Published in J Med Chem on July 23, 2009
Probing the probes: fitness factors for small molecule tools. Chem Biol (2010) 2.08
Hsp90, an unlikely ally in the war on cancer. FEBS J (2013) 1.33
Advances in the discovery and development of heat-shock protein 90 inhibitors for cancer treatment. Expert Opin Drug Discov (2011) 1.12
Amplification and high-level expression of heat shock protein 90 marks aggressive phenotypes of human epidermal growth factor receptor 2 negative breast cancer. Breast Cancer Res (2012) 1.09
A systematic protocol for the characterization of Hsp90 modulators. Bioorg Med Chem (2010) 1.04
Inhibition of heat-shock protein 90 reduces Ebola virus replication. Antiviral Res (2010) 1.04
Alternate strategies of Hsp90 modulation for the treatment of cancer and other diseases. Curr Top Med Chem (2009) 1.02
Design, synthesis, and evaluation of small molecule Hsp90 probes. Bioorg Med Chem (2011) 0.97
Macrocyclic drugs and synthetic methodologies toward macrocycles. Molecules (2013) 0.96
Experimental and structural testing module to analyze paralogue-specificity and affinity in the Hsp90 inhibitors series. J Med Chem (2013) 0.94
A highly selective Hsp90 affinity chromatography resin with a cleavable linker. Bioorg Med Chem (2012) 0.86
Hsp90 inhibitors as new leads to target parasitic diarrheal diseases. Antimicrob Agents Chemother (2014) 0.82
Thermodynamics of aryl-dihydroxyphenyl-thiadiazole binding to human Hsp90. PLoS One (2012) 0.81
Three-component synthesis of C2F5-substituted pyrazoles from C2F5CH2NH2·HCl, NaNO2 and electron-deficient alkynes. Beilstein J Org Chem (2015) 0.81
Comparative analysis of novel and conventional Hsp90 inhibitors on HIF activity and angiogenic potential in clear cell renal cell carcinoma: implications for clinical evaluation. BMC Cancer (2011) 0.81
Inhibition of heat shock protein 90 suppresses squamous carcinogenic progression in a mouse model of esophageal cancer. J Cancer Res Clin Oncol (2015) 0.79
Exploring the Trypanosoma brucei Hsp83 potential as a target for structure guided drug design. PLoS Negl Trop Dis (2013) 0.79
Applications of Palladium-Catalyzed C-N Cross-Coupling Reactions. Chem Rev (2016) 0.78
HSP90 Inhibitor SNX5422/2112 Targets the Dysregulated Signal and Transcription Factor Network and Malignant Phenotype of Head and Neck Squamous Cell Carcinoma. Transl Oncol (2013) 0.77
Heat-shock protein 90 promotes nuclear transport of herpes simplex virus 1 capsid protein by interacting with acetylated tubulin. PLoS One (2014) 0.77
Reverse the Resistance to PARP Inhibitors. Int J Biol Sci (2017) 0.75
Identification and characterization of the antiplasmodial activity of Hsp90 inhibitors. Malar J (2017) 0.75
Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing. Nature (2003) 5.04
MiPred: classification of real and pseudo microRNA precursors using random forest prediction model with combined features. Nucleic Acids Res (2007) 3.69
Mutations in ponA, the gene encoding penicillin-binding protein 1, and a novel locus, penC, are required for high-level chromosomally mediated penicillin resistance in Neisseria gonorrhoeae. Antimicrob Agents Chemother (2002) 2.05
Death don't have no mercy and neither does calcium: Arabidopsis CYCLIC NUCLEOTIDE GATED CHANNEL2 and innate immunity. Plant Cell (2007) 1.95
Control of petal shape and floral zygomorphy in Lotus japonicus. Proc Natl Acad Sci U S A (2006) 1.78
Palladium-catalyzed enantioselective diboration of prochiral allenes. J Am Chem Soc (2004) 1.76
Choroidal thickness in healthy Chinese subjects. Invest Ophthalmol Vis Sci (2011) 1.74
Discovery of 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a novel and potent vascular endothelial growth factor receptor inhibitor. J Med Chem (2008) 1.66
SNX2112, a synthetic heat shock protein 90 inhibitor, has potent antitumor activity against HER kinase-dependent cancers. Clin Cancer Res (2008) 1.66
Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors. J Med Chem (2005) 1.65
Development of a unified web-based national HIV/AIDS information system in China. Int J Epidemiol (2010) 1.65
The IL-12 family of cytokines in infection, inflammation and autoimmune disorders. Inflamm Allergy Drug Targets (2009) 1.64
Presence of cathepsin B in the human pancreatic secretory pathway and its role in trypsinogen activation during hereditary pancreatitis. J Biol Chem (2002) 1.59
Prevalence of antihypertensive, antidiabetic, and dyslipidemic prescription medication use among children and adolescents. Arch Pediatr Adolesc Med (2009) 1.54
Unbiased plasma proteomics for novel diagnostic biomarkers in cardiovascular disease: identification of quiescin Q6 as a candidate biomarker of acutely decompensated heart failure. Eur Heart J (2012) 1.48
The penC mutation conferring antibiotic resistance in Neisseria gonorrhoeae arises from a mutation in the PilQ secretin that interferes with multimer stability. Mol Microbiol (2005) 1.41
Dominant-negative inhibitors of soluble TNF attenuate experimental arthritis without suppressing innate immunity to infection. J Immunol (2007) 1.41
IL-17A G197A and IL-17F T7488C polymorphisms and cancer risk in Asian populations: a meta-analysis. J BUON (2014) 1.41
Interconversion of ATP binding and conformational free energies by tryptophanyl-tRNA synthetase: structures of ATP bound to open and closed, pre-transition-state conformations. J Mol Biol (2003) 1.39
Brain-permeable small-molecule inhibitors of Hsp90 prevent alpha-synuclein oligomer formation and rescue alpha-synuclein-induced toxicity. J Pharmacol Exp Ther (2009) 1.38
Tumor-stroma ratio is an independent predictor for survival in esophageal squamous cell carcinoma. J Thorac Oncol (2012) 1.30
Small molecule inhibitors of Hsp90 potently affect inflammatory disease pathways and exhibit activity in models of rheumatoid arthritis. Arthritis Rheum (2008) 1.27
A review of current treatment of lumbar posterior ring apophysis fracture with lumbar disc herniation. Eur Spine J (2012) 1.22
Neuronal nitric oxide synthase contributes to chronic stress-induced depression by suppressing hippocampal neurogenesis. J Neurochem (2007) 1.19
Lin28 regulates HER2 and promotes malignancy through multiple mechanisms. Cell Cycle (2012) 1.17
Discovery of novel benzimidazoles as potent inhibitors of TIE-2 and VEGFR-2 tyrosine kinase receptors. J Med Chem (2007) 1.17
In vitro and in vivo protein-bound tyrosine nitration characterized by diagonal chromatography. Mol Cell Proteomics (2009) 1.16
Behavioral and serologic survey of men who have sex with men in Beijing, China: implication for HIV intervention. AIDS Patient Care STDS (2012) 1.16
Monozygotic co-twin analyses of body composition measurements and serum lipids. Prev Med (2007) 1.14
Neuroprotective effect of curcumin on focal cerebral ischemic rats by preventing blood-brain barrier damage. Eur J Pharmacol (2007) 1.14
Physical activity and risk of hypertension: a meta-analysis of prospective cohort studies. Hypertension (2013) 1.12
Chronic diseases knowledge and related factors among the elderly in Jinan, China. PLoS One (2013) 1.10
Enhanced photovoltaic performance by modulating surface composition in bulk heterojunction polymer solar cells based on PBDTTT-C-T/PC71 BM. Adv Mater (2014) 1.10
Application of chemoproteomics to drug discovery: identification of a clinical candidate targeting hsp90. Chem Biol (2010) 1.09
The association of miR-146a rs2910164 and miR-196a2 rs11614913 polymorphisms with cancer risk: a meta-analysis of 32 studies. Mutagenesis (2012) 1.08
Review of therapeutic strategies for osteosarcoma, chondrosarcoma, and Ewing's sarcoma. Med Sci Monit (2011) 1.07
Regiospecific plasmonic assemblies for in situ Raman spectroscopy in live cells. J Am Chem Soc (2012) 1.06
Label-free quantitative proteomics analysis of etiolated maize seedling leaves during greening. Mol Cell Proteomics (2009) 1.06
Distinct role of p38 and c-Jun N-terminal kinases in IL-10-dependent and IL-10-independent regulation of the costimulatory molecule B7.2 in lipopolysaccharide-stimulated human monocytic cells. J Immunol (2002) 1.05
Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 2-exo-2-(2',3'-disubstituted 5'-pyridinyl)-7-azabicyclo[2.2.1]heptanes: epibatidine analogues. J Med Chem (2002) 1.05
Determinants of mRNA recognition and translation regulation by Lin28. Nucleic Acids Res (2011) 1.05
Discovery of novel orally bioavailable oxaborole 6-carboxamides that demonstrate cure in a murine model of late-stage central nervous system african trypanosomiasis. Antimicrob Agents Chemother (2010) 1.04
Multifunctional magnetoplasmonic nanoparticle assemblies for cancer therapy and diagnostics (theranostics). Macromol Rapid Commun (2010) 1.04
Intracellular HIV-Tat expression induces IL-10 synthesis by the CREB-1 transcription factor through Ser133 phosphorylation and its regulation by the ERK1/2 MAPK in human monocytic cells. J Biol Chem (2006) 1.02
Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 3'-substituted deschloroepibatidine analogues. Novel nicotinic antagonists. J Med Chem (2005) 1.01
Risk factors for multidrug resistance among previously treated patients with tuberculosis in eastern China: a case-control study. Int J Infect Dis (2013) 1.01
Reduced neuronal nitric oxide synthase is involved in ischemia-induced hippocampal neurogenesis by up-regulating inducible nitric oxide synthase expression. J Neurochem (2007) 0.99
Mediastinal solitary fibrous tumor with right diaphragm invasion: report of a case. Surg Today (2009) 0.99
Factors associated with willingness to accept oral fluid HIV rapid testing among most-at-risk populations in China. PLoS One (2013) 0.99
Quantitative analysis of burden of infectious diarrhea associated with floods in northwest of anhui province, china: a mixed method evaluation. PLoS One (2013) 0.98
From binary to ternary solvent: morphology fine-tuning of D/A blends in PDPP3T-based polymer solar cells. Adv Mater (2012) 0.98
Synthesis, nicotinic acetylcholine receptor binding, antinociceptive and seizure properties of methyllycaconitine analogs. Bioorg Med Chem (2006) 0.98
Intra-oocyte localization of MAD2 and its relationship with kinetochores, microtubules, and chromosomes in rat oocytes during meiosis. Biol Reprod (2004) 0.97
The Red clover necrotic mosaic virus capsid as a multifunctional cell targeting plant viral nanoparticle. Bioconjug Chem (2010) 0.97
Prevalence and associated factors of diabetes and impaired fasting glucose in Chinese hypertensive adults aged 45 to 75 years. PLoS One (2012) 0.95
An aptamer-based chromatographic strip assay for sensitive toxin semi-quantitative detection. Biosens Bioelectron (2010) 0.95
Synthesis, nicotinic acetylcholine receptor binding, and pharmacological properties of 3'-(substituted phenyl)deschloroepibatidine analogs. Bioorg Med Chem (2007) 0.95
Monoclonal antibody-based sandwich ELISA for the detection of staphylococcal enterotoxin A. Int J Environ Res Public Health (2013) 0.95
PPARγ agonist pioglitazone reverses memory impairment and biochemical changes in a mouse model of type 2 diabetes mellitus. CNS Neurosci Ther (2012) 0.94
The cytotoxicity of CdTe quantum dots and the relative contributions from released cadmium ions and nanoparticle properties. Biomaterials (2010) 0.94
Genetic variants in the HLA-DRB1 gene are associated with Kashin-Beck disease in the Tibetan population. Arthritis Rheum (2011) 0.94
Synthesis and evaluation of pyrazolo[1,5-b]pyridazines as selective cyclin dependent kinase inhibitors. Bioorg Med Chem Lett (2008) 0.94
Self-assembly of chiral nanoparticle pyramids with strong R/S optical activity. J Am Chem Soc (2012) 0.94
Differential regulation of CD44 expression by lipopolysaccharide (LPS) and TNF-alpha in human monocytic cells: distinct involvement of c-Jun N-terminal kinase in LPS-induced CD44 expression. J Immunol (2002) 0.94
Plasmon resonance scattering spectroscopy at the single-nanoparticle level: real-time monitoring of a click reaction. Angew Chem Int Ed Engl (2013) 0.93
Systematic analysis and comparison of nucleotide-binding site disease resistance genes in maize. FEBS J (2012) 0.92
Discovery of a novel and potent series of dianilinopyrimidineurea and urea isostere inhibitors of VEGFR2 tyrosine kinase. Bioorg Med Chem Lett (2005) 0.92
Association of RECQL5 gene polymorphisms and osteosarcoma in a Chinese Han population. Tumour Biol (2013) 0.92
One-pot synthesis of symmetrical and unsymmetrical bisarylethynes by a modification of the sonogashira coupling reaction. Org Lett (2002) 0.92
Discovery of benzamide tetrahydro-4H-carbazol-4-ones as novel small molecule inhibitors of Hsp90. Bioorg Med Chem Lett (2008) 0.92