Molecular mechanisms of 4-hydroxy-2-nonenal and acrolein toxicity: nucleophilic targets and adduct formation.

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Published in Chem Res Toxicol on September 01, 2009

Authors

Richard M LoPachin1, Terrence Gavin, Dennis R Petersen, David S Barber

Author Affiliations

1: Department of Anesthesiology, Albert Einstein College of Medicine, Montefiore Medical Center, 111 East 210th Street, Bronx, New York 10467, USA. lopachin@aecom.yu.edu

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Organochlorine pesticides dieldrin and lindane induce cooperative toxicity in dopaminergic neurons: role of oxidative stress. Neurotoxicology (2009) 0.87

Ethanol metabolism modifies hepatic protein acylation in mice. PLoS One (2013) 0.87

Gene expression networks underlying ovarian development in wild largemouth bass (Micropterus salmoides). PLoS One (2013) 0.86

Proteomic analysis of rat microglia establishes a high-confidence reference data set of over 3000 proteins. Proteomics (2011) 0.85

Profiling impaired hepatic endoplasmic reticulum glycosylation as a consequence of ethanol ingestion. J Proteome Res (2011) 0.85

β-dicarbonyl enolates: a new class of neuroprotectants. J Neurochem (2010) 0.85

Gene expression analysis in the thalamus and cerebrum of horses experimentally infected with West Nile virus. PLoS One (2011) 0.85

Characterization of multidrug resistance-associated protein 2 in the hepatocellular disposition of 4-hydroxynonenal. Arch Biochem Biophys (2003) 0.84

Understanding the tumor suppressor PTEN in chronic alcoholism and hepatocellular carcinoma. Adv Exp Med Biol (2015) 0.84

Increased dietary fat contributes to dysregulation of the LKB1/AMPK pathway and increased damage in a mouse model of early-stage ethanol-mediated steatosis. J Nutr Biochem (2013) 0.84

Protective properties of 2-acetylcyclopentanone in a mouse model of acetaminophen hepatotoxicity. J Pharmacol Exp Ther (2013) 0.83

Inhibition of hydrogen peroxide signaling by 4-hydroxynonenal due to differential regulation of Akt1 and Akt2 contributes to decreases in cell survival and proliferation in hepatocellular carcinoma cells. Free Radic Biol Med (2012) 0.83

Aldose reductase catalyzes reduction of the lipid peroxidation product 4-oxonon-2-enal. Chem Res Toxicol (2003) 0.83

Involvement of phosphatidylinositol 3-kinase and extracellular-regulated kinase in hepatic stellate cell antioxidant response and myofibroblastic transdifferentiation. Arch Biochem Biophys (2006) 0.82

Environmentally relevant exposure to 17alpha-ethinylestradiol affects the telencephalic proteome of male fathead minnows. Aquat Toxicol (2010) 0.82

GSTA is a major glutathione S-transferase gene responsible for 4-hydroxynonenal conjugation in largemouth bass liver. Mar Environ Res (2004) 0.81

Effects of 17β-trenbolone on Eastern and Western mosquitofish (Gambusia holbrooki and G. affinis) anal fin growth and gene expression patterns. Aquat Toxicol (2012) 0.81

Role of the Nrf2-ARE pathway in acrylamide neurotoxicity. Toxicol Lett (2011) 0.81

Involvement of the electrophile responsive element and p53 in the activation of hepatic stellate cells as a response to electrophile menadione. Arch Biochem Biophys (2003) 0.81

Influence of Suwannee River humic acid on particle properties and toxicity of silver nanoparticles. Chemosphere (2012) 0.80

Cloning and expression of the translocator protein (18 kDa), voltage-dependent anion channel, and diazepam binding inhibitor in the gonad of largemouth bass (Micropterus salmoides) across the reproductive cycle. Gen Comp Endocrinol (2011) 0.80

Investigation of acute nanoparticulate aluminum toxicity in zebrafish. Environ Toxicol (2010) 0.80

4-HNE adduct stability characterized by collision-induced dissociation and electron transfer dissociation mass spectrometry. Chem Res Toxicol (2012) 0.80

Stable isotope labeling with amino acids in cell culture-based proteomic analysis of ethanol-induced protein expression profiles in microglia. Methods Mol Biol (2012) 0.80

Protein targets of acrylamide adduct formation in cultured rat dopaminergic cells. Toxicol Lett (2013) 0.79