Forecasting the global burden of Alzheimer's disease.

Multimodal classification of Alzheimer's disease and mild cognitive impairment. Neuroimage (2011) 5.24

Hearing loss and incident dementia. Arch Neurol (2011) 4.65

Biomarkers for Alzheimer's disease: academic, industry and regulatory perspectives. Nat Rev Drug Discov (2010) 4.55

Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease. Cell (2013) 4.45

Elevated serum pesticide levels and risk for Alzheimer disease. JAMA Neurol (2014) 4.30

Prevalence of mild cognitive impairment is higher in men. The Mayo Clinic Study of Aging. Neurology (2010) 3.83

Multi-modal multi-task learning for joint prediction of multiple regression and classification variables in Alzheimer's disease. Neuroimage (2011) 3.47

National estimates of the prevalence of Alzheimer's disease in the United States. Alzheimers Dement (2011) 3.42

Vascular risk factors and dementia: how to move forward? Neurology (2009) 2.97

Epidemiology of Alzheimer's disease: occurrence, determinants, and strategies toward intervention. Dialogues Clin Neurosci (2009) 2.86

A TOMM40 variable-length polymorphism predicts the age of late-onset Alzheimer's disease. Pharmacogenomics J (2009) 2.66

Mechanisms of age-related macular degeneration. Neuron (2012) 2.62

Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease. Nat Neurosci (2014) 2.36

Trends in the incidence and prevalence of Alzheimer's disease, dementia, and cognitive impairment in the United States. Alzheimers Dement (2011) 2.26

Can Alzheimer disease be prevented by amyloid-beta immunotherapy? Nat Rev Neurol (2010) 2.20

Alzheimer disease: are we intervening too late? Pro. J Neural Transm (Vienna) (2011) 2.15

The use of PET in Alzheimer disease. Nat Rev Neurol (2010) 2.13

A blood based 12-miRNA signature of Alzheimer disease patients. Genome Biol (2013) 1.99

Computerized cognitive training with older adults: a systematic review. PLoS One (2012) 1.93

BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases. Nat Rev Neurosci (2013) 1.91

Evidence for neurocognitive plasticity in at-risk older adults: the experience corps program. J Gerontol A Biol Sci Med Sci (2009) 1.87

Multi-method analysis of MRI images in early diagnostics of Alzheimer's disease. PLoS One (2011) 1.79

Identification of MCI individuals using structural and functional connectivity networks. Neuroimage (2011) 1.77

Alzheimer disease in a mouse model: MR imaging-guided focused ultrasound targeted to the hippocampus opens the blood-brain barrier and improves pathologic abnormalities and behavior. Radiology (2014) 1.68

Anti-PrPC monoclonal antibody infusion as a novel treatment for cognitive deficits in an Alzheimer's disease model mouse. BMC Neurosci (2010) 1.66

Perioperative cognitive decline in the aging population. Mayo Clin Proc (2011) 1.66

Cigarette smoking is a risk factor for Alzheimer's Disease: an analysis controlling for tobacco industry affiliation. J Alzheimers Dis (2010) 1.65

Predicting future clinical changes of MCI patients using longitudinal and multimodal biomarkers. PLoS One (2012) 1.64

Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease. Circulation (2015) 1.63

Heart failure and Alzheimer's disease. J Intern Med (2014) 1.54

Midlife vs late-life depressive symptoms and risk of dementia: differential effects for Alzheimer disease and vascular dementia. Arch Gen Psychiatry (2012) 1.53

Targeting aldehyde dehydrogenase 2: new therapeutic opportunities. Physiol Rev (2014) 1.51

No advantage of A beta 42-lowering NSAIDs for prevention of Alzheimer dementia in six pooled cohort studies. Neurology (2008) 1.45

Association between polymorphism in the promoter region of Interleukin 6 (-174 G/C) and risk of Alzheimer's disease: a meta-analysis. J Neurol (2011) 1.44

Induced tauopathy in a novel 3D-culture model mediates neurodegenerative processes: a real-time study on biochips. PLoS One (2012) 1.43

Infection hospitalization increases risk of dementia in the elderly. Crit Care Med (2014) 1.43

Deletion of the alpha 7 nicotinic acetylcholine receptor gene improves cognitive deficits and synaptic pathology in a mouse model of Alzheimer's disease. J Neurosci (2009) 1.42

Protective Effects of Dietary Supplementation with a Combination of Nutrients in a Transgenic Mouse Model of Alzheimer's Disease. PLoS One (2015) 1.39

Biomarker discovery for Alzheimer's disease, frontotemporal lobar degeneration, and Parkinson's disease. Acta Neuropathol (2010) 1.38

Regional magnetic resonance imaging measures for multivariate analysis in Alzheimer's disease and mild cognitive impairment. Brain Topogr (2012) 1.36

A novel matrix-similarity based loss function for joint regression and classification in AD diagnosis. Neuroimage (2014) 1.36

Long-term follow-up of patients immunized with AN1792: reduced functional decline in antibody responders. Curr Alzheimer Res (2009) 1.34

Insulin in central nervous system: more than just a peripheral hormone. J Aging Res (2012) 1.33

C-terminal peptides coassemble into Abeta42 oligomers and protect neurons against Abeta42-induced neurotoxicity. Proc Natl Acad Sci U S A (2008) 1.32

The role of environmental exposures in neurodegeneration and neurodegenerative diseases. Toxicol Sci (2011) 1.31

A commentary on studies presenting projections of the future prevalence of dementia. BMC Public Health (2013) 1.30

Oxidative stress and mitochondrial dysfunction in Alzheimer's disease. Biochim Biophys Acta (2013) 1.29

Alzheimer's Disease Anti-inflammatory Prevention Trial: design, methods, and baseline results. Alzheimers Dement (2009) 1.28

Pre-clinical detection of Alzheimer's disease using FDG-PET, with or without amyloid imaging. J Alzheimers Dis (2010) 1.28

Serum antibodies to periodontal pathogens are a risk factor for Alzheimer's disease. Alzheimers Dement (2012) 1.28

Alzheimer's disease: analyzing the missing heritability. PLoS One (2013) 1.28

Inter-modality relationship constrained multi-modality multi-task feature selection for Alzheimer's Disease and mild cognitive impairment identification. Neuroimage (2013) 1.27

Propofol directly increases tau phosphorylation. PLoS One (2011) 1.25

Partial volume correction in quantitative amyloid imaging. Neuroimage (2014) 1.24

Exercise and cognition in older adults: is there a role for resistance training programmes? Br J Sports Med (2008) 1.24

Quantitative analysis of PiB-PET with FreeSurfer ROIs. PLoS One (2013) 1.21

N-methyl D-aspartate (NMDA) receptor antagonists and memantine treatment for Alzheimer's disease, vascular dementia and Parkinson's disease. Curr Alzheimer Res (2012) 1.20

Applying Hsp104 to protein-misfolding disorders. Biochem Cell Biol (2010) 1.18

Blood-brain-barriers in aging and in Alzheimer's disease. Mol Neurodegener (2013) 1.17

Long-term effects of bilateral oophorectomy on brain aging: unanswered questions from the Mayo Clinic Cohort Study of Oophorectomy and Aging. Womens Health (Lond Engl) (2009) 1.16

Binding of the molecular chaperone αB-crystallin to Aβ amyloid fibrils inhibits fibril elongation. Biophys J (2011) 1.16

Cardiac output as a potential risk factor for abnormal brain aging. J Alzheimers Dis (2010) 1.16

Nutrition and neurodegeneration: epidemiological evidence and challenges for future research. Br J Clin Pharmacol (2013) 1.15

Periodontitis: a potential risk factor for Alzheimer's disease. Br Dent J (2015) 1.15

Association Between Genetic Traits for Immune-Mediated Diseases and Alzheimer Disease. JAMA Neurol (2016) 1.15

Group-constrained sparse fMRI connectivity modeling for mild cognitive impairment identification. Brain Struct Funct (2013) 1.15

Cardiovascular risk factors, cortisol, and amyloid-β deposition in Alzheimer's Disease Neuroimaging Initiative. Alzheimers Dement (2012) 1.15

Using genetics to enable studies on the prevention of Alzheimer's disease. Clin Pharmacol Ther (2012) 1.14

DNA prime-protein boost increased the titer, avidity and persistence of anti-Abeta antibodies in wild-type mice. Gene Ther (2009) 1.13

Aβ monomers transiently sample oligomer and fibril-like configurations: ensemble characterization using a combined MD/NMR approach. J Mol Biol (2013) 1.12

The immunology of traumatic brain injury: a prime target for Alzheimer's disease prevention. J Neuroinflammation (2012) 1.12

Resting-state multi-spectrum functional connectivity networks for identification of MCI patients. PLoS One (2012) 1.10

A review of cardiorespiratory fitness-related neuroplasticity in the aging brain. Front Aging Neurosci (2013) 1.10

Cyanobacterial neurotoxin β-N-methylamino-L-alanine (BMAA) in shark fins. Mar Drugs (2012) 1.10

A randomized controlled trial of multicomponent exercise in older adults with mild cognitive impairment. PLoS One (2013) 1.10

How many dementia cases in France and Europe? Alternative projections and scenarios 2010-2050. Eur J Neurol (2009) 1.10

Amino acid position-specific contributions to amyloid beta-protein oligomerization. J Biol Chem (2009) 1.10

Beneficial effect of repetitive transcranial magnetic stimulation combined with cognitive training for the treatment of Alzheimer's disease: a proof of concept study. J Neural Transm (Vienna) (2011) 1.09

Subtypes based on cerebrospinal fluid and magnetic resonance imaging markers in normal elderly predict cognitive decline. Neurobiol Aging (2010) 1.09

Modifiable Midlife Risk Factors for Late-Life Cognitive Impairment and Dementia. Curr Psychiatry Rev (2009) 1.09

Prediction of Alzheimer's disease and mild cognitive impairment using cortical morphological patterns. Hum Brain Mapp (2012) 1.09

The Role of p38 MAPK and Its Substrates in Neuronal Plasticity and Neurodegenerative Disease. J Signal Transduct (2012) 1.08

Rates of decline in Alzheimer disease decrease with age. PLoS One (2012) 1.07

Gender and race/ethnicity differences in lead dose biomarkers. Am J Public Health (2008) 1.06

An estimate of the prevalence of dementia in Africa: A systematic analysis. J Glob Health (2012) 1.06

5-HT6 receptor antagonists as novel cognitive enhancing agents for Alzheimer's disease. Neurotherapeutics (2008) 1.04

Selective familiarity deficits in otherwise cognitively intact aging individuals with genetic risk for Alzheimer's disease. Alzheimers Dement (Amst) (2015) 1.03

Selected findings from the Religious Orders Study and Rush Memory and Aging Project. J Alzheimers Dis (2013) 1.03

Bi-level multi-source learning for heterogeneous block-wise missing data. Neuroimage (2013) 1.02

Amyloid PET in clinical practice: Its place in the multidimensional space of Alzheimer's disease. Neuroimage Clin (2013) 1.02

Locally linear embedding (LLE) for MRI based Alzheimer's disease classification. Neuroimage (2013) 1.02

Creating a transatlantic research enterprise for preventing Alzheimer's disease. Alzheimers Dement (2009) 1.02

Allosteric activators of muscarinic receptors as novel approaches for treatment of CNS disorders. Mol Biosyst (2010) 1.01

Alzheimer's disease and anesthesia. Front Neurosci (2011) 1.00

Multi-region analysis of longitudinal FDG-PET for the classification of Alzheimer's disease. Neuroimage (2012) 1.00

Imaging of glutamate neurotransmitter alterations in Alzheimer's disease. NMR Biomed (2012) 1.00

Beyond mild cognitive impairment: vascular cognitive impairment, no dementia (VCIND). Alzheimers Res Ther (2009) 1.00

One-carbon metabolism and Alzheimer's disease: focus on epigenetics. Curr Genomics (2010) 0.99

Clinical features and multidisciplinary approaches to dementia care. J Multidiscip Healthc (2011) 0.99

Physical activity improves verbal and spatial memory in older adults with probable mild cognitive impairment: a 6-month randomized controlled trial. J Aging Res (2013) 0.99

Mortality and morbidity in laboratory-maintained Rhesus monkeys and effects of long-term dietary restriction. J Gerontol A Biol Sci Med Sci (2003) 3.77

Voriconazole treatment for less-common, emerging, or refractory fungal infections. Clin Infect Dis (2003) 3.70

MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes. Cancer Res (2009) 3.57

Amyloid-related imaging abnormalities in patients with Alzheimer's disease treated with bapineuzumab: a retrospective analysis. Lancet Neurol (2012) 2.75

New physician-investigators receiving National Institutes of Health research project grants: a historical perspective on the "endangered species". JAMA (2007) 2.59

Global health development assistance remained steady in 2013 but did not align with recipients' disease burden. Health Aff (Millwood) (2014) 2.26

Mild cognitive impairment: disparity of incidence and prevalence estimates. Alzheimers Dement (2012) 2.00

Hip fracture risk and subsequent mortality among Alzheimer's disease patients in the United Kingdom, 1988-2007. Age Ageing (2010) 1.93

Worldwide variation in the doubling time of Alzheimer's disease incidence rates. Alzheimers Dement (2008) 1.89

Adverse events associated with common therapy regimens for moderate-to-severe Crohn's disease. Am J Gastroenterol (2009) 1.86

Nutrient reference values for bioactives: new approaches needed? A conference report. Eur J Nutr (2013) 1.76

Association of mannose-binding lectin deficiency with acute invasive aspergillosis in immunocompromised patients. Clin Infect Dis (2009) 1.55

PTEN has tumor-promoting properties in the setting of gain-of-function p53 mutations. Cancer Res (2008) 1.52

Mu-opioid receptor desensitization in mature rat neurons: lack of interaction between DAMGO and morphine. J Neurosci (2003) 1.51

Prevalence of apolipoprotein E4 genotype and homozygotes (APOE e4/4) among patients diagnosed with Alzheimer's disease: a systematic review and meta-analysis. Neuroepidemiology (2011) 1.48

Loss of the DNA methyltransferase MET1 Induces H3K9 hypermethylation at PcG target genes and redistribution of H3K27 trimethylation to transposons in Arabidopsis thaliana. PLoS Genet (2012) 1.48

Activities of voriconazole, itraconazole and amphotericin B in vitro against 590 moulds from 323 patients in the voriconazole Phase III clinical studies. J Antimicrob Chemother (2008) 1.43

Graft-versus-host disease: a complex long-term side effect of hematopoietic stem cell transplant. Oncology (Williston Park) (2008) 1.42

Modeling the optimum duration of antibiotic prophylaxis in an anthrax outbreak. Proc Natl Acad Sci U S A (2003) 1.41

Modelling the incubation period of anthrax. Stat Med (2005) 1.22

Disparities in osteoporosis screening between at-risk African-American and white women. J Gen Intern Med (2005) 1.16

A consensus on fungal polymerase chain reaction diagnosis?: a United Kingdom-Ireland evaluation of polymerase chain reaction methods for detection of systemic fungal infections. J Mol Diagn (2006) 1.16

Association of amphetamine-induced striatal dopamine release and cortisol responses to psychological stress. Neuropsychopharmacology (2007) 1.16

Apolipoprotein E ε4 prevalence in Alzheimer's disease patients varies across global populations: a systematic literature review and meta-analysis. Dement Geriatr Cogn Disord (2010) 1.15

Oral versus intravenous flucytosine in patients with human immunodeficiency virus-associated cryptococcal meningitis. Antimicrob Agents Chemother (2006) 1.13

Fluoroquinolone-resistant Campylobacter isolates from conventional and antibiotic-free chicken products. Environ Health Perspect (2005) 1.11

Public health vaccination policies for containing an anthrax outbreak. Nature (2004) 1.09

Age-related changes in the expression of schizophrenia susceptibility genes in the human prefrontal cortex. Brain Struct Funct (2008) 1.06

Low effective dispersal of asexual genotypes in heterogeneous landscapes by the endemic pathogen Penicillium marneffei. PLoS Pathog (2005) 1.05

Colinearity of reverse transcriptase inhibitor resistance mutations detected by population-based sequencing. J Acquir Immune Defic Syndr (2003) 1.04

Healthy lifestyles related to subsequent prevalence of age-related macular degeneration. Arch Ophthalmol (2010) 1.02

Whites have a more robust hypothalamic-pituitary-adrenal axis response to a psychological stressor than blacks. Psychoneuroendocrinology (2007) 1.00

Understanding hospital readiness for computerized physician order entry. Jt Comm J Qual Saf (2003) 1.00

Interactions between PTEN and the c-Met pathway in glioblastoma and implications for therapy. Mol Cancer Ther (2009) 0.99

Burden of Alzheimer's disease and association with negative health outcomes. Am J Manag Care (2009) 0.99

Patient preferences for eye drop characteristics: a willingness-to-pay analysis. Arch Ophthalmol (2003) 0.98

Predicted postoperative lung function is associated with all-cause long-term mortality after major lung resection for cancer. Eur J Cardiothorac Surg (2013) 0.98

Web-based application to project the burden of Alzheimer's disease. Alzheimers Dement (2010) 0.97

A home-based nutrition intervention to increase consumption of fruits, vegetables, and calcium-rich foods in community dwelling elders. J Am Diet Assoc (2002) 0.95

Posaconazole therapy of disseminated phaeohyphomycosis in a murine model. Antimicrob Agents Chemother (2004) 0.95

BRCA1/2 testing in hereditary breast and ovarian cancer families: effectiveness of problem-solving training as a counseling intervention. Am J Med Genet A (2004) 0.92

Phenotypic identification of Candida albicans by growth on chocolate agar. Med Mycol (2005) 0.91

Local allocation of lung donors results in transplanting lungs in lower priority transplant recipients. Ann Thorac Surg (2013) 0.90

Remission and survival following monthly intraarterial cisplatinum in nonresectable hepatoma. Cancer Invest (2002) 0.90

Difficulties in the use of risk factors to screen for gestational diabetes mellitus. Diabetes Care (2009) 0.90

Rate of conversion from prodromal Alzheimer's disease to Alzheimer's dementia: a systematic review of the literature. Dement Geriatr Cogn Dis Extra (2013) 0.90

Comparison of chest radiograph scoring to lung weight as a quantitative index of pulmonary edema in organ donors. Clin Transplant (2012) 0.89

Pilot study of antibiotic cycling in a pediatric intensive care unit. Crit Care Med (2002) 0.89

Evaluation of Dynabeads and Cytospheres compared with flow cytometry to enumerate CD4+ T cells in HIV-infected Ugandans on antiretroviral therapy. J Acquir Immune Defic Syndr (2008) 0.88

Association of body mass index and outcomes after major lung resection. Eur J Cardiothorac Surg (2014) 0.87

Antipsychotic treatment patterns and hospitalizations among adults with schizophrenia. Schizophr Res (2008) 0.86

Why do children become vitamin A deficient? J Nutr (2002) 0.86

External quality assessment program for Chlamydia trachomatis diagnostic testing by nucleic acid amplification assays. J Clin Microbiol (2002) 0.86

Schizophyllum commune associated with bronchogenous cyst. Mycoses (2006) 0.84

Effects of varying post-warm-up recovery time on 200-m time-trial swim performance. Int J Sports Physiol Perform (2007) 0.84

Cooperation between c-Met and focal adhesion kinase family members in medulloblastoma and implications for therapy. Mol Cancer Ther (2011) 0.84

BRCA1/2 testing in hereditary breast and ovarian cancer families II: impact on relationships. Am J Med Genet A (2005) 0.84

A randomized trial of an intervention to increase fruit and vegetable intake in curatively treated patients with early-stage head and neck cancer. Cancer Epidemiol Biomarkers Prev (2005) 0.83

Seeing the destination but not the path: Effects of socioeconomic disadvantage on school-focused possible self content and linked behavioral strategies. Self Identity (2011) 0.82

Sternal wound infection by Trichosporon inkin following cardiac surgery. J Clin Microbiol (2006) 0.81

The single nucleotide polymorphism g.1548A >G (K469E) of the ICAM-1 gene is associated with worse prognosis in non-small cell lung cancer. Tumour Biol (2012) 0.81

CREB1/ATF1 activation in photoreceptor degeneration and protection. Invest Ophthalmol Vis Sci (2009) 0.81

Perioperative nurses and patient outcomes--mortality, complications, and length of stay. AORN J (2005) 0.81

How yellow is your banana? Toddlers' language-mediated visual search in referent-present tasks. Dev Psychol (2012) 0.80

Five-year retrospective review of guideline-based management of fungal endophthalmitis. Acta Ophthalmol (2008) 0.80

Comparison of Two Brief Parent-Training Interventions for Child Distress During Parent-Administered Needle Procedures. Child Health Care (2009) 0.80

Modeling the effect of Alzheimer's disease on mortality. Int J Biostat (2007) 0.79

Risk factors for brachial plexus injury with and without shoulder dystocia. Am J Obstet Gynecol (2006) 0.79

Separating the Laparoscopic Camera Cord From the Monopolar "Bovie" Cord Reduces Unintended Thermal Injury From Antenna Coupling: A Randomized Controlled Trial. Ann Surg (2015) 0.79

Understanding the relative importance of preserving functional abilities in Alzheimer's disease in the United States and Germany. Qual Life Res (2014) 0.78

Advancing donor management research: design and implementation of a large, randomized, placebo-controlled trial. Ann Intensive Care (2011) 0.78

Gestational diabetes mellitus: time for consensus on screening and diagnosis. N Z Med J (2006) 0.77

An antibody panel for immunohistochemical analysis of the retina in Davidson's-fixed, paraffin-embedded eyes of rats. Exp Toxicol Pathol (2008) 0.77

Perioperative nurses and patient outcomes: mortality, complications, and length of stay. J Nurs Adm (2010) 0.77

Older Americans' risk-benefit preferences for modifying the course of Alzheimer disease. Alzheimer Dis Assoc Disord (2009) 0.76

Preferences for eye drop characteristics among glaucoma specialists: a willingness-to-pay analysis. J Glaucoma (2005) 0.76

Chart documentation by general physicians of the glaucoma medications taken by their patients. Am J Ophthalmol (2005) 0.76

How to treat persistent vaginal yeast infection due to species other than Candida albicans. Sex Transm Infect (2012) 0.76

Necessity of routine pelvic radiograph in the pediatric blunt trauma patient. Clin Pediatr (Phila) (2008) 0.75

Comments on "Development of the rehabilitation patient experiences questionnaire". J Rehabil Med (2009) 0.75

Science choreography: a movement-based approach to biology teaching. CBE Life Sci Educ (2013) 0.75

Bronchioloalveolar carcinoma: myths and realities in the surgical management. Eur J Cardiothorac Surg (2004) 0.75

Managing diabetes in pregnancy. Interview by Anne Manchester. Nurs N Z (2007) 0.75

Lessons learned from the implementation of a bedside handoff model. J Nurs Adm (2013) 0.75

Burden of Alzheimer's disease: population-based estimates and projections for New Zealand, 2006-2031. Aust N Z J Psychiatry (2008) 0.75

The ADIPS pilot National Diabetes in Pregnancy Audit Project. Aust N Z J Obstet Gynaecol (2007) 0.75

The association between adolescents' beliefs in a just world and their attitudes to victims of bullying. Br J Educ Psychol (2009) 0.75

Clinical profile of the overweight child in the new millennium. Clin Pediatr (Phila) (2008) 0.75

A digital toolkit to implement and manage a multisite study. J Nurs Educ (2012) 0.75

The descent curve of the grand multiparous woman. Am J Obstet Gynecol (2003) 0.75