Robert B Clarke

Author PubWeight™ 56.60‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Regulation of breast cancer stem cell activity by signaling through the Notch4 receptor. Cancer Res 2010 2.77
2 Novel cell culture technique for primary ductal carcinoma in situ: role of Notch and epidermal growth factor receptor signaling pathways. J Natl Cancer Inst 2007 2.75
3 Mammary stem cells and breast cancer--role of Notch signalling. Stem Cell Rev 2007 2.62
4 Targeting CXCR1/2 significantly reduces breast cancer stem cell activity and increases the efficacy of inhibiting HER2 via HER2-dependent and -independent mechanisms. Clin Cancer Res 2012 2.24
5 A detailed mammosphere assay protocol for the quantification of breast stem cell activity. J Mammary Gland Biol Neoplasia 2012 1.98
6 Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer. Breast Cancer Res 2013 1.92
7 The centrosomal kinase Nek2 displays elevated levels of protein expression in human breast cancer. Cancer Res 2004 1.72
8 The mammary gland "side population": a putative stem/progenitor cell marker? J Mammary Gland Biol Neoplasia 2005 1.57
9 Steroid receptors and cell cycle in normal mammary epithelium. J Mammary Gland Biol Neoplasia 2004 1.47
10 The removal of multiplicative, systematic bias allows integration of breast cancer gene expression datasets - improving meta-analysis and prediction of prognosis. BMC Med Genomics 2008 1.41
11 Origins of breast cancer subtypes and therapeutic implications. Nat Clin Pract Oncol 2007 1.36
12 Wnt pathway activity in breast cancer sub-types and stem-like cells. PLoS One 2013 1.21
13 Comprehensive CYP2D6 genotype and adherence affect outcome in breast cancer patients treated with tamoxifen monotherapy. Breast Cancer Res Treat 2010 1.18
14 Recent advances reveal IL-8 signaling as a potential key to targeting breast cancer stem cells. Breast Cancer Res 2013 1.16
15 Prolactin receptor antagonism reduces the clonogenic capacity of breast cancer cells and potentiates doxorubicin and paclitaxel cytotoxicity. Breast Cancer Res 2008 1.14
16 Risk determination and prevention of breast cancer. Breast Cancer Res 2014 1.11
17 Targeting inhibitor of apoptosis proteins in combination with ErbB antagonists in breast cancer. Breast Cancer Res 2009 1.10
18 The embryonic transcription cofactor LBH is a direct target of the Wnt signaling pathway in epithelial development and in aggressive basal subtype breast cancers. Mol Cell Biol 2010 1.10
19 Effect of a farnesyl transferase inhibitor (R115777) on ductal carcinoma in situ of the breast in a human xenograft model and on breast and ovarian cancer cell growth in vitro and in vivo. Breast Cancer Res 2006 1.09
20 Breast cancer stem cells: something out of notching? Cancer Res 2010 1.05
21 Resistance to endocrine therapy: are breast cancer stem cells the culprits? J Mammary Gland Biol Neoplasia 2009 1.02
22 Oestrogen increases the activity of oestrogen receptor negative breast cancer stem cells through paracrine EGFR and Notch signalling. Breast Cancer Res 2013 1.02
23 A differential role for CXCR4 in the regulation of normal versus malignant breast stem cell activity. Oncotarget 2014 1.00
24 Disruption of a Quorum Sensing mechanism triggers tumorigenesis: a simple discrete model corroborated by experiments in mammary cancer stem cells. Biol Direct 2010 1.00
25 Stem cells in breast tumours: are they ready for the clinic? Eur J Cancer 2012 1.00
26 Human breast epithelial stem cells and their regulation. J Pathol 2006 1.00
27 P-cadherin is coexpressed with CD44 and CD49f and mediates stem cell properties in basal-like breast cancer. Stem Cells 2012 0.99
28 High-throughput genomic technology in research and clinical management of breast cancer. Exploiting the potential of gene expression profiling: is it ready for the clinic? Breast Cancer Res 2006 0.98
29 Enrichment of human osteosarcoma stem cells based on hTERT transcriptional activity. Oncotarget 2013 0.97
30 Contrasting hypoxic effects on breast cancer stem cell hierarchy is dependent on ER-α status. Cancer Res 2012 0.96
31 Biomarkers of dietary energy restriction in women at increased risk of breast cancer. Cancer Prev Res (Phila) 2009 0.96
32 Breast cancer stem cells and their role in resistance to endocrine therapy. Horm Cancer 2011 0.95
33 Targeting treatment-resistant breast cancer stem cells with FKBPL and its peptide derivative, AD-01, via the CD44 pathway. Clin Cancer Res 2013 0.90
34 Cell cycle regulators cyclin D1 and CDK4/6 have estrogen receptor-dependent divergent functions in breast cancer migration and stem cell-like activity. Cell Cycle 2013 0.89
35 P-cadherin signals through the laminin receptor α6β4 integrin to induce stem cell and invasive properties in basal-like breast cancer cells. Oncotarget 2014 0.87
36 It's all in the details: methods in breast development and cancer. Breast Cancer Res 2009 0.87
37 Combined inhibition of ErbB1/2 and Notch receptors effectively targets breast ductal carcinoma in situ (DCIS) stem/progenitor cell activity regardless of ErbB2 status. PLoS One 2013 0.85
38 Focal adhesion kinase and Wnt signaling regulate human ductal carcinoma in situ stem cell activity and response to radiotherapy. Stem Cells 2015 0.84
39 Dickkopf1 regulates fate decision and drives breast cancer stem cells to differentiation: an experimentally supported mathematical model. PLoS One 2011 0.83
40 Are stem-like cells responsible for resistance to therapy in breast cancer? Breast Dis 2008 0.82
41 Targeting IL-8 signalling to inhibit breast cancer stem cell activity. Expert Opin Ther Targets 2013 0.82
42 Combining Notch inhibition with current therapies for breast cancer treatment. Ther Adv Med Oncol 2013 0.81
43 Mechanisms of Disease: prediction and prevention of breast cancer--cellular and molecular interactions. Nat Clin Pract Oncol 2005 0.79
44 Multifunctionalized iron oxide nanoparticles for selective drug delivery to CD44-positive cancer cells. Nanotechnology 2016 0.78
45 Normal breast tissue implanted into athymic nude mice identifies biomarkers of the effects of human pregnancy levels of estrogen. Cancer Prev Res (Phila) 2009 0.78
46 Lack of caveolin-1 (P132L) somatic mutations in breast cancer. Breast Cancer Res Treat 2012 0.78
47 17β-estradiol regulates giant vesicle formation via estrogen receptor-alpha in human breast cancer cells. Oncotarget 2014 0.77
48 ‘The charmingest place’: non-coding RNA, lineage tracing, tumor heterogeneity, metastasis and metabolism--new methods in mammary gland development and cancer: the fifth ENBDC Workshop. Breast Cancer Res 2013 0.75
49 The devil is in the methods: lineage tracing, functional screens and sequencing, hormones, tumour-stroma interactions, and expansion of human breast tumours as xenografts. Breast Cancer Res 2011 0.75
50 Estrogen deprivation for breast cancer prevention. Recent Results Cancer Res 2007 0.75
51 Interrogating open issues in cancer medicine with patient-derived xenografts. Nat Rev Cancer 2017 0.75