to adult: implications for postnatal adaptation, pathology, and tissue engineering. Circulation (2006) 2.68

Functional tissue engineering: the role of biomechanics. J Biomech Eng (2000) 2.68

A three-dimensional computational analysis of fluid-structure interaction in the aortic valve. J Biomech (2003) 2.55

Incorporation of experimentally-derived fiber orientation into a structural constitutive model for planar collagenous tissues. J Biomech Eng (2003) 2.43

Biaxial mechanical properties of the native and glutaraldehyde-treated aortic valve cusp: Part II--A structural constitutive model. J Biomech Eng (2000) 2.37

Biaxial mechanical properties of the natural and glutaraldehyde treated aortic valve cusp--Part I: Experimental results. J Biomech Eng (2000) 2.29

Unique morphology and focal adhesion development of valvular endothelial cells in static and fluid flow environments. Arterioscler Thromb Vasc Biol (2004) 2.28

In-vivo dynamic deformation of the mitral valve anterior leaflet. Ann Thorac Surg (2006) 2.28

Insights from three-dimensional echocardiography into the mechanism of functional mitral regurgitation: direct in vivo demonstration of altered leaflet tethering geometry. Circulation (1997) 2.22

Mechanical stress mechanisms and the cell. An endothelial paradigm. Circ Res (1993) 2.20

A small angle light scattering device for planar connective tissue microstructural analysis. Ann Biomed Eng (1997) 2.02

Dynamic and reversible changes of interstitial cell phenotype during remodeling of cardiac valves. J Heart Valve Dis (2004) 2.02

Size and motion of the mitral valve annulus in man. I. A two-dimensional echocardiographic method and findings in normal subjects. Circulation (1981) 1.88

Finite element implementation of a generalized Fung-elastic constitutive model for planar soft tissues. Biomech Model Mechanobiol (2005) 1.76

The cardiac valve interstitial cell. Int J Biochem Cell Biol (2003) 1.76

Dynamic three-dimensional imaging of the mitral valve and left ventricle by rapid sonomicrometry array localization. J Thorac Cardiovasc Surg (1996) 1.76

Heart valve function: a biomechanical perspective. Philos Trans R Soc Lond B Biol Sci (2007) 1.75

The effect of regional ischemia on mitral valve annular saddle shape. Ann Thorac Surg (2004) 1.74

Founder's Award, 25th Annual Meeting of the Society for Biomaterials, perspectives. Providence, RI, April 28-May 2, 1999. Tissue heart valves: current challenges and future research perspectives. J Biomed Mater Res (1999) 1.73

Correlation between heart valve interstitial cell stiffness and transvalvular pressure: implications for collagen biosynthesis. Am J Physiol Heart Circ Physiol (2005) 1.73

On the biaxial mechanical properties of the layers of the aortic valve leaflet. J Biomech Eng (2007) 1.71

Finite element analysis of the mitral valve. J Heart Valve Dis (1993) 1.60

Biaixal stress-stretch behavior of the mitral valve anterior leaflet at physiologic strain rates. Ann Biomed Eng (2006) 1.60

Biaxial mechanical behavior of excised porcine mitral valve leaflets. Am J Physiol (1995) 1.56

Interstitial cells of the heart valves possess characteristics similar to smooth muscle cells. Circ Res (1986) 1.55

Bioengineering challenges for heart valve tissue engineering. Annu Rev Biomed Eng (2009) 1.54

An assessment of the mechanical properties of leaflets from four second-generation porcine bioprostheses with biaxial testing techniques. J Thorac Cardiovasc Surg (1989) 1.51

The role of elastin in aortic valve mechanics. J Biomech (1998) 1.49

Surface strains in the anterior leaflet of the functioning mitral valve. Ann Biomed Eng (2003) 1.45

Dual structural and functional phenotypes of the porcine aortic valve interstitial population: characteristics of the leaflet myofibroblast. J Surg Res (1994) 1.42

Simulated bioprosthetic heart valve deformation under quasi-static loading. J Biomech Eng (2005) 1.40

Porcine aortic valve interstitial cells in three-dimensional culture: comparison of phenotype with aortic smooth muscle cells. J Heart Valve Dis (2004) 1.39

A constitutive law for mitral valve tissue. J Biomech Eng (1998) 1.39

Nonlinear ligament viscoelasticity. Ann Biomed Eng (2001) 1.38

Dynamics of mitral regurgitant flow and orifice area. Physiologic application of the proximal flow convergence method: clinical data and experimental testing. Circulation (1994) 1.38

Localization and pattern of expression of extracellular matrix components in human heart valves. J Heart Valve Dis (2005) 1.36

A novel bioreactor for the dynamic flexural stimulation of tissue engineered heart valve biomaterials. Biomaterials (2003) 1.34

The effects of cellular contraction on aortic valve leaflet flexural stiffness. J Biomech (2005) 1.33

Cell biology of valvular interstitial cells. Can J Cardiol (1996) 1.33

Dynamic simulation of bioprosthetic heart valves using a stress resultant shell model. Ann Biomed Eng (2007) 1.32

Glycosaminoglycans and proteoglycans in normal mitral valve leaflets and chordae: association with regions of tensile and compressive loading. Glycobiology (2004) 1.30

The aortic valve microstructure: effects of transvalvular pressure. J Biomed Mater Res (1998) 1.29

Stress variations in the human aortic root and valve: the role of anatomic asymmetry. Ann Biomed Eng (1998) 1.26

Deformational dynamics of the aortic root: modes and physiologic determinants. Circulation (1999) 1.25

An experimentally derived stress resultant shell model for heart valve dynamic simulations. Ann Biomed Eng (2006) 1.22

Fiber kinematics of small intestinal submucosa under biaxial and uniaxial stretch. J Biomech Eng (2006) 1.20

In vitro dynamic strain behavior of the mitral valve posterior leaflet. J Biomech Eng (2005) 1.19

Planar biaxial creep and stress relaxation of the mitral valve anterior leaflet. Ann Biomed Eng (2006) 1.17

Clinical practice. Evaluation and management of chronic mitral regurgitation. N Engl J Med (2001) 1.16

In vivo dynamic deformation of the mitral valve annulus. Ann Biomed Eng (2009) 1.16

Micromechanics of the fibrosa and the ventricularis in aortic valve leaflets. J Biomech (1992) 1.16

Cardiac valves and valvular pathology: update on function, disease, repair, and replacement. Cardiovasc Pathol (2005) 1.15

Time-dependent biaxial mechanical behavior of the aortic heart valve leaflet. J Biomech (2007) 1.14

Patterns of calcific deposits in operatively excised stenotic or purely regurgitant aortic valves and their relation to mechanical stress. Am J Cardiol (1986) 1.14

Anatomic basis for mitral valve modelling. J Heart Valve Dis (1994) 1.14

Evolution of cell phenotype and extracellular matrix in tissue-engineered heart valves during in-vitro maturation and in-vivo remodeling. J Heart Valve Dis (2002) 1.13

A two-dimensional fluid-structure interaction model of the aortic valve [correction of value]. J Biomech (2000) 1.12

In-situ deformation of the aortic valve interstitial cell nucleus under diastolic loading. J Biomech Eng (2007) 1.12

Estimation of the shear stress on the surface of an aortic valve leaflet. Ann Biomed Eng (1999) 1.12

Velocity-encoded cine MRI in the evaluation of left ventricular diastolic function: measurement of mitral valve and pulmonary vein flow velocities and flow volume across the mitral valve. Am Heart J (1993) 1.12

A numerical simulation of mechanical heart valve closure fluid dynamics. J Biomech (2002) 1.11

Differences in tissue-remodeling potential of aortic and pulmonary heart valve interstitial cells. Tissue Eng (2007) 1.11

The relation between collagen fibril kinematics and mechanical properties in the mitral valve anterior leaflet. J Biomech Eng (2007) 1.10

The effects of collagen fiber orientation on the flexural properties of pericardial heterograft biomaterials. Biomaterials (2005) 1.09

Dynamic in vitro quantification of bioprosthetic heart valve leaflet motion using structured light projection. Ann Biomed Eng (2001) 1.09

Fluid mechanics of the mitral valve. Nature (1969) 1.07

Degeneration of bioprosthetic heart valve cusp and wall tissues is initiated during tissue preparation: an ultrastructural study. J Heart Valve Dis (2003) 1.05

Role of preconditioning and recovery time in repeated testing of aortic valve tissues: validation through quasilinear viscoelastic theory. Ann Biomed Eng (2000) 1.04

Flexible versus rigid ring annuloplasty for mitral valve annular dilatation: a finite element model. J Heart Valve Dis (1998) 1.04

Endothelial cell orientation on aortic valve leaflets. Cardiovasc Res (1986) 1.04

The mechanism of opening of the aortic valve. J Thorac Cardiovasc Surg (1979) 1.04

Effects of mechanical fatigue on the bending properties of the porcine bioprosthetic heart valve. ASAIO J (1999) 1.03

Functional collagen fiber architecture of the pulmonary heart valve cusp. Ann Thorac Surg (2009) 1.03

The design of the normal aortic valve. Am J Physiol (1981) 1.02

Improved prediction of the collagen fiber architecture in the aortic heart valve. J Biomech Eng (2005) 1.01

Age-dependent changes in the radial stretch of human aortic valve leaflets determined by biaxial testing. Ann Thorac Surg (1995) 1.01

Clinical pulmonary autograft valves: pathologic evidence of adaptive remodeling in the aortic site. J Thorac Cardiovasc Surg (2004) 1.01

Ligament creep cannot be predicted from stress relaxation at low stress: a biomechanical study of the rabbit medial collateral ligament. J Orthop Res (1997) 1.00

Aortic valve structure-function correlations: role of elastic fibers no longer a stretch of the imagination. J Heart Valve Dis (1997) 1.00

Long-term function of cryopreserved aortic homografts. A ten-year study. J Thorac Cardiovasc Surg (1993) 0.99

Computational analyses of mechanically induced collagen fiber remodeling in the aortic heart valve. J Biomech Eng (2003) 0.98

An alternate formulation of blood vessel mechanics and the meaning of the in vivo property. J Biomech (1995) 0.98

The elastic modulus of canine aortic valve leaflets in vivo and in vitro. Circ Res (1980) 0.98

Effects of papillary muscle position on in-vitro dynamic strain on the porcine mitral valve. J Heart Valve Dis (2003) 0.97

The flexural rigidity of the aortic valve leaflet in the commissural region. J Biomech (2005) 0.97

Stresses in the closed mitral valve: a model study. J Biomech (1983) 0.97

Anatomy of aortic heart valve leaflets: the influence of glutaraldehyde fixation on function. Eur J Cardiothorac Surg (1992) 0.96

Endothelium and valvular diseases of the heart. Microsc Res Tech (2003) 0.95

Glutaraldehyde fixation alters the internal shear properties of porcine aortic heart valve tissue. Ann Thorac Surg (1995) 0.94

Haemodynamic determinants of the mitral valve closure sound: a finite element study. Med Biol Eng Comput (2004) 0.93

Relationship between collagen fibrils, glycosaminoglycans, and stress relaxation in mitral valve chordae tendineae. Ann Biomed Eng (2004) 0.92

Comparison of the compressive buckling of porcine aortic valve cusps and bovine pericardium. J Heart Valve Dis (1998) 0.92

Normal aortic valve function in dogs. Am J Cardiol (1977) 0.91

Viscoelastic properties of the aortic valve interstitial cell. J Biomech Eng (2009) 0.91

Ultrastructure of proteoglycans in tissue-engineered cardiovascular structures. Tissue Eng (2002) 0.90

Characteristics of compressive strains in porcine aortic valves cusps. J Heart Valve Dis (2002) 0.90

Internal shear properties of fresh porcine aortic valve cusps: implications for normal valve function. J Heart Valve Dis (1996) 0.90

Dynamic simulation pericardial bioprosthetic heart valve function. J Biomech Eng (2006) 0.89