Published in Bioorg Med Chem Lett on July 18, 2009
Synthesis of novel analogs of cabergoline: improving cardiovascular safety by removing 5-HT2B receptor agonism. ACS Med Chem Lett (2013) 0.83
A meta-analysis of cytokines in Alzheimer's disease. Biol Psychiatry (2010) 2.06
A role for beta-cell-expressed G protein-coupled receptor 119 in glycemic control by enhancing glucose-dependent insulin release. Endocrinology (2007) 1.91
Nondietary ingestion of pesticides by children in an agricultural community on the US/Mexico border: preliminary results. J Expo Anal Environ Epidemiol (2003) 1.84
Niacin lipid efficacy is independent of both the niacin receptor GPR109A and free fatty acid suppression. Sci Transl Med (2012) 1.71
Lysophosphatidic acid induces hypertrophy of neonatal cardiac myocytes via activation of Gi and Rho. J Mol Cell Cardiol (2004) 1.71
Galphaq expression activates EGFR and induces Akt mediated cardiomyocyte survival: dissociation from Galphaq mediated hypertrophy. J Mol Cell Cardiol (2006) 1.57
Langerhans cells release prostaglandin D2 in response to nicotinic acid. J Invest Dermatol (2006) 1.49
Comparison of techniques for corneal power assessment after myopic LASIK without the use of preoperative data. J Refract Surg (2008) 1.40
Discovery and structure-activity relationship of (1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine (Lorcaserin), a selective serotonin 5-HT2C receptor agonist for the treatment of obesity. J Med Chem (2007) 1.27
GPR119 agonists for the treatment of type 2 diabetes. Expert Opin Ther Pat (2009) 1.17
Nicotinic acid receptor agonists differentially activate downstream effectors. J Biol Chem (2007) 1.16
Discovery of the first potent and orally efficacious agonist of the orphan G-protein coupled receptor 119. J Med Chem (2008) 1.16
International Union of Basic and Clinical Pharmacology. LXXXII: Nomenclature and Classification of Hydroxy-carboxylic Acid Receptors (GPR81, GPR109A, and GPR109B). Pharmacol Rev (2011) 1.11
Akt-mediated cardiomyocyte survival pathways are compromised by G alpha q-induced phosphoinositide 4,5-bisphosphate depletion. J Biol Chem (2003) 1.05
Anxiolytic- and antidepressant-like profile of ATC0065 and ATC0175: nonpeptidic and orally active melanin-concentrating hormone receptor 1 antagonists. J Pharmacol Exp Ther (2005) 1.01
Ca2+ dysregulation induces mitochondrial depolarization and apoptosis: role of Na+/Ca2+ exchanger and AKT. J Biol Chem (2005) 1.00
1-Alkyl-benzotriazole-5-carboxylic acids are highly selective agonists of the human orphan G-protein-coupled receptor GPR109b. J Med Chem (2006) 0.99
Children's working memory: investigating performance limitations in complex span tasks. J Exp Child Psychol (2005) 0.99
Agonist lead identification for the high affinity niacin receptor GPR109a. Bioorg Med Chem Lett (2007) 0.97
A new family of H3 receptor antagonists based on the natural product Conessine. Bioorg Med Chem Lett (2007) 0.96
Miniature inverted-repeat transposable elements: discovery, distribution, and activity. Genome (2013) 0.96
Effects of a niacin receptor partial agonist, MK-0354, on plasma free fatty acids, lipids, and cutaneous flushing in humans. J Clin Lipidol (2008) 0.94
Utilization of the least shrew as a rapid and selective screening model for the antiemetic potential and brain penetration of substance P and NK1 receptor antagonists. Brain Res (2008) 0.93
Dynamic regulation of the endocannabinoid system: implications for analgesia. Mol Pain (2009) 0.93
Spurious hyperphosphatemia in patients on hemodialysis with catheters. Am J Kidney Dis (2008) 0.92
A re-evaluation of the neurotransmitter basis of chemotherapy-induced immediate and delayed vomiting: evidence from the least shrew. Brain Res (2008) 0.92
The contribution of the endogenous TRPV1 ligands 9-HODE and 13-HODE to nociceptive processing and their role in peripheral inflammatory pain mechanisms. Br J Pharmacol (2013) 0.89
Pigment-dispersing factor modulates pheromone production in clock cells that influence mating in drosophila. Neuron (2013) 0.89
5-HT(2A) inverse-agonists for the treatment of insomnia. Curr Top Med Chem (2008) 0.89
Fused tricyclic indoles as S1P₁ agonists with robust efficacy in animal models of autoimmune disease. Bioorg Med Chem Lett (2012) 0.87
Context-dependent role of ATG4B as target for autophagy inhibition in prostate cancer therapy. Biochem Biophys Res Commun (2013) 0.87
Potent tricyclic pyrazole tetrazole agonists of the nicotinic acid receptor (GPR109a). Bioorg Med Chem Lett (2010) 0.86
Comparison of rat and dog models of vasodilatation and lipolysis for the calculation of a therapeutic index for GPR109A agonists. J Pharmacol Toxicol Methods (2007) 0.86
G protein-coupled receptors as therapeutic targets for obesity and type 2 diabetes. Curr Opin Investig Drugs (2004) 0.86
The bioceramic implant: evaluation of implant exposures in 419 implants. Ophthal Plast Reconstr Surg (2010) 0.84
Discovery of fused bicyclic agonists of the orphan G-protein coupled receptor GPR119 with in vivo activity in rodent models of glucose control. Bioorg Med Chem Lett (2011) 0.84
Inhibition of Mas G-protein signaling improves coronary blood flow, reduces myocardial infarct size, and provides long-term cardioprotection. Am J Physiol Heart Circ Physiol (2011) 0.83
APD791, 3-methoxy-n-(3-(1-methyl-1h-pyrazol-5-yl)-4-(2-morpholinoethoxy)phenyl)benzamide, a novel 5-hydroxytryptamine 2A receptor antagonist: pharmacological profile, pharmacokinetics, platelet activity and vascular biology. J Pharmacol Exp Ther (2009) 0.83
Stimulus similarity decrements in children's working memory span. Q J Exp Psychol A (2005) 0.82
Nicotinic acid receptor agonists. J Med Chem (2008) 0.82
Bigram frequency, number of syllables and morphemes and their effects on lexical decision and word naming. J Psycholinguist Res (2014) 0.82
Receptor mechanism and antiemetic activity of structurally-diverse cannabinoids against radiation-induced emesis in the least shrew. Eur J Pharmacol (2007) 0.82
Validation of a one-page patient-reported Charlson comorbidity index questionnaire for upper aerodigestive tract cancer patients. Oral Oncol (2013) 0.82
3-Nitro-4-amino benzoic acids and 6-amino nicotinic acids are highly selective agonists of GPR109b. Bioorg Med Chem Lett (2007) 0.81
Does the degree of preoperative subluxation or soft tissue tension affect the incidence of postoperative luxation in dogs after total hip replacement? Vet Surg (2010) 0.81
ATon, abundant novel nonautonomous mobile genetic elements in yellow fever mosquito (Aedes aegypti). BMC Genomics (2012) 0.81
Obatoclax mesylate, a pan-bcl-2 inhibitor, in combination with docetaxel in a phase 1/2 trial in relapsed non-small-cell lung cancer. J Thorac Oncol (2014) 0.81
Design and evaluation of novel biphenyl sulfonamide derivatives with potent histamine H(3) receptor inverse agonist activity. J Med Chem (2009) 0.81
Preclinical analysis of resistance and cross-resistance to low-dose metronomic chemotherapy. Invest New Drugs (2013) 0.80
Migration over the life course in XIXth century Netherlands and the American north: a comparative analysis based on genealogies and population registers. Ann Demogr Hist (Paris) (2002) 0.80
Synthesis and SAR of N-benzoyl-L-biphenylalanine derivatives: discovery of TR-14035, a dual alpha(4)beta(7)/alpha(4)beta(1) integrin antagonist. Bioorg Med Chem (2002) 0.80
Nelotanserin, a novel selective human 5-hydroxytryptamine2A inverse agonist for the treatment of insomnia. J Pharmacol Exp Ther (2009) 0.79
RNAi‑mediated knockdown of PRL‑3 inhibits cell invasion and downregulates ERK 1/2 expression in the human gastric cancer cell line, SGC‑7901. Mol Med Rep (2013) 0.79
Analogues of acifran: agonists of the high and low affinity niacin receptors, GPR109a and GPR109b. J Med Chem (2007) 0.79
Alpha-2 adrenergic receptors stimulate actin organization in developing fetal rat cardiac myocytes. Life Sci (2003) 0.79
Transcatheter closure of perimembranous ventricular septal defect with the Amplatzer(®) membranous VSD occluder 2: initial world experience and one-year follow-up. Catheter Cardiovasc Interv (2013) 0.79
Discovery of a second generation agonist of the orphan G-protein coupled receptor GPR119 with an improved profile. Bioorg Med Chem Lett (2011) 0.78
Antenatal identification of major depressive disorder: a cohort study. Am J Obstet Gynecol (2012) 0.78
Distribution and sources of polybrominated diphenyl ethers in the Southern California Bight. Environ Toxicol Chem (2012) 0.78
Recent progress in the discovery of niacin receptor agonists. Curr Opin Drug Discov Devel (2007) 0.78
Seasonal pesticide use in a rural community on the US/Mexico border. J Expo Anal Environ Epidemiol (2004) 0.78
Design, synthesis and in vitro evaluation of potent, novel, small molecule inhibitors of plasminogen activator inhibitor-1. Bioorg Med Chem Lett (2002) 0.78
Lead optimization of 4-(dimethylamino)quinazolines, potent and selective antagonists for the melanin-concentrating hormone receptor 1. Bioorg Med Chem Lett (2005) 0.78
Discovery of 1-[3-(4-bromo-2-methyl-2h-pyrazol-3-yl)-4-methoxyphenyl]-3-(2,4-difluorophenyl)urea (nelotanserin) and related 5-hydroxytryptamine2A inverse agonists for the treatment of insomnia. J Med Chem (2010) 0.77
Fluorinated pyrazole acids are agonists of the high affinity niacin receptor GPR109a. Bioorg Med Chem Lett (2007) 0.77
ATC0175: an orally active melanin-concentrating hormone receptor 1 antagonist for the potential treatment of depression and anxiety. CNS Drug Rev (2005) 0.77
Ablation of least shrew central neurokinin NK1 receptors reduces GR73632-induced vomiting. Behav Neurosci (2009) 0.77
In vivo passage of human prostate cancer cells in mice results in stable gene expression changes affecting numerous cancer-associated biological processes. Prostate (2014) 0.77
5-N,N-Disubstituted 5-aminopyrazole-3-carboxylic acids are highly potent agonists of GPR109b. Bioorg Med Chem Lett (2009) 0.77
(1aR,5aR)1a,3,5,5a-Tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic acid (MK-1903): a potent GPR109a agonist that lowers free fatty acids in humans. J Med Chem (2012) 0.77