Published in Physiol Genomics on July 07, 2009
Effects of a new SGLT2 inhibitor, luseogliflozin, on diabetic nephropathy in T2DN rats. J Pharmacol Exp Ther (2013) 1.12
Fine-mapping a locus for glucose tolerance using heterogeneous stock rats. Physiol Genomics (2010) 0.95
Identification of a novel gene for diabetic traits in rats, mice, and humans. Genetics (2014) 0.89
Heterogeneous stock rats: a new model to study the genetics of renal phenotypes. Am J Physiol Renal Physiol (2010) 0.89
Genetic and genomic analysis of hyperlipidemia, obesity and diabetes using (C57BL/6J × TALLYHO/JngJ) F2 mice. BMC Genomics (2010) 0.87
Fine-mapping diabetes-related traits, including insulin resistance, in heterogeneous stock rats. Physiol Genomics (2012) 0.87
Identification of genetic loci involved in diabetes using a rat model of depression. Mamm Genome (2009) 0.86
Obese locus in WNIN/obese rat maps on chromosome 5 upstream of leptin receptor. PLoS One (2013) 0.79
Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature (2004) 24.40
Knockout rats via embryo microinjection of zinc-finger nucleases. Science (2009) 12.33
The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nat Genet (2004) 9.37
Making a definitive diagnosis: successful clinical application of whole exome sequencing in a child with intractable inflammatory bowel disease. Genet Med (2011) 9.03
Progress and prospects in rat genetics: a community view. Nat Genet (2008) 6.01
The Rat Genome Database, update 2007--easing the path from disease to data and back again. Nucleic Acids Res (2006) 4.80
Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice. Biochem J (2008) 4.51
Exploring concordance and discordance for return of incidental findings from clinical sequencing. Genet Med (2012) 4.04
The Rat Genome Database 2009: variation, ontologies and pathways. Nucleic Acids Res (2008) 3.92
Comparative recombination rates in the rat, mouse, and human genomes. Genome Res (2004) 3.50
A comprehensive linkage analysis for myocardial infarction and its related risk factors. Nat Genet (2002) 3.19
Efficient transgenic rat production by a lentiviral vector. Am J Physiol Heart Circ Physiol (2007) 3.07
The rat genome database curators: who, what, where, why. PLoS Comput Biol (2009) 2.86
Distinct heritable patterns of angiographic coronary artery disease in families with myocardial infarction. Circulation (2005) 2.81
Lymphopenia in the BB rat model of type 1 diabetes is due to a mutation in a novel immune-associated nucleotide (Ian)-related gene. Genome Res (2002) 2.45
A timely arrival for genomic medicine. Genet Med (2011) 2.38
Role of the WNK-activated SPAK kinase in regulating blood pressure. EMBO Mol Med (2010) 2.36
Physiogenomic resources for rat models of heart, lung and blood disorders. Nat Genet (2006) 2.05
Hypomorphic mutation of PDK1 suppresses tumorigenesis in PTEN(+/-) mice. Curr Biol (2005) 2.00
Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice. J Clin Invest (2003) 1.95
What everybody should know about the rat genome and its online resources. Nat Genet (2008) 1.94
The Rat Genome Database 2013--data, tools and users. Brief Bioinform (2013) 1.94
Targeting AMPK: a new therapeutic opportunity in breast cancer. Crit Rev Oncol Hematol (2008) 1.73
Abnormal skeletal and cardiac development, cardiomyopathy, muscle atrophy and cataracts in mice with a targeted disruption of the Nov (Ccn3) gene. BMC Dev Biol (2008) 1.62
The RNA helicase p68 is a novel androgen receptor coactivator involved in splicing and is overexpressed in prostate cancer. Cancer Res (2008) 1.58
Multiple blood pressure loci on rat chromosome 13 attenuate development of hypertension in the Dahl S hypertensive rat. Physiol Genomics (2007) 1.57
Genetic mapping and characterization of the bleeding disorder in the fawn-hooded hypertensive rat. Thromb Haemost (2003) 1.53
Generation of gene-specific mutated rats using zinc-finger nucleases. Methods Mol Biol (2010) 1.51
Ontology searching and browsing at the Rat Genome Database. Database (Oxford) (2012) 1.51
Application of chromosomal substitution techniques in gene-function discovery. J Physiol (2004) 1.47
Analyzing complex traits with congenic strains. Mamm Genome (2010) 1.43
Rats! Dis Model Mech (2009) 1.42
The Rat Genome Database pathway portal. Database (Oxford) (2011) 1.40
Histological evaluation of AMPK signalling in primary breast cancer. BMC Cancer (2009) 1.38
Chromosome substitution reveals the genetic basis of Dahl salt-sensitive hypertension and renal disease. Am J Physiol Renal Physiol (2008) 1.37
Implications of circadian gene expression in kidney, liver and the effects of fasting on pharmacogenomic studies. Pharmacogenetics (2002) 1.37
Genomic map of cardiovascular phenotypes of hypertension in female Dahl S rats. Physiol Genomics (2003) 1.37
Impact of genomics on research in the rat. Genome Res (2005) 1.37
Identifying multiple causative genes at a single GWAS locus. Genome Res (2013) 1.25
Use of a three-color cDNA microarray platform to measure and control support-bound probe for improved data quality and reproducibility. Nucleic Acids Res (2003) 1.25
Chromosomal mapping of the genetic basis of hypertension and renal disease in FHH rats. Am J Physiol Renal Physiol (2007) 1.24
Renal tumors associated with germline SDHB mutation show distinctive morphology. Am J Surg Pathol (2011) 1.21
Integrative genomics: in silico coupling of rat physiology and complex traits with mouse and human data. Genome Res (2004) 1.21
The Rat Genome Database curation tool suite: a set of optimized software tools enabling efficient acquisition, organization, and presentation of biological data. Database (Oxford) (2011) 1.21
Molecular networks in Dahl salt-sensitive hypertension based on transcriptome analysis of a panel of consomic rats. Physiol Genomics (2008) 1.21
High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Genome Res (2004) 1.21
Exploring genetic, genomic, and phenotypic data at the rat genome database. Curr Protoc Bioinformatics (2012) 1.20
CD247 modulates blood pressure by altering T-lymphocyte infiltration in the kidney. Hypertension (2013) 1.16
Influence of diet and genetics on hypertension and renal disease in Dahl salt-sensitive rats. Physiol Genomics (2004) 1.15
Genetic linkage and association of the growth hormone secretagogue receptor (ghrelin receptor) gene in human obesity. Diabetes (2005) 1.13
Succinate dehydrogenase (SDH)-deficient renal carcinoma: a morphologically distinct entity: a clinicopathologic series of 36 tumors from 27 patients. Am J Surg Pathol (2014) 1.11
Renal medullary genes in salt-sensitive hypertension: a chromosomal substitution and cDNA microarray study. Physiol Genomics (2002) 1.10
Creation and characterization of a renin knockout rat. Hypertension (2011) 1.09
RF-2 gene modulates proteinuria and albuminuria independently of changes in glomerular permeability in the fawn-hooded hypertensive rat. J Am Soc Nephrol (2005) 1.09
BN phenome: detailed characterization of the cardiovascular, renal, and pulmonary systems of the sequenced rat. Physiol Genomics (2006) 1.09
Mapping the genetic determinants of hypertension, metabolic diseases, and related phenotypes in the lyon hypertensive rat. Hypertension (2004) 1.09
Transposon-mediated transgenesis, transgenic rescue, and tissue-specific gene expression in rodents and rabbits. FASEB J (2012) 1.07
Transfer of the CYP4A region of chromosome 5 from Lewis to Dahl S rats attenuates renal injury. Am J Physiol Renal Physiol (2008) 1.06
Dynamic convergence and divergence of renal genomic and biological pathways in protection from Dahl salt-sensitive hypertension. Physiol Genomics (2009) 1.06
Tools and strategies for physiological genomics: the Rat Genome Database. Physiol Genomics (2005) 1.04
Efficient mammalian germline transgenesis by cis-enhanced Sleeping Beauty transposition. Transgenic Res (2010) 1.04
Both p110α and p110β isoforms of PI3K can modulate the impact of loss-of-function of the PTEN tumour suppressor. Biochem J (2012) 1.03
Sequence analysis of the complete mitochondrial DNA in 10 commonly used inbred rat strains. Am J Physiol Cell Physiol (2006) 1.03
Renal carcinoma with giant mitochondria associated with germ-line mutation and somatic loss of the succinate dehydrogenase B gene. Histopathology (2010) 1.03
Genetic basis of the impaired renal myogenic response in FHH rats. Am J Physiol Renal Physiol (2012) 1.02
Genome-wide scanning with SSLPs in the rat. Methods Mol Med (2005) 1.02
Phosducin influences sympathetic activity and prevents stress-induced hypertension in humans and mice. J Clin Invest (2009) 0.98
Increased resistance to myocardial ischemia in the Brown Norway vs. Dahl S rat: role of nitric oxide synthase and Hsp90. J Mol Cell Cardiol (2005) 0.98
Rab38 modulates proteinuria in model of hypertension-associated renal disease. J Am Soc Nephrol (2013) 0.98
Comparative genomics for detecting human disease genes. Adv Genet (2008) 0.98
Identification of a QTL on chromosome 1 for impaired autoregulation of RBF in fawn-hooded hypertensive rats. Am J Physiol Renal Physiol (2005) 0.98
Transgenic rescue demonstrates involvement of the Ian5 gene in T cell development in the rat. Physiol Genomics (2004) 0.98
Characterization of blood pressure and renal function in chromosome 5 congenic strains of Dahl S rats. Am J Physiol Renal Physiol (2006) 0.97
Context and strain-dependent behavioral response to stress. Behav Brain Funct (2008) 0.97
Substitution of chromosome 1 ameliorates L-NAME hypertension and renal disease in the fawn-hooded hypertensive rat. Am J Physiol Renal Physiol (2005) 0.97
Genetic dissection of lymphopenia from autoimmunity by introgression of mutated Ian5 gene onto the F344 rat. J Autoimmun (2003) 0.97
Initial characterization of a rat model of diabetic nephropathy. Diabetes (2004) 0.97
Role of 20-HETE in the antihypertensive effect of transfer of chromosome 5 from Brown Norway to Dahl salt-sensitive rats. Am J Physiol Regul Integr Comp Physiol (2012) 0.96
The pathway ontology - updates and applications. J Biomed Semantics (2014) 0.96
Rat Genome Database: a unique resource for rat, human, and mouse quantitative trait locus data. Physiol Genomics (2013) 0.96
Centre variation in incidence, indication and diagnosis of adult native renal biopsy in Scotland. Nephrol Dial Transplant (2008) 0.95
Narrowing a region on rat chromosome 13 that protects against hypertension in Dahl SS-13BN congenic strains. Am J Physiol Heart Circ Physiol (2011) 0.95
The wt1-heterozygous mouse; a model to study the development of glomerular sclerosis. J Pathol (2003) 0.94
Dickkopf homologs in squamous mucosa of esophagitis patients are overexpressed compared with Barrett's patients and healthy controls. Am J Gastroenterol (2006) 0.93
Consomic strategies to localize genomic regions related to vascular reactivity in the Dahl salt-sensitive rat. Physiol Genomics (2006) 0.93
Rats are the smart choice: Rationale for a renewed focus on rats in behavioral genetics. Neuropharmacology (2013) 0.92
Increased proliferative cells in the medullary thick ascending limb of the loop of Henle in the Dahl salt-sensitive rat. Hypertension (2012) 0.92
Identification of hypertension susceptibility loci on rat chromosome 12. Hypertension (2012) 0.92
Microalterations of inherently unstable genomic regions in rat mammary carcinomas as revealed by long oligonucleotide array-based comparative genomic hybridization. Cancer Res (2009) 0.89
Targeting the endothelial progenitor cell surface proteome to identify novel mechanisms that mediate angiogenic efficacy in a rodent model of vascular disease. Physiol Genomics (2013) 0.88
Temporal characterization of the development of renal injury in FHH rats and FHH.1BN congenic strains. Am J Physiol Renal Physiol (2010) 0.88
Asparagine endopeptidase is required for normal kidney physiology and homeostasis. FASEB J (2011) 0.88
Murine Denys-Drash syndrome: evidence of podocyte de-differentiation and systemic mediation of glomerulosclerosis. Hum Mol Genet (2003) 0.87
Rat model of familial combined hyperlipidemia as a result of comparative mapping. Physiol Genomics (2004) 0.86
Comprehensive quality control utilizing the prehybridization third-dye image leads to accurate gene expression measurements by cDNA microarrays. BMC Bioinformatics (2006) 0.86
Angiotensin-converting enzyme is a modifier of hypertensive end organ damage. J Biol Chem (2009) 0.85
Rat Strain Ontology: structured controlled vocabulary designed to facilitate access to strain data at RGD. J Biomed Semantics (2013) 0.85
Disease pathways at the Rat Genome Database Pathway Portal: genes in context-a network approach to understanding the molecular mechanisms of disease. Hum Genomics (2014) 0.84
Female-specific hypertension loci on rat chromosome 13. Hypertension (2013) 0.84